Whipple’s disease-associated infective endocarditis: a systematic review

References

• Whipple G. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull John Hopkins Hosp. 1907;198:382–391.
   Google Scholar
• Relman DA, Schmidt TM, MacDermott RP, et al. Identification of the uncultured bacillus of Whipple’s disease. N Engl J Med. 1992;327(5):293–301.
   PubMed Web of Science ®Google Scholar
• Lepidi H, Fenollar F, Dumler JS, et al. Cardiac valves in patients with Whipple endocarditis: microbiological, molecular, quantitative histologic, and immunohistochemical studies of 5 patients. J Infect Dis. 2004;190(5):935–945.
   PubMed Web of Science ®Google Scholar
• Fenollar F, Lepidi H, Raoult D. Whipple’s endocarditis: review of the literature and comparisons with Q fever, Bartonella infection, and blood culture-positive endocarditis. Clin Infect Dis. 2001;33(8):1309–1316.
   PubMed Web of Science ®Google Scholar
• Gubler JG, Kuster M, Dutly F, et al. Whipple endocarditis without overt gastrointestinal disease: report of four cases. Ann Intern Med. 1999;131(2):112–116.
   PubMed Web of Science ®Google Scholar
• Elkins C, Shuman TA, Pirolo JS. Cardiac Whipple’s disease without digestive symptoms. Ann Thorac Surg. 1999;67(1):250–251.
   PubMed Web of Science ®Google Scholar
• Raoult D, Birg ML, La Scola B, et al. Cultivation of the bacillus of Whipple’s disease. N Engl J Med. 2000;342(9):620–625.
   PubMed Web of Science ®Google Scholar
• Lagier JC, Papazian L, Fenollar F, et al. Tropheryma whipplei DNA in bronchoalveolar lavage samples: a case control study. Clin Microbiol Infect. 2016;22(10):875–879.
   PubMed Web of Science ®Google Scholar
• Damaraju D, Steiner T, Wade J, et al. CLINICAL PROBLEM-SOLVING. A surprising cause of chronic cough. N Engl J Med. 2015;373(6):561–566.
   PubMedGoogle Scholar
• Urbanski G, Rivereau P, Artru L, et al. Whipple disease revealed by lung involvement: a case report and literature review. Chest. 2012;141(6):1595–1598.
   PubMed Web of Science ®Google Scholar
• Riemer H, Hainz R, Stain C, et al. Severe pulmonary hypertension reversed by antibiotics in a patient with Whipple’s disease. Thorax. 1997;52(11):1014–1015.
   PubMed Web of Science ®Google Scholar
• Günther U, Moos V, Offenmüller G, et al. Gastrointestinal diagnosis of classical Whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. Medicine (Baltimore). 2015;94(15):e714.
   PubMed Web of Science ®Google Scholar
• Schneider T, Moos V, Loddenkemper C, et al. Whipple’s disease: new aspects of pathogenesis and treatment. Lancet Infect Dis. 2008;8(3):179–190.
   PubMed Web of Science ®Google Scholar
• Durand DV, Lecomte C, Cathébras P, et al. Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Société Nationale Française de Médecine Interne. Medicine (Baltimore). 1997;76(3):170–184.
   PubMed Web of Science ®Google Scholar
• Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435–1486.
   PubMed Web of Science ®Google Scholar
• Wang A, Gaca JG, Chu VH. Management considerations in infective endocarditis: a review. JAMA. 2018;320(1):72–83.
   PubMed Web of Science ®Google Scholar
• Habib G, Erba PA, Iung B, et al. Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. Eur Heart J. 2019;40(39):3222–3232.
   PubMed Web of Science ®Google Scholar
• Shah ASV, McAllister DA, Gallacher P, et al. Incidence, microbiology, and outcomes in patients hospitalized with infective endocarditis. Circulation. 2020;141(25):2067–2077.
   PubMed Web of Science ®Google Scholar
• Cresti A, Chiavarelli M, Scalese M, et al. Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study. Cardiovasc Diagn Ther. 2017;7(1):27–35.
   PubMed Web of Science ®Google Scholar
• Papakonstantinou PE, Samonis G, Andrianaki AM, et al. Epidemiology, microbiological and clinical features, treatment, and outcomes of infective endocarditis in Crete, Greece. Infect Chemother. 2018;50(1):21–28.
   PubMed Web of Science ®Google Scholar
• Fournier PE, Gouriet F, Casalta JP, et al. Blood culture-negative endocarditis: improving the diagnostic yield using new diagnostic tools. Medicine (Baltimore). 2017;96(47):e8392.
   PubMed Web of Science ®Google Scholar
• Fournier PE, Thuny F, Richet H, et al. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis. 2010;51(2):131–140.
   PubMed Web of Science ®Google Scholar
• Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–2012.
   PubMed Web of Science ®Google Scholar
• Wallace BC, Small K, Brodley CE, et al. Deploying an interactive machine learning system in an evidence-based practice center: abstrackr. Proceedings of the ACM International Health Informatics Symposium (IHI). Miami, FL; 2012. p. 819–824.
   Google Scholar
• Li JS, Sexton DJ, Mick N, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30(4):633–638.
   PubMed Web of Science ®Google Scholar
• Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–926.
   PubMed Web of Science ®Google Scholar
• Lie JT, Davis JS. Pancarditis in Whipple’s disease: electronmicroscopic demonstration of intracardiac bacillary bodies. Am J Clin Pathol. 1976;66(1):22–30.
   PubMed Web of Science ®Google Scholar
• Wright CB, Hiratzka LF, Crossland S, et al. Aortic insufficiency requiring valve replacement in Whipple’s disease. Ann Thorac Surg. 1978;25(5):466–469.
   PubMed Web of Science ®Google Scholar
• Rose AG. Mitral stenosis in Whipple’s disease. Thorax. 1978;33(4):500–503.
   PubMed Web of Science ®Google Scholar
• Bostwick DG, Bensch KG, Burke JS, et al. Whipple’s disease presenting as aortic insufficiency. N Engl J Med. 1981;305(17):995–998.
   PubMed Web of Science ®Google Scholar
• Ratliff NB, McMahon JT, Naab TJ, et al. Whipple’s disease in the porcine leaflets of a Carpentier-Edwards prosthetic mitral valve. N Engl J Med. 1984;311(14):902–903.
   PubMed Web of Science ®Google Scholar
• Gupta S, Pinching AJ, Onwubalili J, et al. Whipple’s disease with unusual clinical, bacteriologic, and immunologic findings. Gastroenterology. 1986;90(5 Pt 1):1286–1289.
   PubMed Web of Science ®Google Scholar
• Jeserich M, Ihling C, Holubarsch C. Aortic valve endocarditis with Whipple disease. Ann Intern Med. 1997;126(11):920.
   PubMed Web of Science ®Google Scholar
• Schneider T, Salamon-Looijen M, von Herbay A, et al. Whipple’s disease with aortic regurgitation requiring aortic valve replacement. Infection. 1998;26(3):178–180.
   PubMed Web of Science ®Google Scholar
• Célard M, de Gevigney G, Mosnier S, et al. Polymerase chain reaction analysis for diagnosis of Tropheryma whippelii infective endocarditis in two patients with no previous evidence of Whipple’s disease. Clin Infect Dis. 1999;29(5):1348–1349.
   PubMed Web of Science ®Google Scholar
• Wolfert AL, Wright JE. Whipple’s disease presenting as sarcoidosis and valvular heart disease. South Med J. 1999;92(8):820–825.
   PubMed Web of Science ®Google Scholar
• Smith MA. Whipple endocarditis without gastrointestinal disease. Ann Intern Med. 2000;132(7):595.
   PubMed Web of Science ®Google Scholar
• Naegeli B, Bannwart F, Bertel O. An uncommon cause of recurrent strokes: Tropheryma whippelii endocarditis. Stroke. 2000;31(8):2002–2003.
   PubMed Web of Science ®Google Scholar
• Ferrari M de L, Vilela EG, Faria LC, et al. Whipple’s disease. Report of five cases with different clinical features. Rev Inst Med Trop Sao Paulo. 2001;43(1):45–50.
   PubMedGoogle Scholar
• Geissdörfer W, Wittmann I, Seitz G, et al. A case of aortic valve disease associated with Tropheryma whippelii infection in the absence of other signs of Whipple’s disease. Infection. 2001;29(1):44–47.
   PubMed Web of Science ®Google Scholar
• Richardson DC, Burrows LL, Korithoski B, et al. Tropheryma whippelii as a cause of afebrile culture-negative endocarditis: the evolving spectrum of Whipple’s disease. J Infect. 2003;47(2):170–173.
   PubMed Web of Science ®Google Scholar
• Dreier J, Szabados F, von Herbay A, et al. Tropheryma whipplei infection of an acellular porcine heart valve bioprosthesis in a patient who did not have intestinal Whipple’s disease. J Clin Microbiol. 2004;42(10):4487–4493.
   PubMed Web of Science ®Google Scholar
• West D, Hutcheon S, Kain R, et al. Whipple’s endocarditis. J R Soc Med. 2005;98(8):362–364.
   PubMed Web of Science ®Google Scholar
• Houpikian P, Raoult D. Blood culture-negative endocarditis in a reference center: etiologic diagnosis of 348 cases. Medicine (Baltimore). 2005;84(3):162–173.
   PubMed Web of Science ®Google Scholar
• Marín M, Muñoz P, Sánchez M, et al. Tropheryma whipplei infective endocarditis as the only manifestation of Whipple’s disease. J Clin Microbiol. 2007;45(6):2078–2081.
   PubMed Web of Science ®Google Scholar
• Berent R, Auer J, Lassnig E, et al. Whipple’s disease: misdiagnosed as sarcoidosis with further tricuspid valve endocarditis and pulmonary embolism - a case report. BMJ Case Rep. 2009;2009:bcr07.2008.0441.
   PubMedGoogle Scholar
• Besnard S, Cady A, Flecher E, et al. Should we systematically perform Central nervous system imaging in patients with Whipple’s endocarditis? Am J Med. 2010;123(10):962.e1–962.e4.
   PubMed Web of Science ®Google Scholar
• Gabus V, Grenak-Degoumois Z, Jeanneret S, et al. Tropheryma whipplei tricuspid endocarditis: a case report and review of the literature. J Med Case Rep. 2010;4:245.
   PubMedGoogle Scholar
• Daïen CI, Cohen JD, Makinson A, et al. Whipple’s endocarditis as a complication of tumour necrosis factor-alpha antagonist treatment in a man with ankylosing spondylitis. Rheumatology (Oxford). 2010;49(8):1600–1602.
   PubMed Web of Science ®Google Scholar
• Escher R, Roth S, Droz S, et al. Endocarditis due to Tropheryma whipplei: rapid detection, limited genetic diversity, and long-term clinical outcome in a local experience. Clin Microbiol Infect. 2010; Aug16(8):1213–1222.
   PubMed Web of Science ®Google Scholar
• Ansemant T, Celard M, Tavernier C, et al. Whipple’s disease endocarditis following anti-TNF therapy for atypical rheumatoid arthritis. Joint Bone Spine. 2010;77(6):622–623.
   PubMed Web of Science ®Google Scholar
• Lagier JC, Lepidi H, Raoult D, et al. Systemic Tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center. Medicine (Baltimore). 2010;89(5):337–345.
   PubMed Web of Science ®Google Scholar
• Miguelena J, Muñoz R, Maseda R, et al. Endocarditis due to Tropheryma whipplei. Rev Esp Cardiol. 2010;63(2):250–251.
   PubMed Web of Science ®Google Scholar
• Hoppé E, Masson C, Audran M, et al. Whipple’s disease diagnosed during biological treatment for joint disease. Joint Bone Spine. 2010;77(4):335–339.
   PubMed Web of Science ®Google Scholar
• Whistance RN, Elfarouki GWE, Vohra HA, et al. A case of Tropheryma whipplei infective endocarditis of the aortic and mitral valves in association with psoriatic arthritis and lumbar discitis. J Heart Valve Dis. 2011;20(3):353–356.
   PubMed Web of Science ®Google Scholar
• Chan V, Wang B, Veinot JP, et al. Tropheryma whipplei aortic valve endocarditis without systemic Whipple’s disease. Int J Infect Dis. 2011;15(11):e804-806–e806.
   Web of Science ®Google Scholar
• Love SM, Morrison L, Appleby C, et al. Tropheryma whipplei endocarditis without gastrointestinal involvement. Interact Cardiovasc Thorac Surg. 2012;15(1):161–163.
   PubMed Web of Science ®Google Scholar
• Algin A, Wegdam-Blans M, Verduin K, et al. Tropheryma whipplei aortic valve endocarditis, cured without surgical treatment. BMC Res Notes. 2012;5:600.
   PubMedGoogle Scholar
• Geissdörfer W, Moos V, Moter A, et al. High frequency of Tropheryma whipplei in culture-negative endocarditis. J Clin Microbiol. 2012; Feb50(2):216–222.
   PubMed Web of Science ®Google Scholar
• Fenollar F, Lagier JC, Rolain JM, et al. Tropheryma whipplei endocarditis relapses after treatment with trimethoprim/sulfamethoxazole. Int J Antimicrob Agents. 2013;41(6):592–594.
   PubMed Web of Science ®Google Scholar
• Weisman A, Rebick G, Morris A, et al. Whipple’s endocarditis: an enigmatic cause of culture-negative bacterial endocarditis. Can J Infect Dis Med Microbiol. 2013;24(2):e29–e30.
   PubMed Web of Science ®Google Scholar
• Fenollar F, Célard M, Lagier JC, et al. Tropheryma whipplei endocarditis. Emerg Infect Dis. 2013;19(11):1721–1730.
   PubMed Web of Science ®Google Scholar
• Lloret-Linares C, Brumpt C, Dray X, et al. Monoclonal B-cell lymphocyte proliferation in a patient presenting with historical Whipple disease. Intern Med J. 2013;43(3):338–341.
   PubMed Web of Science ®Google Scholar
• Kattan JN, Rehm SJ, van Duin D, et al. Whipple’s disease: a case revisited 14 years after diagnosis. Infect Dis Clin Pract. 2013;21(3):201–203.
   Google Scholar
• Obma KL, Marx GE, Mauchley D, et al. CASE 12–2015: Tropheryma Whipplei endocarditis. J Cardiothorac Vasc Anesth. 2015;29(6):1712–1716.
   PubMed Web of Science ®Google Scholar
• Loughran D, Beale L, Lodge F, et al. Whipple’s in the valleys: a case of Whipple’s with thrombocytopenia and endocarditis. J Clin Pathol. 2014;67(5):445–448.
   PubMed Web of Science ®Google Scholar
• Herrmann MD, Neumayr A, Essig A, et al. Isolated Whipple’s endocarditis: an underestimated diagnosis that requires molecular analysis of surgical material. Ann Thorac Surg. 2014;98(1):e1–e3.
   PubMed Web of Science ®Google Scholar
• Lahoud R, Kwon DH, Tan CD, et al. All in the farm: an unusual case of endocarditis and pericarditis. J Am Coll Cardiol. 2014;63(10):e19.
   PubMed Web of Science ®Google Scholar
• Rose D, Guleri A, Tang A. Tropheryma whipplei endocarditis: the value of valve polymerase chain reaction in cardiac surgery. J Thorac Cardiovasc Surg. 2014;148(4):e195-197–e197.
   Web of Science ®Google Scholar
• Gruber JR, Sarro R, Delaloye J, et al. Tropheryma whipplei bivalvular endocarditis and polyarthralgia: a case report. J Med Case Rep. 2015;9:259.
   PubMedGoogle Scholar
• Borne RT, Babu A, Levi M, et al. Tropheryma whipplei endocarditis: a two-patient case series. Am J Med. 2015;128(12):1364–1366.
   PubMed Web of Science ®Google Scholar
• Emonet S, Wuillemin T, Harbarth S, et al. Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline. Int J Infect Dis. 2015;30:17–19.
   PubMed Web of Science ®Google Scholar
• Jos SL, Angelakis E, Caus T, et al. Positron emission tomography in the diagnosis of Whipple’s endocarditis: a case report. BMC Res Notes. 2015;8:56.
   PubMedGoogle Scholar
• Gaudé M, Tébib J, Puéchal X. Atypical focal forms of Whipple’s disease seen by rheumatologists. Joint Bone Spine. 2015;82(1):56–59.
   PubMed Web of Science ®Google Scholar
• Alozie A, Zimpfer A, Köller K, et al. Arthralgia and blood culture-negative endocarditis in middle age men suggest Tropheryma whipplei infection: report of two cases and review of the literature. BMC Infect Dis. 2015;15:339.
   PubMed Web of Science ®Google Scholar
• Lagier JC, Cammilleri S, Raoult D. Classic Whipple’s disease diagnosed by (18)F-fluorodeoxyglucose PET. Lancet Infect Dis. 2016;16(1):130.
   PubMed Web of Science ®Google Scholar
• García-Álvarez L, Sanz MM, Marín M, et al. Tropheryma whipplei endocarditis in Spain: case reports of 17 prospective cases. Medicine (Baltimore). 2016;95(26):e4058.
   PubMed Web of Science ®Google Scholar
• Seddon O, Hettiarachchi I. Whipple’s endocarditis presenting as ulnar artery aneurysm; if you don’t look, you won’t find. BMJ Case Rep. 2017;2017:bcr2017221327.
   PubMedGoogle Scholar
• Dugdale C, Brown S, Davila C, et al. Out of sight: culture-negative endocarditis and endophthalmitis. Am J Med. 2017;130(2):e51–e53.
   PubMed Web of Science ®Google Scholar
• Parkash V, Mudhar HS, Wagner BE, et al. Bilateral ocular myositis associated with Whipple’s disease. Ocul Oncol Pathol. 2017;3(1):17–21.
   PubMedGoogle Scholar
• Paymard M, Sukumaran V, Senanayake S, et al. Tropheryma whipplei endocarditis: case report and literature review. Heart Views. 2018;19(4):150–151.
   PubMedGoogle Scholar
• McGee M, Brienesse S, Chong B, et al. Tropheryma whipplei endocarditis: case presentation and review of the literature. Open Forum Infect Dis. 2019;6(1):ofy330.
   PubMed Web of Science ®Google Scholar
• Thornton CS, Wang Y, Köebel M, et al. Another Whipple’s triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective. BMC Cardiovasc Disord. 2019;19(1):312.
   PubMed Web of Science ®Google Scholar
• Elodie O, Labeyrie PE, Aubry M, et al. Whipple’s endocarditis diagnosed by thrombus analysis retrieved by successful mechanical thrombectomy. J Neurol Sci. 2019;400:42–43.
   PubMed Web of Science ®Google Scholar
• Scheurwater MA, Verduin CM, van Dantzig JM. Whipple’s endocarditis: a case report of a blood culture-negative endocarditis. Eur Heart J Case Rep. 2019;3(4):1–6.
   PubMedGoogle Scholar
• Naso JR, Wong D, Wong DR, et al. Tropheryma whipplei endocarditis presenting as chronic valvular disease: a case report and review of literature. Hum Pathol Case Rep. 2019;18:200321.
   Google Scholar
• Sullivan A, Shrestha P, Basnet S, et al. A rare case of Whipple’s disease with endocarditis in a patient with dextrocardia. SAGE Open Med Case Rep. 2020;8:2050313X20936952.
   PubMed Web of Science ®Google Scholar
• Olivier M, Licitra C, Field Z, et al. Thrombocytopenia and endocarditis in a patient with Whipple’s disease: case report. BMC Infect Dis. 2020;20(1):71.
   PubMed Web of Science ®Google Scholar
• Muretti M, Keiralla A, Jeffery K, et al. Tropheryma whipplei endocarditis: an uncommon infection with potentially fatal consequences. J Card Surg. 2020;35(4):923–925.
   PubMed Web of Science ®Google Scholar
• He YT, Peterson K, Crothers J, et al. Endocarditis and systemic embolization from Whipple’s disease. IDCases. 2021;24:e01105.
   PubMed Web of Science ®Google Scholar
• Knol S, Nijhuis RL, Geeraedts F, et al. Blood culture-negative endocarditis caused by Tropheryma whipplei: Whipple’s endocarditis. Eur J Case Rep Intern Med. 2021;8(5):002596.
   PubMedGoogle Scholar
• Sarvananthan S, Velissaris T, Miskolczi S, et al. Tropheryma whipplei endocarditis. Echocardiography. 2021;38(4):697–700.
   PubMed Web of Science ®Google Scholar
• Berman M, Ben-Ami R, Berliner S, et al. The effect of tocilizumab on inflammatory markers in patients hospitalized with serious infections. Case series and review of literature. Life (Basel). 2021;11(3):258.
   PubMed Web of Science ®Google Scholar
• García-Olea Jurado A, Ramírez-Escudero Ugalde G, García Ibarrondo N, et al. Early biological prosthetic mitral valve endocarditis due to Tropheryma whipplei: experience of an antimicrobial treatment approach. Rev Esp Cardiol (Engl Ed). 2022;75(3):271–273.
   PubMed Web of Science ®Google Scholar
• Arnold CA, Moreira RK, Lam-Himlin D, et al. Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. Am J Surg Pathol. 2012;36(7):1066–1073.
   PubMed Web of Science ®Google Scholar
• Fenollar F, Laouira S, Lepidi H, et al. Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first‐line screening. Clin Infect Dis. 2008; Sep47(5):659–667.
   PubMed Web of Science ®Google Scholar
• Fenollar F, Trani M, Davoust B, et al. Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates. J Infect Dis. 2008;197(6):880–887.
   PubMed Web of Science ®Google Scholar
• Keita AK, Dubot-Pérès A, Phommasone K, et al. High prevalence of Tropheryma whipplei in lao kindergarten children. PLoS Negl Trop Dis. 2015;9(2):e0003538.
   PubMed Web of Science ®Google Scholar
• Vinnemeier CD, Klupp EM, Krumkamp R, et al. Tropheryma whipplei in children with diarrhoea in rural Ghana. Clin Microbiol Infect. 2016;22(1):65.e1-65–e3.
   Web of Science ®Google Scholar
• Fenollar F, Puéchal X, Raoult D. Whipple’s disease. N Engl J Med. 2007;356(1):55–66.
   PubMed Web of Science ®Google Scholar
• Dobbins WO. HLA antigens in Whipple’s disease. Arthritis Rheum. 1987;30(1):102–105.
   PubMedGoogle Scholar
• Ehrbar HU, Bauerfeind P, Dutly F, et al. PCR-positive tests for Tropheryma whippelii in patients without Whipple’s disease. Lancet. 1999;353(9171):2214.
   PubMed Web of Science ®Google Scholar
• Street S, Donoghue HD, Neild GH. Tropheryma whippelii DNA in saliva of healthy people. Lancet. 1999;354(9185):1178–1179.
   PubMed Web of Science ®Google Scholar
• Kono M, Yamamoto K, Nagamatsu M, et al. Use of polymerase chain reaction in the diagnosis of Whipple’s disease. J Infect Chemother. 2015;21(12):885–888.
   PubMedGoogle Scholar
• Kadian R, Wang J, Freitas E. Could CT abdomen and PET/CT be helpful in early diagnosis of Whipple’s disease? A case report. IDCases. 2021;26:e01286.
   PubMed Web of Science ®Google Scholar
• Mahmood M, Kendi AT, Ajmal S, et al. Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis. J Nucl Cardiol. 2019;26(3):922–935.
   PubMed Web of Science ®Google Scholar
• Giannitsioti E, Skiadas I, Antoniadou A, et al. Nosocomial vs. community-acquired infective endocarditis in Greece: changing epidemiological profile and mortality risk. Clin Microbiol Infect. 2007;13(8):763–769.
   PubMed Web of Science ®Google Scholar
• Lamas CC, Fournier PE, Zappa M, et al. Diagnosis of blood culture-negative endocarditis and clinical comparison between blood culture-negative and blood culture-positive cases. Infection. 2016;44(4):459–466.
   PubMed Web of Science ®Google Scholar
• Feurle GE, Junga NS, Marth T. Efficacy of ceftriaxone or meropenem as initial therapies in Whipple’s disease. Gastroenterology. 2010;138(2):478–486. quiz 11–2.
   PubMed Web of Science ®Google Scholar
• Feurle GE, Moos V, Bläker H, et al. Intravenous ceftriaxone, followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in Whipple’s disease. J Infect. 2013;66(3):263–270.
   PubMed Web of Science ®Google Scholar
• Boulos A, Rolain JM, Raoult D. Antibiotic susceptibility of Tropheryma whipplei in MRC5 cells. Antimicrob Agents Chemother. 2004;48(3):747–752.
   PubMed Web of Science ®Google Scholar
• Boulos A, Rolain JM, Mallet MN, et al. Molecular evaluation of antibiotic susceptibility of Tropheryma whipplei in axenic medium. J Antimicrob Chemother. 2005;55(2):178–181.
   PubMed Web of Science ®Google Scholar
• Masselot F, Boulos A, Maurin M, et al. Molecular evaluation of antibiotic susceptibility: Tropheryma whipplei paradigm. Antimicrob Agents Chemother. 2003;47(5):1658–1664.
   PubMed Web of Science ®Google Scholar