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Structural Heart
The Journal of the Heart Team
Volume 4, 2020 - Issue 6
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Review Article

Mixed Aortic Valve Disease: A Diagnostic Challenge, a Prognostic Threat

, MD, PhDORCID Icon & , DVM, PhDORCID Icon
Pages 468-474 | Received 13 Jun 2020, Accepted 05 Aug 2020, Published online: 07 Oct 2020

References

  • Andell P, Li X, Martinsson A, et al. Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study. Heart. 2017;103(21):1696–1703. doi:10.1136/heartjnl-2016-310894.
  • Rashedi N, Popović ZB, Stewart WJ, Marwick T. Outcomes of asymptomatic adults with combined aortic stenosis and regurgitation. J Am Soc Echocardiogr. 2014;27(8):829–837. doi:10.1016/j.echo.2014.04.013.
  • Watkins DA, Johnson CO, Colquhoun SM, et al. Global, regional, and national burden of rheumatic heart disease, 1990–2015. N Engl J Med. 2017;377(8):713–722. doi:10.1056/NEJMoa1603693.
  • Unger P, Tribouilloy C. Aortic stenosis with other concomitant valvular disease. Aortic regurgitation, mitral regurgitation, mitral stenosis, or tricuspid regurgitation. Cardiol Clin. 2020;38:33–46. doi:10.1016/j.ccl.2019.09.002.
  • Egbe AC, Luis SA, Padang R, Warnes CA. Outcomes in moderate mixed aortic valve disease: is it time for a paradigm shift? J Am Coll Cardiol. 2016;67(20):2321–2329. doi:10.1016/j.jacc.2016.03.509.
  • Parker MW, Aurigemma GP. The simple arithmetic of mixed aortic valve disease: LVH + Volume Load = Trouble. J Am Coll Cardiol. 2016;67(20):2330–2333. doi:10.1016/j.jacc.2016.03.549.
  • Hess OM, Ritter M, Schneider J, Grimm J, Turina M, Krayenbuehl HP. Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement. Circulation. 1984;69(5):855–865. doi:10.1161/01.CIR.69.5.855.
  • Baumgartner H, Falk V, Bax JJ, et al. ESC/EACTS guidelines for the management of valvular heart disease: the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2017;38:2739–2791.
  • Nishimura RA, Otto CM, Bonow RO, et al. AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation. 2014;129(23):e521–643. doi:10.1161/CIR.0000000000000031.
  • Nishimura RA, Otto CM, Bonow RO, et al. AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Circulation. 2017;135(25):e1159–95. doi:10.1161/CIR.0000000000000503.
  • Krayenbuehl HP, Hess OM, Monrad ES, Schneider J, Mall G, Turina M. Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement. Circulation. 1989;79(4):744–755. doi:10.1161/01.CIR.79.4.744.
  • Michail M, Davies JE, Cameron JD, Parker KH, Brown AJ. Pathophysiological coronary and microcirculatory flow alterations in aortic stenosis. Nat Rev Cardiol. 2018;15(7):420–431. doi:10.1038/s41569-018-0011-2.
  • Lindman BR, Clavel MA, Mathieu P, et al. Calcific aortic stenosis. Nat Rev Dis Primers. 2016;2:16006. doi:10.1038/nrdp.2016.6.
  • Honda S, Kitai T, Okada Y, et al. Impact of aortic regurgitation on the prognosis of severe aortic stenosis. Heart. 2012;98(21):1591–1594. doi:10.1136/heartjnl-2012-302089.
  • Zilberszac R, Gabriel H, Schemper M, et al. Outcome of combined stenotic and regurgitant aortic valve disease. J Am Coll Cardiol. 2013;61(14):1489–1495. doi:10.1016/j.jacc.2012.11.070.
  • Egbe AC, Poterucha JT, Warnes CA. Mixed aortic valve disease: midterm outcome and predictors of adverse events. Eur Heart J. 2016;37(34):2671–2678. doi:10.1093/eurheartj/ehw079.
  • Rosenhek R, Zilberszac R, Schemper M, et al. Natural history of very severe aortic stenosis. Circulation. 2010;121(1):151–156. doi:10.1161/CIRCULATIONAHA.109.894170.
  • Isaza N, Desai MY, Kapadia SR, et al. Long-term outcomes in patients with mixed aortic valve disease and preserved left ventricular ejection fraction. J Am Heart Assoc. 2020;9(7):e014591. doi:10.1161/JAHA.119.014591.
  • Yang LT, Pellikka PA, Enriquez-Sarano M, et al. Can aortic regurgitation evolve into aortic stenosis? New insights on mixed aortic valve disease. J Am Soc Echocardiogr. 2020;33(3):406–408. doi:10.1016/j.echo.2019.10.008.
  • Grayburn PA, Smith MD, Harrison MR, Gurley JC, DeMaria AN. Pivotal role of aortic valve area calculation by the continuity equation for Doppler assessment of aortic stenosis in patients with combined aortic stenosis and regurgitation. Am J Cardiol. 1988;61(4):376–381. doi:10.1016/0002-9149(88)90948-4.
  • Gamaza-Chulián S, Díaz-Retamino E, Camacho-Freire S, Ruiz-Fernández D, Gutiérrez-Barrios A, Oneto-Otero J. Acceleration time and ratio of acceleration time to ejection time in aortic stenosis: new echocardiographic diagnostic parameters. J Am Soc Echocardiogr. 2017;10:947–955. doi:10.1016/j.echo.2017.06.001.
  • Blais C, Burwash IG, Mundigler G, et al. Projected valve area at normal flow rate improves the assessment of stenosis severity in patients with low-flow, low-gradient aortic stenosis: the multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) study. Circulation. 2006;113(5):711–721. doi:10.1161/CIRCULATIONAHA.105.557678.
  • Lancellotti P, Tribouilloy C, Hagendorff A, et al. Scientific Document Committee of the European Association of Cardiovascular Imaging. Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2013;14(7):611–644. doi:10.1093/ehjci/jet105.
  • Zoghbi WA, Adams D, Bonow RO, et al. Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the society for cardiovascular magnetic resonance. J Am Soc Echocardiogr. 2017;30(4):303–371. doi:10.1016/j.echo.2017.01.007.
  • de Marchi SF, Windecker S, Aeschbacher BC, Seiler C. Influence of left ventricular relaxation on the pressure half time of aortic regurgitation. Heart. 1999;82(5):607–613. doi:10.1136/hrt.82.5.607.
  • Kammerlander AA, Wiesinger M, Duca F, et al. Diagnostic and prognostic utility of cardiac magnetic resonance imaging in aortic regurgitation. J Am Coll Cardiol Img. 2019;12(8):1474–1483. doi:10.1016/j.jcmg.2018.08.036.
  • Lee JKT, Franzone A, Lanz J, et al. Early detection of subclinical myocardial damage in chronic aortic regurgitation and strategies for timely treatment of asymptomatic patients. Circulation. 2018;137(2):184–196. doi:10.1161/CIRCULATIONAHA.117.029858.
  • Azevedo CF, Nigri M, Higuchi ML, et al. Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease. J Am Coll Cardiol. 2010;56(4):278–287. doi:10.1016/j.jacc.2009.12.074.
  • Ong G, Pibarot P. Combined aortic stenosis and regurgitation: double the trouble. Heart. 2019;105(19):1515–1522. doi:10.1136/heartjnl-2017-312303.
  • Egbe AC, Khan AR, Boler A, et al. Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease. Eur Heart J Cardiovasc Imaging. 2018;19(6):668–674. doi:10.1093/ehjci/jex148.
  • Egbe AC, Warnes CA. Predictor of left ventricular dysfunction after aortic valve replacement in mixed aortic valve disease. Int J Cardiol. 2017;228:511–517. doi:10.1016/j.ijcard.2016.11.237.
  • Magne J, Cosyns B, Popescu BA, et al. Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: an individual participant data meta-analysis. J Am Coll Cardiol Img. 2019;12(1):84–92. doi:10.1016/j.jcmg.2018.11.005.
  • Alashi A, Khullar T, Mentias A, et al. Long-term outcomes after aortic valve surgery in patients with asymptomatic chronic aortic regurgitation and preserved LVEF: impact of baseline and follow-up global longitudinal strain. J Am Coll Cardiol Img. 2020;13(1):12–21. doi:10.1016/j.jcmg.2018.12.021.
  • Kong WKF, Vollema EM, Prevedello F, et al. Prognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. Oct 21, 2019:pii: jez252. doi:10.1093/ehjci/jez252. [Epub ahead of print].
  • Chambers JB, Prendergast B, Iung B, et al. Standards defining a ‘Heart Valve Centre’: ESC working group on valvular heart disease and European association for cardiothoracic surgery viewpoint. Eur Heart J. 2017;38(28):2177–2183. doi:10.1093/eurheartj/ehx370.
  • Lancellotti P, Rosenhek R, Pibarot P, et al. ESC Working Group on Valvular Heart Disease position paper–heart valve clinics: organization, structure, and experiences. Eur Heart J. 2013;34(21):1597–1606. doi:10.1093/eurheartj/ehs443.
  • Chahine J, Kadri AN, Gajulapalli RD, et al. Outcomes of transcatheter aortic valve replacement in mixed aortic valve disease. J Am Coll Cardiol Cardiovasc Interv. 2019;12(22):2299–2306. doi:10.1016/j.jcin.2019.06.020.
  • Heidari B, Al-Hijji MA, Alkhouli MA, et al. Transcatheter aortic valve replacement outcomes in mixed aortic valve disease compared to predominant aortic stenosis. Int J Cardiol. Jan 15, 2020;299:209–214. doi:10.1016/j.ijcard.2019.07.099.
  • Colli A, Besola L, Salizzoni S, et al. Does pre-existing aortic regurgitation protect from death in patients who develop paravalvular leak after TAVI? Int J Cardiol. 2017;233:52–60. doi:10.1016/j.ijcard.2017.02.005.

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