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Review

Nutrition Provides the Essential Foundation for Optimizing Mental Health

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References

  • Adams, J. B., Audhya, T., Geis, E., Gehn, E., Fimbres, V., Pollard, E., Mitchell, J., Ingram, J., Hellmers, R., Laake, D., Matthews, J., Li, K., Naviaux, J., Naviaux, R., Adams, R., Coleman, D., & Quig, D. (2018). Comprehensive nutritional and dietary intervention for autism spectrum disorder—A randomized, controlled 12-month trial. Nutrients, 10(3), 369. http://www.mdpi.com/2072-6643/10/3/369
  • Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S., Barnhouse, S., & Lee, W. (2011). Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatrics, 11, 111. https://doi.org/10.1186/1471-2431-11-111
  • Adams, J. B., & Holloway, C. (2004). Pilot study of a moderate dose multivitamin/mineral supplement for children with autism spectrum disorder. Journal of Alternative and Complementary Medicine, 10(6), 1033–1039. http://online.liebertpub.com/doi/abs/10.1089/acm.2004.10.1033
  • Ames, B. N., Elson-Schwab, I., & Silver, E. A. (2002). High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): Relevance to genetic disease and polymorphisms. American Journal of Clinical Nutrition, 75(4), 616–658. https://doi.org/10.1093/ajcn/75.4.616
  • Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2019). Making sense of … the microbiome in psychiatry. International Journal of Neuropsychopharmacology, 22(1), 37–52. https://doi.org/10.1093/ijnp/pyy067
  • Benton, D. (2007). The impact of diet on anti-social, violent and criminal behaviour. Neuroscience and Biobehavioral Reviews, 31(5), 752–774. https://doi.org/10.1093/j.jaac.2011.10.015/j.neubiorev.2007.02.002
  • Benton, D., & Cook, R. (1991). The impact of selenium supplementation on mood. Biological Psychiatry, 29(11), 1092–1098. https://doi.org/10.1016/0006-3223(91)90251-G
  • Benton, D., Griffiths, R., & Haller, J. (1997). Thiamine supplementation mood and cognitive functioning. Psychopharmacology, 129(1), 66–71. https://doi.org/10.1007/s002130050163
  • Bolduc, F. V., Lau, A., Rosenfelt, C. S., Langer, S., Wang, N., Smithson, L., Lefebvre, D., Alexander, R. T., Dickson, C. T., Li, L., Becker, A. B., Subbarao, P., Turvey, S. E., Pei, J., Sears, M. R., Mandhane, P. J., & Investigators, C. S. (2016). Cognitive enhancement in infants associated with increased maternal fruit intake during pregnancy: Results from a birth cohort study with validation in an animal model. EBioMedicine, 8, 331–340. https://doi.org/10.1016/j.ebiom.2016.04.025
  • Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018). Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Frontiers in Psychiatry, 9, 44. https://doi.org/10.3389/fpsyt.2018.00044
  • Brown, A. S., & Susser, E. S. (2008). Prenatal nutritional deficiency and risk of adult schizophrenia. Schizophrenia Bulletin, 34(6), 1054–1063. https://doi.org/10.1093/schbul/sbn096
  • Cantor, J., Breck, A., & Elbel, B. (2016). Correlates of sugar-sweetened beverages purchased for children at fast-food restaurants. American Journal of Public Health, 106(11), 2038–2041. https://doi.org/10.2105/AJPH.2016.303427
  • Carlson, G. A. (2020). Presidential address: Emotion dysregulation in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 59(1), 15–19. https://doi.org/10.1016/j.jaac.2019.11.004
  • Cenit, M. C., Sanz, Y., & Codoner-Franch, P. (2017). Influence of gut microbiota on neuropsychiatric disorders. World Journal of Gastroenterology, 23(30), 5486–5498. https://doi.org/10.3748/wjg.v23.i30.5486
  • Chang, J., Su, K.-P., Mondelli, V., & Pariante, C. (2018). Omega-3 polyunsaturated fatty acids in youths with attention deficit hyperactivity disorder: A systematic review and meta-analysis of clinical trials and biological studies. Neuropsychopharmacology, 43(3), 534–545. https://doi.org/10.1038/npp.2017.160
  • Collins, S. M., Kassam, Z., & Bercik, P. (2013). The adoptive transfer of behavioral phenotype via the intestinal microbiota: Experimental evidence and clinical implications. Current Opinions in Microbiology, 16(3), 240–245. https://doi.org/10.1016/j.mib.2013.06.004
  • Conner, T. S., Brookie, K. L., Carr, A. C., Mainvil, L. A., & Vissers, M. C. (2017). Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomized controlled trial. PloS One, 12(2), e0171206. https://doi.org/10.1371/journal.pone.0171206
  • Cryan, J. F., O’Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., Guzzetta, K. E., Jaggar, M., Long-Smith, C. M., Lyte, J. M., Martin, J. A., Molinero-Perez, A., Moloney, G., Morelli, E., Morillas, E., O’Connor, R., & Dinan, T. G. (2019). The microbiota-gut-brain axis. Physiological Reviews, 99(4), 1877–2013. https://doi.org/10.1152/physrev.00018.2018
  • Darling, K. A., Eggleston, M. J. F., Retallick-Brown, H., & Rucklidge, J. J. (2019). Mineral-vitamin treatment associated with remission in attention-deficit/hyperactivity disorder symptoms and related problems: 1-year naturalistic outcomes of a 10-week randomized placebo-controlled trial. Journal of Child and Adolescent Psychopharmacology, 29(9), 688–704. https://doi.org/10.1089/cap.2019.0036
  • Datnoff, L. E., Elmer, W. H., & Huber, D. M. (Eds.). (2007). Mineral nutrition and plant disease. American Phytopathological Society.
  • Davis, D. R., Epp, M. D., & Riordan, H. D. (2004). Changes in USDA food composition data for 43 garden crops, 1950 to 1999. Journal of the American College of Nutrition, 23(6), 669–682. https://doi.org/10.1080/07315724.2004.10719409
  • Ejaredar, M., Nyanza, E. C., Ten Eycke, K., & Dewey, D. (2015). Phthalate exposure and childrens neurodevelopment: A systematic review. Environmental Research, 142, 51–60. https://doi.org/10.1016/j.envres.2015.06.014
  • Ekwaru, J. P., Ohinmaa, A., Loehr, S., Setayeshgar, S., Thanh, N. X., & Veugelers, P. J. (2017). The economic burden of inadequate consumption of vegetables and fruit in Canada. Public Health Nutrition, 20(3), 515–523. https://doi.org/10.1017/S1368980016002846
  • Firth, J., Marx, W., Dash, S., Carney, R., Teasdale, S. B., Solmi, M., Stubbs, B., Schuch, F. B., Carvalho, A. F., Jacka, F., & Sarris, J. (2019). The effects of dietary improvement on symptoms of depression and anxiety: A meta-analysis of randomized controlled trials. Psychosomatic Medicine, 81(3), 265–280. https://doi.org/10.1097/PSY.0000000000000673
  • Firth, J., Stubbs, B., Sarris, J., Rosenbaum, S., Teasdale, S., Berk, M., & Yung, A. R. (2017). The effects of vitamin and mineral supplementation on symptoms of schizophrenia: A systematic review and meta-analysis. Psychological Medicine, 47(9), 1515–1527. https://doi.org/10.1017/S0033291717000022
  • Firth, J., Teasdale, S. B., Allott, K., Siskind, D., Marx, W., Cotter, J., Veronese, N., Schuch, F., Smith, L., Solmi, M., Carvalho, A. F., Vancampfort, D., Berk, M., Stubbs, B., & Sarris, J. (2019). The efficacy and safety of nutrient supplements in the treatment of mental disorders: A meta-review of meta-analyses of randomized controlled trials. World Psychiatry, 18(3), 308–324. https://doi.org/10.1002/wps.20672
  • Flannery, J. E., Stagaman, K., Burns, A. R., Hickey, R. J., Roos, L. E., Giuliano, R. J., Fisher, P. A., & Sharpton, T. J. (2020). Gut feelings begin in childhood: The gut metagenome correlates with early environment, caregiving, and behavior. mBio, 11(1), e02780–02719. https://doi.org/10.1128/mBio.02780-19
  • Francis, H. M., Stevenson, R. J., Chambers, J. R., Gupta, D., Newey, B., & Lim, C. K. (2019). A brief diet intervention can reduce symptoms of depression in young adults - A randomised controlled trial. PloS One, 14(10), e0222768. https://doi.org/10.1371/journal.pone.0222768
  • Frazier, E. A., Gracious, B., Arnold, L. E., Failla, M., Chitchumroonchokchai, C., Habash, D., & Fristad, M. A. (2013). Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 23(8), 558–567. https://doi.org/10.1089/cap.2012.0098
  • Galera, C., Heude, B., Forhan, A., Bernard, J. Y., Peyre, H., Van der Waerden, J., Pryor, L., Bouvard, M. P., Melchior, M., Lioret, S., de Lauzon-guillain, B., & Group, E. M.-C.-C. S. (2018). Prenatal diet and children’s trajectories of hyperactivity-inattention and conduct problems from 3 to 8 years: The EDEN mother-child cohort. Journal of Child Psychology and Psychiatry and Allied Disciplines, 59(9), 1003–1011. https://doi.org/10.1111/jcpp.12898
  • Gately, D., & Kaplan, B. (2009). Database analysis of adults with bipolar disorder consuming a multinutrient formula. Clinical Medicine: Psychiatry, 4, 3–16. https://doi.org/10.4137/2FCMPsy.S2278
  • Gesch, C. B., Hammond, S. M., Hampson, S. E., Eves, A., & Crowder, M. J. (2002). Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Randomised, placebo-controlled trial. British Journal of Psychiatry, 181(1), 22–28. https://doi.org/10.1192/bjp.181.1.22
  • Gordon, H. A., Rucklidge, J. J., Blampied, N. M., & Johnstone, J. M. (2015). Clinically significant symptom reduction in children with attention-deficit/hyperactivity disorder treated with micronutrients: An open-label reversal design study. Journal of Child and Adolescent Psychopharmacology, 25(10), 783–798. https://doi.org/10.1089/cap.2015.0105
  • Guu, T-W., Mischoulon, D., Sarris, J., Hibbeln, J., McNamara, R. K., Hamazaki, K., Freeman, M. P., Maes, M., Matsuoka, Y. J., Belmaker, R. H., Jacka, F., Pariante, C., Berk, M., Marx, W., & Su, K-P. (2019). International society for nutritional psychiatry research practice guidelines for omega-3 fatty acids in the treatment of major depressive disorder. Psychotherapy and Psychosomatics, 88(5), 263–273. https://doi.org/10.1159/0005026525
  • Hambly, J. L., Francis, K., Khan, S., Gibbons, K. S., Walsh, W. J., Lambert, B., Testa, C., & Haywood, A. (2017). Micronutrient therapy for violent and aggressive male youth: An open-label trial. Journal of Child and Adolescent Psychopharmacology, 27(9), 823–832. https://doi.org/10.1089/cap.2016.0199
  • Heilskov Rytter, M. J., Andersen, L. B., Houmann, T., Bilenberg, N., Hvolby, A., Molgaard, C., Michaelsen, K. F., & Lauritzen, L. (2015). Diet in the treatment of ADHD in children - a systematic review of the literature. Nordic Journal of Psychiatry, 69(1), 1–18. https://doi.org/10.3109/08039488.2014.921933
  • Hennig, B., Ormsbee, L., McClain, C. J., Watkins, B. A., Blumberg, B., Bachas, L. G., Sanderson, W., Thompson, C., & Suk, W. A. (2012). Nutrition can modulate the toxicity of environmental pollutants: Implications in risk assessment and human health. Environmental Health Perspectives, 120(6), 771–774. https://doi.org/10.1289/ehp.1104712
  • Hoare, E., Hockey, M., Ruusunen, A., & Jacka, F. N. (2018). Does fruit and vegetable consumption during adolescence predict adult depression? A longitudinal study of US adolescents [Original Research]. Frontiers in Psychiatry, 9(581), 581. https://doi.org/10.3389/fpsyt.2018.00581
  • Hogy, P., Wieser, H., Kohler, P., Schwadorf, K., Breuer, J., Franzaring, J., Muntifering, R., & Fangmeier, A. (2009). Effects of elevated CO2 on grain yield and quality of wheat: Results from a 3-year free-air CO2 enrichment experiment. Plant Biology (Stuttgart, Germany), 11 Suppl 1, 60–69. https://doi.org/10.1111/j.1438-8677.2009.00230.x
  • Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., Patterson, P. H., & Mazmanian, S. K. (2013). Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell, 155(7), 1451–1463. https://doi.org/10.1016/j.cell.2013.11.024
  • Huffman, S. L., Harika, R. K., Eilander, A., & Osendarp, S. J. M. (2011). Essential fats: How do they affect growth and development of infants and young children in developing countries? A literature review. Maternal & Child Nutrition, 7(s3), 44–65. https://doi.org/10.1111/j.1740-8709.2011.00356.x
  • Jacka, F. N., Kremer, P. J., Berk, M., de Silva-sanigorski, A. M., Moodie, M., Leslie, E. R., Pasco, J. A., & Swinburn, B. A. (2011). A prospective study of diet quality and mental health in adolescents. PloS One, 6(9), e24805. https://doi.org/10.1371/journal.pone.0024805
  • Jacka, F. N., O’Neil, A., Opie, R., Itsiopoulos, C., Cotton, S., Mohebbi, M., Castle, D., Dash, S., Mihalopoulos, C., Chatterton, M. L., Brazionis, L., Dean, O. M., Hodge, A. M., & Berk, M. (2017). A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial) [journal article]. BMC Medicine, 15(1), 23. https://doi.org/10.1186/s12916-017-0791-y
  • Jacka, F. N., Ystrom, E., Brantsaeter, A. L., Karevold, E., Roth, C., Haugen, M., Meltzer, H. M., Schjolberg, S., & Berk, M. (2013). Maternal and early postnatal nutrition and mental health of offspring by age 5 years: A prospective cohort study. Journal of the American Academy of Child and Adolescent Psychiatry, 52(10), 1038–1047. https://doi.org/10.1016/j.jaac.2013.07.002
  • Jacobson, M. F., & Schardt, M. S. (1999). Diet, ADHD and behaviour: A quarter-century review. Centre for Science in the Public Interest.
  • Johnstone, J., Hughes, A., Goldenberg, J. Z., Romijn, A. R., & Rucklidge, J. J. (2020). Multinutrients for the treatment of psychiatric symptoms in clinical samples: A systematic review and meta-analysis of randomized controlled trials. Nutrients, 12(11), 3394. https://doi.org/10.3390/nu12113394
  • Johnstone, J., Leung, B., Gracious, B., Perez, L., Tost, G., Savoy, A., Hatsu, I., Hughes, A., Bruton, A., & Arnold, E. (2019). Rationale and design of an international randomized placebo-controlled trial of a 36-ingredient micronutrient supplement for children with ADHD and irritable mood: The micronutrients for ADHD in youth (MADDY) study. Contemporary Clinical Trials Communications, 16, 100478. https://doi.org/10.1016/j.conctc.2019.100478
  • Kanissery, R., Gairhe, B., Kadyampakeni, D., Batuman, O., & Alferez, F. (2019). Glyphosate: Its environmental persistence and impact on crop health and nutrition. Plants (Basel, Switzerland), 8(11), 499. https://doi.org/10.3390/plants8110499
  • Kaplan, B. J., Crawford, S. G., Field, C. J., & Simpson, J. S. (2007). Vitamins, minerals, and mood. Psychological Bulletin, 133(5), 747–760. https://doi.org/10.1037/0033-2909.133.5.747
  • Kaplan, B. J., Crawford, S. G., Gardner, B., & Farrelly, G. (2002). Treatment of mood lability and explosive rage with minerals and vitamins: Two case studies in children. Journal of Child and Adolescent Psychopharmacology, 12(3), 205–219. https://doi.org/10.1089/104454602760386897
  • Kaplan, B. J., Fisher, J. E., Crawford, S. G., Field, C. J., & Kolb, B. (2004). Improved mood and behavior during treatment with a mineral-vitamin supplement: An open-label case series of children. Journal of Child and Adolescent Psychopharmacology, 14(1), 115–122. https://doi.org/10.1089/104454604773840553
  • Kaplan, B. J., Hilbert, P., & Tsatsko, E. (2015). Micronutrient treatment for children with emotional and behavioral dysregulation: A case series. Journal of Medical Case Reports, 9(1), 240. https://doi.org/10.1186/s13256-015-0735-0
  • Kaplan, B. J., Isaranuwatchai, W., & Hoch, J. S. (2017). Hospitalization cost of conventional psychiatric care compared to broad-spectrum micronutrient treatment: Literature review and case study of adult psychosis. International Journal of Mental Health Systems, 11(1), 14. https://doi.org/10.1186/s13033-017-0122-x
  • Kaplan, B. J., Rucklidge, J., Romijn, A., & Dolph, M. (2015). A randomized trial of nutrient supplements to minimize psychological stress after a natural disaster. Psychiatry Research, 228(3), 373–379. http://ac.els-cdn.com/S0165178115003935/1-s2.0-S0165178115003935-main.pdf?_tid=a6528ac4-b83a-11e6-8d2c-00000aab0f6c&acdnat=1480647452_07c0d1a05c43c6b64e66dd72b5633b7c
  • Kaplan, B. J., Rucklidge, J. J., Romijn, A., & McLeod, K. (2015). The emerging field of nutritional mental health: Inflammation, the microbiome, oxidative stress, and mitochondrial function. Clinical Psychological Science, 3(6), 964–980. https://doi.org/10.1177/2167702614555413
  • Kaplan, B. J., & Shannon, S. (2007). Nutritional aspects of child and adolescent psychopharmacology. Pediatric Annals, 36(9), 600–609. https://doi.org/10.3928/0090-4481-20070901-11
  • Kaplan, B. J., Simpson, J. S., Ferre, R. C., Gorman, C. P., McMullen, D. M., & Crawford, S. G. (2001). Effective mood stabilization with a chelated mineral supplement: An open-label trial in bipolar disorder. Journal of Clinical Psychiatry, 62(12), 936–944. https://doi.org/10.4088/JCP.v62n1204
  • Karp, G. (2012). Cell and molecular biology: Concepts and experiments. John Wiley.
  • Lee-Kwan, S. H., Moore, L. V., Blanck, H. M., Harris, D. M., & Galuska, D. (2017). Disparities in state-specific adult fruit and vegetable consumption - United States, 2015. MMWR: Morbidity and Mortality Weekly Report, 66(45), 1241–1247. https://doi.org/10.15585/mmwr.mm6645a1
  • Leonard, W. R., Robertson, M. L., Snodgrass, J. J., & Kuzawa, C. W. (2003). Metabolic correlates of hominid brain evolution. Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology, 136(1), 5–15. https://doi.org/10.1016/s1095-6433(03)00132-6
  • Li, C., Miles, T., Shen, L., Shen, Y., Liu, T., Zhang, M., Li, S., & Huang, C. (2018). Early-life exposure to severe famine and subsequent risk of depressive symptoms in late adulthood: The China health and retirement longitudinal study. British Journal of Psychiatry, 213(4), 579–586. https://doi.org/10.1192/bjp.2018.116
  • Li, Y., Lv, M. R., Wei, Y. J., Sun, L., Zhang, J. X., Zhang, H. G., & Li, B. (2017). Dietary patterns and depression risk: A meta-analysis. Psychiatry Research, 253, 373–382. https://doi.org/10.1016/j.psychres.2017.04.020
  • Loewen, O. K., Maximova, K., Ekwaru, J. P., Asbridge, M., Ohinmaa, A., & Veugelers, P. J. (2020). Adherence to life-style recommendations and attention-deficit/hyperactivity disorder: A population-based study of children aged 10 to 11 years. Psychosomatic Medicine, 82(3), 305–315. https://doi.org/10.1097/PSY.0000000000000787
  • Loewen, O. K., Maximova, K., Ekwaru, J. P., Faught, E. L., Asbridge, M., Ohinmaa, A., & Veugelers, P. J. (2019). Lifestyle behavior and mental health in early adolescence. Pediatrics, 143(5), e20183307. https://doi.org/10.1542/peds.2018-3307
  • Ly, V., Bottelier, M., Hoekstra, P. J., Arias Vasquez, A., Buitelaar, J. K., & Rommelse, N. N. (2017). Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. European Child and Adolescent Psychiatry, 26(9), 1067–1079. https://doi.org/10.1007/s00787-017-0959-1
  • Mao, W., Schuler, M. A., & Berenbaum, M. R. (2015). A dietary phytochemical alters caste-associated gene expression in honey bees. Science Advances, 1(7), e1500795. https://doi.org/10.1126/sciadv.1500795
  • Marles, R. J. (2017). Mineral nutrient composition of vegetables, fruits and grains: The context of reports of apparent historical declines. Journal of Food Composition and Analysis, 56, 93–103. https://doi.org/10.1016/j.jfca.2016.11.012
  • Martinez, A., & Al-Ahmad, A. J. (2019). Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier. Toxicology Letters, 304, 39–49. https://doi.org/10.1016/j.toxlet.2018.12.013
  • Masi, G., Fantozzi, P., Muratori, P., Bertolucci, G., Tacchi, A., Villafranca, A., Pfanner, C., & Cortese, S. (2020). Emotional dysregulation and callous unemotional traits as possible predictors of short-term response to methylphenidate monotherapy in drug-naive youth with ADHD. Comprehensive Psychiatry, 100, 152178. https://doi.org/10.1016/j.comppsych.2020.152178
  • Mathee, K., Cickovski, T., Deoraj, A., Stollstorff, M., & Narasimhan, G. (2020). The gut microbiome and neuropsychiatric disorders: Implications for attention deficit hyperactivity disorder (ADHD). Journal of Medical Microbiology, 69(1), 14–24. https://doi.org/10.1099/jmm.0.001112
  • McCann, J. C., & Ames, B. N. (2009). Vitamin K, an example of triage theory: Is micronutrient inadequacy linked to diseases of aging? American Journal of Clinical Nutrition, 90(4), 889–907. https://doi.org/10.3945/ajcn.2009.27930
  • McNamara, R. K., & Carlson, S. E. (2006). Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins, Leukotrienes and Essential Fatty Acids, 75(4–5), 329–349. https://doi.org/10.1016/j.plefa.2006.07.010
  • McVey Neufeld, K. A., Luczynski, P., Seira Oriach, C., Dinan, T. G., & Cryan, J. F. (2016). What’s bugging your teen?-The microbiota and adolescent mental health. Neuroscience and Biobehavioral Reviews, 70, 300–312. https://doi.org/10.1016/j.neubiorev.2016.06.005
  • Mehl-Madrona, L., Leung, B., Kennedy, C., Paul, S., & Kaplan, B. J. (2010). Micronutrients versus standard medication management in autism: A naturalistic case-control study. Journal of Child and Adolescent Psychopharmacology, 20(2), 95–103. https://doi.org/10.1089/cap.2009.0011
  • Mehl-Madrona, L., & Mainguy, B. (2017). Adjunctive treatment of psychotic disorders with micronutrients. Journal of Alternative and Complementary Medicine, 23(7), 526–533. https://doi.org/10.1089/acm.2016.0215
  • Mohn, E. S., Kern, H. J., Saltzman, E., Mitmesser, S. H., & McKay, D. L. (2018). Evidence of drug-nutrient interactions with chronic use of commonly prescribed medications: An update. Pharmaceutics, 10(1), 36. https://doi.org/10.3390/pharmaceutics10010036
  • Moubarac, J. C., Batal, M., Louzada, M. L., Martinez Steele, E., & Monteiro, C. A. (2017). Consumption of ultra-processed foods predicts diet quality in Canada. Appetite, 108, 512–520. https://doi.org/10.1016/j.appet.2016.11.006
  • Nanri, A., Mizoue, T., Poudel-Tandukar, K., Noda, M., Kato, M., Kurotani, K., Goto, A., Oba, S., Inoue, M., & Tsugane, S., & Japan Public Health Center-based Prospective Study, G. (2013). Dietary patterns and suicide in Japanese adults: The Japan public health center-based prospective study. British Journal of Psychiatry, 203(6), 422–427.
  • Nigg, J. T., Lewis, K., Edinger, T., & Falk, M. (2012). Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives [doi:10.1016/j.jaac.2011.10.015]. Journal of the American Academy of Child and Adolescent Psychiatry, 51(1), 86–97 e88. https://doi.org/10.1016/j.jaac.2011.10.015
  • O’Neil, A., Quirk, S. E., Housden, S., Brennan, S. L., Williams, L. J., Pasco, J. A., Berk, M., & Jacka, F. N. (2014). Relationship between diet and mental health in children and adolescents: A systematic review. American Journal of Public Health, 104(10), e31–42. https://doi.org/10.2105/AJPH.2014.302110
  • Opie, R. S., O’Neil, A., Itsiopoulos, C., & Jacka, F. N. (2015). The impact of whole-of-diet interventions on depression and anxiety: A systematic review of randomised controlled trials. Public Health Nutrition, 18(11), 2074–2093. https://doi.org/10.1017/S1368980014002614
  • Opie, R. S., O’Neil, A., Jacka, F., Pizzinga, J., & Itsiopoulos, C. (2018). A modified Mediterranean dietary intervention for adults with major depression: Dietary protocol and feasibility data from the SMILES trial. Nutritional Neuroscience, 21(7), 487–501. https://doi.org/10.1080/1028415X.2017.1312841
  • Opie, R. S., Segal, L., Jacka, F. N., Nicholls, L., Dash, S., & Pizzinga, J. (2015). Assessing healthy diet affordability in a cohort with major depressive disorder. Journal of Public Health Epidemiology, 7. https://doi.org/10.5897/jphe2014.0668
  • Parletta, N., Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., Blunden, S., Meyer, B., Segal, L., Baune, B. T., & O’Dea, K. (2019). A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED). Nutritional Neuroscience, 22(7), 474–487. https://doi.org/10.1080/1028415X.2017.1411320
  • Pauling, L. (1968). Orthomolecular psychiatry. Science, 160(3825), 265–271. https://doi.org/10.1126/science.160.3825.265
  • Paxton, A. E., Strycker, L. A., Toobert, D. J., Ammerman, A. S., & Glasgow, R. E. (2011). Starting the conversation performance of a brief dietary assessment and intervention tool for health professionals. American Journal of Preventive Medicine, 40(1), 67–71. https://doi.org/10.1016/j.amepre.2010.10.009
  • Phillips, J. G. P. (1910). The treatment of melancholia by the lactic acid bacillus. British Journal of Psychiatry, 56(234), 422-NP.
  • Popper, C. (2001). Do vitamins or minerals (apart from lithium) have mood-stabilising effects? Journal of Clinical Psychiatry, 62(12), 933–935. http://www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/jcp/article/pages/2001/v62n12/v62n1203.aspx&Type=Article
  • Popper, C., Kaplan, B. J., & Rucklidge, J. J. (2017). Single and broad-spectrum micronutrient treatments in psychiatry practice. In P. L. Gerbarg, P. R. Muskin, & R. P. Brown (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 75–104). American Psychiatric Association Publishing.
  • Rios-Hernandez, A., Alda, J. A., Farran-Codina, A., Ferreira-Garcia, E., & Izquierdo-Pulido, M. (2017). The Mediterranean diet and ADHD in children and adolescents. Pediatrics, 139(2), e20162027. https://doi.org/10.1542/peds.2016-2027
  • Robertson, R. C., Seira Oriach, C., Murphy, K., Moloney, G. M., Cryan, J. F., Dinan, T. G., Paul Ross, R., & Stanton, C. (2017). Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood. Brain, Behavior, and Immunity, 59, 21–37. https://doi.org/10.1016/j.bbi.2016.07.145
  • Rodway, M., Vance, A., Watters, A., Lee, H., Bos, E., & Kaplan, B. J. (2012). Efficacy and cost of micronutrient treatment of childhood psychosis. BMJ Case Reports, 10.1136/bcr-2012-007213. https://doi.org/10.1136/bcr-2012-007213
  • Rucklidge, J. J. (2019). 20.1 micronutrients for emotional dysregulation in children. Journal of the American Academy of Child and Adolescent Psychiatry, 58(10), S329. https://doi.org/10.1016/j.jaac.2019.07.773
  • Rucklidge, J. J., Andridge, R., Gorman, B., Blampied, N., Gordon, H., & Boggis, A. (2012). Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Human Psychopharmacology, 27(5), 440–454. https://doi.org/10.1002/hup.2246
  • Rucklidge, J. J., Eggleston, M. J. F., Boggis, A., Darling, K., Gorman, B., & Frampton, C. M. (2019). Do changes in blood nutrient levels mediate treatment response in children and adults with ADHD consuming a vitamin-mineral supplement? Journal of Attention Disorders, 1087054719886363. https://doi.org/10.1177/1087054719886363
  • Rucklidge, J. J., Eggleston, M. J. F., Darling, K. A., Stevens, A. J., Kennedy, M. A., & Frampton, C. M. (2019). Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 89, 181–192. https://doi.org/10.1016/j.pnpbp.2018.09.007
  • Rucklidge, J. J., Eggleston, M. J. F., Ealam, B., Beaglehole, B., & Mulder, R. T. (2019). An observational preliminary study on the safety of long-term consumption of micronutrients for the treatment of psychiatric symptoms. Journal of Alternative and Complementary Medicine, 25(6), 613–622. https://doi.org/10.1089/acm.2018.0352
  • Rucklidge, J. J., Eggleston, M. J. F., Johnstone, J. M., Darling, K., & Frampton, C. M. (2018). Vitamin-mineral treatment improves aggression and emotional regulation in children with ADHD : A fully blinded, randomized, placebo-controlled trial. Journal of Child Psychology and Psychiatry and Allied Disciplines, 59(3), 232–246. https://doi.org/10.1111/jcpp.12817
  • Rucklidge, J. J., Frampton, C. M., Gorman, B., & Boggis, A. (2014). Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: Double-blind randomised placebo-controlled trial. British Journal of Psychiatry, 204(4), 306–315. https://doi.org/10.1192/bjp.bp.113.132126
  • Rucklidge, J. J., Frampton, C. M., Gorman, B., & Boggis, A. (2017). Vitamin-mineral treatment of ADHD in adults: A 1-year naturalistic follow-up of a randomized controlled trial. Journal of Attention Disorders, 21(6), 522–532. https://doi.org/10.1177/1087054714530557
  • Rucklidge, J. J., Gately, D., & Kaplan, B. J. (2010). Database analysis of children and adolescents with bipolar disorder consuming a micronutrient formula. BMC Psychiatry, 10(1), 74. https://doi.org/10.1186/1471-244X-10-74
  • Rucklidge, J. J., Harris, A., & Shaw, I. (2014). Are the amounts of vitamins in commercially available dietary supplement formulations relevant for the management of psychiatric disorders in children? New Zealand Medical Journal, 127(1392), 73–85. https://www.ncbi.nlm.nih.gov/pubmed/24806250
  • Rucklidge, J. J., Johnstone, J., Gorman, B., Boggis, A., & Frampton, C. M. (2014). Moderators of treatment response in adults with ADHD treated with a vitamin-mineral supplement. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 50, 163–171. https://doi.org/10.1016/j.pnpbp.2013.12.014
  • Rucklidge, J. J., Johnstone, J., & Kaplan, B. J. (2009). Nutrient supplementation approaches in the treatment of ADHD. Expert Review of Neurotherapeutics, 9(4), 461–476. https://doi.org/10.1586/ern.09.7
  • Rucklidge, J. J., Taylor, M., & Whitehead, K. (2011). Effect of micronutrients on behavior and mood in adults with ADHD: Evidence from an 8-week open label trial with natural extension. Journal of Attention Disorders, 15(1), 79–91. https://doi.org/10.1177/1087054709356173
  • Sanchez-Villegas, A., Delgado-Rodriguez, M., Alonso, A., Schlatter, J., Lahortiga, F., Serra Majem, L., & Martinez-Gonzalez, M. A. (2009). Association of the Mediterranean dietary pattern with the incidence of depression: The Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Archives of General Psychiatry, 66(10), 1090–1098. https://doi.org/10.1001/archgenpsychiatry.2009.129
  • Sarris, J., Mischoulon, D., & Schweitzer, I. (2011). Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: A systematic review of clinical trials. Bipolar Disord, 13(5–6), 454–465. https://doi.org/10.1111/j.1399-5618.2011.00945.x
  • Schab, D. W., & Trinh, N. H. (2004). Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. Journal of Developmental and Behavioral Pediatrics, 25(6), 423–434. http://ovidsp.tx.ovid.com/ovftpdfs/FPDDNCDCJECMCN00/fs047/ovft/live/gv031/00004703/00004703-200412000-00007.pdf
  • Schoenthaler, S., Amos, S., Doraz, W., Kelly, M.-A., Muedeking, G., Wakefield, J., Amos, S., Doraz, W., Kelly, M.-A., Muedeking, G., Wakefield, J., Doraz, W., Kelly, M.-A., Muedeking, G., Wakefield, J., Kelly, M.-A., Muedeking, G., Wakefield, J., Muedeking, G., Wakefield, J., & Wakefield, J. (1997). The effect of randomized vitamin-mineral supplementation on violent and non-violent antisocial behavior among incarcerated juveniles. Journal of Nutritional and Environmental Medicine, 7(4), 343–352. https://doi.org/10.1080/13590849762475
  • Schoenthaler, S., & Bier, I. (2000). The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: A randomized, double-blind placebo-controlled trial. Journal of Alternative and Complementary Medicine, 6(1), 7–17. https://www.liebertpub.com/doi/abs/10.1089/acm.2000.6.7
  • Simpson, S., Crawford, S., Goldstein, E., Field, C., Burgess, E., & Kaplan, B. (2011). Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. BMC Psychiatry, 11(1), 62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094286/pdf/1471-244X-11-62.pdf
  • Steenweg-de Graaff, J., Tiemeier, H., Steegers-Theunissen, R. P., Hofman, A., Jaddoe, V. W., Verhulst, F. C., & Roza, S. J. (2014). Maternal dietary patterns during pregnancy and child internalising and externalising problems. The generation R study. Clinical Nutrition, 33(1), 115–121. https://doi.org/10.1016/j.clnu.2013.03.002
  • Stevens, A. J., Purcell, R. V., Darling, K. A., Eggleston, M. J. F., Kennedy, M. A., & Rucklidge, J. J. (2019). Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Scientific Reports, 9(1), 10128. https://doi.org/10.1038/s41598-019-46146-3
  • Stevens, A. J., Rucklidge, J. J., Darling, K. A., Eggleston, M. J., Pearson, J. F., & Kennedy, M. A. (2018). Methylomic changes in response to micronutrient supplementation and MTHFR genotype. Epigenomics, 10(9), 1201–1214. https://doi.org/10.2217/epi-2018-0029
  • Szopinska-Tokov, J., Dam, S., Naaijen, J., Konstanti, P., Rommelse, N., Belzer, C., Buitelaar, J., Franke, B., Aarts, E., & Arias Vasquez, A. (2020). Investigating the gut microbiota composition of individuals with attention-deficit/hyperactivity disorder and association with symptoms. Microorganisms, 8(3), 406. https://doi.org/10.3390/microorganisms8030406
  • Tammam, J. D., Steinsaltz, D., Bester, D. W., Semb-Andenaes, T., & Stein, J. F. (2016). A randomised double-blind placebo-controlled trial investigating the behavioural effects of vitamin, mineral and n-3 fatty acid supplementation in typically developing adolescent schoolchildren. British Journal of Nutrition, 115(2), 361–373. https://doi.org/10.1017/S0007114515004390
  • Tengeler, A. C., Dam, S. A., Wiesmann, M., Naaijen, J., van Bodegom, M., Belzer, C., Dederen, P. J., Verweij, V., Franke, B., Kozicz, T., Arias Vasquez, A., & Kiliaan, A. J. (2020). Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice. Microbiome, 8(1), 44. https://doi.org/10.1186/s40168-020-00816-x
  • Tenore, G. C., Daglia, M., Orlando, V., D’Urso, E., Saadat, S. H., Novellino, E., Nabavi, S. F., & Nabavi, S. M. (2015). Coffee and Depression: A Short Review of Literature. Current Pharmaceutical Design, 21(34), 5034–5040. https://doi.org/10.2174/1381612821666150825145112
  • Thys-Jacobs, S., Starkey, P., Bernstein, D., & Tian, J. (1998). Calcium carbonate and the premenstrual syndrome: Effects on premenstrual and menstrual symptoms. Premenstrual syndrome study group. American Journal of Obstetrics and Gynecology, 179(2), 444–452. https://doi.org/10.1016/S0002-9378(98)70377-1
  • Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., Claes, S., Van Oudenhove, L., Zhernakova, A., Vieira-Silva, S., & Raes, J. (2019). The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 4(4), 623–632. https://doi.org/10.1038/s41564-018-0337-x
  • Valzelli, L. (1984). Reflections on experimental and human pathology of aggression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 8(3), 311–325. https://www.ncbi.nlm.nih.gov/pubmed/6385139
  • van der Burg, K., Cribb, L., Firth, J., Karmacoska, D., & Sarris, J. (2019). Nutrient and genetic biomarkers of nutraceutical treatment response in mood and psychotic disorders: A systematic review. Nutritional Neuroscience, 1–17. https://doi.org/10.1080/1028415X.2019.1625222
  • Walsh, R. (2011). Lifestyle and mental health. American Psychologist, 66(7), 579–592. https://doi.org/10.1037/a0021769
  • West, A. E., Celio, C. I., Henry, D. B., & Pavuluri, M. N. (2011). Child mania rating scale-parent version: A valid measure of symptom change due to pharmacotherapy. Journal of Affective Disorders, 128(1–2), 112–119. https://doi.org/10.1016/j.jad.2010.06.013
  • Young, L., Pipingas, A., White, D., Gauci, S., & Scholey, A. (2019). A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: Effects on healthy and ‘At-Risk’ individuals. Nutrients, 11(9), 2232. https://www.mdpi.com/2072-6643/11/9/2232
  • Zaalberg, A., Nijman, H., Bulten, E., Stroosma, L., & van der Staak, C. (2010). Effects of nutritional supplements on aggression, rule-breaking, and psychopathology among young adult prisoners. Aggressive Behavior, 36(2), 117–126. https://doi.org/10.1002/ab.20335
  • Zhu, C., Kobayashi, K., Loladze, I., Zhu, J., Jiang, Q., Xu, X., Liu, G., Seneweera, S., Ebi, K. L., Drewnowski, A., Fukagawa, N. K., & Ziska, L. H. (2018). Carbon dioxide (CO2) levels this century will alter the protein, micronutrients, and vitamin content of rice grains with potential health consequences for the poorest rice-dependent countries. Science Advances, 4(5), eaaq1012. https://doi.org/10.1126/sciadv.aaq1012
  • Zobiole, L. H., Oliveira, R. S., Visentainer, J. V., Kremer, R. J., Bellaloui, N., & Yamada, T. (2010). Glyphosate affects seed composition in glyphosate-resistant soybean. Journal of Agricultural and Food Chemistry, 58(7), 4517–4522. https://doi.org/10.1021/jf904342t

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