1,395
Views
0
CrossRef citations to date
0
Altmetric
Biochemistry, Cell and Molecular Biology

Six-ingredient-Xiao-qing-long decoction inhibited TGF-β1-induced proliferation and migration of human airway smooth muscle cells by regulating FKBP51/AKT signaling

, , , , , , & show all
Pages 80-90 | Received 16 Aug 2020, Accepted 07 Jan 2021, Published online: 20 Jan 2021

References

  • Allen DB. 2020 Dec. Inhaled corticosteroids and endocrine effects in childhood. Endocrinol Metab Clin North Am. 49(4):651–665.
  • Baarsma HA, Menzen MH, Halayko AJ, Meurs H, Kerstjens HA, Gosens R. 2011. β-Catenin signaling is required for TGF-β1-induced extracellular matrix production by airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 301(6):L956–65.
  • Bentley JK, Hershenson MB. 2008. Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration. Proc Am Thorac Soc. 5(1):89–96.
  • Boulet LP. 2018. Airway remodeling in asthma: update on mechanisms and therapeutic approaches. Curr Opin Pulm Med. 24(1):56–62.
  • Chang X, Zhang T, Meng QY, Zhang QX. 2018. Research progress of xiaoqinglong decoction in treatment of bronchial asthma. J Hubei Univ Chin Med. 20(04):121–125. Chinese.
  • Chen M, Shi JT, Lv ZQ, Huang LJ, Lin XL, Zhang W, Liang RY, Li YQ, Jiang SP. 2014. Triptolide inhibits TGF-β1 induced proliferation and migration of rat airway smooth muscle cells by suppressing NF-κB but not ERK1/2. Immunology. 144(3):486–94.
  • Chun E, Lee HS, Bang BR, Kim TW, Lee SH, Kim JH, Cho SH, Min KU, Kim YY, Park HW. 2011. Dexamethasone-induced FKBP51 expression in peripheral blood mononuclear cells could play a role in predicting the response of asthmatics to treatment with corticosteroids. J Clin Immunol. 31(1):122–127.
  • Deng Y, Zhang Y, Wu H, Shi Z, Sun X. 2017. Knockdown of FSTL1 inhibits PDGF-BB-induced human airway smooth muscle cell proliferation and migration. Mol Med Rep. 15(6):3859–3864.
  • Dong J, Jiao Y, Mu W, Lu B, Wei M, Sun L, Hu S, Cui B, Liu X, Chen Z, Zhao Y. 2017. FKBP51 decreases cell proliferation and increases progestin sensitivity of human endometrial adenocarcinomas by inhibiting Akt. Oncotarget. 8(46):80405–80415.
  • Fuchs O, Bahmer T, Rabe KF, von Mutius E. 2017. Asthma transition from childhood into adulthood. Lancet Respir Med. 5(3):224–234.
  • Gao Y, Wang B, Luo H, Zhang Q, Xu M. 2018. miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1. Biomed Pharmacother. 108:27–35.
  • Golebski K, Kabesch M, Melén E, Potočnik U, van Drunen CM, Reinartz S. 2020. Maitland-van der Zee AH, Vijverberg SJH; PERMEABLE consortium. 2020. Childhood asthma in the new omics era: challenges and perspectives. Curr Opin Allergy Clin Immunol. 20(2):155–161.
  • Hirota N, Martin JG. 2013. Mechanisms of airway remodeling. Chest. 144(3):1026–1032.
  • Ish P, Malhotra N, Gupta N. 2020. GINA 2020: what’s new and why? J Asthma. 2:1–5.
  • Jiang ZY, Li X. 2015. Introduction of “six-ingredient xiaoqinglong decoction” in Xu’s pediatrics. Shanghai J. TCM. 49(02):63–64. Chinese.
  • Li J, Guo Y, Duan L, Hu X, Zhang X, Hu J, Huang L, He R, Hu Z, Luo W, et al. 2017. AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling. Oncotarget. 8(20):33694–33703.
  • Li LH, Lu B, Wu HK, Zhang H, Yao FF. 2015. Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. Int J Clin Exp Pathol. 8(10):12557–12563.
  • Li RL, Zhang Q, Liu J, Sun JY, He LY, Duan HXY, Peng W, Wu CJ. 2020. Hydroxy-α-sanshool possesses protective potentials on H2O2-stimulated PC12 cells by suppression of oxidative stress-induced apoptosis through regulation of PI3K/Akt signal pathway. Oxid. Med. Cell. Longev. 2020:3481758.
  • Liao Y, Hung MC. 2010. Physiological regulation of Akt activity and stability. Am J Transl Res. 2(1):19–42.
  • Lin L, Li Q, Hao W, Zhang Y, Zhao L, Han W. 2019. Upregulation of LncRNA Malat1 induced proliferation and migration of airway smooth muscle cells via miR-150-eIF4E/Akt Signaling. Front Physiol. 10:1337.
  • Liu Y, Miao Y, Gao X, Wang YY, Wang H, Zheng YW, Zhao ZY. 2018. MicroRNA-200a affects the proliferation of airway smooth muscle cells and airway remodeling by targeting FOXC1 via the PI3K/AKT signaling pathway in ovalbumin-induced asthmatic mice. Cell Physiol Biochem. 50(6):2365–2389.
  • Liu YD, Sun X, Zhang Y, Wu HJ, Wang H, Yang R. 2019. Protocatechuic acid inhibits TGF-β1-induced proliferation and migration of human airway smooth muscle cells. J Pharmacol Sci. 139(1):9–14.
  • Luo K, Li Y, Yin Y, Li L, Wu C, Chen Y, Nowsheen S, Hu Q, Zhang L, Lou Z, Yuan J. 2017. USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. EMBO J. 36(10):1434–1446.
  • Lv X, Li Y, Gong Q, Jiang Z. 2019. TGF-β1 induces airway smooth muscle cell proliferation and remodeling in asthmatic mice by up-regulating miR-181a and suppressing PTEN. Int J Clin Exp Pathol. 12(1):173–181.
  • Malmström K, Pelkonen AS, Mäkelä MJ. 2013. Remodeling, inflammation and airway responsiveness in early childhood asthma. Curr Opin Allergy Clin Immunol. 13(2):203–210.
  • Noutsios GT, Floros J. 2014. Childhood asthma: causes, risks, and protective factors; a role of innate immunity. Swiss Med Wkly. 144:w14036.
  • Ojiaku CA, Cao G, Zhu W, Yoo EJ, Shumyatcher M, Himes BE, An SS, PanettieriJrRA. 2018. TGF-β1 evokes human airway smooth muscle cell shortening and hyperresponsiveness via Smad3. Am J Respir Cell Mol Biol. 58(5):575–584.
  • Pan Y, Liu L, Li S, Wang K, Ke R, Shi W, Wang J, Yan X, Zhang Q, Wang Q, et al. 2018. Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms. Sci Rep. 8(1):3624.
  • Qi M, Zhou J, Zhang X, Zhong X, Zhang Y, Zhang X, Deng X, Li H, Wang Q. 2017. Effect of xiaoqinglong decoction on mucus hypersecretion in the airways and cilia function in a murine model of asthma. J Trad Chin Med Sci. 4(3):290–296.
  • Risso G, Blaustein M, Pozzi B, Mammi P, Srebrow A. 2015. Akt/PKB: one kinase, many modifications. Biochem J. 468(2):203–214.
  • Song M, Bode AM, Dong Z, Lee MH. 2019. AKT as a therapeutic target for cancer. Cancer Res. 79(6):1019–1031.
  • Song G, Zhang Y, Zhao K, Sun M, Cheng P, Wang J. 2018. Regulatory effect of xiaoqinglong decoction on thymic stromal lymphopoietin (TSLP) inflammation promoter in mice with cold asthma. Iran J Allergy Asthma Immunol. 17(1):39–46.
  • Stechschulte LA, Sanchez ER. 2011. FKBP51-a selective modulator of glucocorticoid and androgen sensitivity. Curr Opin Pharmacol. 11(4):332–337.
  • Tajiri T, Matsumoto H, Niimi A, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, et al. 2013. Association of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma. PLoS One. 8(6):e65284.
  • Wang L. 2011. FKBP51 regulation of AKT/protein kinase B phosphorylation. Curr Opin Pharmacol. 11(4):360–364.
  • Wang W, Liu QB, Jing W. 2019. Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells. Chin J Nat Med. 17(4):252–263.
  • Wei M, Gao Y, Lu B, Jiao Y, Liu X, Cui B, Hu S, Sun L, Mao S, Dong J, et al. 2018. FKBP51 regulates decidualization through Ser473 dephosphorylation of AKT. Reproduction. 155(3):283–295.
  • Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, et al. 2007. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA. 104(40):15858–15863.
  • Xie S, Sukkar MB, Issa R, Khorasani NM, Chung KF. 2007. Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol. 293(1):L245–L253.
  • Zhang X, Clark AF, Yorio T. 2008. FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. Invest Ophthalmol Vis Sci. 49(3):1037–47.
  • Zhang Q, Liu J, Li R, Zhao R, Zhang M, Wei S, Ran D, Jin W, Wu CJ. 2020. A network pharmacology approach to investigate the anticancer mechanism and potential active ingredients of Rheum palmatum L. against lung cancer via induction of apoptosis. Front Pharmacol. 11:528308.
  • Zhang X, Wang L, Shi Q. 2003. Effect of fluticasone inhalation combined with xiaoqinglong decoction on pulmonary function and serum interleukin-16 level in asthma patients. Chin J Integr Trad West. 23(6):426–429. Chinese.
  • Zhou H, Wu Q, Wei L, Peng S. 2018. Paeoniflorin inhibits PDGF-BB-induced human airway smooth muscle cell growth and migration. Mol Med Rep. 17(2):2660–2664.