Alterations in mtDNA, gastric carcinogenesis and early diagnosis

References

• Amieva M, Peek RM. Jr. 2016. Pathobiology of Helicobacter pylori-induced gastric cancer. Gastroenterology. 150:64–78.
   PubMed Web of Science ®Google Scholar
• Bi R, Li WL, Chen MQ, Zhu Z, Yao YG. 2011. Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny. Mutat Res. 709–710:15–20.
   PubMed Web of Science ®Google Scholar
• Boroughts LK, DeBerardinis RJ. 2015. Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol. 17:351–359.
   PubMed Web of Science ®Google Scholar
• Borriello A, Ragione FD. 2017. The new anticancer era: tumor metabolism targeting. Cell Cycle. 16:310–311.
   PubMed Web of Science ®Google Scholar
• Burgart LJ, Zheng J, Shu Q, Strickler JG, Shibata D. 1995. Somatic mitochondrial mutation in gastric cancer. Am J Pathol. 147:1105–1111.
   PubMed Web of Science ®Google Scholar
• Bussard KM, Siracusa LD. 2017. Understanding mitochondrial polymorphisms in cancer. Cancer Res. 77:6051–6059.
   PubMed Web of Science ®Google Scholar
• Butcher LD, Den Hartog G, Ernst PB, Crowe SE. 2017. Oxidative stress resulting from Helicobacter pylori infection contributes to gastric carcinogenesis. Cell Mol Gastroenterol Hepatol. 3:316–322.
   PubMed Web of Science ®Google Scholar
• Cairns RA, Mak TW. 2016. The current state of cancer metabolism. Nat Rev Cancer. 16:613–614.
   Web of Science ®Google Scholar
• Chen X, Fang Y, Shi Y, Cui J, Li L, Xu Y, Ling B. 2016. Mitochondrial D310 instability in Chinese lung cancer patients. Mitochondrial DNA A DNA Mapp Seq Anal. 27:1177–1180.
   PubMedGoogle Scholar
• Cutsem EV, Sagaert X, Topal B, Haustermans K, Prenem H. 2016. Gastric cancer. Lancet. 388:2654–2664.
   PubMed Web of Science ®Google Scholar
• DeBerardinis RJ, Chandel NS. 2016. Fundamentals of cancer metabolism. Sci Adv. 2:e1600200.
   PubMed Web of Science ®Google Scholar
• Errichiello E, Venesio TJ. 2017. Mitochondrial DNA variants in colorectal carcinogenesis: drivers or passengers? J Cancer Res Clin Oncol. 143:1905–1914.
   PubMed Web of Science ®Google Scholar
• Fernandes J, Michel V, Camorlinga-Ponce M, Gomez A, Maldonado C, De Reuse H, Torres J, Touati E. 2014. Circulating mitochondrial DNA level, a noninvasive biomarker for the early detection of gastric cancer. Cancer Epidemiol Biomarkers Prev. 23:2430–2438.
   PubMed Web of Science ®Google Scholar
• Geurts-Giele WRR, Gathier GHGK, Atmodimedjo PN, Dubbink HJ, Dinjens WNM. 2015. Mitochondrial D310 mutation as clonal marker for solid tumors. Virchows Arch. 467:595–602.
   PubMed Web of Science ®Google Scholar
• Giannattasio S, Guaragnella N, Arbini AA, Moro L. 2013. Stress-related mitochondrial components and mitochondrial genome as targets of anticancer therapy. Chem Biol Drug Des. 81:102–112.
   PubMed Web of Science ®Google Scholar
• Govatati S, Saradamma B, Malempati S, Dasi D, Thupurani MK, Nagesh N, Shivaji S, Bhanoori M, Tamanam RR, Nallanchakravarthula V, et al. 2017. Association of mitochondrial displacement loop polymorphisms with risk of colorectal cancer in south Indian population. Mitochondrial DNA A DNA Mapp Seq Anal. 28:632–637.
   PubMedGoogle Scholar
• Grimm A, Friedland K, Eckert A. 2016. Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease. Biogerontology. 17:281–296.
   PubMed Web of Science ®Google Scholar
• Guggenheim DE, Shah MA. 2013. Gastric cancer epidemiology and risk factors. J Surg Oncol. 107:230–236.
   PubMed Web of Science ®Google Scholar
• Guo Z, Zhao S, Fan H, Du Y, Zhao Y, Wang G. 2016. Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer. Mitochondr A. 27:1–2.
   PubMed Web of Science ®Google Scholar
• Habano W, Sugai T, Nakamura SI, Uesugi N, Yoshida T, Sasou S. 2000. Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma. Gastroenterology. 118:835–841.
   PubMed Web of Science ®Google Scholar
• Han CB, Li F, Zhao YJ, Ma JM, Wu DY, Zhang YK, Xin Y. 2003. Variations of mitochondrial D-loop region plus downstream gene 12S rRNA-tRNAphe and gastric carcinomas. World J Gastroenterol. 9:1925–1929.
   PubMed Web of Science ®Google Scholar
• Han CB, Ma JM, Xin Y, Mao XY, Zhao YJ, Wu DY, Zhang SM, Zhang YK. 2005. Mutations of mitochondrial 12S rRNA in gastric carcinoma and their significance. World J Gastroenterol. 11:31–35.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell. 144:646–674.
   PubMed Web of Science ®Google Scholar
• Hansford S, Kaurah P, Li-Chang H, Woo M, Senz J, Pinheiro H, Schrader KA, Schaeffer DF, Shumansky K, Zogopoulos G, et al. 2015. Hereditary diffuse gastric cancer syndrome CDH1 mutations and beyond. JAMA Oncol. 1:23–32.
   PubMed Web of Science ®Google Scholar
• Hardie R, van Dam E, Cowley M, Han T, Balaban S, Pajic M, Pinese M, Iconomou M, Shearer RF, McKenna J, et al. 2017. Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer Metabol. 5:2.
   PubMed Web of Science ®Google Scholar
• Hiyama T, Tanaka S, Shima H, Kose K, Kitadai Y, Ito M, Sumii M, Yoshihara M, Shimamoto F, Haruma K, et al. 2003. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer. Int J Mol Med. 12:169–174.
   PubMed Web of Science ®Google Scholar
• Hofmann JN, Hosgood HD, Liu C, Chow W, Shuch B, Cheng W, Lin T, Moore LE, Lan Q, Rothman N, et al. 2014. A nested case-control study of leukocyte mitochondrial DNA copy number and renal cell carcinoma in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Carcinogenesis. 35:1028–1031.
   PubMed Web of Science ®Google Scholar
• Houten BV, Hunter SE, Meyer JN. 2016. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed). 21:42–54.
   PubMed Web of Science ®Google Scholar
• Hung WY, Lin JC, Lee LM, Wu CW, Tseng LM, Yin PH, Chi CW, Lee HC. 2008. Tandem duplication/triplication correlated with poly-cytosine stretch variation in human mitochondrial DNA D-loop region. Mutagenesis. 23:137–142.
   PubMed Web of Science ®Google Scholar
• Hung WY, Wu CW, Yin PH, Chang CJ, Li AFY, Chi CW, Wei YH, Lee HC. 2010. Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer. Biochim Biophys Acta. 1800:264–270.
   PubMed Web of Science ®Google Scholar
• Ježek J, Cooper KF, Strich R. 2018. Reactive oxygen species and mitochondrial dynamics: the Yin and Yang of mitochondrial dysfunction and cancer progression. Antioxidants. 7:13.
   Web of Science ®Google Scholar
• Jiang J, Zhao JH, Wang XL, Di J, Liu ZB, Li GY, Wang MZ, Li Y, Chen R, Ge RL. 2015. Analysis of mitochondrial DNA in Tibetan gastric cancer patients at high altitude. Mol Clin Oncol. 3:875–879.
   PubMed Web of Science ®Google Scholar
• Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F. 2014. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 23:700–713.
   PubMed Web of Science ®Google Scholar
• Kauppila TES, Kauppila JHK, Larsson N. 2017. Mammalian mitochondria and aging: an update. Cell Metabol. 25:57–71.
   PubMed Web of Science ®Google Scholar
• Kirches E. 2017. MtDNA as a cancer marker: a finally closed chapter? Curr Genom. 18:255–267.
   PubMed Web of Science ®Google Scholar
• Kleist B, Meurer T, Poetsch M. 2016. Mitochondrial DNA alteration in primary and metastatic colorectal cancer: different frequency and association with selected clinicopathological and molecular markers. Tumor Biol. 39:1010428317692246.
   Google Scholar
• Lambertini L, Byun H. 2016. Mitochondrial epigenetics and environmental exposure. Curr Environ Health Rep. 3:214–224.
   PubMedGoogle Scholar
• Lauren P. 1965. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49.
   PubMedGoogle Scholar
• Lee H, Geng C, Cheng M, Lee Z, Guo Z. 2014. Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of familial breast cancer. Mitochondr A. 27:3082–3085.
   Web of Science ®Google Scholar
• Lee HC, Huang KH, Yeh TS, Chi CW. 2014. Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression. World J Gastroenterol. 20:3950–3959.
   PubMed Web of Science ®Google Scholar
• Lee HC, Yin PH, Lin JC, Wu CC, Chen CY, Wu CW, Chi CW, Tam TN, Wei YH. 2005. Mitochondrial genome instability and mtDNA depletion in human cancers. Ann NY Acad Sci. 1042:109–122.
   PubMed Web of Science ®Google Scholar
• Liao LM, Baccarelli A, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Hoxha M, Dioni L, Rothman N, et al. 2011. Mitochondrial DNA copy number and risk of gastric cancer: a report from the Shanghai women's health study. Cancer Epidemiol Biomarkers Prev. 20:1944–1949.
   PubMed Web of Science ®Google Scholar
• Lim S, Li C, Xia W, Lee H, Chang S, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, et al. 2016. EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape. Cancer Res. 76:1284–1296.
   PubMed Web of Science ®Google Scholar
• Lima NCB, Prosdocimi F. 2017. The heavy strand dilemma of vertebrate mitochondria on genome sequencing age: number of encoded genes or G1T content? Mitochondr DNA A. 29:300–302.
   PubMed Web of Science ®Google Scholar
• Machado AMD, Desler C, Bøggild S, Strickertsson JAB, Friis-Hansen L, Figueiredo C, Seruca R, Rasmussen LJ. 2013. Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. Mech Age Dev. 134:460–466.
   PubMed Web of Science ®Google Scholar
• Machado AMD, Figueiredo C, Touati E, Maximo V, Sousa S, Michel V, Carneiro F, Nielsen FC, Seruca R, Rasmussen LJ. 2009. Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clin Cancer Res. 15:2995–3002.
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Kroemer G. 2014. Essential role for oxidative phosphorylation in cancer progression. Cell Metabol. 21:11–12.
   Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Peiris-Pagés M, Pestell RG, Sotgia F, Lisanti MP. 2017. Cancer metabolism: a therapeutic perspective. Nat Rev Clin Oncol. 14:11–31.
   PubMed Web of Science ®Google Scholar
• Maximo V, Soares P, Seruca R, Rocha AS, Castro P, Sobrinho-Simões M. 2001. Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma. Genes Chromosomes Cancer. 32:136–143.
   PubMed Web of Science ®Google Scholar
• McMahon S, LaFramboise T. 2014. Mutational patterns in the breast cancer mitochondrial genome, with clinical correlates. Carcinogenesis. 35:1046–1054.
   PubMed Web of Science ®Google Scholar
• Mousavizadeh K, Rajabi P, Alaee M, Dadgar R, Houshmand M. 2015. Usage of mitochondrial D-loop variation to predict risk for Huntington disease. Mitochondr DNA. 26:579–582.
   PubMed Web of Science ®Google Scholar
• Osellame LD, Blacker TS, Duchen MR. 2012. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab. 26:711–723.
   PubMed Web of Science ®Google Scholar
• Panieri E, Santoro MM. 2016. ROS homeostasis and metabolism: a dangerous liason in cancer cells. Cell Death Dis. 7:e2253.
   PubMed Web of Science ®Google Scholar
• Pavlov NN, Thompson CB. 2016. The emerging Hallmarks of cancer metabolism. Cell Metabol. 23:27–47.
   PubMed Web of Science ®Google Scholar
• Qian M, Spada C, Wang X. 2017. Approach, application, and bioethics of mtDNA sequencing in cancer. In: Sun H, Wang X, editors. Mitochondrial DNA and diseases. Advances in experimental medicine and biology, vol. 1038. Singapore: Springer.
   Google Scholar
• Reznik E, Miller ML, Senbabaoglu Y, Riaz N, Sarungbam J, Tickoo SK, Al-Ahmadie HA, Lee W, Seshan VE, Hakimi AA, et al. 2016. Mitochondrial DNA copy number variation across human cancers. eLife. 5:e10769.
   PubMed Web of Science ®Google Scholar
• Roubicek DA, Souza-Pinto NC. 2017. Mitochondria and mitochondrial DNA as relevant targets for environmental contaminants. Toxicology. 391:100–108.
   PubMed Web of Science ®Google Scholar
• Sabharwal SS, Schumacker PT. 2014. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat Rev Cancer. 14:709–721.
   PubMed Web of Science ®Google Scholar
• Stoccoroa A, Siciliano G, Migliorea L, Coppede F. 2017. Decreased methylation of the mitochondrial D-loop region in late-onset Alzheimer's disease. J Alzheimers Dis. 59:559–564.
   PubMed Web of Science ®Google Scholar
• Strickertsson JAB, Desler C, Rasmussen LJ. 2017. Bacterial infection increases risk of carcinogenesis by targeting mitochondria. Semin Cancer Biol. 47:95–100.
   PubMed Web of Science ®Google Scholar
• Sun X, St. John JC. 2017. The role of the mtDNA set point in differentiation, development and tumorigenesis. Biochem J. 473:2955–2971.
   Web of Science ®Google Scholar
• Tamura G, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Sakata K, Endoh Y, Motoyama T. 1999. Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients. Eur J Cancer. 35:316–319.
   PubMed Web of Science ®Google Scholar
• Tommasi S, Favia P, Weigl S, Bianco A, Pilato B, Russo L, Paradiso A, Petruzzella V. 2014. Mitochondrial DNA variants and risk of familial breast cancer: an exploratory study. Int J Oncol. 44:1691–1698.
   PubMed Web of Science ®Google Scholar
• Trachootham D, Chingsuwanrote P, Yoosadiang P, Mekkriangkrai D, Ratchawong T, Buraphacheep N, Kijanukul S, Saekhow S, Pongpitchayadej O, Vongvachvasin K, et al. 2017. Partial substitution of glucose with xylitol suppressed the glycolysis and selectively inhibited the proliferation of oral cancer cells. Nutr Cancer. 69:1–11.
   PubMed Web of Science ®Google Scholar
• Van der Post RS, Vogelaar IP, Carneiro F, Guilford P, Huntsman D, Hoogerbrugge N, Caldas C, Schreiber KEC, Hardwick RH, Ausems MGEM, et al. 2015. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 52:361–374.
   PubMed Web of Science ®Google Scholar
• Vyas S, Zaganjor E, Haigis MC. 2016. Mitochondria and cancer. Cell. 166:555–566.
   PubMed Web of Science ®Google Scholar
• Wallace DC. 2012. Mitochondria and cancer. Nat Rev Cancer. 12:685–698.
   PubMed Web of Science ®Google Scholar
• Wallace DC. 2013. A mitochondrial bioenergetic etiology of disease. J Clin Invest. 123:1405–1412.
   PubMed Web of Science ®Google Scholar
• Wang C, Wang Y, Wang H, Zhang R, Guo Z. 2014. Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer. Tumour Biol. 35:12555–12559.
   PubMed Web of Science ®Google Scholar
• Wang H, Wang Y, Zhao Q, Guo Z, Zhang F, Zhao Y, Zhang R. 2014. Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer. Mitochondr DNA. 27:1045–1047.
   Web of Science ®Google Scholar
• Warburg O. 1956. On the origin of cancer cells. Science. 123:309–314.
   PubMed Web of Science ®Google Scholar
• Ward PS, Thompson CB. 2012. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell. 21:297–308.
   PubMed Web of Science ®Google Scholar
• Wei L, Zhao Y, Guo TK, Li PQ, Wu H, Xie HB, Ma KJ, Gao F, Xie XD. 2011. Association of mtDNA D-Loop polymorphisms with risk of gastric cancer in Chinese population. Pathol Oncol Res. 17:735–742.
   PubMed Web of Science ®Google Scholar
• Wu CW, Yin PH, Hung WY, Li AFY, Li SH, Chi CW, Wei YH, Lee HC. 2005. Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosomes Cancer. 44:19–28.
   PubMed Web of Science ®Google Scholar
• Xu J, Guo Z, Bai Y, Zhang J, Cui L, Zhang H, Zhang S, Ai X. 2015. Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with the kidney survival time in chronic kidney disease patients. Renal Fail. 37:108–112.
   PubMed Web of Science ®Google Scholar
• Young MJ, Copeland WC. 2016. Human mitochondrial DNA replication machinery and disease. Curr Opin Genet Dev. 38:52–62.
   PubMed Web of Science ®Google Scholar
• Zhao YB, Yang HY, Zhang XW, Chen GY. 2005. Mutation in D-loop region of mitochondrial DNA in gastric cancer and its significance. World J Gastroenterol. 11:3304–3306.
   PubMed Web of Science ®Google Scholar
• Zhu X, Mao Y, Huang T, Yan C, Yu F, Du J, Dai J, Ma H, Jin G. 2017. High mitochondrial DNA copy number was associated with an increased gastric cancer risk in a Chinese population. Mol Carcinogen. 56:2593–2600.
   PubMed Web of Science ®Google Scholar
• Zong W, Rabinowitz JD, White E. 2016. Mitochondria and cancer. Mol Cell. 61:667–676.
   PubMed Web of Science ®Google Scholar