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Infectious Diseases Volume 50, 2018 - Issue 4
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Original Article

Does more favourable handling of the cerebrospinal fluid increase the diagnostic sensitivity of Borrelia burgdorferi sensu lato-specific PCR in Lyme neuroborreliosis?

Kristine J. N. ForselvDepartment of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway; View further author information
,
Åslaug R. LorentzenDepartment of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway; ;The Norwegian National Advisory Unit on Tick-borne Diseases, Sørlandet Hospital Trust, Arendal, Norway; Correspondence[email protected]
View further author information
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Unn LjøstadDepartment of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway; ;Department of Clinical Medicine, University of Bergen, Bergen, Norway; View further author information
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Åse MyglandDepartment of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway; ;Department of Clinical Medicine, University of Bergen, Bergen, Norway; View further author information
,
Randi EikelandDepartment of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway; ;The Norwegian National Advisory Unit on Tick-borne Diseases, Sørlandet Hospital Trust, Arendal, Norway; View further author information
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Vivian KjellandDepartment of Engineering and Science, University of Agder, Kristiansand, Norway; ;Research Unit, Sørlandet Hospital Trust, Kristiansand, Norway; View further author information
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Sølvi NoraasDepartment of Medical Microbiology, Sørlandet Hospital Trust, Kristiansand, NorwayView further author information
&
Hanne QuarstenDepartment of Medical Microbiology, Sørlandet Hospital Trust, Kristiansand, NorwayView further author information
 show all
Pages 297-302 | Received 27 Jun 2017, Accepted 22 Oct 2017, Published online: 10 Nov 2017

References

  • Mygland A, Skarpaas T, Ljostad U. Chronic polyneuropathy and Lyme disease. Eur J Neurol. 2006;13:1213–1215.
  • Mygland A, Ljostad U, Fingerle V, et al. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol. 2010;17:8–16, e1-4.
  • Cerar T, Ogrinc K, Cimperman J, et al. Validation of cultivation and PCR methods for diagnosis of Lyme neuroborreliosis. J Clin Microbiol. 2008;46:3375–3379.
  • Gooskens J, Templeton KE, Claas EC, et al. Evaluation of an internally controlled real-time PCR targeting the ospA gene for detection of Borrelia burgdorferi sensu lato DNA in cerebrospinal fluid. Clin Microbiol Infect. 2006;12:894–900.
  • Alby K, Capraro GA. Alternatives to serologic testing for diagnosis of Lyme disease. Clin Lab Med. 2015;35:815–825.
  • Bossuyt PM, Reitsma JB, Bruns DE, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ. 2015;351:h5527.
  • Reiber H, Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem. 1991;37:1153–1160.
  • Quarsten H, Skarpaas T, Fajs L, et al. Tick-borne bacteria in Ixodes ricinus collected in southern Norway evaluated by a commercial kit and established real-time PCR protocols. Ticks Tick Borne Dis. 2015;6:538–544.
  • Aguero-Rosenfeld ME, Wang G, Schwartz I, et al. Diagnosis of lyme borreliosis. Clin Microbiol Rev. 2005;18:484–509.
  • Molloy PJ, Persing DH, Berardi VP. False-positive results of PCR testing for Lyme disease. Clin Infect Dis. 2001;33:412–413.

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