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Structural Heart
The Journal of the Heart Team
Volume 3, 2019 - Issue 6
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Original Research

Early Aortic Valve Replacement versus Watchful Waiting in Asymptomatic Severe Aortic Stenosis: A Study-Level Meta-Analysis

, MD, MSc, PhDORCID Icon, , MDORCID Icon, , MD, , MDORCID Icon, , MD, , DVM, PhD, FAHAORCID Icon, , DVM, PhD, FAHA, FACC, FESC, FASEORCID Icon & , MD, MSc, PhD, ChM show all
Pages 483-490 | Received 14 May 2019, Accepted 30 Jul 2019, Published online: 30 Aug 2019

References

  • Falk V, Baumgartner H, Bax JJ, et al., ESC Scientific Document Group. ESC/EACTS guidelines for the management of valvular heart disease. Eur J Cardiothorac Surg. 2017;52(4):616–664. doi:10.1093/ejcts/ezx324.
  • Green P, Cohen DS, Genereux P, et al. Relation between six-minute walk test performance and outcomes after transcatheter aortic valve implantation (from the PARTNER trial). Am J Cardiol. 2013;112:700–706. doi:10.1016/j.amjcard.2013.04.046.
  • Otto CM, Burwash IG, Legget ME, et al. Prospective study of asymptomatic valvular stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation. 1997;95:2262–2270. doi:10.1161/01.CIR.95.9.2262.
  • Pellikka PA, Sarano ME, Nishimura RA. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation. 2005;111:3290–3295.
  • Rosenhek R, Binder T, Porenta G, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med. 2000;343:611–617.
  • Kang DH, Jang JY, Park SJ, et al. Watchful observation versus early aortic valve replacement for symptomatic patients with normal flow, low-gradient severe aortic stenosis. Heart. 2015;101:1375–1381.
  • Moher D, Liberati A, Tetzlaff J, Altman DG; for the PRISMA Group. Preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement. Ann Intern Med. 2009;151:264–269.
  • Stroup DF, Berlin JA, Morton SA, et al. For the Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. Metaanalysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000;283:2008–2012.
  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560.
  • DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials. 2007;28:105–114. doi:10.1016/j.cct.2006.04.004.
  • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101. doi:10.2307/2533446.
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test. BMJ. 1997;315:629–634. doi:10.1136/bmj.315.7109.629.
  • George SA, Prisko S, Onizuka T, et al. An observational study of elderly veterans with initially asymptomatic severe aortic stenosis. [published online ahead of print March 15, 2019]. J Invasive Cardiol. 2019;31(6):166–170.
  • Campo J, Tsoris A, Kruse J, et al. Prognosis of severe asymptomatic aortic stenosis with and without surgery. Ann Thorac Surg. 2019;108(1):74–79. doi:10.1016/j.athoracsur.2019.01.031.
  • Kim HJ, Kim JB, Kim HR, et al. Impact of valve replacement on long-term survival in asymptomatic patients with severe aortic stenosis. Am J Cardiol. 2019;123(8):1321–1328. doi:10.1016/j.amjcard.2019.01.035.
  • Bohbot Y, Pasquet A, Rusinaru D, et al. Asymptomatic severe aortic stenosis with preserved ejection fraction. J Am Coll Cardiol. 2018;72(23):2934–2944. doi:10.1016/j.jacc.2018.09.047.
  • Taniguchi T, Morimoto T, Shiomi H, et al. Initial surgical versus conservative strategies in patients with asymptomatic severe aortic stenosis. J Am Coll Cardiol. 2015;66(23):2827–2838. doi:10.1016/j.jacc.2015.10.001.
  • Pai RG, Kapoor N, Bansal RC, Varadarajan P. Malignant natural history of asymptomatic severe aortic stenosis: benefit of aortic valve replacement. Ann Thorac Surg. 2006;82:2116–2122. doi:10.1016/j.athoracsur.2006.07.043.
  • Tastet L, Tribouilloy C, Maréchaux C, et al. Usefulness of cardiac damage based staging classification in asymptomatic moderate to severe aortic valve stenosis. JACC. 2019;in Press. doi:10.1016/j.jacc.2019.04.065.
  • Milavetz DL, Hayes SN, Weston SA, Seward JB, Mullany CJ, Roger VL. Sex differences in left ventricular geometry in aortic stenosis: impact on outcome. Chest. 2000;117:1094–1099. doi:10.1378/chest.117.4.1094.
  • Fuchs C, Mascherbauer J, Rosenhek R, Pernicka E, Klaar U. Gender differences in clinical presentation and surgical outcome of aortic stenosis. Heart. 2010;96:539–545. doi:10.1136/hrt.2009.173765.
  • Stamou SC, Robich M, Wolf RE, et al. Effects of gender and ethnicity on outcomes after aortic valve replacement. J Thorac Cardiovasc Surg. 2012;144:486–492. doi:10.1016/j.jtcvs.2012.08.032.
  • Hayashida K, Morice MC, Chevalier B, et al. Sex-related differences in clinical presentation and outcome of transcatheter aortic valve implantation for severe aortic stenosis. J Am Coll Cardiol. 2012;59:566–571. doi:10.1016/j.jacc.2011.10.877.
  • Humphries KH, Toggweiler S, Rodes-Cabau J, et al. Sex differences in mortality after transcatheter aortic valve replacement for severe aortic stenosis. J Am Coll Cardiol. 2012;60(10):882–886. doi:10.1016/j.jacc.2012.05.009.
  • Smith CR, Leon MB, Mack MJ, et al. Transcatheter versus surgical aorticvalve replacement in high-risk patients. N Engl J Med. 2011;364:2187–2198. doi:10.1056/NEJMoa1007994.
  • Liakos CI, Grassos CA, Papadopoulos DP, Dimitriadis KS, Tsioufis CP, Tousoulis D. Arterial hypertension and aortic valve stenosis: shedding light on a common “liaison”. Hellenic J Cardiol. 2017;58(4):261–266. doi:10.1016/j.hjc.2017.03.005.
  • Rieck AE, Cramariuc D, Staal EM, Rossebø AB, Wachtell K, Gerdts E. Impact of hypertension on left ventricular structure in patients with asymptomatic aortic valve stenosis (a SEAS substudy). J Hypertens. 2010;28(2):377–383. doi:10.1097/HJH.0b013e328332fa44.
  • Capoulade R, Clavel MA, Mathieu P, et al. Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis. Eur J Clin Invest. 2013;43(12):1262–1272. doi:10.1111/eci.12169.
  • Lindman BR, Arnold SV, Madrazo JA, et al. The adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis. Circ Heart Fail. 2011;4(3):286–292. doi:10.1161/CIRCHEARTFAILURE.110.960039.
  • Halkos ME, Kilgo P, Lattouf OM, et al. The effect of diabetes mellitus on in-hospital and long-term outcomes after heart valve operations. Ann Thorac Surg. 2010;90(1):124–130. doi:10.1016/j.athoracsur.2010.03.111.
  • Smith RL 2nd, Herbert MA, Dewey TM, et al. Does body mass index affect outcomes for aortic valve replacement surgery for aortic stenosis? Ann Thorac Surg. 2012;93(3):742–746. doi:10.1016/j.athoracsur.2011.11.027.
  • Guzzetti E, Annabi MS, Ong G, et al. Impact of metabolic syndrome and/or diabetes mellitus on left ventricular mass and remodeling in patients with aortic stenosis before and after aortic valve replacement. Am J Cardiol. 2019 Jan 1;123(1):123–131. doi:10.1016/j.amjcard.2018.09.015.
  • Kang DH Early surgery versus conventional treatment in very severe aortic stenosis (RECOVERY). https://clinicaltrials.gov/ct2/show/NCT01161732.
  • Banovic M, Lung B, Bartunek J, et al. The Aortic Valve replAcemenT versus conservative treatment in Asymptomatic seveRe aortic stenosis (AVATAR trial): protocol update. Am Heart J. 2018;195:153–154. doi:10.1016/j.ahj.2017.10.005.
  • Monin JL Early surgery for patients with asymptomatic aortic stenosis (ESTIMATE). https://clinicaltrials.gov/ct2/show/NCT02627391. Accessed May 1, 2019.
  • Généreux P Evaluation of transcatheter aortic valve replacement compared to surveillance for patients with asymptomatic severe aortic stenosis (EARLY TAVR). https://clinicaltrials.gov/ct2/show/NCT03042104.  Accessed May 1, 2019.
  • Ledwoch J, Thiele H. Treatment of asymptomatic aortic stenosis: watchful waiting or early intervention? Herz. 2017;42:528–535. doi:10.1007/s00059-017-4584-z.
  • Dweck M Early valve replacement guided by biomarkers of LV decompensation in asymptomatic patients with severe AS (EVoLVeD). https://clinicaltrials.gov/ct2/show/NCT03094143. Accessed May 1, 2019.

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