Development of Alginate- Neusilin US2 (Magnesium alumino-metasilicate) micro-composite hydrogel beads for oral sustained release of cilnidipine: a statistical optimization

References

• Chandra, K. S.; Ramesh, G. The Fourth-Generation Calcium Channel Blocker: Cilnidipine. Indian Heart J. 2013, 65(6), 691–695. DOI: 10.1016/j.ihj.2013.11.001.
   PubMedGoogle Scholar
• Singh, B.; Sahu, A. K.; Prasad, R. K.; Gautam, S. S. Preparation and Characterization of Cilnidipine Nanoparticles for Oral Antihypertensive Drug Using Anti-Solvent Precipitation Method. Der Pharmacia Lettre. 2016, 8(3), 296–307.
   Google Scholar
• Leung, H. S.; Yao, X.; Leung, F. P.; Ko, W. H.; Chen, Z. Y.; Gollasch, M.; Huang, Y. Cilnidipine, a Slow‐Acting Ca2+ Channel Blocker, Induces Relaxation in Porcine Coronary Artery: Role of Endothelial Nitric Oxide and [Ca2+]. Br. J. Pharmacol. 2006, 147(1), 55–63. DOI: 10.1038/sj.bjp.0706450.
   Web of Science ®Google Scholar
• Liu, X. Q.; Zhao, Y.; Li, D.; Qian, Z. Y.; Wang, G. J. Metabolism and Metabolic Inhibition of Cilnidipine in Human Liver Microsomes. Acta Pharmacol. Sin. 2003, 24(3), 263–268.
   PubMed Web of Science ®Google Scholar
• Wang, J. G.; Kario, K.; Lau, T.; Wei, Y. Q.; Park, C. G.; Kim, C. H.; Huang, J.; Zhang, W.; Li, Y.; Yan, P.; et al. Use of Dihydropyridine Calcium Channel Blockers in the Management of Hypertension in Eastern Asians: A Scientific Statement from the Asian Pacific Heart Association. Hypertens. Res. 2011, 34(4), 423–430. DOI: 10.1038/hr.2010.259.
   PubMed Web of Science ®Google Scholar
• Kontermann, R. E.;. Half-Life Extended Biotherapeutics. Expert Opin. Biol. Ther. 2016, 16(7), 903–915. DOI: 10.1517/14712598.2016.1165661.
   PubMed Web of Science ®Google Scholar
• Xie, M.; Olderoy, M. O.; Andreassen, J. P.; Selbach, S. M.; Strand, B. L.; Sikorski, P. Alginate-Controlled Formation of Nanoscale Calcium Carbonate and Hydroxyapatite Mineral Phase within Hydrogel Networks. Acta Biomater. 2010, 6, 3665–3675. DOI: 10.1016/j.actbio.2009.12.017.
   Web of Science ®Google Scholar
• Wu, C.; Fan, W.; Gelinsky, M.; Xiao, Y.; Chang, J.; Friis, T.; Cuniberti, G. In Situ Preparation and Protein Delivery of Silicate–Alginate Composite Microspheres with Core-Shell Structure. J. R. Soc. Interface. 2011, 8, 1804–1814. DOI: 10.1098/rsif.2011.0201.
   PubMed Web of Science ®Google Scholar
• Gombotz, W. R.; Wee, S. F. Protein Release from Alginate Matrices. Adv. Drug Deliv. Rev. 1998, 31(3), 267–285. DOI: 10.1016/S0169-409X(97)00124-5.
   PubMed Web of Science ®Google Scholar
• Kusuktham, B.; Prasertgul, J.; Srinun, P. Morphology and Property of Calcium Silicate Encapsulated with Alginate Beads. Silicon. 2014, 6(3), 191–197. DOI: 10.1007/s12633-013-9173-z.
   Web of Science ®Google Scholar
• Murata, Y.; Kodama, Y.; Isobe, T.; Kofuji, K.; Kawashima, S. Drug Release Profile from Calcium-Induced Alginate–Phosphate Composite Gel Beads. Int. J. Polym. Sci. 2009, 1–4. DOI:10.1155/2009/729057.
   Web of Science ®Google Scholar
• Mørch, Y. A.; Donati, I.; Strand, B. L.; Skjak-Bræk, G. Effect of Ca2+, Ba2+, and Sr2+ on Alginate Microbeads. Biomacromolecules. 2006, 7(5), 1471–1480. DOI: 10.1021/bm060010d.
   PubMed Web of Science ®Google Scholar
• Rees, D. A.;. Polysaccharide Shapes and Their Interactions-Some Recent Advances. Pure Appl. Chem. 1981, 53(1), 1–14. DOI: 10.1351/pac198153010001.
   Web of Science ®Google Scholar
• Mallappa, M. K.; Kesarla, R.; Banakar, S. Calcium Alginate-Neusilin US2 Nanocomposite Microbeads for Oral Sustained Drug Delivery of Poor Water Soluble Drug Aceclofenac Sodium. J. Drug Deliv. 2015, 1–14. DOI:10.1155/2015/826981.
   Web of Science ®Google Scholar
• Puttipipatkhachorn, P. T.;. Sodium Alginate–Magnesium Aluminum Silicate Composite Gels: Characterization of Flow Behavior, Microviscosity, and Drug Diffusivity. AAPS PharmSciTech. 2007, 8(3), E158–E165. DOI: 10.1208/pt0803072.
   Web of Science ®Google Scholar
• Qiu, M.; Chen, D.; Shen, C.; Shen, J.; Zhaoa, H.; He, Y. Preparation of in Situ Forming and Injectable Alginate/Mesoporous Sr-Containing Calcium Silicate Composite Cement for Bone Repair. RSC Adv. 2017, 7, 23671–23679. DOI: 10.1039/C6RA28860J.
   Web of Science ®Google Scholar
• Wang, L.; Shelton, R. M.; Cooper, P. R.; Lawson, M.; Triffitt, J. T.; Barralet, J. E. Evaluation of Sodium Alginate for Bone Marrow Cell Tissue Engineering. Biomaterials. 2003, 24, 3475–3481. DOI: 10.1016/S0142-9612(03)00167-4.
   PubMed Web of Science ®Google Scholar
• Chen, J. P.; Lin, Y. S. Decolorization of Azo Dye by Immobilized Pseudomonas Luteola Entrapped in Alginate–Silicate Sol–Gel Beads. Process Biochem. 2007, 42, 934–942. DOI: 10.1016/j.procbio.2007.03.001.
   Web of Science ®Google Scholar
• Han, Y.; Zeng, Q.; Li, H.; Chang, J. The Calcium Silicate/Alginate Composite: Preparation and Evaluation of Its Behavior as Bioactive Injectable Hydrogels. Acta Biomater. 2013, 9(11), 9107–9117. DOI: 10.1016/j.actbio.2013.06.022.
   PubMed Web of Science ®Google Scholar
• Khunawattanakula, W.; Puttipipatkhachornb, S.; Rades, T.; Pongjanyakula, T. Chitosan–Magnesium Aluminum Silicate Nanocomposite Films: Physicochemical Characterization and Drug Permeability. Int. J. Pharm. 2010, 393, 219–229. DOI: 10.1016/j.ijpharm.2010.04.007.
   Google Scholar
• Boissiere, M.; Allouche, J.; Chaneac, C.; Brayner, R.; Devoisselle, J. M.; Livage, J.; Coradin, T. Potentialities of Silica/Alginate Nanoparticles as Hybrid Magnetic Carriers. Int. J. Pharm. 2007, 344, 128–134. DOI: 10.1016/j.ijpharm.2007.05.055.
   PubMed Web of Science ®Google Scholar
• Javadzadeh, Y.; Hamedeyazdan, S.; Adibkia, K.; Kiafar, F.; M H, Z.; Jalali, M. B. Evaluation of Drug Release Kinetics and Physicochemical Characteristics of Metronidazole Floating Beads Based on Calcium Silicate and Gas-Forming Agents. Pharm. Dev. Tech. 2010, 15(4), 329–338. DOI: 10.3109/10837450903196843.
   PubMed Web of Science ®Google Scholar
• Nadpara, N. P.; Thumar, R. V.; Kalola, V. N.; Patel, P. B. Quality by Design (Qbd): A Complete Review. Int. J. Pharm. Sci. Rev. Res. 2012, 17(2), 20–28.
   Google Scholar
• Chowdary, K. P.; Shankar, K. R.; Kumar, P. S. Recent Research on QbD Approach in Formulation Development: A Review. Int. J. Chem. Sci. Techn. 2014, 4, 282–292.
   Google Scholar
• Rathore, A. S.;. Roadmap for Implementation of Quality by Design (Qbd) for Biotechnology Products. Trends Biotechnol. 2009, 27(9), 546–553. DOI: 10.1016/j.tibtech.2009.06.006.
   PubMed Web of Science ®Google Scholar
• Joshi, S. A.; Chavan, S. S.; Sawant, K. K. Rivastigmine- Loaded PLGA and PBCA Nanoparticles: Preparation, Optimization, Characterization, in Vitro and Pharmacodynamic Studies. Eur. J. Pharm. Biopharm. 2010, 76, 189–199. DOI: 10.1016/j.ejpb.2010.07.007.
   PubMed Web of Science ®Google Scholar
• Umaredkar, A. A.; Dangre, P. V.; Mahapatra, D. K.; Dhabarde, D. M. Fabrication of Chitosan-Alginate Polyelectrolyte Complexed Hydrogel for Controlled Release of Cilnidipine: A Stastical Design Approach. Mat. Tech. 2018. DOI: 10.1080/10667857.2018.1456617.
   Google Scholar
• Vidart, M.; Silva, T.; Rosa, P.; Melissa Vieira, A.; Silva, M. Development of Sericin/Alginate Particles by Ionic Gelation Technique for the Controlled Release of Diclofenac Sodium. J. Appl. Polym. Sci. 2017, 135(12), 45919. DOI: 10.1002/app.45919.
   Web of Science ®Google Scholar
• Costa, P.; Lobo, J. M. S. Modelling and Comparison of Dissolution Profiles. Eur. J. Pharm. Sci.. 2001, 13, 123–133.
   PubMed Web of Science ®Google Scholar
• Dangre, P.; Badhe, R.; Shorolkar, S.; Dhole, S. Formulation, Evaluation and Optimization of Fungal Alpha Amylase Loaded Alginate Bead. J. Adv. Pharm. Res. 2013, 4(3), 74–85.
   Google Scholar
• Xing, L.; Dawel, C.; Liping, X.; Rongqing, Z. Oral Colon-Specific Drug Delivery for Bee Venom Peptide: Develpoment of a Coated Calcium Alginate Gel Beads-Entrapped Liposome. J. Control. Release. 2003, 93, 293–300.
   PubMed Web of Science ®Google Scholar
• Sriamornsak, P.; Nunthanid, J. Calcium Pectinate Gel Beads for Controlled Release Drug Delivery: I. Preparation and in Vitro Release Studies. Int. J. Pharm. 1998, 160(2), 207–212. DOI: 10.1016/S0378-5173(97)00310-4.
   Google Scholar
• Sankalia, M. G.; Mashru, R. C.; Sankalia, J. M.; Sutariya, V. B. Papain Entrapment in Alginate Beads for Stability Improvement and Site-Specific Delivery: Physicochemical Characterization and Factorial Optimization Using Neural Network Modeling. AAPS PharmSciTech. 2005, 6(2), E209–E222. DOI: 10.1208/pt060231.
   Web of Science ®Google Scholar
• Mujtaba, A.; Ali, M.; Kohli, K. Formulation of Extended Release Cefpodoxime Proxetil Chitosan-Alginate Beads Using Quality by Design Approach. Int. J. Biol. Macromol. 2014, 69, 420–429. DOI: 10.1016/j.ijbiomac.2014.05.066.
   PubMed Web of Science ®Google Scholar
• Wong, T. W.; Chan, L. W.; Kho, S. B.; Heng, P. W. S. Design of Controlled-Release Solid Dosage Forms of Alginate and Chitosan Using Microwave. J. Control. Release. 2002, 84, 99–114.
   PubMed Web of Science ®Google Scholar