Advanced search
Publication Cover
HIV Research & Clinical Practice Volume 22, 2021 - Issue 2
Submit an article Journal homepage
3,423
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Dolutegravir-based regimens in treatment-naive and treatment-experienced aging populations: analyses of 6 phase III clinical trials

Frank Spinelli1 ViiV Healthcare, Research Triangle Park, NC, USACorrespondence[email protected]
View further author information
,
Manyu Prakash2 ViiV Healthcare, Brentford, UKView further author information
,
Jill Slater1 ViiV Healthcare, Research Triangle Park, NC, USAView further author information
,
Mike van der Kolk3 ViiV Healthcare, Amersfoort, NetherlandsView further author information
,
Niccolò Bassani4 Quanticate, Hitchin, UKView further author information
,
Richard Grove5 GlaxoSmithKline, Uxbridge, UKView further author information
,
Brian Wynne1 ViiV Healthcare, Research Triangle Park, NC, USAView further author information
,
Jean van Wyk2 ViiV Healthcare, Brentford, UKView further author information
&
Andrew Clark2 ViiV Healthcare, Brentford, UKView further author information
 show all
Pages 46-54 | Received 04 Mar 2021, Accepted 08 Jun 2021, Published online: 28 Jun 2021

References

  • Burgess MJ, Zeuli JD, Kasten MJ. Management of HIV/AIDS in older patients-drug/drug interactions and adherence to antiretroviral therapy . HIV AIDS (Auckl). 2015;7:251–264.
  • Wing EJ. HIV and aging. Int J Infect Dis. 2016;53:61–68.
  • Nideröst S, Imhof C. Aging with HIV in the era of antiretroviral treatment: living conditions and the quality of life of people aged above 50 living with HIV/AIDS in Switzerland. Gerontol Geriatr Med. 2016;2:233372141663630. 2333721416636300.
  • Centers for Disease Control and Prevention. HIV and Older Americans. Washington, DC: US Department of Health and Human Services, 2020. https://www.cdc.gov/hiv/group/age/olderamericans/index.html. Accessed September 29, 2020.
  • Smit M, Brinkman K, Geerlings S, ATHENA observational cohort, et al. Future challenges for clinical care of an ageing population infected with HIV: a modelling study. Lancet Infect Dis. 2015;15(7):810–818.
  • Althoff KN, Smit M, Reiss P, Justice AC. HIV and ageing: improving quantity and quality of life. Curr Opin HIV Aids. 2016;11(5):527–536.
  • Guaraldi G, Pintassilgo I, Milic J, Mussini C. Managing antiretroviral therapy in the elderly HIV patient. Expert Rev Clin Pharmacol. 2018;11(12):1171–1181.
  • Tivicay [package insert]. Triangle Park, NC: ViiV Healthcare: Research; 2020.
  • Aboud M, Kaplan R, Lombaard J, et al. Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial. Lancet Infect Dis. 2019;19(3):253–264.
  • Orrell C, Hagins DP, Belonosova E, ARIA study team, et al. Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study. Lancet Hiv. 2017;4(12):e536–e546.
  • Clotet B, Feinberg J, van Lunzen J, et al. Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study. Lancet 2014;383(9936):2222–2231.
  • Raffi F, Rachlis A, Stellbrink H-J, et al. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. Lancet 2013;381(9868):735–743.
  • Walmsley SL, Antela A, Clumeck N, et al. Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection. N Engl J Med. 2013;369(19):1807–1818.
  • Cahn P, Pozniak AL, Mingrone H, extended SAILING Study Team, et al. Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study. Lancet. 2013;382(9893):700–708.
  • Gnjidic D, Hilmer SN, Blyth FM, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65(9):989–995.
  • Hadigan C, Kattakuzhy S. Diabetes mellitus type 2 and abnormal glucose metabolism in the setting of human immunodeficiency virus. Endocrinol Metab Clin North Am. 2014;43(3):685–696.
  • Schoen JC, Erlandson KM, Anderson PL. Clinical pharmacokinetics of antiretroviral drugs in older persons. Expert Opin Drug Metab Toxicol. 2013;9(5):573–588.
  • Nguyen N, Holodniy M. HIV infection in the elderly. Clin Interv Aging. 2008;3(3):453–472.
  • Johnston RE, Heitzeg MM. Sex, age, race and intervention type in clinical studies of HIV cure: a systematic review. AIDS Res Hum Retroviruses. 2015;31(1):85–97.
  • Cerreta F, Eichler H-G, Rasi G. Drug policy for an aging population—the European Medicines Agency's geriatric medicines strategy. N Engl J Med. 2012;367(21):1972–1974.
  • US Food and Drug Administration. Inclusion of older adults in cancer clinical trials: guidance for industry. Silver Spring, MD: US Department of Health and Human Services, 2020. https://www.fda.gov/media/135804/download. Accessed December 2, 2020.
  • European Medicines Agency. ICH topic E 7: studies in support of special populations: geriatrics. ICH harmonised tripartite guideline. London, UK: European Medicines Agency, 1994. https://www.ema.europa.eu/en/documents/scientific-guideline/ich-e-7-studies-support-special-populations-geriatrics-step-5_en.pdf. Accessed December 2, 2020.
  • Guaraldi G, Calza S, Milic J, et al. Dolutegravir is not associated with weight gain in antiretroviral therapy experienced geriatric patients living with HIV. AIDS. 2021;35(6):939–945.
  • Andany N, Kennedy VL, Aden M, Loutfy M. Perspectives on menopause and women with HIV. Int J Womens Health. 2016;8:1–22.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.