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Original Articles

Lower antibiotic prescription rates in hospitalized COVID-19 patients than influenza patients, a prospective study

ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 79-89 | Received 21 May 2021, Accepted 26 Aug 2021, Published online: 16 Sep 2021

References

  • Holmes AH, Moore LS, Sundsfjord A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2016;387(10014):176–187.
  • Fridkin S, Baggs J, Fagan R, Centers for Disease Control and Prevention (CDC), et al. Vital signs: improving antibiotic use among hospitalized patients. MMWR Morb Mortal Wkly Rep. 2014;63(9):194–200.
  • Holter JC, Muller F, Bjorang O, et al. Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway. BMC Infect Dis. 2015;15(1):64.
  • Clark TW, Medina M-J, Batham S, et al. Adults hospitalised with acute respiratory illness rarely have detectable bacteria in the absence of COPD or pneumonia; viral infection predominates in a large prospective UK sample. J Infect. 2014;69(5):507–515.
  • Falsey AR, Becker KL, Swinburne AJ, et al. Bacterial complications of respiratory tract viral illness: a comprehensive evaluation. J Infect Dis. 2013;208(3):432–441.
  • Langford BJ, So M, Raybardhan S, et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26(12):1622–1629.
  • Feng Y, Ling Y, Bai T, et al. COVID-19 with different severities: a multicenter study of clinical features. Am J Respir Crit Care Med. 2020;201(11):1380–1388.
  • Zheng F, Tang W, Li H, et al. Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur Rev Med Pharmacol Sci. 2020;24(6):3404–3410.
  • Contou D, Claudinon A, Pajot O, et al. Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU. Ann Intensive Care. 2020;10(1):119.
  • Sepulveda J, Westblade LF, Whittier S, et al. Bacteremia and blood culture utilization during COVID-19 surge in New York city. J Clin Microbiol. 2020;58(8):e00875–20.
  • World Health Organization. COVID-19 Clinical Managment: living guidance. [last updated 2021 Jan 25, cited 2021 Apr 4]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1.
  • Iuliano AD, Roguski KM, Chang HH, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018;391(10127):1285–1300.
  • Klein EY, Monteforte B, Gupta A, et al. The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. Influenza Other Respir Viruses. 2016;10(5):394–403.
  • Bartley PS, Deshpande A, Yu PC, et al. Bacterial coinfection in influenza pneumonia: rates, pathogens, and outcomes. Infect Control Hosp Epidemiol. 2021:1–6. DOI:https://doi.org/10.1017/ice.2021.96
  • Gill JR, Sheng ZM, Ely SF, et al. Pulmonary pathologic findings of fatal 2009 pandemic influenza a/H1N1 viral infections. Arch Pathol Lab Med. 2010;134(2):235–243.
  • Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis. 2008;198(7):962–970.
  • Havers FP, Hicks LA, Chung JR, et al. Outpatient antibiotic prescribing for acute respiratory infections during influenza seasons. JAMA Netw Open. 2018;1(2):e180243.
  • Durkin MJ, Jafarzadeh SR, Hsueh K, et al. Outpatient antibiotic prescription trends in the United States: a national cohort study. Infect Control Hosp Epidemiol. 2018;39(5):584–589.
  • Fjelltveit EB, Cox R, Østensjø J, et al. Point-of-care influenza testing impacts clinical decision, patient flow and length of stay in hospitalized adults. J Infect Dis. 2020;jiaa690. DOI:https://doi.org/10.1093/infdis/jiaa690
  • Menzel M, Akbarshahi H, Bjermer L, et al. Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients. Sci Rep. 2016;6:28698.
  • Lee N, Wong CK, Chan MCW, et al. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: a randomized controlled trial. Antiviral Res. 2017;144:48–56.
  • Piroth L, Cottenet J, Mariet AS, et al. Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study. Lancet Respir Med. 2021;9(3):251–259.
  • Auvinen R, Nohynek H, Syrjanen R, et al. Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients – a prospective observational study. Infect Dis (Lond). 2021;53(2):111–121.
  • Helsedirektoratet. Nasjonale faglige retningslinjer for bruk av antibiotika bør følges også under covid-19-pandemien 2020. [last updated 2020 Apr 3, cited 2021 Apr 8]. Available from: https://www.helsedirektoratet.no/veiledere/koronavirus/vaksiner-smittevernutstyr-og-legemidler/legemidler-og-medisinsk-utstyr/nasjonale-faglige-retningslinjer-for-bruk-av-antibiotika-bor-folges-ogsa-under-covid-19-pandemien.
  • Brehm TT, van der Meirschen M, Hennigs A, et al. Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza. Sci Rep. 2021;11(1):5803.
  • Youngs J, Wyncoll D, Hopkins P, et al. Improving antibiotic stewardship in COVID-19: bacterial co-infection is less common than with influenza. J Infect. 2020;81(3):e55–e57.
  • Butler CC, Dorward J, Yu L-M, et al. Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021;397(10279):1063–1074.
  • Abaleke E, Abbas M, Abbasi S, et al. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021;397(10274):605–612.
  • Karami Z, Knoop BT, Dofferhoff ASM, et al. Few bacterial co-infections but frequent empiric antibiotic use in the early phase of hospitalized patients with COVID-19: results from a multicentre retrospective cohort study in The Netherlands. Infect Dis (Lond). 2021;53(2):102–110.
  • Thelen JM, Buenen AGN, van Apeldoorn M, et al. Community-acquired bacteraemia in COVID-19 in comparison to influenza A and influenza B: a retrospective cohort study. BMC Infect Dis. 2021;21(1):199.
  • Brehm TT, Heyer A, Roedl K, et al. Patient characteristics and clinical course of COVID-19 patients treated at a German tertiary center during the first and second waves in the year 2020. J Clin Med. 2021;10(11): 2274.
  • Vaughn VM, Gandhi T, Petty LA, et al. Empiric antibacterial therapy and community-onset bacterial co-infection in patients hospitalized with COVID-19: a multi-hospital cohort study. Clin Infect Dis. 2021;72(10):e533–e541.
  • Grabowska K, Hogberg L, Penttinen P, et al. Occurrence of invasive pneumococcal disease and number of excess cases due to influenza. BMC Infect Dis. 2006;6:58.
  • Weinberger DM, Simonsen L, Jordan R, et al. Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States. J Infect Dis. 2012;205(3):458–465.
  • Cohen R, Babushkin F, Geller K, et al. Characteristics of hospitalized adult patients with laboratory documented influenza A, B and respiratory syncytial virus – a single center retrospective observational study. PLoS One. 2019;14(3):e0214517.
  • Akers IE, Weber R, Sax H, et al. Influence of time to diagnosis of severe influenza on antibiotic use, length of stay, isolation precautions, and mortality: a retrospective study. Influenza Other Respir Viruses. 2017;11(4):337–344.
  • Brendish NJ, Malachira AK, Beard KR, et al. Impact of turnaround time on outcome with point-of-care testing for respiratory viruses: a post hoc analysis from a randomised controlled trial. Eur Respir J. 2018;52(2):1800555.
  • Verma AA, Hora T, Jung HY, et al. Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area. CMAJ. 2021;193(12):E410–E418.
  • Sutton SS, Magagnoli J, Cummings T, et al. Association between the use of antibiotics, antivirals, and hospitalizations among patients with laboratory-confirmed influenza. Clin Infect Dis. 2021;72(4):566–573.
  • Pormohammad A, Ghorbani S, Khatami A, et al. Comparison of influenza type a and B with COVID-19: a global systematic review and meta-analysis on clinical, laboratory and radiographic findings. Rev Med Virol. 2021;31(3):e2179.
  • McKay R, Mah A, Law MR, et al. Systematic review of factors associated with antibiotic prescribing for respiratory tract infections. Antimicrob Agents Chemother. 2016;60(7):4106–4118.
  • Morris DE, Cleary DW, Clarke SC. Secondary bacterial infections associated with influenza pandemics. Front Microbiol. 2017;8:1041.
  • Hughes S, Troise O, Donaldson H, et al. Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clin Microbiol Infect. 2020;26(10):1395–1399.
  • Giacomelli A, Ridolfo AL, Milazzo L, et al. 30-Day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study. Pharmacol Res. 2020;158:104931.
  • Suleyman G, Fadel RA, Malette KM, et al. Clinical characteristics and morbidity associated with coronavirus disease 2019 in a series of patients in metropolitan Detroit. JAMA Netw Open. 2020;3(6):e2012270.
  • Gulseth HL, Helland E, Johansen KI, et al. Deaths after confirmed SARS-CoV-2 in Norway. Tidsskr nor Laegeforen. 2020;140(18). DOI:https://doi.org/10.4045/tidsskr.20.0693
  • Waehre T, Tunheim G, Bodin J, et al. Clinical risk scores as predictors of severe outcome in hospitalized influenza patients: an observational cohort study from Norway 2014–2018. Authorea. 2020. DOI:https://doi.org/10.22541/au.160349168.82323157/v1