Blepharismins used for chemical defense in two ciliate species of the genus Blepharisma, B. stoltei and B. undulans (Ciliophora: Heterotrichida)

References

• Anesi A , Buonanno F , Di Giuseppe G , Ortenzi C , Guella G. 2016. Metabolites from the euryhaline ciliate Pseudokeronopsis erythrina . European Journal of Organic Chemistry 7:1330–1336. DOI:10.1002/ejoc.201501424.
   Web of Science ®Google Scholar
• Buonanno F. 2005. Variations in the efficiency of ciliate extrusomal toxins against a common ciliate predator, the catenulid Stenostomum sphagnetorum . Italian Journal of Zoology 72:293–295. DOI:10.1080/11250000509356688.
   Web of Science ®Google Scholar
• Buonanno F . 2009. Antipredator behavior of freshwater microturbellarian Stenostomum sphagnetorum against the predatory ciliate Dileptus margaritifer . Zoological Science 26:443–447. DOI:10.2108/zsj.26.443.
   Web of Science ®Google Scholar
• Buonanno F . 2011. The changes in the predatory behavior of the microturbellarian Stenostomum sphagnetorum on two species of toxin-secreting ciliates of the genus Spirostomum . Biologia 66/4:648–653. DOI:10.2478/s11756-011-0061-y.
   Web of Science ®Google Scholar
• Buonanno F , Anesi A , Di Giuseppe G , Guella G , Ortenzi C . 2017. Chemical defense by erythrolactones in the euryhaline ciliated protist, Pseudokeronopsis erythrina . Zoological Science 34:42–51. DOI:10.2108/zs160123.
   Web of Science ®Google Scholar
• Buonanno F , Anesi A , Guella G , Kumar S , Bharti D , La Terza A , Quassinti L , Bramucci M , Ortenzi C . 2014. Chemical offence by means of toxicysts in the freshwater ciliate, Colpes hirtus . Journal of Eukaryotic Microbiology 61:293–304. DOI:10.1111/jeu.12106.
   PubMed Web of Science ®Google Scholar
• Buonanno F , Guella G , Strim C , Ortenzi C . 2012. Chemical defence by mono-prenyl hydroquinone in a freshwater ciliate, Spirostomum ambiguum . Hydrobiologia 684:97–107. DOI:10.1007/s10750-011-0972-1.
   Web of Science ®Google Scholar
• Buonanno F , Harumoto T , Ortenzi C . 2013. The defensive function of trichocysts in Paramecium tetraurelia against metazoan predators compared with the chemical defense of two species of toxin-containing ciliates. Zoological Science 30:255–261. DOI:10.2108/zsj.30.255.
   Web of Science ®Google Scholar
• Buonanno F , Ortenzi C . 2016. Cold-shock based method to induce the discharge of extrusomes in ciliated protists and its efficiency. Journal of Basic Microbiology 56:586–590. DOI:10.1002/jobm.201500438.
   Web of Science ®Google Scholar
• Buonanno F , Saltalamacchia P , Miyake A . 2005. Defense function of pigmentocysts in the karyorelictid ciliate Loxodes striatus . European Journal Protistology 41:151–158. DOI:10.1016/j.ejop.2005.01.001.
   Web of Science ®Google Scholar
• Catalani E , Proietti Serafini F , Zecchini S , Picchietti S , Fausto AM , Marcantoni E , Buonanno F , Ortenzi C , Perrotta C , Cervia D . 2016. Natural products from aquatic eukaryotic microorganisms for cancer therapy: Perspectives on anti-tumour properties of ciliate bioactive molecules. Pharmacological Research 113(A):409–420. DOI:10.1016/j.phrs.2016.09.018.
   Web of Science ®Google Scholar
• Guella G , Skropeta D , Di Giuseppe G , Dini F . 2010. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes . Marine Drugs 8:2080–2116. DOI:10.3390/md8072080.
   Web of Science ®Google Scholar
• Harumoto T , Miyake A , Ishikawa N , Sugibayashi R , Zenfuku K , Iio H . 1998. Chemical defense by means of pigmented extrusomes in the ciliate Blepharisma japonicum . European Journal Protistology 34:458–470. DOI:10.1016/S0932-4739(98)80014-X.
   Web of Science ®Google Scholar
• Höfle G , Reinecke S , Laude U , Kabbe K , Dietrich S . 2014. Amethystin, the coloring principle of Stentor amethystinus . Journal of Natural Products 77:1383−1389. DOI:10.1021/np5001363.
   Web of Science ®Google Scholar
• Kato Y , Matsuoka T . 1995. Photodynamic action of the pigment in ciliated protozoan Blepharisma . Journal of Protozoology Research 5:136–140.
   Web of Science ®Google Scholar
• Kobayashi M , Miura M , Takusagawa M , Sugiura M , Harumoto T . 2015. Two possible barriers blocking conjugation between different megakaryotypes of Blepharisma . Zoological Science 32:53–61. DOI:10.2108/zs140151.
   Web of Science ®Google Scholar
• Lobban CS , Hallam SJ , Mukherjee P , Petrich JW . 2007. Photophysics and multifunctionality of hypericin-like pigments in heterotrich ciliates: A phylogenetic perspective. Photochemistry and Photobiology 83:1074–1094. DOI:10.1111/j.1751-1097.2007.00191.x.
   Web of Science ®Google Scholar
• Matsuoka T , Kotsuki H , Muto Y . 2010. Multi-functions of photodynamic pigments in ciliated ptotozoans. In: Méndez-Vilas A , editor. Current research, technology and education topics in applied microbiology and microbial biotechnology. Badajoz: Formatex. pp. 419–426.
   Google Scholar
• Matsuoka T , Satol M , Maeda M , Naoki H , Tanaka T , Kotsuki H . 1997. Localization of Blepharismin photosensors and identification of a photoreceptor complex mediating the step-up photophobic response of the unicellular organism, Blepharisma . Photochemistry and Photobiology 65:915–921. DOI:10.1111/php.1997.65.issue-5.
   Web of Science ®Google Scholar
• Miyake A . 1981. Cell interaction by gamones in Blepharisma . In: O’Day DH , Horgen PA , editors. Sexual interaction in eukaryotic microbes. New York: Academic Press. pp. 95–129.
   Google Scholar
• Miyake A , Harumoto T , Salvi B , Rivola V . 1990. Defensive function of pigment granules in Blepharisma japonicum . European Journal of Protistology 25:310–315. DOI:10.1016/S0932-4739(11)80122-7.
   Web of Science ®Google Scholar
• Muto Y , Matsuoka T , Kida A , Okano Y , Kirino Y . 2001. Blepharismins, produced by the protozoan, Blepharisma japonicum, form ion-permeable channels in planar lipid bilayer membranes. FEBS Letters 508:423–426. DOI:10.1016/S0014-5793(01)03110-6.
   Web of Science ®Google Scholar
• Pant B , Kato Y , Kumagai T , Matsuoka T , Sugiyama M . 1997. Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus . FEMS Microbiology Letters 155:67–71. DOI:10.1111/j.1574-6968.1997.tb12687.x.
   Web of Science ®Google Scholar
• Perrotta C , Buonanno F , Zecchini S , Giavazzi A , Proietti Serafini F , Catalani E , Guerra L , Belardinelli MC , Picchietti S , Fausto AM , Giorgi S , Marcantoni E , Clementi E , Ortenzi C , Cervia D . 2016. Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme. Scientific Reports 6:27281. DOI:10.1038/srep27281.
   PubMed Web of Science ®Google Scholar
• Petrelli D , Buonanno F , Vitali LA , Ortenzi C . 2012. Antimicrobial activity of the protozoan toxin climacostol and its derivatives. Biologia 67:525–529. DOI:10.2478/s11756-012-0030-0.
   Web of Science ®Google Scholar
• Sera Y , Masaki ME , Doe M , Buonanno F , Miyake A , Usuki Y , Iio H . 2015. Spirostomin, defense toxin of the ciliate Spirostomum teres: Isolation, structure elucidation, and synthesis. Chemistry Letters 44:633–635. DOI:10.1246/cl.150044.
   Web of Science ®Google Scholar
• Terazima MN , Harumoto T . 2004. Defense function of pigment granules in the ciliate Blepharisma japonicum against two predatory protists, Amoeba proteus (Rhizopodea) and Climacostomum virens (Ciliata). Zoological Science 21:823–828. DOI:10.2108/zsj.21.823.
   Web of Science ®Google Scholar
• Uruma Y , Sakamoto K , Takumi K , Doe M , Usuki Y , Iio H . 2007. Assignment of 13C NMR spectrum for blepharismin C based on biosynthetic studies. Tetrahedron 63:5548–5553. DOI:10.1016/j.tet.2007.04.015.
   Web of Science ®Google Scholar