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Review

The Etiology and management of radiotherapy-induced fatigue

, &
Pages 323-328 | Received 07 Apr 2016, Accepted 17 May 2016, Published online: 07 Jun 2016

References

  • Zagar TM, Willett CG, Czito BG. Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes. Oncology (Williston Park). 2010;24(9):815–23, 828.
  • Khan HA, Alhomida AS. A review of the logistic role of L-carnitine in the management of radiation toxicity and radiotherapy side effects. J Appl Toxicol. 2011;31(8):707–713. doi:10.1002/jat.1716.
  • Damber J-E, Aus G. Prostate cancer. Lancet. 2008;371(9625):1710–1721. doi:10.1016/S0140-6736(08)60729-1.
  • Berger AM, Mooney K, Alvarez-Perez A, et al. Cancer-related fatigue, version 2.2015. J Natl Compr Cancer Netw. 2015;13(8):1012–1039.
  • Bower JE. Cancer-related fatigue–mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11(10):597–609. doi:10.1038/nrclinonc.2014.127.
  • Stone HB, Coleman CN, Anscher MS, et al. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. 2003;4(9):529–536.
  • Bucci MK, Bevan A, Roach M 3rd. Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond. CA Cancer J Clin. 2005;55(2):117–134.
  • Piper BF, Cella D. Cancer-related fatigue: definitions and clinical subtypes. J Natl Compr Canc Netw. 2010;8(8):958–966.
  • Barsevick A, Frost M, Zwinderman A, et al. I’m so tired: biological and genetic mechanisms of cancer-related fatigue. Qual Life Res. 2010;19(10):1419–1427. doi:10.1007/s11136-010-9757-7.
  • Weis J. Cancer-related fatigue: prevalence, assessment and treatment strategies. Expert Rev Pharmacoecon Outcomes Res. 2011;11(4):441–446. doi:10.1586/erp.11.44.
  • Oh HS, Seo WS. Systematic review and meta-analysis of the correlates of cancer-related fatigue. Worldviews Evid Based Nurs. 2011;8(4):191–201. doi:10.1111/j.1741-6787.2011.00214.x.
  • Campos MP, Hassan BJ, Riechelmann R, et al. Cancer-related fatigue: a practical review. Ann Oncol. 2011;22(6):1273–1279. doi:10.1093/annonc/mdq458.
  • Mitchell SA. Cancer-related fatigue: state of the science. PM&R. 2010;2(5):364–383. doi:10.1016/j.pmrj.2010.03.024.
  • Holliday EB, Dieckmann NF, McDonald TL, et al. Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer: a prospective study. Radiother Oncol. 2016;118(1):105–111. doi:10.1016/j.radonc.2015.12.015.
  • Hickok JT, Morrow GR, Roscoe JA, et al. Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer. J Pain Symptom Manage. 2005;30(5):433–442. doi:10.1016/j.jpainsymman.2005.04.012.
  • Berger AM, Mitchell SA. Modifying cancer-related fatigue by optimizing sleep quality. J Natl Compr Canc Netw. 2008;6(1):3–13.
  • Pinto BM, Dunsiger S, Waldemore M. Physical activity and psychosocial benefits among breast cancer patients. Psycho-Oncol. 2013;22(10):2193–2199.
  • Langston, B., Armes, J., Levy A, et al. The prevalence and severity of fatigue in men with prostate cancer: a systematic review of the literature. Supportive Care in Cancer. 2013;21(6):1761–1771.
  • Hsiao C-P, Wang D, Kaushal A, et al. Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam radiation therapy. Cancer Nurs. 2013;36(3):189–197. doi:10.1097/NCC.0b013e318263f514.
  • Danjoux C, Gardner S, Fitch M. Prospective evaluation of fatigue during a course of curative radiotherapy for localised prostate cancer. Support Care Cancer. 2007;15(10):1169–1176. doi:10.1007/s00520-007-0229-8.
  • Dhruva AMD, Dodd M, Paul SM, et al. Trajectories of fatigue in patients with breast cancer before, during, and after radiation therapy. Cancer Nursing May/June. 2010;33(3):201–212. doi:10.1097/NCC.0b013e3181c75f2a.
  • Hsiao C-P, Wang D, Kaushal A, et al. Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy. J Pain Symptom Manage. 2014;48(6):1080–1090. doi:10.1016/j.jpainsymman.2014.03.010.
  • Eghbal MA, Pennefather PS, O’Brien PJ. H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. Toxicology. 2004;203(1–3):69–76. doi:10.1016/j.tox.2004.05.020.
  • Schaue D, McBride WH. T lymphocytes and normal tissue responses to radiation. Front Oncol. 2012;2:119. doi:10.3389/fonc.2012.00119.
  • Bower JE, Ganz PA, Tao ML, et al. Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer. Clin Cancer Res. 2009;15(17):5534–5540. doi:10.1158/1078-0432.CCR-08-2584.
  • Ryan JL, Carroll JK, Ryan EP, et al. Mechanisms of cancer-related fatigue. Oncologist. 2007;12 Suppl 1(suppl_1):22–34. doi:10.1634/theoncologist.12-S1-22.
  • Courtier N, Gambling T, Enright S, et al. Psychological and immunological characteristics of fatigued women undergoing radiotherapy for early-stage breast cancer. Support Care Cancer. 2013;21(1):173–181. doi:10.1007/s00520-012-1508-6.
  • Wang XS, Shi Q, Williams LA, et al. Inflammatory cytokines are associated with the development of symptom burden in patients with NSCLC undergoing concurrent chemoradiation therapy. Brain Behav Immun. 2010;24(6):968–974. doi:10.1016/j.bbi.2010.03.009.
  • Wang XS, Williams LA, Krishnan S, et al. Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy. Brain Behav Immun. 2012;26(5):699–705. doi:10.1016/j.bbi.2011.12.007.
  • Miaskowski C, Dodd M, Lee K, et al. Preliminary evidence of an association between a functional interleukin-6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers. J Pain Symptom Manage. 2010;40(4):531–544. doi:10.1016/j.jpainsymman.2009.12.006.
  • Watkins LR, Maier SF, Goehler LE. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 1995;57(11):1011–1026.
  • Dantzer R, Bluthé RM, Layé S, et al. Cytokines and sickness behavior. Ann N Y Acad Sci. 1998;840:586–590.
  • Saligan LN, Olson K, Filler K, et al. The biology of cancer-related fatigue: a review of the literature. Support Care Cancer. 2015;23(8):2461–2478. doi:10.1007/s00520-015-2763-0.
  • Saligan LN, Hsiao CP, Wang D, et al. Upregulation of alpha-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain Behav Immun. 2013;27(1):63–70. doi:10.1016/j.bbi.2012.09.009.
  • Saligan LN, Lukkahatai N, Holder G, et al. Lower brain-derived neurotrophic factor levels associated with worsening fatigue in prostate cancer patients during repeated stress from radiation therapy. World J Biol Psychiatry. 2015;1–7. doi:10.3109/15622975.2015.1012227.
  • Hsiao C-P, Araneta M, Wang XM, et al. The association of IFI27 expression and fatigue intensification during localized radiation therapy: implication of a para-inflammatory bystander response. Int J Mol Sci. 2013;14(8):16943–16957. doi:10.3390/ijms140816943.
  • Hsiao C-P, Reddy SY, Chen M-K, et al. Genomic profile of fatigued men receiving localized radiation therapy. Biol Res Nurs. 2016;18(3):281–289. doi:10.1177/1099800415618786.
  • Pettet AG, Flinton DM. Radiotherapy related fatigue: strategies and knowledge of the UK radiographer and nurse. Radiography. 2002;8:149–158. doi:10.1053/radi.2002.0371.
  • Grellier N, Deray G, Yousfi A, et al. [Functional iron deficiency, inflammation and fatigue after radiotherapy]. Bull Cancer. 2015;102(9):780–785. French. doi:10.1016/j.bulcan.2015.06.001
  • Mock V, Olsen M. Current management of fatigue and anemia in patients with cancer. Semin Oncol Nurs. 2003;19(4 Suppl 2):36–41.
  • Feng L, Chen M-K, Lukkahatai N, et al. Clinical predictors of fatigue in men with non-metastatic prostate cancer receiving external beam radiation therapy. Clin J Oncol Nurs. 2015;19(6):744–750. doi:10.1188/15.CJON.744-750.
  • Hoskin PJ, Robinson M, Slevin N, et al. Effect of epoetin alfa on survival and cancer treatment–related anemia and fatigue in patients receiving radical radiotherapy with curative intent for head and neck cancer. J Clin Oncol. 2009;27(34):5751–5756. doi:10.1200/JCO.2009.22.3693.
  • Wratten C, Kilmurray J, Nash S, et al. Fatigue during breast radiotherapy and its relationship to biological factors. Int J Radiat Oncol Biol Phys. 2004;59(1):160–167. doi:10.1016/j.ijrobp.2003.10.008.
  • Lind M, Vernon C, Cruickshank D, et al. The level of haemoglobin in anaemic cancer patients correlates positively with quality of life. Br J Cancer. 2002;86(8):1243–1249. doi:10.1038/sj.bjc.6600247.
  • Pieczenik SR, Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol. 2007;83(1):84–92. doi:10.1016/j.yexmp.2006.09.008.
  • Zhao W, Robbins ME. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem. 2009;16(2):130–143.
  • Nicolson GL, Conklin KA. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy. Clin Exp Metastasis. 2008;25(2):161–169. doi:10.1007/s10585-007-9129-z.
  • Zabbarova I, Kanai A. Targeted delivery of radioprotective agents to mitochondria. Mol Interv. 2008;8(6):294–302. doi:10.1124/mi.8.6.7.
  • Mandelker L. Introduction to oxidative stress and mitochondrial dysfunction. Vet Clin North Am Small Anim Pract. 2008;38(1):1–30. doi:10.1016/j.cvsm.2007.10.005.
  • Borisov VB, Liebl U, Rappaport F, et al. Interactions between heme d and heme b595 in quinol oxidase bd from Escherichia coli: a photoselection study using femtosecond spectroscopy. Biochemistry. 2002;41(5):1654–1662.
  • Hinson JT, Fantin VR, Schönberger J, et al. Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome. New England J Med. 2007;356(8):809–819. doi:10.1056/NEJMoa055262.
  • Lesnefsky EJ, Hoppel CL. Oxidative phosphorylation and aging. Ageing Res Rev. 2006;5(4):402–433. doi:10.1016/j.arr.2006.04.001.
  • Kotarsky H, Keller M, Davoudi M, et al. Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation. PLoS One. 2012;7(7):e41156. doi:10.1371/journal.pone.0041156.
  • Morán M, Marín-Buera L, Gil-Borlado MC, et al. Cellular pathophysiological consequences of BCS1L mutations in mitochondrial complex III enzyme deficiency. Hum Mutat. 2010;31(8):930–941. doi:10.1002/humu.21294.
  • Lill, R., Diekert K, Kaut A, et al. The essential role of mitochondria in the biogenesis of cellular iron-sulfur proteins. Biol Chem. 1999;380(10):1157–1166.
  • Hsiao CP, Daly B, Hoppel C. Association between mitochondrial bioenergetics and radiation-related fatigue: a possible mechanism and novel target iMedPub journals. Arch Cancer Res. 2015;3(4):1–9.
  • National Comprehensive Cancer Network. Cancer-related fatigue. Natl Compr Cancer Netw Pract Guidel Oncol. 2016;1:1–56.
  • Bruera E, Valero V, Driver L, et al. Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trial. J Clin Oncol. 2006;24(13):2073–2078. doi:10.1200/JCO.2005.02.8506.
  • Page BR, Shaw EG, Lu L, et al. Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. Neuro Oncol. 2015;17(10):1393–1401. doi:10.1093/neuonc/nov084.
  • Lee EQ, Muzikansky A, Drappatz J, et al. A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy. Neuro Oncol. 2016;18(6):849–854. doi:10.1093/neuonc/now007.
  • Rahmani S, Talepasand S. The effect of group mindfulness - based stress reduction program and conscious yoga on the fatigue severity and global and specific life quality in women with breast cancer. Med J Islam Repub Iran. 2015;29:175–175.
  • Armes J, Chalder T, Addington-Hall J, et al. A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancer-related fatigue. Cancer. 2007;110(6):1385–1395. doi:10.1002/cncr.22923.
  • Potthoff K, Schmidt ME, Wiskemann J, et al. Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study. BMC Cancer. 2013;13(1):162. doi:10.1186/1471-2407-13-162.
  • Bardy J, Finnegan-John J, Molassiotis A, et al. Providing acupuncture in a breast cancer and fatigue trial: the therapists’ experience. Complement Ther Clin Pract. 2015;21(4):217–222. doi:10.1016/j.ctcp.2015.08.003.
  • Zick SM, Alrawi S, Merel G, et al. Relaxation acupressure reduces persistent cancer-related fatigue. Evid Based Complement Alternat Med. 2011. doi:10.1155/2011/142913.
  • Zick SM, Wyatt G, Murphy S, et al. Acupressure for persistent cancer-related fatigue in breast cancer survivors (AcuCrft): a study protocol for a randomized controlled trial. BMC Complement Altern Med. 2012;12:132. doi:10.1186/1472-6882-12-132.
  • Yang L, Li -T-T, Chu Y-T, et al. Traditional Chinese medical comprehensive therapy for cancer-related fatigue. Chin J Integr Med. 2015;22(1):67–72. doi:10.1007/s11655-015-2105-6.
  • Barsevick AM, Dudley W, Beck S, et al. A randomized clinical trial of energy conservation for patients with cancer-related fatigue. Cancer. 2004;100(6):1302–1310. doi:10.1002/cncr.20111.
  • Schmidt ME, Meynköhn A, Habermann N, et al. Resistance exercise and inflammation in breast cancer patients undergoing adjuvant radiation therapy: mediation analysis from a randomized, controlled intervention trial. Int J Radiat Oncol Biol Phys. 2016;94(2):329–337. doi:10.1016/j.ijrobp.2015.10.058.
  • Al-Majid S, Wilson LD, Rakovski C, et al. Effects of exercise on biobehavioral outcomes of fatigue during cancer treatment: results of a feasibility study. Biol Res Nurs. 2015;17(1):40–48. doi:10.1177/1099800414523489.
  • Rogers LQ, Anton PM, Fogleman A, et al. Pilot, randomized trial of resistance exercise during radiation therapy for head and neck cancer. Head Neck. 2013;35(8):1178–1188. doi:10.1002/hed.23118.
  • Rogers LQ, Fogleman A, Trammell R, et al. Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breast cancer survivors: pilot randomized trial. Integr Cancer Ther. 2013;12(4):323–335. doi:10.1177/1534735412449687.
  • Capozzi LC, McNeely ML, Lau HY, et al. Patient-reported outcomes, body composition, and nutrition status in patients with head and neck cancer: results from an exploratory randomized controlled exercise trial. Cancer. 2016. doi:10.1002/cncr.v122.8.
  • Grabenbauer A, Grabenbauer AJ, Lengenfelder R, et al. Feasibility of a 12-month-exercise intervention during and after radiation and chemotherapy in cancer patients: impact on quality of life, peak oxygen consumption, and body composition. Radiat Oncol. 2016;11(1):42. doi:10.1186/s13014-016-0619-5.
  • Reis D, Walsh ME, Young-McCaughan S, et al. Effects of Nia exercise in women receiving radiation therapy for breast cancer. Oncol Nurs Forum. 2013;40(5):E374–E381. doi:10.1188/13.ONF.E374-E381.
  • Nicolson GL, Ash ME. Lipid replacement therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function. Biochim Biophys Acta. 2014;1838(6):1657–1679. doi:10.1016/j.bbamem.2013.11.010.
  • Nicolson GL. Lipid replacement therapy: a nutraceutical approach for reducing cancer-associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial function. Cancer Metastasis Rev. 2010;29(3):543–552. doi:10.1007/s10555-010-9245-0.
  • Iwase S, Kawaguchi T, Yotsumoto D, et al. Efficacy and safety of an amino acid jelly containing coenzyme Q10 and L-carnitine in controlling fatigue in breast cancer patients receiving chemotherapy: a multi-institutional, randomized, exploratory trial (JORTC-CAM01). Support Care Cancer. 2016;24(2):637–646. doi:10.1007/s00520-015-2824-4.
  • Stubbe CE, Valero M. Complementary strategies for the management of radiation therapy side effects. J Adv Pract Oncol. 2013;4(4):219–231.
  • Mustian KM, Morrow GR, Carroll JK, et al. Integrative nonpharmacologic behavioral interventions for the management of cancer-related fatigue. Oncologist. 2007;12(Suppl 1):52–67. doi:10.1634/theoncologist.12-S1-52.
  • Graziano F, Bisonni R, Catalano V, et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. Br J Cancer. 2002;86(12):1854–1857. doi:10.1038/sj.bjc.6600413.
  • Filler K, Saligan LN. Defining cancer-related fatigue for biomarker discovery. Supportive Care in Cancer. 2015;24(1):5–7. doi:10.1007/s00520-015-2965-5.
  • O’Gorman C, Sasiadek W, Denieffe S, et al. Predicting radiotherapy-related Clinical toxicities in cancer: a literature review. Clin J Oncol Nurs. 2014;18(3):E37–44.
  • Appling SE, Scarvalone S, MacDonald R, et al. Fatigue in breast cancer survivors: the impact of a mind-body medicine intervention. Oncol Nurs Forum. 2012;39(3):278–286. doi:10.1188/12.ONF.278-286.

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