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Canadian Journal of Pain
Revue canadienne de la douleur
Volume 2, 2018 - Issue 1
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Original Articles

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model

Catherine E. FerlandQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Research Centre, Shriners Hospitals for Children-Canada, Montreal, QC, Canada;Department of Anesthesia, Faculty of Medicine, McGill University, Montreal, QC, CanadaView further author information
,
Chantal VillemureAlan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, CanadaView further author information
,
Pierre-Emmanuel MichonDivision des Neurosciences cliniques et cognitives, centre de recherche CERVO, Université Laval, Quebec, QC, CanadaView further author information
,
Wiebke GandhiCentre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UKView further author information
,
My-Linh MaResearch Centre, Shriners Hospitals for Children-Canada, Montreal, QC, CanadaView further author information
,
Florian ChouchouDépartement santé buccale, Faculté de médecine dentaire, Université de Montréal, Montreal, QC, CanadaView further author information
,
Alexandre J. ParentQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, CanadaView further author information
,
M. Catherine BushnellNational Centre for Complementary and Integrative Health, NIH, Bethesda, MD, USAView further author information
,
Gilles LavigneQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Département santé buccale, Faculté de médecine dentaire, Université de Montréal, Montreal, QC, CanadaView further author information
,
Pierre RainvilleQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM), Montreal, QC, Canada;Département de stomatologie, Faculté de médecine dentaire, Université de Montréal, Montreal, QC, CanadaView further author information
,
Mark A. WareQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, CanadaView further author information
,
Philip L. JacksonQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Division des Neurosciences cliniques et cognitives, centre de recherche CERVO, Université Laval, Quebec, QC, Canada;School of Psychology, Université Laval, Quebec, QC, CanadaView further author information
,
Petra SchweinhardtQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, CanadaView further author information
&
Serge MarchandQuebec Pain Research Network, Université de Sherbrooke, Sherbrooke, QC, Canada;Centre de recherche du CHUS, Sherbrooke, QC, Canada;Department of Surgery, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Québec, CanadaCorrespondence[email protected]
View further author information
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Pages 266-279 | Received 13 Mar 2018, Accepted 16 Sep 2018, Published online: 23 Oct 2018

References

  • Geber C , Klein T , Azad S , Birklein F , Gierthmuhlen J , Huge V , Lauchart M , Nitzsche D , Stengel M , Valet M , et al. Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German research network on neuropathic pain (DFNS): a multi-centre study. Pain. 2011;152(3):548–56. doi:10.1016/j.pain.2010.11.013.
  • Grone E , Crispin A , Fleckenstein J , Irnich D , Treede RD , Lang PM. Test order of quantitative sensory testing facilitates mechanical hyperalgesia in healthy volunteers. J Pain. 2012;13(1):73–80. doi:10.1016/j.jpain.2011.10.005.
  • Rolke R , Baron R , Maier C , Tolle TR , Treede RD , Beyer A , Binder A , Birbaumer N , Birklein F , Botefur IC , et al. Quantitative sensory testing in the German research network on neuropathic pain (DFNS): standardized protocol and reference values. Pain. 2006;123(3):231–43. doi:10.1016/j.pain.2006.01.041.
  • Backonja MM , Walk D , Edwards RR , Sehgal N , Moeller-Bertram T , Wasan A , Irving G , Argoff C , Wallace M. Quantitative sensory testing in measurement of neuropathic pain phenomena and other sensory abnormalities. Clin J Pain. 2009;25(7):641–47. doi:10.1097/AJP.0b013e3181a68c7e.
  • Kemler MA , Schouten HJ , Gracely RH. Diagnosing sensory abnormalities with either normal values or values from contralateral skin: comparison of two approaches in complex regional pain syndrome I. Anesthesiology. 2000;93:718–27.
  • Hooten WM , Lamer TJ , Twyner C. Opioid-induced hyperalgesia in community-dwelling adults with chronic pain. Pain. 2015;156(6):1145–52. doi:10.1097/j.pain.0000000000000170.
  • van de Vusse AC , Stomp-van Den Berg SG , Kessels AH , Weber WE . Randomised controlled trial of gabapentin in complex regional pain syndrome type 1 [ISRCTN84121379]. BMC Neurol. 2004;4:13. doi:10.1186/1471-2377-4-13.
  • Hansson P , Backonja M , Bouhassira D . Usefulness and limitations of quantitative sensory testing: clinical and research application in neuropathic pain states. Pain. 2007;129(3):256–59. doi:10.1016/j.pain.2007.03.030.
  • Yarnitsky D , Granot M . Chapter 27 quantitative sensory testing. Handb Clin Neurol. 2006;81:397–409. doi:10.1016/S0072-9752(06)80031-X.
  • Nilsson T , Burstrom L , Hagberg M , Lundstrom R . Thermal perception thresholds among young adults exposed to hand-transmitted vibration. Int Arch Occup Environ Health. 2008;81(5):519–33. doi:10.1007/s00420-007-0258-0.
  • Shy ME , Frohman EM , So YT , Arezzo JC , Cornblath DR , Giuliani MJ , Kincaid JC , Ochoa JL , Parry GJ , Weimer LH . Quantitative sensory testing: report of the therapeutics and technology assessment subcommittee of the American academy of neurology. Neurology. 2003;60:898–904.
  • Valensi P , Attali JR , Gagant S . Reproducibility of parameters for assessment of diabetic neuropathy. The French Group for Research and Study of Diabetic Neuropathy. Diabet Med. 1993;10:933–39.
  • Binder A . Human surrogate models of neuropathic pain: validity and limitations. Pain. 2016;157(Suppl 1):S48–52. doi:10.1097/j.pain.0000000000000460.
  • Eisenach JC , Hood DD , Curry R . Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicin-induced pain and hyperalgesia in normal volunteers. Anesth Analg. 1998;87:591–96.
  • Eisenach JC , Hood DD , Curry R . Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia. Pain. 2000;84:57–64.
  • Olesen AE , Andresen T , Staahl C , Drewes AM . Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs. Pharmacol Rev. 2012;64(3):722–79. doi:10.1124/pr.111.005447.
  • Lotsch J , Dimova V , Hermens H , Zimmermann M , Geisslinger G , Oertel BG , Ultsch A . Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects. Pain. 2015;156(3):405–14. doi:10.1097/01.j.pain.0000460328.10515.c9.
  • Caterina MJ , Julius D . The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci. 2001;24:487–517. doi:10.1146/annurev.neuro.24.1.487.
  • Gandhi W , Becker S , Schweinhardt P . Pain increases motivational drive to obtain reward, but does not affect associated hedonic responses: A behavioural study in healthy volunteers. Eur J P. 2013;17:1093–103.
  • Konopka KH , Harbers M , Houghton A , Kortekaas R , van Vliet A , Timmerman W , Den Boer JA , Struys MM , van Wijhe M . Somatosensory profiles but not numbers of somatosensory abnormalities of neuropathic pain patients correspond with neuropathic pain grading. PLoS One. 2012;7(8):e43526. doi:10.1371/journal.pone.0043526.
  • Maier C , Baron R , Tolle TR , Binder A , Birbaumer N , Birklein F , Gierthmuhlen J , Flor H , Geber C , Huge V , et al. Quantitative sensory testing in the German research network on neuropathic pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain. 2010;150(3):439–50. doi:10.1016/j.pain.2010.05.002.
  • Treede RD , Jensen TS , Campbell JN , Cruccu G , Dostrovsky JO , Griffin JW , Hansson P , Hughes R , Nurmikko T , Serra J . Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70(18):1630–35. doi:10.1212/01.wnl.0000282763.29778.59.
  • Vollert J , Attal N , Baron R , Freynhagen R , Haanpaa M , Hansson P , Jensen TS , Rice AS , Segerdahl M , Serra J , et al. Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects. Pain. 2016;157(3):750–58. doi:10.1097/j.pain.0000000000000433.
  • Enax-Krumova EK , Pohl S , Westermann A , Maier C . Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia. BMC Neurol. 2017;17(1):60. doi:10.1186/s12883-017-0839-9.
  • Geber C , Magerl W , Fondel R , Fechir M , Rolke R , Vogt T , Treede RD , Birklein F . Numbness in clinical and experimental pain–a cross-sectional study exploring the mechanisms of reduced tactile function. Pain. 2008;139(1):73–81. doi:10.1016/j.pain.2008.03.006.
  • Magerl W , Treede RD . Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects. Neurosci Lett. 2004;361(1–3):136–39. doi:10.1016/j.neulet.2003.12.001.
  • Lumpkin EA , Caterina MJ . Mechanisms of sensory transduction in the skin. Nature. 2007;445(7130):858–65. doi:10.1038/nature05662.
  • Mucke M , Cuhls H , Radbruch L , Baron R , Maier C , Tolle T , Treede RD , Rolke R Quantitative sensory testing (QST). English version. Schmerz, 2016. DOI: 10.1007/s00482-015-0093-2
  • Woolf CJ , Mannion RJ . Neuropathic pain: aetiology, symptoms, mechanisms, and management. The Lancet. 1999;353(9168):1959–64. doi:10.1016/S0140-6736(99)01307-0.
  • Dray A . Mechanism of action of capsaicin-like molecules on sensory neurons. Life Sci. 1992;51:1759–65.
  • Woolf CJ . Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2–S15. doi:10.1016/j.pain.2011.02.053.
  • Buonocore M , Demartini L , Aloisi AM , Bonezzi C . Dynamic mechanical allodynia–one clinical sign, several mechanisms: Five illustrative cases. Pain Pract. 2016;16(3):E48–E55. doi:10.1111/papr.12416.
  • Jensen TS , Finnerup NB . Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. Lancet Neurol. 2014;13(9):924–35. doi:10.1016/S1474-4422(14)70102-4.
  • Liljencrantz J , Bjornsdotter M , Morrison I , Bergstrand S , Ceko M , Seminowicz DA , Cole J , Bushnell MC , Olausson H . Altered C-tactile processing in human dynamic tactile allodynia. Pain. 2013;154(2):227–34. doi:10.1016/j.pain.2012.10.024.
  • Weissner W , Winterson BJ , Stuart-Tilley A , Devor M , Bove GM . Time course of substance P expression in dorsal root ganglia following complete spinal nerve transection. J Comp Neurol. 2006;497(1):78–87. doi:10.1002/cne.20981.
  • Woolf CJ , Max MB . Mechanism-based pain diagnosis: issues for analgesic drug development. Anesthesiology. 2001;95:241–49.
  • Lotsch J , Oertel BG , Ultsch A . Human models of pain for the prediction of clinical analgesia. Pain. 2014;155(10):2014–21. doi:10.1016/j.pain.2014.07.003.
  • Buonocore M , Demartini L , Bonezzi C . Can topical capsaicin induce a neuropathic pain? Pain. 2015;156(7):1368–69. doi:10.1097/j.pain.0000000000000166.
  • Simone DA , Ochoa J . Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans. Pain. 1991;47:285–94.
  • Petersen KL , Rowbotham MC . A new human experimental pain model: the heat/capsaicin sensitization model. Neuroreport. 1999;10:1511–16.
  • Helme RD , McKernan S . Neurogenic flare responses following topical application of capsaicin in humans. Ann Neurol. 1985;18(4):505–09. doi:10.1002/ana.410180414.
  • Kilo S , Schmelz M , Koltzenburg M , Handwerker HO . Different patterns of hyperalgesia induced by experimental inflammation in human skin. Brain. 1994;117:385–96.
  • Sluka KA , Wright A . Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint. Eur J Pain. 2001;5(1):81–87. doi:10.1053/eujp.2000.0223.
  • Lewis RA , Said G . Tackling neuropathic pain: different perspectives of clinicians and investigators. Neurology. 2008;70(18):1582–83. doi:10.1212/01.wnl.0000310977.41077.6d.
  • Freeman R , Baron R , Bouhassira D , Cabrera J , Emir B . Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain. 2014;155(2):367–76. doi:10.1016/j.pain.2013.10.023.
  • Bishop GH , Landau WM , Jones MH . Evidence for a double peripheral pathway for pain. Science. 1958;128:712–14.
  • Lundstrom R , Nilsson T , Hagberg M , Burstrom L . Grading of sensorineural disturbances according to a modified Stockholm workshop scale using self-reports and QST. Int Arch Occup Environ Health. 2008;81(5):553–57. doi:10.1007/s00420-007-0249-1.
  • Hoffman-Snyder C , Smith BE , Ross MA , Hernandez J , Bosch EP . Value of the oral glucose tolerance test in the evaluation of chronic idiopathic axonal polyneuropathy. Arch Neurol. 2006;63(8):1075–79. doi:10.1001/archneur.63.8.noc50336.
  • Gelber DA , Pfeifer MA , Broadstone VL , Munster EW , Peterson M , Arezzo JC , Shamoon H , Zeidler A , Clements R , Greene DA , et al. Components of variance for vibratory and thermal threshold testing in normal and diabetic subjects. J Diabetes Complications. 1995;9(3):170–76.
  • Backonja MM , Attal N , Baron R , Bouhassira D , Drangholt M , Dyck PJ , Edwards RR , Freeman R , Gracely R , Haanpaa MH , et al. Value of quantitative sensory testing in neurological and pain disorders: neuPSIG consensus. Pain. 2013;154(9):1807–19. doi:10.1016/j.pain.2013.05.047.
  • Potvin S , Marchand S . Pain facilitation and pain inhibition during conditioned pain modulation in fibromyalgia and in healthy controls. Pain. 2016;157(8):1704–10. doi:10.1097/j.pain.0000000000000573.

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