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Cancer Biology

Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G2/M cell cycle arrest and inhibition of GROα expression

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Pages 392-400 | Received 18 Jan 2021, Accepted 13 Apr 2021, Published online: 11 May 2021

References

  • Anwanwan D, Singh SK, Singh S, Saikam V, Singh R. 2020 Jan 1. Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 1873(1):188314.
  • Boloker G, Wang C, Zhang J. 2018 Mar. Updated statistics of lung and bronchus cancer in United States (2018). J Thorac Dis. 10(3):1158.
  • Chen S, Jin Z, Dai L, Wu H, Wang J, Wang L, Zhou Z, Yang L, Gao W. 2018 Jan 1. Aloperine induces apoptosis and inhibits invasion in MG-63 and U2OS human osteosarcoma cells. Biomed Pharmacother. 97:45–52.
  • Chen X, Liu HP, Li M, Qiao L. 2014 Nov 28. Advances in non-surgical management of primary liver cancer. World J Gastroenterol. 20(44):16630.
  • Dang Z, Zhu L, Lai W, Bogerd H, Lee KH, Huang L, Chen CH. 2016. Aloperine and Its derivatives as a New class of HIV-1 entry inhibitors. ACS Med. Chem. Lett. 7:240–244. doi:10.1021/acsmedchemlett.5b00339.
  • de Martel C, Maucort-Boulch D, Plummer M, Franceschi S. 2015 Oct 1. World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 62(4):1190–1200.
  • Han W, Kong D, Lu Q, Zhang W, Fan Z. 2021. Aloperine inhibits proliferation and promotes apoptosis in colorectal cancer cells by regulating the circNSUN2/miR-296-5p/STAT3 pathway. Drug Des Devel Ther. 15:857.
  • Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF. 2010 Sep 1. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest. 120(9):3326–3339.
  • Lee YR, Chen SH, Lin CY, Chao WY, Lim YP, Yu HI, Lu CH. 2018 Jan. In vitro antitumor activity of aloperine on human thyroid cancer cells through caspase-dependent apoptosis. Int J Mol Sci. 19(1):312.
  • Li L, Wang H. 2016 Sep 1. Heterogeneity of liver cancer and personalized therapy. Cancer Lett. 379(2):191–197.
  • Lin Z, Huang CF, Liu XS, Jiang J. 2011 May. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 108(5):304–309.
  • Lin WC, Lin JY. 2011 Jan 12. Five bitter compounds display different anti-inflammatory effects through modulating cytokine secretion using mouse primary splenocytes in vitro. J Agric Food Chem. 59(1):184–192.
  • Ling Z, Guan H, You Z, Wang C, Hu L, Zhang L, Wang Y, Chen S, Xu B, Chen M. 2018. Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo. Onco Targets Ther. 11:2735.
  • Liu JS, Huo CY, Cao HH, Fan CL, Hu JY, Deng LJ, Lu ZB, Yang HY, Yu LZ, Mo ZX, Yu ZL. 2019 Aug 1. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3 K/Akt signaling pathway. Phytomedicine. 61:152843.
  • Liu Z, Suo C, Mao X, Jiang Y, Jin L, Zhang T, Chen X. 2020 May 15. Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017. Cancer. 126(10):2267–2278.
  • Ma NT, Zhou R, Chang RY, Hao YJ, Ma L, Jin SJ, Du J, Zheng J, Zhao CJ, Niu Y, Sun T. 2015 Oct 1. Protective effects of aloperine on neonatal rat primary cultured hippocampal neurons injured by oxygen–glucose deprivation and reperfusion. J Nat Med. 69(4):575–583.
  • Ogata H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Ito Y, Fujita M, Tsubaki M, Kato H, Fujimori T. 2010 Dec 1. GROα promotes invasion of colorectal cancer cells. Oncol Rep. 24(6):1479–1486.
  • Qiu M, Liu J, Su Y, Liu J, Wu C, Zhao B. 2020 Sep 1. Aloperine induces apoptosis by a reactive oxygen species activation mechanism in human ovarian cancer cells. Protein Pept Lett. 27(9):860–869.
  • Shi JF, Cao M, Wang Y, Bai FZ, Lei L, Peng J, Feletto E, Canfell K, Qu C, Chen W. 2020 Sep 30. Is it possible to halve the incidence of liver cancer in China by 2050? Int J Cancer. 148(5):1051–1065.
  • Siegel RL, Miller KD, Jemal A. 2019 Jan. Cancer statistics, 2019. CA Cancer J Clin. 69(1):7–34.
  • Tian D, Li Y, Li X, Tian Z. 2018 Oct 1. Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells. Mol Med Rep. 18(4):3699–3710.
  • Xu W, Li K, Song C, Wang X, Li Y, Bai X, Liang X, Deng W, Wang J, Liu J. 2020. Knockdown of lncRNA LINC01234 suppresses the tumorigenesis of liver cancer via sponging miR-513a-5p. Front Oncol. 10:571565.
  • Yuan XY, Liu W, Zhang P, Wang RY, Guo JY. 2010 Mar 10. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 629(1-3):147–152.
  • Zhang L, Liang J, Liu X, Wu J, Tan D, Hu W. 2020. Aloperine exerts antitumor effects on bladder cancer in vitro. Onco Targets Ther. 13:10351.
  • Zhang L, Zheng Y, Deng H, Liang L, Peng J. 2014 Jun 1. Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells. Int J Mol Med. 33(6):1613–1620.
  • Zhou CC, Gao HB, Sun XB, Shi HB, Liu W, Yuan HN, Wang ZX. 1989. Anti-inflammatory and anti-allergic action of aloperine. Acta Pharmacol. Sin. 10:360–365.
  • Zhou H, Li J, Sun F, Wang F, Li M, Dong Y, Fan H, Hu D. 2020. A review on recent advances in aloperine research: pharmacological activities and underlying biological mechanisms. Front Pharmacol. 11. https://doi.org/10.3389/fphar.2020.538137.