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Infectious Diseases Volume 51, 2019 - Issue 10
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Brief Report

Viral infections and immune reconstitution interaction after pediatric allogenic hematopoietic stem cell transplantation

Adam AlexanderssonDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland; ;Faculty of Medicine, University of Helsinki, Helsinki, Finland; ;New Children’s Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-5341-2891View further author information
ORCID Icon,
Minna KoskenvuoDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland; ;Faculty of Medicine, University of Helsinki, Helsinki, Finland; View further author information
,
Anette TidermanFaculty of Medicine, University of Helsinki, Helsinki, Finland; View further author information
,
Mitja LääperiNew Children’s Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland; View further author information
,
Pasi HuttunenDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland; ;Faculty of Medicine, University of Helsinki, Helsinki, Finland; View further author information
,
Ulla Saarinen-PihkalaDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland; View further author information
,
Veli-Jukka AnttilaFaculty of Medicine, University of Helsinki, Helsinki, Finland; ;Inflammation Center, Helsinki University Hospital, Helsinki, Finland; View further author information
,
Irmeli LautenschlagerFaculty of Medicine, University of Helsinki, Helsinki, Finland; ;Department of Virology and Immunology, Helsinki University Hospital, Helsinki, FinlandView further author information
&
Mervi TaskinenDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland; ;Faculty of Medicine, University of Helsinki, Helsinki, Finland; View further author information
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Pages 772-778 | Received 20 Jul 2019, Accepted 25 Jul 2019, Published online: 05 Aug 2019

References

  • Mateos MK, O’Brien TA, Oswald C, et al. Transplant-related mortality following allogeneic hematopoeitic stem cell transplantation for pediatric acute lymphoblastic leukemia: 25-year retrospective review. Pediatr Blood Cancer. 2013;60:1520–1527.
  • Mohty B, Mohty M. Long-term complications and side effects after allogeneic hematopoietic stem cell transplantation: an update. Blood Cancer J. 2011;1:e16.
  • Leung W, Ahn H, Rose SR, et al. A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Medicine (Baltimore). 2007;86:215–224.
  • Koskenvuo M, Rahiala J, Sadeghi M, et al. Viremic co-infections in children with allogeneic haematopoietic stem cell transplantation are predominated by human polyomaviruses. Infect Dis. 2017;49:35–41.
  • Ljungman P, Hakki M, Boeckh M. Cytomegalovirus in hematopoietic stem cell transplant recipients. Infect Dis Clin North Am. 2010;24:319–337.
  • Talano JM, Pulsipher MA, Symons HJ, et al. New frontiers in pediatric Allo-SCT. Bone Marrow Transplant. 2014;49:1139–1145.
  • van den Brink MR, Velardi E, Perales MA. Immune reconstitution following stem cell transplantation. Hematology Am Soc Hematol Educ Prog. 2015;2015:215–219.
  • Reddehase MJ. Mutual interference between cytomegalovirus and reconstitution of protective immunity after hematopoietic cell transplantation. Front Immunol. 2016;7:294.
  • Illiaquer M, Imbert-Marcille BM, Guillaume T, et al. Impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults. J Clin Virol. 2017;93:30–36.
  • Huttunen P, Taskinen M, Siitonen S, et al. Impact of very early CD4(+)/CD8(+) T cell counts on the occurrence of acute graft-versus-host disease and NK cell counts on outcome after pediatric allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2015;62:522–528.
  • de Koning C, Plantinga M, Besseling P, et al. Immune reconstitution after allogeneic hematopoietic cell transplantation in children. Biol Blood Marrow Transplant. 2016;22:195–206.
  • Cesaro S, Tridello G, Pillon M, et al. A prospective study on the predictive value of plasma BK Virus-DNA load for hemorrhagic cystitis in pediatric patients after stem cell transplantation. J Pediatric Infect Dis Soc. 2015;4:134–142.
  • Laskin BL, Denburg M, Furth S, et al. BK viremia precedes hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:1175–1182.
  • Hirsch HH, Vincenti F, Friman S, et al. Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. Am J Transplant. 2013;13:136–145.
  • Verdeguer A, de Heredia CD, Gonzalez M, et al. Observational prospective study of viral infections in children undergoing allogeneic hematopoietic cell transplantation: a 3-year GETMON experience. Bone Marrow Transplant. 2011;46:119–124.
  • Zawilinska B, Szostek S, Kopec J, et al. Multiplex real-time PCR to identify a possible reinfection with different strains of human cytomegalovirus in allogeneic hematopoietic stem cell transplant recipients. Acta Biochim Pol. 2016;63:161–166.
  • Hiwarkar P, Gaspar HB, Gilmour K, et al. Impact of viral reactivations in the era of pre-emptive antiviral drug therapy following allogeneic haematopoietic SCT in paediatric recipients. Bone Marrow Transplant. 2013;48:803–808.
  • Bartelink IH, Belitser SV, Knibbe CA, et al. Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children. Biol Blood Marrow Transplant. 2013;19:305–313.
  • Koskenvuo M. The interaction between viral infections and immunosuppressed hosts is a challenging battle. Pediatr Transplant. 2017;21:e12811.

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