Micronized flavonoid fraction Daflon 500 protects heart against ischemia–reperfusion injury: an old medicine for a new target

References

• Abdel-Rafei M, Amin MM, Hasan HF. 2017. Novel effect of Daflon and low-dose gamma-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats. Hum Exp Toxicol. 36(1):62–81. doi: https://doi.org/10.1177/0960327116637657
   Google Scholar
• Abwainy A, Babiker F, Akhtar S, Benter IF. 2016. Endogenous angiotensin-(1-7)/Mas receptor/NO pathway mediates the cardioprotective effects of pacing postconditioning. Am J Physiol Heart Circ Physiol. 310(1):H104–H112. eng. doi: https://doi.org/10.1152/ajpheart.00121.2015
   Google Scholar
• Al-Herz W, Babiker F. 2017. Acute intravenous infusion of immunoglobulins protects against myocardial ischemia-reperfusion injury through inhibition of caspase-3. Cell Physiol Biochem. 42(6):2295–2306. doi: https://doi.org/10.1159/000480002
   PubMedGoogle Scholar
• Babiker F, Al-Jarallah A, Al-Awadi M. 2019. Effects of cardiac hypertrophy, diabetes, aging, and pregnancy on the cardioprotective effects of postconditioning in male and female rats. Cardiol Res Pract. 2019:3403959. doi: https://doi.org/10.1155/2019/3403959
   Google Scholar
• Babiker FA, Elkhalifa LA, Moukhyer ME. 2013. Awareness of hypertension and factors associated with uncontrolled hypertension in Sudanese adults. Cardiovasc J Afr. 24(6):208–212. doi: https://doi.org/10.5830/CVJA-2013-035
   PubMed Web of Science ®Google Scholar
• Babiker FA, Hoteit LJ, Joseph S, Mustafa AS, Juggi JS. 2012. The role of 17-beta estradiol in ischemic preconditioning protection of the heart. Exp Clin Cardiol. 17(3):95–100. eng.
   Google Scholar
• Babiker FA, Joseph S, Juggi JS. 2011. What's new in salvage of the ischemic myocardium: estrogen postconditioning. Med Princ Pract Int J Kuwait Univ Health Sci Cent. 20(6):495–496. eng.
   Web of Science ®Google Scholar
• Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, et al. 2018. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med. 24(8):1234–1245. doi: https://doi.org/10.1038/s41591-018-0059-x
   PubMed Web of Science ®Google Scholar
• Banerjee SK, Dinda AK, Manchanda SC, Maulik SK. 2002. Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury. BMC Pharmacol. 2:16. doi: https://doi.org/10.1186/1471-2210-2-16
   PubMedGoogle Scholar
• Bellandi F, Maioli M, Gallopin M, Toso A, Dabizzi RP. 2004. Increase of myocardial salvage and left ventricular function recovery with intracoronary Abciximab downstream of the coronary occlusion in patients with acute myocardial infarction treated with primary coronary intervention. Catheter Cardiovasc Interv. 62(2):186–192. doi: https://doi.org/10.1002/ccd.20041
   PubMed Web of Science ®Google Scholar
• Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, et al. 2019. Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Circulation. 139(10):e56–e528. doi: https://doi.org/10.1161/CIR.0000000000000659
   PubMed Web of Science ®Google Scholar
• Boisseau MR. 2007. Leukocyte involvement in the signs and symptoms of chronic venous disease. Perspectives for therapy. Clin Hemorheol Microcirc. 37(3):277–290.
   Web of Science ®Google Scholar
• Bolli R, Becker L, Gross G, Mentzer R Jr, Balshaw D, Lathrop DA, NHLBI Working Group on the Translation of Therapies for Protecting the Heart from Ischemia. 2004. Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res. 95(2):125–134. doi: https://doi.org/10.1161/01.RES.0000137171.97172.d7
   Google Scholar
• Braunersreuther V, Jaquet V. 2012. Reactive oxygen species in myocardial reperfusion injury: from physiopathology to therapeutic approaches. Curr Pharm Biotechnol. 13(1):97–114. doi: https://doi.org/10.2174/138920112798868782
   PubMedGoogle Scholar
• Burgoyne JR, Oka S, Ale-Agha N, Eaton P. 2013. Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system. Antioxid Redox Signal. 18(9):1042–1052. doi: https://doi.org/10.1089/ars.2012.4817
   Google Scholar
• Burns RJ, Gibbons RJ, Yi Q, Roberts RS, Miller TD, Schaer GL, Anderson JL, Yusuf S, Investigators CS. 2002. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. J Am Coll Cardiol. 39(1):30–36. doi: https://doi.org/10.1016/S0735-1097(01)01711-9
   Google Scholar
• Cadenas S. 2018. ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection. Free Radic Biol Med. 117:76–89. doi: https://doi.org/10.1016/j.freeradbiomed.2018.01.024
   PubMed Web of Science ®Google Scholar
• Canty JM Jr, Suzuki G. 2012. Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease. J Mol Cell Cardiol. 52(4):822–831. doi: https://doi.org/10.1016/j.yjmcc.2011.08.019
   Google Scholar
• Cassar A, Holmes DR, Jr, Rihal CS, Gersh BJ. 2009. Chronic coronary artery disease: diagnosis and management. Mayo Clin Proc. 84(12):1130–1146. doi: https://doi.org/10.4065/mcp.2009.0391
   PubMed Web of Science ®Google Scholar
• Chen X, Li X, Zhang W, He J, Xu B, Lei B, Wang Z, Cates C, Rousselle T, Li J. 2018. Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-kappaB pathway. Metabolism. 83:256–270. doi: https://doi.org/10.1016/j.metabol.2018.03.004
   PubMed Web of Science ®Google Scholar
• Dare AJ, Logan A, Prime TA, Rogatti S, Goddard M, Bolton EM, Bradley JA, Pettigrew GJ, Murphy MP, Saeb-Parsy K. 2015. The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model. J Heart Lung Transplant. 34(11):1471–1480. eng. doi: https://doi.org/10.1016/j.healun.2015.05.007
   PubMed Web of Science ®Google Scholar
• D'Autreaux B, Toledano MB. 2007. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol. 8(10):813–824. doi: https://doi.org/10.1038/nrm2256
   PubMed Web of Science ®Google Scholar
• Delbarre B, Delbarre G, Calinon F. 1995. Effect of Daflon 500 mg, a flavonoid drug, on neurological signs, levels of free radicals and electroretinogram in the gerbil after ischemia-reperfusion injury. Int J Microcirc Clin Exp. 15(Suppl 1):27–33. doi: https://doi.org/10.1159/000179092
   Google Scholar
• de Souza M, Cyrino FZ, Mayall MR, Virgini-Magalhaes CE, Sicuro FL, Carvalho JJ, Verbeuren TJ, Bouskela E. 2016. Beneficial effects of the micronized purified flavonoid fraction (MPFF, daflon(R) 500 mg) on microvascular damage elicited by sclerotherapy. Phlebology. 31(1):50–56. eng. doi: https://doi.org/10.1177/0268355514564414
   Google Scholar
• Dinarello CA. 2000. Proinflammatory cytokines. Chest. 118(2):503–508. doi: https://doi.org/10.1378/chest.118.2.503
   PubMed Web of Science ®Google Scholar
• Erel O. 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 37(4):277–285. doi: https://doi.org/10.1016/j.clinbiochem.2003.11.015
   PubMed Web of Science ®Google Scholar
• Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 38(12):1103–1111. doi: https://doi.org/10.1016/j.clinbiochem.2005.08.008
   PubMed Web of Science ®Google Scholar
• Ferrera R, Benhabbouche S, Bopassa JC, Li B, Ovize M. 2009. One hour reperfusion is enough to assess function and infarct size with TTC staining in Langendorff rat model. Cardiovasc Drugs Ther. 23(4):327–331. doi: https://doi.org/10.1007/s10557-009-6176-5
   Google Scholar
• Gersh BJ, Stone GW, White HD, Holmes DR Jr. 2005. Pharmacological facilitation of primary percutaneous coronary intervention for acute myocardial infarction: is the slope of the curve the shape of the future? JAMA. 293(8):979–986. doi: https://doi.org/10.1001/jama.293.8.979
   Google Scholar
• Halliwell B, Rafter J, Jenner A. 2005. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr. 81(1 Suppl):268S–276S. doi: https://doi.org/10.1093/ajcn/81.1.268S
   PubMed Web of Science ®Google Scholar
• Hausenloy DJ, Yellon DM. 2013. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest. 123(1):92–100. doi: https://doi.org/10.1172/JCI62874
   PubMed Web of Science ®Google Scholar
• Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wulfers EM, Seemann G, Courties G, et al. 2017. Macrophages facilitate electrical conduction in the heart. Cell. 169(3):510–522.e520. doi: https://doi.org/10.1016/j.cell.2017.03.050
   PubMed Web of Science ®Google Scholar
• Jong WM, Ten Cate H, Linnenbank AC, de Boer OJ, Reitsma PH, de Winter RJ, Zuurbier CJ. 2016. Reduced acute myocardial ischemia-reperfusion injury in IL-6-deficient mice employing a closed-chest model. Inflamm Res. 65(6):489–499. doi: https://doi.org/10.1007/s00011-016-0931-4
   Google Scholar
• Juggi JS, Hoteit LJ, Babiker FA, Joseph S, Mustafa AS. 2011. Protective role of normothermic, hyperthermic and estrogen preconditioning and pretreatment on tumour necrosis factor-alpha-induced damage. Exp Clin Cardiol. 16(2):e5–e10. eng.
   Google Scholar
• Khalaf A, Babiker F. 2016. Discrepancy in calcium release from the sarcoplasmic reticulum and intracellular acidic stores for the protection of the heart against ischemia/reperfusion injury. J Physiol Biochem. 72(3):495–508. doi: https://doi.org/10.1007/s13105-016-0498-0
   PubMed Web of Science ®Google Scholar
• Kobo PI, Ayo JO, Aluwong T, Zezi AU, Maikai V, Ambali SF. 2014. Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats. Res Vet Sci. 96(1):139–142. eng. doi: https://doi.org/10.1016/j.rvsc.2013.10.005
   PubMed Web of Science ®Google Scholar
• Levraut J, Iwase H, Shao ZH, Vanden Hoek TL, Schumacker PT. 2003. Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation. Am J Physiol Heart Circ Physiol. 284(2):H549–H558. doi: https://doi.org/10.1152/ajpheart.00708.2002
   PubMed Web of Science ®Google Scholar
• Lim SH. 2017. Larch arabinogalactan attenuates myocardial injury by inhibiting apoptotic cascades in a rat model of ischemia-reperfusion. J Med Food. 20(7):691–699. doi: https://doi.org/10.1089/jmf.2016.3886
   Google Scholar
• Liu H, Li S, Jiang W, Li Y. 2019. MiR-484 protects rat myocardial cells from ischemia-reperfusion injury by inhibiting caspase-3 and caspase-9 during apoptosis. Korean Circ J. 50(3):250–263. doi: https://doi.org/10.4070/kcj.2019.0107
   Google Scholar
• Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, et al. 2018. Intra-cardiac release of extracellular vesicles shapes inflammation following myocardial infarction. Circ Res. 123(1):100–106. doi: https://doi.org/10.1161/CIRCRESAHA.117.311326
   Web of Science ®Google Scholar
• Lyseng-Williamson KA, Perry CM. 2003. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs. 63(1):71–100. doi: https://doi.org/10.2165/00003495-200363010-00005
   PubMed Web of Science ®Google Scholar
• Marquez Loza A, Elias V, Wong CP, Ho E, Bermudez M, Magnusson KR. 2017. Effects of ibuprofen on cognition and NMDA receptor subunit expression across aging. Neuroscience. 344:276–292. doi: https://doi.org/10.1016/j.neuroscience.2016.12.041
   PubMed Web of Science ®Google Scholar
• Mulvihill NT, Foley JB. 2002. Inflammation in acute coronary syndromes. Heart. 87(3):201–204. doi: https://doi.org/10.1136/heart.87.3.201
   Google Scholar
• Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. 2001. Flavonoids: a review of probable mechanisms of action and potential applications. . Am J Clin Nutr. 74(4):418–425. eng. doi: https://doi.org/10.1093/ajcn/74.4.418
   PubMed Web of Science ®Google Scholar
• Pagliaro P, Penna C. 2015. Redox signalling and cardioprotection: translatability and mechanism. Br J Pharmacol. 172(8):1974–1995. doi: https://doi.org/10.1111/bph.12975
   PubMed Web of Science ®Google Scholar
• Palazzo AL, Evensen E, Huang YW, Cesano A, Nolan GP, Fantl WJ. 2011. Association of reactive oxygen species-mediated signal transduction with in vitro apoptosis sensitivity in chronic lymphocytic leukemia B cells. PloS one. 6(10):e24592. doi: https://doi.org/10.1371/journal.pone.0024592
   Google Scholar
• Penna C, Mancardi D, Rastaldo R, Pagliaro P. 2009. Cardioprotection: a radical view free radicals in pre and postconditioning. Biochim Biophys Acta. 1787(7):781–793. doi: https://doi.org/10.1016/j.bbabio.2009.02.008
   PubMed Web of Science ®Google Scholar
• Raffetto JD., Eberhardt RT., Dean SM., Ligi D., Mannello F. 2016. Pharmacologic treatment to improve venous leg ulcer healing. J Vascular Surg Venous Lymphat Disord. 4(3):371–374. english. doi: https://doi.org/10.1016/j.jvsv.2015.10.002
   Google Scholar
• Ramelet AA. 2001. Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency [Review]. Angiology. 52(Suppl 1):S49–S56. eng. doi: https://doi.org/10.1177/0003319701052001S07
   Google Scholar
• Ridker PM, Howard CP, Walter V, Everett B, Libby P, Hensen J, Thuren T, Group CPI. 2012. Effects of interleukin-1beta inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial. Circulation. 126(23):2739–2748. doi: https://doi.org/10.1161/CIRCULATIONAHA.112.122556
   PubMed Web of Science ®Google Scholar
• Shah S, Mohan M, Kasture S, Ballero M, Maxia A, Sanna C. 2013. Protective effect of Hypericum hircinum on doxorubicin-induced cardiotoxicity in rats. Nat Prod Res. 27(16):1502–1507. doi: https://doi.org/10.1080/14786419.2012.724409
   PubMed Web of Science ®Google Scholar
• Sirlak M, Akar AR, Eryilmaz S, Cetinkanat EK, Ozcinar E, Kaya B, Elhan AH, Ozyurda U. 2010. Micronized purified flavonoid fraction in pretreating CABG patients. Tex Heart Inst J. 37(2):172–177.
   Web of Science ®Google Scholar
• Sugamura K, Keaney JF Jr. 2011. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 51(5):978–992. doi: https://doi.org/10.1016/j.freeradbiomed.2011.05.004
   PubMed Web of Science ®Google Scholar
• Suzuki K. 2009. Anti-oxidants for therapeutic use: why are only a few drugs in clinical use? [Review]. Adv Drug Deliv Rev. 61(4):287–289. eng. doi: https://doi.org/10.1016/j.addr.2009.03.002
   Google Scholar
• Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y, Yacoub MH. 2001. Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation. 104(12 Suppl 1):I308–I303. doi: https://doi.org/10.1161/hc37t1.094871
   Google Scholar
• Techapiesancharoenkij N, Fiala JL, Navasumrit P, Croy RG, Wogan GN, Groopman JD, Ruchirawat M, Essigmann JM. 2015. Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Toxicol Appl Pharmacol. 282(1):52–60. doi: https://doi.org/10.1016/j.taap.2014.11.004
   Google Scholar
• Trommer H, Neubert RH. 2005. The examination of polysaccharides as potential antioxidative compounds for topical administration using a lipid model system. Int J Pharm. 298(1):153–163. doi: https://doi.org/10.1016/j.ijpharm.2005.04.024
   PubMed Web of Science ®Google Scholar
• Unlu A, Sucu N, Tamer L, Coskun B, Yucebilgic G, Ercan B, Gul A, Dikmengil M, Atik U. 2003. Effects of Daflon on oxidative stress induced by hindlimb ischemia/reperfusion. Pharmacol Res. 48(1):11–15.
   Web of Science ®Google Scholar
• Yu M, Wen N, Wenzhong Z, Yuanchang X, Xiaoming D, Yongjin L. 2010. Effect of repeated ischaemic preconditioning on TLR4 and proinflammatory cytokines TNF-alpha and IL-1beta in myocardial ischaemia-reperfusion injury in a rat model. Arch Med Sci. 6(6):843–847. doi: https://doi.org/10.5114/aoms.2010.19289
   Google Scholar
• Zhang ML, Li ZP, Xiao H. 2007. [Different expressions of inflammatory cytokines in two types of cardiac hypertrophy in rats]. Beijing da Xue Xue Bao Yi Xue Ban = J Peking Univ Health Sci. 39(6):570–575.
   Google Scholar
• Zhang W, Xing B, Yang L, Shi J, Zhou X. 2015. Icaritin attenuates myocardial ischemia and reperfusion injury via anti-inflammatory and anti-oxidative stress effects in rats. Am J Chin Med. 43(6):1083–1097. doi: https://doi.org/10.1142/S0192415X15500627
   PubMed Web of Science ®Google Scholar