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Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil
Volume 7, 2023 - Issue 5
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Clinical Respiratory Review

Triple inhaled therapy for asthma in Canada

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Pages 250-257 | Received 09 Feb 2023, Accepted 13 Jul 2023, Published online: 16 Aug 2023

References

  • Asthma Canada. Asthma facts and statistics. www.asthma.ca
  • Yang CL, Hicks EA, Mitchell P, et al. Canadian Thoracic Society 2021 Guideline update: Diagnosis and management of asthma in preschoolers, children and adults. Can J Respir Crit Care Sleep Med. 2021;5(6):348–361. doi:10.1080/24745332.2021.1945887.
  • McIvor RA, Boulet LP, FitzGerald JM, Zimmerman S, Chapman KR. Asthma control in Canada: no improvement since we last looked in 1999. Can Fam Phys. 2007;53(4):672–677.
  • Sadatsafavi M, McTaggart-Cowan H, Chen W, Mark Fitzgerald J. Quality of life and asthma symptom control: room for improvement in care and measurement. Value Health. 2015;18(8):1043–1049. doi:10.1016/j.jval.2015.07.008.
  • Busse WW, Kraft M. Current unmet needs and potential solutions to uncontrolled asthma. Eur Respir Rev. 2022;31:210176. doi:10.1183/16000617.0176-2021.
  • de Marco R, Locatelli F, Cazzoletti L, Bugianio M, Carosso A, Marinoni A. Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study. Respir Res. 2005;6(1):95. doi:10.1186/1465-9921-6-95.
  • To T, Zhu J, Williams DP, et al. Frequency of health service use in the year prior to asthma death. J Asthma. 2016;53(5):505–509. doi:10.3109/02770903.2015.1064949.
  • Sadatsafavi M, Chen W, Tavakoli H, Rolf JD, Rousseau R, FitzGerald JM. Saving in medical costs by achieving guideline-based asthma symptom control: a population-based study. Allergy. 2016;71(3):371–377. doi:10.1111/all.12803.
  • Zafari Z, Sadatsafavi M, Chen W, Fitzgerald JM. The projected economic and health burden of sub-optimal asthma control in Canada. Respir Med. 2018;138:7–12. doi:10.1016/j.rmed.2018.03.018.
  • Vathenen AS, Knox AJ, Wisniewski A, Tattersfield AE. Time course of change in bronchial reactivity with an inhaled corticosteroid in asthma. Am Rev Respir Dis. 1991;143(6):1317–1321. doi:10.1164/ajrccm/143.6.1317.
  • Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The gaining optimal asthma ControL study. Am J Respir Crit Care Med. 2004;170(8):836–844. doi:10.1164/rccm.200401-033OC.
  • Newton R, Giembycz MA. Understanding how long-acting β2-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma – an update. Br J Pharmacol. 2016;173(24):3405–3430. doi:10.1111/bph.13628.
  • Global Initiative for Athma. Global strategy for asthma management and prevention. 2022. www.ginasthma.org
  • Aaron SD, Vandemheen KL, Boulet LP, et al. Overdiagnosis of asthma in obese and nonobese adults. CMAJ. 2008;179(11):1121–1131. doi:10.1503/cmaj.081332.
  • Tilles SA. Differential diagnosis of adult asthma. Med Clin North Am. 2006;90(1):61–76. doi:10.1016/j.mcna.2005.08.004.
  • Express Scripts Canada. Prescription Drug Trend Report. 2019. https://www.express-scripts.ca/sites/default/files/2020-12/Express_Scripts_Canada_2018_Prescription_Drug_Trend_Report_FINAL.pdf. Accessed July 12, 2022.
  • Amin S, Soliman M, McIvor A, Cave A, Cabrera C. Understanding patient perspectives on medication adherence in asthma: a targeted review of qualitative studies. Patient Prefer Adherence. 2020;14:541–551. doi:10.2147/PPA.S234651.
  • D'Ancona G, Weinman J. Improving adherence in chronic airways disease: are we doing it wrongly? Breathe (Sheff). 2021;17(2):210022. doi:10.1183/20734735.0022-2021.
  • Advisory Council on the Implementation of National Pharmacare. A Prescription for Canada: Achieving Pharmacare for All. Ottawa, ON: Government of Canada; 2019.
  • Price D, Chrystyn H, Kaplan A, et al. Effectiveness of same versus mixed asthma inhaler devices: a retrospective observational study in primary care. Allergy Asthma Immunol Res. 2012;4(4):184–191. doi:10.4168/aair.2012.4.4.184.
  • Rogliani P, Matera MG, Facciolo F, Page C, Cazzola M, Calzetta L. Beclomethasone dipropionate, formoterol fumarate and glycopyrronium bromide: synergy of triple combination therapy on human airway smooth muscle ex vivo. Br J Pharmacol. 2020;177(5):1150–1163. doi:10.1111/bph.14909.
  • Chapman KR. The history of antimuscarinic bronchodilator therapy. In: Spector SL, ed. Anticholinergics in Clinical Allergy Practice Lung Biology in Health and Disease. New York: Marcel Dekker; 1999:155–169.
  • Rebuck AS, Chapman KR, Abboud R, et al. Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room. Am J Med. 1987;82(1):59–64. doi:10.1016/0002-9343(87)90378-0.
  • Rebuck AS, Gent M, Chapman KR. Anticholinergic and sympathomimetic combination therapy of asthma. J Allergy Clin Immunol. 1983;71(3):317–323. doi:10.1016/0091-6749(83)90086-6.
  • Bourbeau J, Bhutani M, Hernandez P, et al. Canadian Thoracic Society Clinical Practice Guideline on pharmacotherapy in patients with COPD – 2019 update of evidence. Can J Respir Crit Care Sleep Med. 2019;3(4):210–232. doi:10.1080/24745332.2019.1668652.
  • Kew KM, Dahri K. Long-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma. Cochrane Database Syst Rev. 2016;2016(1):CD011721. doi:10.1002/14651858.CD011721.pub2.
  • Chari VM, McIvor RA. Tiotropium for the treatment of asthma: patient selection and perspectives. Can Respir J. 2018;2018:3464960. doi:10.1155/2018/3464960.
  • Kerstjens HA, Engel M, Dahl R, et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367(13):1198–1207. doi:10.1056/NEJMoa1208606.
  • SPIRIVA Product Monograph. 2022. https://pdf.hres.ca/dpd_pm/00065560.PDF.
  • Zhang S, King D, Rosen VM, Ismaila AS. Impact of single combination inhaler versus multiple inhalers to deliver the same medications for patients with asthma or COPD: a systematic literature review. Int J Chron Obstruct Pulmon Dis. 2020;15:417–438. doi:10.2147/COPD.S234823.
  • Enerzair Product Monograph. 2021. https://pdf.hres.ca/dpd_pm/00063748.PDF
  • Trelegy Product Monograph. 2022. https://pdf.hres.ca/dpd_pm/00068965.PDF
  • European Medicines Agency. Trimbow: EPAR - medicine overview. https://www.ema.europa.eu/en/medicines/human/EPAR/trimbow. 2017. Accessed April 5, 2023.
  • Bibliothèque et Archives nationales du Québec. RAMQ list of medications. https://www.ramq.gouv.qc.ca/sites/default/files/documents/non_indexes/liste_med_2023-05-25_en_maj.pdf. Published May 25, 2023. Accessed March 31, 2023.
  • Ontario Ministry of Health. Ontario drug benefit: formulary/comparative drug index (edition 43). https://www.health.gov.on.ca/en/pro/programs/drugs/odbf_mn.aspx. 2023. Accessed May 31, 2023.
  • Kaplan A, Chang K-L. Tiotropium in asthma – perspectives for the primary care physician. Postgrad Med. 2021;133(5):552–564. doi:10.1080/00325481.2020.1816329.
  • Busse WW, Abbott CB, Germain G, et al. Adherence and persistence to single-inhaler versus multiple-inhaler triple therapy for asthma management. J Allergy Clin Immunol Pract. 2022;10(11):2904–2913.e6. doi:10.1016/j.jaip.2022.06.010.
  • Averell CM, Stanford RH, Laliberté F, Wu JW, Germain G, Duh MS. Medication adherence in patients with asthma using once-daily versus twice-daily ICS/LABAs. J Asthma. 2021;58(1):102–111. doi:10.1080/02770903.2019.1663429.
  • Averell CM, Laliberte F, Duh MS, Wu JW, Germain G, Faison S. Characterizing real-world use of tiotropium in asthma in the USA. J Asthma Allergy. 2019;12:309–321. doi:10.2147/JAA.S216932.
  • Collier DJ, Wielders P, Van Der Palen J, et al. Critical error frequency and the impact of training with inhalers commonly used for maintenance treatment in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2020;15:1301–1313. doi:10.2147/COPD.S224209.
  • Kerstjens HAM, Maspero J, Chapman KR, et al. Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study. Lancet Respir Med. 2020;8(10):1000–1012. doi:10.1016/S2213-2600(20)30190-9.
  • Gessner C, Kornmann O, Maspero J, et al. Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: a randomised, Phase IIIb, non-inferiority study (ARGON). Respir Med. 2020;175:106186. doi:10.1016/j.rmed.2020.106186.
  • Lee LA, Bailes Z, Barnes N, et al. Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med. 2021;9(1):69–84. doi:10.1016/S2213-2600(20)30389-1.
  • Keith PK, Koch C, Djandji M, et al. Montelukast as add-on therapy with inhaled corticosteroids alone or inhaled corticosteroids and long-acting beta-2-agonists in the management of patients diagnosed with asthma and concurrent allergic rhinitis (the RADAR trial). Can Respir J. 2009;16 Suppl A(Suppl A):17a–31a. doi:10.1155/2009/145071.
  • Fortescue R, Kew KM, Leung MT. Sublingual immunotherapy for asthma. Cochrane Database Syst Rev. 2020;9(9):CD011293. doi:10.1002/14651858.CD011293.pub3.
  • Kim LHY, Saleh C, Whalen-Browne A, O'Byrne PM, Chu DK. Triple vs dual inhaler therapy and asthma outcomes in moderate to severe asthma: a systematic review and meta-analysis. JAMA. 2021;325(24):2466–2479. doi:10.1001/jama.2021.7872.
  • Singh D, Virchow JC, Canonica GW, et al. Determinants of response to inhaled extrafine triple therapy in asthma: analyses of TRIMARAN and TRIGGER. Respir Res. 2020;21(1):285. doi:10.1186/s12931-020-01558-y.
  • Cazzola M, Braido F, Calzetta L, et al. The 5T approach in asthma: Triple Therapy Targeting Treatable Traits. Respir Med. 2022;200:106915. doi:10.1016/j.rmed.2022.106915.
  • Fulford B, Mezzi K, Whiting A, Aumônier S. Life-cycle assessment of the breezhaler® breath-actuated dry powder inhaler. Sustainability. 2021;13(12):6657. doi:10.3390/su13126657.
  • BREZTRI™ AEROSPHERE® Product Monograph. 2021. https://pdf.hres.ca/dpd_pm/00062143.PDF.
  • Rogliani P, Cavalli F, Chetta A, Cazzola M, Calzetta L. Potential drawbacks of ICS/LABA/LAMA triple fixed-dose combination therapy in the treatment of asthma: a quantitative synthesis of safety profile. J Asthma Allergy. 2022;15:565–577. doi:10.2147/JAA.S283489.