The Efficacy of Graded Motor Imagery and Its Components on Phantom Limb Pain and Disability: A Systematic Review and Meta-Analysis

References

• Stankevicius A, Wallwork SB, Summers SJ, Hordacre B, Stanton TR. Prevalence and incidence of phantom limb pain, phantom limb sensations and telescoping in amputees: a systematic rapid review. Eur J Pain. 2021;25(1):23–11. doi:10.1002/ejp.1657.
   PubMed Web of Science ®Google Scholar
• Fuchs X, Flor H, Psychological Factors B-BR. Associated with phantom limb pain: a review of recent findings. Pain Res Manage. 2018;2018:5080123. doi:10.1155/2018/5080123.
   PubMed Web of Science ®Google Scholar
• Ehde DM, Czerniecki JM, Smith DG, Campbell KM, Edwards WT, Jensen MP, Robinson LR. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation. Arch Phys Med Rehabil. 2000;81(8):1039–44. doi:10.1053/apmr.2000.7583.
   PubMed Web of Science ®Google Scholar
• Dietrich C, Nehrdich S, Seifert S, Blume KR, Miltner WHR, Hofmann GO, Weiss T. Leg prosthesis with somatosensory feedback reduces phantom limb pain and increases functionality. Front Neurol. 2018;9:270. doi:10.3389/fneur.2018.00270.
   PubMed Web of Science ®Google Scholar
• Polat CS, Konak HE, Altas EU, Akıncı MG, Onat S S. Factors related to phantom limb pain and its effect on quality of life. Somatosens Mot Res. 2021;38(4):322–26. doi:10.1080/08990220.2021.1973405.
   PubMed Web of Science ®Google Scholar
• Limakatso K, Madden VJ, Manie S, Parker R. The effectiveness of graded motor imagery for reducing phantom limb pain in amputees: a randomised controlled trial. Physiotherapy. 2020;109:65‐74. doi:10.1016/j.physio.2019.06.009.
   PubMed Web of Science ®Google Scholar
• Schone HR, Baker CI, Katz J, Nikolajsen L, Limakatso K, Flor H, Makin TR. Making sense of phantom limb pain. J Neurol Neurosurg Psychiatry. 2022;93(8):833–43. doi:10.1136/jnnp-2021-328428.
   PubMed Web of Science ®Google Scholar
• Alviar MJ, Hale T, Dungca M. Pharmacologic interventions for treating phantom limb pain. The Cochrane Database Syst Rev. 2016;10(10):Cd006380. doi:10.1002/14651858.CD006380.pub3.
   PubMedGoogle Scholar
• Alviar M, Hale T, Dungca M. Pharmacologic interventions for treating phantom limb pain. Cochrane Database Syst Rev. 2011;12.
   Google Scholar
• Aternali A, Katz J. Recent advances in understanding and managing phantom limb pain. F1000Research. 2019;8.
   Google Scholar
• Raffin E, Richard N, Giraux P, Reilly KT. Primary motor cortex changes after amputation correlate with phantom limb pain and the ability to move the phantom limb. NeuroImage. 2016;130:134–44. doi:10.1016/j.neuroimage.2016.01.063.
   PubMed Web of Science ®Google Scholar
• Kikkert S, Mezue M, Slater DH, Johansen-Berg H, Tracey I, Makin TR. Motor correlates of phantom limb pain. cortex. 2017;95:29–36. doi:10.1016/j.cortex.2017.07.015.
   PubMed Web of Science ®Google Scholar
• Makin TR, Scholz J, Filippini N, Henderson Slater D, Tracey I, Johansen-Berg H. Phantom pain is associated with preserved structure and function in the former hand area. Nat Commun. 2013;4(1):1570. doi:10.1038/ncomms2571.
   PubMedGoogle Scholar
• Makin TR. Phantom limb pain: thinking outside the (mirror) box. Brain. 2021;144(7):1929. doi:10.1093/brain/awab139.
   PubMedGoogle Scholar
• Muret D, Makin TR. The homeostatic homunculus: rethinking deprivation-triggered reorganisation. Curr Opin Neurobiol. 2021;67:115–22. doi:10.1016/j.conb.2020.08.008.
   PubMed Web of Science ®Google Scholar
• Ortiz-Catalan M. The stochastic entanglement and phantom motor execution hypotheses: a theoretical framework for the origin and treatment of phantom limb pain. Front Neurol. 2018;9. doi:10.3389/fneur.2018.00009.
   PubMed Web of Science ®Google Scholar
• Wang F, Zhang R, Zhang J, Li D, Wang Y, Yang Y-H WQ. Effects of mirror therapy on phantom limb sensation and phantom limb pain in amputees: a systematic review and meta-analysis of randomized controlled trials. Clin Rehabil. 2021;35(12):1710–21. doi:10.1177/02692155211027332.
   PubMed Web of Science ®Google Scholar
• Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc R Soc B: Biol Sci. 1996;263(1369):377–386.
   Google Scholar
• Moseley GL. Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial. Pain. 2004;108(1‐2):192‐8. doi:10.1016/j.pain.2004.01.006.
   PubMed Web of Science ®Google Scholar
• Bowering KJ, O’Connell NE, Tabor A, Catley MJ, Leake HB, Moseley GL, Stanton TR. The effects of graded motor imagery and its components on chronic pain: a systematic review and meta-analysis. The Journal of Pain. 2013;14(1):3–13. doi:10.1016/j.jpain.2012.09.007.
   PubMed Web of Science ®Google Scholar
• Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E. Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: a systematic review. J Back Musculoskelet Rehabil. 2017;30(3):441–49. doi:10.3233/BMR-150500.
   PubMed Web of Science ®Google Scholar
• Acerra NE, Souvlis T, Moseley GL. Stroke, complex regional pain syndrome and phantom limb pain: can commonalities direct future management? J Rehabil Med. 2007;39(2):109–14. doi:10.2340/16501977-0027.
   PubMed Web of Science ®Google Scholar
• Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane handbook for systematic reviews of interventions. 2nd ed. Chichester (UK): John Wiley & Sons; 2019.
   Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10(1):1–11. doi:10.1186/s13643-021-01626-4.
   PubMed Web of Science ®Google Scholar
• Limakatso K, Corten L, Parker R. The effects of graded motor imagery and its components on phantom limb pain and disability in upper and lower limb amputees: a systematic review protocol. Syst Rev. 2016;5(1):145. doi:10.1186/s13643-016-0322-5.
   PubMedGoogle Scholar
• Meursinge Reynders R, Ladu L, Di Girolamo N. Contacting of authors by systematic reviewers: protocol for a cross-sectional study and a survey. Syst Rev. 2017;6(1):1–12. doi:10.1186/s13643-017-0643-z.
   PubMedGoogle Scholar
• Cohen J. A coefficient of agreement for nominal scales. Educ Psychol Meas. 1960;20(1):37–46. doi:10.1177/001316446002000104.
   Web of Science ®Google Scholar
• Higgins J, Altman DG. Assessing risk of bias in included studies. In: Cochrane handbook for systematic reviews of interventions: cochrane book series. Chichester (UK): 2008. p. 187–241.
   Google Scholar
• Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–26. doi:10.1136/bmj.39489.470347.AD.
   PubMed Web of Science ®Google Scholar
• RevMan R. The nordic cochrane centre, the cochrane collaboration. Book [computer program]; 2014.
   Google Scholar
• Dworkin RH, Turk DC, McDermott MP, Peirce-Sandner S, Burke LB, Cowan P, Farrar JT, Hertz S, Raja SN, Rappaport BA. Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations. Pain. 2009;146(3):238–44. doi:10.1016/j.pain.2009.08.019.
   PubMed Web of Science ®Google Scholar
• Rothgangel A, Braun S, Winkens B, Beurskens A, Smeets R. Traditional and augmented reality mirror therapy for patients with chronic phantom limb pain (PACT study): results of a three-group, multicentre single-blind randomized controlled trial. Clin Rehabil. 2018;32(12):1591–608. doi:10.1177/0269215518785948.
   PubMed Web of Science ®Google Scholar
• Wewege MA, Jones MD, Williams SA, Kamper SJ, McAuley JH. Rescaling pain intensity measures for meta-analyses of analgesic medicines for low back pain appears justified: an empirical examination from randomised trials. BMC Med Res Methodol. 2022;22(1):1–9. doi:10.1186/s12874-022-01763-x.
   PubMed Web of Science ®Google Scholar
• Olsen MF, Bjerre E, Hansen MD, Hilden J, Landler NE, Tendal B, Hróbjartsson A. Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain. BMC Med. 2017;15(1):1–18. doi:10.1186/s12916-016-0775-3.
   PubMedGoogle Scholar
• Moseley GL. Graded motor imagery for pathologic pain a randomized controlled trial. Neurology. 2006;67:2129–34.
   PubMed Web of Science ®Google Scholar
• Brodie EE, Whyte A, Niven CA. Analgesia through the looking‐glass? A randomized controlled trial investigating the effect of viewing a ‘virtual’limb upon phantom limb pain, sensation and movement. Eur J Pain. 2007;11(4):428–36. doi:10.1016/j.ejpain.2006.06.002.
   PubMed Web of Science ®Google Scholar
• Chan BL, Witt R, Charrow AP, Magee A, Howard R, Pasquina PF, Heilman KM, Tsao JW. Mirror therapy for phantom limb pain. N Engl J Med. 2007;357(21):2206–07. doi:10.1056/NEJMc071927.
   PubMed Web of Science ®Google Scholar
• Finn SB, Perry BN, Clasing JE, Walters LS, Jarzombek SL, Curran S, Rouhanian M, Keszler MS, Hussey-Andersen LK, Weeks SR, et al. A randomized, controlled trial of mirror therapy for upper extremity phantom limb pain in male amputees. Front Neurol. 2017;8(JUL). doi:10.3389/fneur.2017.00267.
   PubMedGoogle Scholar
• Ramadugu S, Nagabushnam SC, Katuwal N, Chatterjee K. Intervention for phantom limb pain: a randomized single crossover study of mirror therapy. Indian J Psychiatry. 2017;59(4):457–64. doi:10.4103/psychiatry.IndianJPsychiatry_259_16.
   PubMed Web of Science ®Google Scholar
• Anaforoğlu Külünkoğlu B, Erbahçeci F, Alkan A. A comparison of the effects of mirror therapy and phantom exercises on phantom limb pain. Turkish J Med Sci. 2019;49(1):101‐9. doi:10.3906/sag-1712-166.
   PubMed Web of Science ®Google Scholar
• Ol HS, Van Heng Y, Danielsson L, Husum H. Mirror therapy for phantom limb and stump pain: a randomized controlled clinical trial in landmine amputees in Cambodia. Scand Actuarial J. 2018;18(4):603–10. doi:10.1515/sjpain-2018-0042.
   Google Scholar
• Tilak M, Isaac SA, Fletcher J, Vasanthan LT, Subbaiah RS, Babu A, Bhide R, Tharion G. Mirror therapy and transcutaneous electrical nerve stimulation for management of phantom limb pain in amputees—a single blinded randomized controlled trial. Physiother Res Int. 2016;21(2):109–15. doi:10.1002/pri.1626.
   PubMed Web of Science ®Google Scholar
• Tung ML, Murphy IC, Griffin SC, Alphonso AL, Hussey‐Anderson L, Hughes KE, Weeks SR, Merritt V, Yetto JM, Pasquina PF, et al. Observation of limb movements reduces phantom limb pain in bilateral amputees. Ann Clin Transl Neurol. 2014;1:633–38.
   PubMed Web of Science ®Google Scholar
• Nugent SM, Lovejoy TI, Shull S, Dobscha SK, Morasco BJ. Associations of pain numeric rating scale scores collected during usual care with research administered patient reported pain outcomes. Pain Med. 2021;22(10):2235–41. doi:10.1093/pm/pnab110.
   PubMed Web of Science ®Google Scholar
• Horn KK, Jennings S, Richardson G, Van Vliet D, Hefford C, Abbott JH. The patient-specific functional scale: psychometrics, clinimetrics, and application as a clinical outcome measure. J Orthop Sports Phys. 2012;42(1):30–D17. doi:10.2519/jospt.2012.3727.
   PubMed Web of Science ®Google Scholar
• Hinkel M. Graded motor imagery for the treatment of phantom limb pain. Arch Phys Med Rehabil. 2017;98(10):e72. doi:10.1016/j.apmr.2017.08.225.
   PubMedGoogle Scholar
• Limakatso K, Parker R. Treatment recommendations for phantom limb pain in people with amputations: an expert consensus Delphi study. Pm R. 2021;13(11):1216–26. doi:10.1002/pmrj.12556.
   PubMedGoogle Scholar
• Kim SY, Kim YY. Mirror therapy for phantom limb pain. Korean J Pain. 2012;25(4):272–74. doi:10.3344/kjp.2012.25.4.272.
   PubMedGoogle Scholar
• MacLachlan M, McDonald D, Waloch J. Mirror treatment of lower limb phantom pain: a case study. Disabil Rehabil. 2004;26(14–15):901–04. doi:10.1080/09638280410001708913.
   PubMed Web of Science ®Google Scholar
• Ramachandran VS, Altschuler EL. The use of visual feedback, in particular mirror visual feedback, in restoring brain function. Brain. 2009;132(7):1693–710. doi:10.1093/brain/awp135.
   PubMed Web of Science ®Google Scholar
• Schmalzl L, Ragno C, Ehrsson HH. An alternative to traditional mirror therapy illusory touch can reduce phantom pain when; 2013.
   Google Scholar
• Mercier C, Sirigu A. Training with virtual visual feedback to alleviate phantom limb pain. Neurorehabil Neural Repair. 2009;23(6):587–94. doi:10.1177/1545968308328717.
   PubMed Web of Science ®Google Scholar
• Mallik AK, Pandey SK, Srivastava A, Kumar S, Kumar A. Comparison of relative benefits of mirror therapy and mental imagery in phantom limb pain in amputee patients at a tertiary care center. Arch Rehabil Res Clin Transl. 2020;2(4):100081. doi:10.1016/j.arrct.2020.100081.
   PubMedGoogle Scholar
• Hunter JP, Katz J, Davis KD. The effect of tactile and visual sensory inputs on phantom limb awareness. Brain: A J Neurol. 2003;126(3):579–89. doi:10.1093/brain/awg054.
   Google Scholar
• Raffin E, Giraux P, Reilly KT. The moving phantom: motor execution or motor imagery? Cortex. 2012;48(6):746–57. doi:10.1016/j.cortex.2011.02.003.
   PubMed Web of Science ®Google Scholar
• Raffin E, Mattout J, Reilly KT, Giraux P. Disentangling motor execution from motor imagery with the phantom limb. Brain. 2012;135:582–95. doi:10.1093/brain/awr337.
   PubMed Web of Science ®Google Scholar
• Beisheim-Ryan EH, Pohlig RT, Medina J, Hicks GE, Sions JM. Body representation among adults with phantom limb pain: results from a foot identification task. Eur J Pain (London, England). 2022;26(1):255–69. doi:10.1002/ejp.1860.
   PubMed Web of Science ®Google Scholar
• Moseley G. Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial. Pain. 2004;108:192–98.
   PubMed Web of Science ®Google Scholar