264
Views
14
CrossRef citations to date
0
Altmetric
Review Article

Head-to-head comparison of the diagnostic accuracy of Xpert MTB/RIF and Xpert MTB/RIF Ultra for tuberculosis: a meta-analysis

, , , , , , & show all
Pages 763-775 | Received 23 Dec 2019, Accepted 22 Jun 2020, Published online: 03 Jul 2020

References

  • WHO. Global Tuberculosis Report 2019. [cited 2020 Jun 30]. Available from: https://www.who.int/tb/publications/global_report/en/. 2019.
  • Boehme CC, Nabeta P, Hillemann D, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med. 2010;363(11):1005–1015.
  • WHO. World Health Organization model list of essential in vitro diagnostics. WHO; 2018. Available from: https://www.who.int/medical_devices/diagnostics/selection_in-vitro/en/
  • Andrews JR, Lawn SD, Rusu C, et al. The cost-effectiveness of routine tuberculosis screening with Xpert MTB/RIF prior to initiation of antiretroviral therapy: a model-based analysis. AIDS. 2012;26(8):987–995.
  • Abimbola TO, Marston BJ, Date AA, et al. Cost-effectiveness of tuberculosis diagnostic strategies to reduce early mortality among persons with advanced HIV infection initiating antiretroviral therapy. J Acquir Immune Defic Syndr. 2012;60(1):e1–E7.
  • Nicol MP, Workman L, Isaacs W, et al. Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. Lancet Infect Dis. 2011;11(11):819–824.
  • Sohn H, Aero AD, Menzies D, et al. Xpert MTB/RIF testing in a low tuberculosis incidence, high-resource setting: limitations in accuracy and clinical impact. Clin Infect Dis. 2014;58(7):970–976.
  • Theron G, Peter J, van Zyl-Smit R, et al. Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. Am J Respir Crit Care Med. 2011;184(1):132–140.
  • MacLean E, Sulis G, Denkinger CM, et al. Diagnostic accuracy of Stool Xpert MTB/RIF for detection of pulmonary tuberculosis in children: a systematic review and meta-analysis. J Clin Microbiol. 2019;57(6):e0205718.
  • Chakravorty S, Simmons AM, Rowneki M, et al. The new Xpert MTB/RIF Ultra: improving detection of Mycobacterium tuberculosis and resistance to rifampin in an assay suitable for point-of-care testing. Mbio. 2017;8(4):e0081217.
  • Whiting PF, Rutjes AWS, Westwood ME, QUADAS-2 Group, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529–536.
  • Reitsma JB, Glas AS, Rutjes AWS, et al. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol. 2005;58(10):982–990.
  • Moses LE, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med. 1993;12(14):1293–1316.
  • Higgins JPT, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–560.
  • Bahr NC, Nuwagira E, Evans EE, ASTRO-CM Trial Team, et al. Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study. Lancet Infect Dis. 2018;18(1):68–75.
  • Nicol MP, Workman L, Prins M, et al. Accuracy of Xpert Mtb/Rif ultra for the diagnosis of pulmonary tuberculosis in children. Pediatr Infect Dis J. 2018;37(10):E261–E263.
  • Berhanu RH, David A, da Silva P, et al. Performance of Xpert MTB/RIF, Xpert Ultra, and Abbott RealTime MTB for diagnosis of pulmonary tuberculosis in a high-HIV-burden setting. J Clin Microbiol. 2018;56(12):e00560.
  • Dorman SE, Schumacher SG, Alland D, study team, et al. Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis. 2018;18(1):76–84.
  • Sabi I, Rachow A, Mapamba D, et al. Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study. J Infect. 2018;77(4):321–327.
  • Wang G, Wang S, Jiang G, et al. Xpert MTB/RIF Ultra improved the diagnosis of paucibacillary tuberculosis: a prospective cohort study. J Infect. 2019;78(4):311–316.
  • Wu X, Tan G, Gao R, et al. Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis. Int J Infect Dis. 2019;81:91–96.
  • Sun Q, Wang S, Dong W, et al. Diagnostic value of Xpert MTB/RIF Ultra for osteoarticular tuberculosis. J Infect. 2019;79(2):153–158.
  • Meldau R, Randall P, Pooran A, et al. Same-day tools, including Xpert Ultra and IRISA-TB, for rapid diagnosis of pleural tuberculosis: a prospective observational study. J Clin Microbiol. 2019;57(9):e0061419.
  • Wang G, Wang S, Yang X, et al. Accuracy of Xpert MTB/RIF ultra for the diagnosis of pleural TB in a multicenter cohort study. Chest. 2020;157(2):268–275.
  • Barcellini L, Borroni E, Cimaglia C, members of the E-Detect TB Consortium, et al. App-based symptoms screening with Xpert MTB/RIF Ultra assay used for active tuberculosis detection in migrants at point of arrivals in Italy: The E-DETECT TB intervention analysis. Plos One. 2019;14(7):e0218039.
  • Opota O, Zakham F, Mazza-Stalder J, et al. Added value of Xpert MTB/RIF ultra for diagnosis of pulmonary tuberculosis in a low-prevalence setting. J Clin Microbiol. 2018;57(2):e0171718.
  • Kolia-Diafouka P, Carrere-Kremer S, Lounnas M, et al. Detection of Mycobacterium tuberculosis in paucibacillary sputum: performances of the Xpert MTB/RIF ultra compared to the Xpert MTB/RIF, and IS6110 PCR. Diagn Microbiol Infect Dis. 2019; 94(4):365–370.
  • Piersimoni C, Gherardi G, Gracciotti N, et al. Comparative evaluation of Xpert MTB/RIF and the new Xpert MTB/RIF ultra with respiratory and extra-pulmonary specimens for tuberculosis case detection in a low incidence setting. J Clin Tuberc Other Mycobact Dis. 2019;15:100094.
  • Sun L, Qi X, Liu F, et al. A test for more accurate diagnosis of pulmonary tuberculosis. Pediatrics. 2019; 144(5):e20190262.
  • Turner CT, Gupta RK, Tsaliki E, et al. Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study. Lancet Respir Med. 2020; 8(4):407–419.
  • Pereira GR, Barbosa MS, Dutra Dias NJ, et al. Evaluation of Xpert MTB/RIF Ultra performance for pulmonary tuberculosis (TB) diagnosis in a city with high TB incidence in Brazil. Respir Med. 2020;162:105876.
  • Mishra H, Reeve BWP, Palmer Z, et al. Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study. Lancet Respir Med. 2020;8(4):368–382.
  • Whiteley R. Screening and likelihood ratio infographic. Br J Sports Med. 2016;50(14):837–838.
  • Mengoli C, Cruciani M, Barnes RA, et al. Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis. Lancet Infect Dis. 2009;9(2):89–96.
  • Arend SM, van Soolingen D. Performance of Xpert MTB/RIF Ultra: a matter of dead or alive. Lancet Infect Dis. 2018;18(1):8–10.
  • Theron G, Venter R, Smith L, et al. False-positive Xpert MTB/RIF results in retested patients with previous tuberculosis: frequency, profile, and prospective clinical outcomes. J Clin Microbiol. 2018;56(3):e0169617.
  • Horne DJ, Kohli M, Zifodya JS, et al. Xpert MTB/RIF and Xpert MTB/RIF ultra for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2019;6:CD009593.
  • Kohli M, Schiller I, Dendukuri N, et al. Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance. Cochrane Database Syst Rev. 2018;8:CD012768.
  • Light RW. Update on tuberculous pleural effusion. Respirology. 2010;15(3):451–458.
  • Rock RB, Olin M, Baker CA, et al. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev. 2008;21(2):243–261.
  • Graham SM, Sismanidis C, Menzies HJ, et al. Importance of tuberculosis control to address child survival. Lancet. 2014;383(9928):1605–1607.
  • Tebruegge M, Connell T, Curtis N. Tuberculosis in children. N Engl J Med. 2012;367(16):1568.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.