1,562
Views
0
CrossRef citations to date
0
Altmetric
Cancer Biology

Apolipoprotein E deficiency enhances the anti-tumor immunity via repressing T cell exhaustion

, , &
Pages 1054-1062 | Received 12 Apr 2021, Accepted 20 Sep 2021, Published online: 16 Nov 2021

References

  • Avila EM, Holdsworth G, Sasaki N, Jackson RL, Harmony JA. 1982. Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells. J Biol Chem. 257(10):5900–5909.
  • Azuma M, Kojimab T, Yokoyama I, et al. 2000. A synthetic peptide of human apoprotein E with antibacterial activity. Peptides. 21(3):327–330.
  • Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P, Pellegatta F, Grigore L, et al. 2018. Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. Nat Commun. 9(1):3083.
  • Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, et al. 2018. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 562(7728):605–609.
  • Domínguez-Soto A, de las Casas-Engel M, Bragado R, Medina-Echeverz J, Aragoneses-Fenoll L, Martín-Gayo E, van Rooijen N, Berraondo P, Toribio ML, Moro MA, et al. 2014. Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization. J Immunol. 193(10):5181–5189.
  • Drijvers JM, Sharpe AH, Haigis MC. 2020. The effects of age and systemic metabolism on anti-tumor T cell responses. Elife. 9:e62420.
  • Gaglione R, Pizzo E, Notomista E, de la Fuente-Nunez C, Arciello A. 2020. Host defence cryptides from human apolipoproteins: applications in medicinal chemistry. Curr Top Med Chem. 20(14):1324–1337.
  • Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, He L, Huang F, Xu Y, Anami Y, et al. 2019. Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development. Cancer Immunol Res. 7(8):1244–1257.
  • Huvila J, Brandt A, Rojas CR, Pasanen S, Talve L, Hirsimäki P, Fey V, Kytömäki L, Saukko P, Carpén O, et al. 2009. Gene expression profiling of endometrial adenocarcinomas reveals increased apolipoprotein E expression In poorly differentiated tumors. Int J Gynecol Cancer. 19(7):1226–1231.
  • Jeong H, Hwang I, Kang SH, Shin HC, Kwon SY. 2019. Tumor-associated macrophages as potential prognostic biomarkers of invasive breast cancer. J Breast Cancer. 22(1):38–51.
  • Kojima T, Fujimitsu Y, Kojima H. 2005. Anti-tumor activity of an antibiotic peptide derived from apoprotein E. In Vivo. 19(1):261–264.
  • Lee YS, Yeo IJ, Kim KC, Han SB, Hong JT. 2019. Inhibition of lung tumor development in ApoE knockout mice via enhancement of TREM-1 dependent NK cell cytotoxicity. Front Immunol. 10:1379.
  • Maezawa I, Nivison M, Montine KS, Maeda N, Montine TJ. 2006. Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. FASEB J. 20(6):797–799.
  • Maimela NR, Liu S, Zhang Y. 2019. Fates of CD8+ T cells in tumor microenvironment. Comput Struct Biotechnol J. 17:1–13.
  • Mantovani A, Sica A, Locati M. 2005. Macrophage polarization comes of age. Immunity. 23(4):344–346.
  • Martins IJ, Hone E, Foster JK, Sünram-Lea SI, Gnjec A, Fuller SJ, Nolan D, Gandy SE, Martins RN. 2006. Apolipoprotein e, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer’s disease and cardiovascular disease. Mol Psychiatry. 11(8):721–736.
  • McNeill E, Channon KM, Greaves DR. 2010. Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications. Clin Sci (Lond). 118(11):641–655.
  • Munhoz RR, Postow MA. 2016. Recent advances in understanding antitumor immunity. F1000Res. 5:2545.
  • Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H, Yasui W. 2004. Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 64(7):2397–2405.
  • Parisi L, Gini E, Baci D, Tremolati M, Fanuli M, Bassani B, Farronato G, Bruno A, Mortara L. 2018. Macrophage polarization in chronic inflammatory diseases: killers or builders? J Immunol Res. 2018:1–25.
  • Patil S, Rao RS, Majumdar B. 2015. T-cell exhaustion and cancer immunotherapy. J Int Oral Health. 7(8):i–ii.
  • Phillips MC. 2014. Apolipoprotein E isoforms and lipoprotein metabolism. IUBMB Life. 66(9):616–623.
  • Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting In embryonic stem cells. Proc Natl Acad Sci U S A. 89(10):4471–4475.
  • Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, et al. 2020. Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell. 183(7):1848–1866.e26.
  • Sharma N, Atolagbe OT, Ge Z, Allison JP. 2021. LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy. J Exp Med. 218(7):e20201811.
  • Su WP, Chen YT, Lai WW, Lin CC, Yan JJ, Su WC. 2011. Apolipoprotein E expression promotes lung adenocarcinoma proliferation and migration and as a potential survival marker in lung cancer. Lung Cancer. 71(1):28–33.
  • Suárez-Sánchez FJ, Lequerica-Fernández P, Suárez-Canto J, Rodrigo JP, Rodriguez-Santamarta T, Domínguez-Iglesias F, García-Pedrero JM, de Vicente JC. 2020. Macrophages in oral carcinomas: relationship with cancer stem cell markers and PD-L1 expression. Cancers (Basel). 12(7):1764.
  • Tavazoie MF, Pollack I, Tanqueco R, Ostendorf BN, Reis BS, Gonsalves FC, Kurth I, Andreu-Agullo C, Derbyshire ML, Posada J, et al. 2018. LXR/ApoE activation restricts innate immune suppression in cancer. Cell. 172(4):825–840.e18.
  • Van Oosten M, Rensen PC, Van Amersfoort ES, Van Eck M, Van Dam AM, Brevé JJ, Vogel T, Panet A, Van Berkel TJ, Kuiper J. 2001. Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality: a new therapeutic approach to treat gram-negative sepsis. J Biol Chem. 276(12):8820–8824.
  • Vitek MP, Snell J, Dawson H, Colton CA. 1997. Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide. Biochem Biophys Res Commun. 240(2):391–394.
  • Wherry EJ. 2011. T cell exhaustion. Nat Immunol. 12(6):492–499.
  • Zanfardino A, Bosso A, Gallo G, et al. 2018. Human apolipoprotein E as a reservoir of cryptic bioactive peptides: the case of ApoE 133-167. J Pept Sci. 24(7):e3095.
  • Zhang HL, Wu J, Zhu J. 2010. The immune-modulatory role of apolipoprotein E with emphasis on multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Dev Immunol. 2010:186813.