NGF activates NFAT via the MEK1/2 pathway in PC12 cells

References

• Aloe L. 2011. Rita Levi-Montalcini and the discovery of NGF, the first nerve cell growth factor. Arch Ital Biol. 149(2):175–181.
   PubMed Web of Science ®Google Scholar
• Cai Y-Q, Chen S-R, Pan H-L. 2013. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther. 345(1):161–168.
   PubMed Web of Science ®Google Scholar
• Crabtree GR, Olson EN. 2002. NFAT signaling: choreographing the social lives of cells. Cell. 109(Suppl):S67–S79.
   PubMed Web of Science ®Google Scholar
• Dravid A, Parittotokkaporn S, Aqrawe Z, O'Carroll SJ, Svirskis D. 2020. Determining Neurotrophin gradients in vitro to direct axonal outgrowth following spinal cord injury. ACS Chem Neurosci. 11(2):121–132.
   PubMed Web of Science ®Google Scholar
• Duncia JV, Santella JB, 3rd, Higley CA, Pitts WJ, Wityak J, Frietze WE, Rankin FW, Sun J-H, Earl RA, Tabaka AC, et al. 1998. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 8(20):2839–2844.
   PubMed Web of Science ®Google Scholar
• Eibl JK, Strasser BC, Ross GM. 2012. Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem Int. 61(8):1266–1275.
   PubMed Web of Science ®Google Scholar
• Graef IA, Wang F, Charron F, Chen Lei, Neilson J, Tessier-Lavigne M, Crabtree GR. 2003. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 113(5):657–670.
   PubMed Web of Science ®Google Scholar
• Groth RD, Coicou LG, Mermelstein PG, Seybold VS. 2007. Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes. J Neurochem. 102(4):1162–1174.
   PubMed Web of Science ®Google Scholar
• Huang W, Huang J, Jiang Y, Huang X, Xing W, He Y, Ouyang H. 2018. Oxaliplatin regulates chemotherapy induced peripheral neuropathic pain in the dorsal horn and dorsal root ganglion via the calcineurin/NFAT pathway. Anticancer Agents Med Chem. 18(8):1197–1207.
   PubMed Web of Science ®Google Scholar
• Jung H, Miller RJ. 2008. Activation of the nuclear factor of activated T-cells (NFAT) mediates upregulation of CCR2 chemokine receptors in dorsal root ganglion (DRG) neurons: a possible mechanism for activity-dependent transcription in DRG neurons in association with neuropathic pain. Mol Cell Neurosci. 37(1):170–177.
   PubMed Web of Science ®Google Scholar
• Kim M-S, Shutov LP, Gnanasekaran A, Lin Z, Rysted JE, Ulrich JD, Usachev YM. 2014. Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway. J Biol Chem. 289(45):31349–31360.
   PubMed Web of Science ®Google Scholar
• Kim M-S, Usachev YM. 2009. Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons. J Neurosci. 29(39):12101–12114.
   PubMed Web of Science ®Google Scholar
• Knusel B, Hefti F. 1992. K-252 compounds: modulators of neurotrophin signal transduction. J Neurochem. 59(6):1987–1996.
   PubMed Web of Science ®Google Scholar
• Lee S, Lee DK. 2020. What is the proper way to apply the multiple comparison test? Korean J Anesthesiol. 73(6):572.
   PubMed Web of Science ®Google Scholar
• Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, et al. 2009. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 69(2):565–572.
   PubMed Web of Science ®Google Scholar
• Rao A, Luo C, Hogan PG. 1997. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 15:707–747.
   PubMed Web of Science ®Google Scholar
• Reichardt LF. 2006. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 361(1473):1545–1564.
   PubMed Web of Science ®Google Scholar
• Sanna B, Bueno OF, Dai Y-S, Wilkins Benjamin J., Molkentin Jeffery D. 2005. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Mol Cell Biol. 25(3):865–878.
   PubMed Web of Science ®Google Scholar
• Serrano-Perez MC, Fernandez M, Neria F, Berjón-Otero M, Doncel-Pérez E, Cano E, Tranque P. 2015. NFAT transcription factors regulate survival, proliferation, migration, and differentiation of neural precursor cells. Glia. 63(6):987–1004.
   PubMed Web of Science ®Google Scholar
• Sharma N, Deppmann CD, Harrington AW, St. Hillaire C, Chen Z-Y, Lee F, Ginty DD. 2010. Long-distance control of synapse assembly by target-derived NGF. Neuron. 67(3):422–434.
   PubMed Web of Science ®Google Scholar
• Shaw JP, Utz PJ, Durand DB, Toole J, Emmel E, Crabtree G. 1988. Identification of a putative regulator of early T cell activation genes. Science. 241(4862):202–205.
   PubMed Web of Science ®Google Scholar
• Sofroniew MV, Howe CL, Mobley WC. 2001. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 24:1217–1281.
   PubMed Web of Science ®Google Scholar
• Stefos GC, Soppa U, Dierssen M, Becker W, Gong C-X. 2013. NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. PLoS One. 8(6):e67470.
   PubMed Web of Science ®Google Scholar
• Turke AB, Song Y, Costa C, Cook R, Arteaga CL, Asara JM, Engelman JA. 2012. MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors. Cancer Res. 72(13):3228–3237.
   PubMed Web of Science ®Google Scholar
• Ulrich JD, Kim M-S, Houlihan PR, Shutov LP, Mohapatra DP, Strack S, Usachev YM. 2012. Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. J Biol Chem. 287(45):37594–37609.
   PubMed Web of Science ®Google Scholar