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Editorial Commentary

Sensitisation of Forest workers to the oligosaccharide galactose alpha-1, 3-galactose (alpha-gal) is strongly associated with tick bites but not with evidence of tick borne infections

Pages 580-582 | Received 21 Mar 2022, Accepted 21 Mar 2022, Published online: 05 Apr 2022

References

  • Rutkowski  K, Sowa P, Mroczko B. et al. Sensitisation and allergic reactions to alpha-1, 3-galactose in Podlasi, Poland, an area endemic for tick-borne infections. Infect Dis. 2022. (In press)
  • Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol. 2009;123(2):426–433.e2.
  • Commins SP, James HR, Kelly LA, et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1, 3-galactose. J Allergy Clin Immunol. 2011;127(5):1286–1293.e6.
  • Fischer J, Lupberger E, Hebsaker J, et al. Prevalence of type I sensitization to alpha-gal in forest service employees and hunters. Allergy. 2017;72(10):1540–1547.
  • Mitchell CL, Lin F-C, Vaughn M, et al. Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers. Parasites Vectors. 2020;13(1):1–4.
  • Wilson JM, Keshavarz B, Retterer M, et al. A dynamic relationship between two regional causes of IgE-mediated anaphylaxis: α-Gal syndrome and imported fire ant. J Allergy Clin Immunol. 2021;147(2):643–652.e7.
  • Chung CH, Mirakhur B, Chan E, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1, 3-galactose. N Engl J Med. 2008;358(11):1109–1117.
  • Qian J, Liu T, Yang L, et al. Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion. Anal Biochem. 2007;364(1):8–18.
  • Lammerts van Bueren JJ, Rispens T, Verploegen S, et al. Anti-galactose-α-1, 3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains. Nat Biotechnol. 2011;29(7):574–576.
  • Straesser M, Keshavarz B, Borish L, et al. α-Gal on Crotalidae-polyvalent Fab antivenom (CroFab): investigating the relevance to immediate hypersensitivity reactions. J Allergy Clin Immunol Pract. 2021;9(2):1015–1017.e1.
  • Wilson JM, Nguyen AT, Schuyler AJ, et al. IgE to the mammalian oligosaccharide galactose-α-1, 3-galactose is associated with increased atheroma volume and plaques with unstable characteristics. ATVB. 2018;38(7):1665–1669.
  • Vernon ST, Kott KA, Hansen T, et al. Immunoglobulin E sensitization to mammalian oligosaccharide galactose-a-1, 3 (α-Gal) is associated with noncalcified plaque, obstructive coronary artery disease, and ST-segment–elevated myocardial infarction. ATVB. 2022;42(3):352–361.
  • Landsteiner K, Miller CP. SEROLOGICAL STUDIES ON THE BLOOD OF THE PRIMATES: III. DISTRIBUTION OF SEROLOGICAL FACTORS RELATED TO HUMAN ISOAGGLUTINOGENS IN THE BLOOD OF LOWER MONKEYS. J Exp Med. 1925;42(6):863–872.
  • Galili U. Discovery of the natural anti-Gal antibody and its past and future relevance to medicine. Xenotransplantation. 2013;20(3):138–147.
  • Galili U. The natural anti-Gal antibody as foe turned friend in medicine. London: Academic Press; 2017.
  • Wilson JM, Platts-Mills TA. The oligosaccharide galactose-α-1, 3-galactose and the α-Gal syndrome: insights from an epitope that is causal in immunoglobulin E-mediated immediate and delayed anaphylaxis. EMJ Allergy Immunol. 2018;3:89–98.
  • Cabezas-Cruz A, Hodžić A, Román-Carrasco P, et al. Environmental and molecular drivers of the α-Gal syndrome. Front Immunol. 2019;10:1210.
  • Hashizume H, Fujiyama T, Umayahara T, et al. Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: a retrospective cohort study in a single institution. J Am Acad Dermatol. 2018;78(6):1135–1141.e3.

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