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Toxicology Communications Volume 6, 2022 - Issue 1
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Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series

Constance A. Mackenziea Ontario Poison Centre, Hospital for Sick Children, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada;b Divisions of Clinical Pharmacology and Toxicology/Respirology, Western University, London, Ontario, CanadaCorrespondence[email protected]
,
Emily Austina Ontario Poison Centre, Hospital for Sick Children, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada;c St. Michael’s Hospital, Division of Emergency Medicine, Toronto, Ontario, Canada
,
Margaret Thompsona Ontario Poison Centre, Hospital for Sick Children, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada;c St. Michael’s Hospital, Division of Emergency Medicine, Toronto, Ontario, Canada
&
Rommel G. Tironad Departments of Physiology & Pharmacology and Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada
Pages 23-27 | Published online: 05 Jan 2022

Refere nces

  • Liu J, Chen Y, Gao Y, et al. N-acetylcysteine as a treatment for amatoxin poisoning: a systematic review. Clin Toxicol (Phila). 2020 Nov;58(11):1015–1022. PMID: 32609548.
  • Le Daré B, Ferron PJ, Gicquel T. Toxic effects of amanitins: repurposing toxicities toward new therapeutics. Toxins (Basel). 2021 Jun;13(6):417. PMID: 34208167; PMCID: PMC8230822.
  • Zuker-Herman R, Tong R, Wong A. Intravenous rifampicin use in the management of amanita phalloides toxicity. Clin Toxicol (Phila). 2021 Sep;59(9):843–845. PMID: 33605821.
  • Letschert K, Faulstich H, Keller D, et al. Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci. 2006 May;91(1):140–149. Epub 2006 Feb 22. PMID: 16495352.
  • Kalliokoski A, Niemi M. Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693–705. PMID: 19785645; PMCID: PMC2765590.
  • Agha RA, Sohrabi C, Mathew G, ROCESS Group, et al. The PROCESS 2020 guideline: updating consensus preferred reporting of CasESeries in Surgery (PROCESS) Guidelines. Int J Surg. 2020;84:231–235.
  • Zhang S, Zhao Y, Li H, et al. A simple and high-throughput analysis of amatoxins and phallotoxins in human plasma, serum and urine using UPLC-MS/MS combined with PRiME HLB μElution platform. Toxins (Basel). 2016 May;48(5):128. PMID: 27153089; PMCID: PMC4885043.
  • Jouan E, Le Vee M, Denizot C, et al. Drug transporter expression and activity in human hepatoma HuH-7 cells. Pharmaceutics. 2016;9(4):3.
  • Sun J, Niu YM, Zhang YT, et al. Toxicity and toxicokinetics of amanita exitialis in beagle dogs. Toxicon. 2018;143:59–67.
  • Yu W, Zhang X, Liu J, et al. Cyclosporine a suppressed glucose oxidase induced P53 mitochondrial translocation and hepatic cell apoptosis through blocking mitochondrial permeability transition. Int J Biol Sci. 2016;12(2):198–209.
  • Enjalbert F, Rapior S, Nouguier-Soule J, et al. Treatment of amatoxin poisoning: 20-year retrospective analysis. J Toxicol Clin Toxicol. 2002;40(6):715–757.
  • Mengs U, Pohl RT, Mitchell T. Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol. 2012 Aug;13(10):1964–1970. PMID: 22352731; PMCID: PMC3414726.
  • https://clinicaltrials.gov/ct2/history/NCT00915681?V_14=View#StudyPageTop.
  • Goupil RC, Davis M, Kaufman A, et al. Clinical recovery of 5 dogs from amatoxin mushroom poisoning using an adapted Santa Cruz protocol for people. J Vet Emerg Crit Care (San Antonio). 2021 May;31(3):414–427. PMID: 33458945.
  • Visentin M, Stieger B, Merz M, et al. Octreotide inhibits the bilirubin carriers organic anion transporting polypeptides 1B1 and 1B3 and the multidrug resistance-associated protein 2. J Pharmacol Exp Ther. 2015 Nov; 355(2):145–151. PMID: 26330539.

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