Gastric cancer-derived exosomes induce PD-L1 expression on human bone marrow mesenchymal stem cells through the AKT-c-Myc signal axis

References

• Antonangeli F, Natalini A, Garassino MC, Sica A, Santoni A, Di Rosa F. 2020. Regulation of PD-L1 expression by NF-kappaB in cancer. Front Immunol. 11:584626.
   PubMed Web of Science ®Google Scholar
• Baglio SR, Lagerweij T, Perez-Lanzon M, Ho XD, Leveille N, Melo SA, Cleton-Jansen AM, Jordanova ES, Roncuzzi L, Greco M, et al. 2017. Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression. Clin Cancer Res. 23:3721–3733.
   PubMed Web of Science ®Google Scholar
• Chen B, Yu J, Wang Q, Zhao Y, Sun L, Xu C, Zhao X, Shen B, Wang M, Xu W, et al. 2018. Human bone marrow mesenchymal stem cells promote gastric cancer growth via regulating c-Myc. Stem Cells Int. 18:9501747.
   Google Scholar
• Chen L, Wang L, Li X, Zhang G, Li Z, Wang Y. 2021. Clinic-pathological characteristics and prognostic value of PD-L1 and HER2 in gastric cancer. DNA Cell Biol. 40:405–413.
   PubMed Web of Science ®Google Scholar
• Daassi D, Mahoney K, Freeman GJ. 2020. The importance of exosomal PDL1 in tumour immune evasion. Nat Rev Immunol. 20:209–215.
   PubMed Web of Science ®Google Scholar
• Davies LC, Heldring N, Kadri N, Le Blanc K. 2017. Mesenchymal stromal cell secretion of programmed death-1 ligands regulates T cell mediated immunosuppression. Stem Cells. 35:766–776.
   PubMed Web of Science ®Google Scholar
• Ghoshdastider U, Rohatgi N, Mojtabavi Naeini M, Baruah P, Revkov E, Guo Y, Rizzetto S, Wong A, Solai S, Nguyen T, et al. 2021. Pan-cancer analysis of ligand-receptor crosstalk in the tumor microenvironment. Cancer Res. 81:1802–1812.
   PubMed Web of Science ®Google Scholar
• Haga H, Yan IK, Takahashi K, Wood J, Zubair A, Patel T. 2015. Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth. J Extracell Vesicles. 4:24900.
   PubMed Web of Science ®Google Scholar
• Hochheuser C, van Zogchel LMJ, Kleijer M, Kuijk C, Tol S, van der Schoot CE, Voermans C, Tytgat GAM, Timmerman I. 2020. The metastatic bone marrow niche in neuroblastoma: altered phenotype and function of mesenchymal stromal cells. Cancers. 12:3231.
   PubMed Web of Science ®Google Scholar
• Jena BC, Mandal M. 2020. The emerging roles of exosomes in anti-cancer drug resistance and tumor progression: An insight towards tumor-microenvironment interaction. Biochim Biophys Acta Rev Cancer. 1875:188488.
   PubMed Web of Science ®Google Scholar
• Ju X, Zhang H, Zhou Z, Chen M, Wang Q. 2020. Tumor-associated macrophages induce PD-L1 expression in gastric cancer cells through IL-6 and TNF-α signaling. Exp Cell Res. 396:112315.
   PubMed Web of Science ®Google Scholar
• Krueger TE, Thorek DLJ, Meeker AK, Isaacs JT, Brennen WN. 2018. Tumor-infiltrating mesenchymal stem cells: drivers of the immunosuppressive tumor microenvironment in prostate cancer? Prostate. 79:320–330.
   PubMed Web of Science ®Google Scholar
• Li F, Zhu T, Yue Y, Zhu X, Wang J, Liang L. 2018. Preliminary mechanisms of regulating PDL1 expression in nonsmall cell lung cancer during the EMT process. Oncol Rep. 40:775–782.
   PubMed Web of Science ®Google Scholar
• Li T, Ma R, Zhu J. 2021. Up-regulation of donor dendritic cell PD-L1 expression reduced recipient lymphocyte activation and proliferation in vitro. Transpl Proc. 53:716–723.
   PubMed Web of Science ®Google Scholar
• Liang Y, Liu Y, Zhang Q, Zhang H, Du J. 2020. Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer. Transl Res. 13:S1931–S5244.
   Google Scholar
• Lin LY, Du LM, Cao K, Huang Y, Yu PF, Zhang LY, Li FY, Wang Y, Shi YF. 2016. Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities. Oncogene. 35:6038–6042.
   PubMed Web of Science ®Google Scholar
• Lin W, Chang Y, Hong M, Hsu T, Lee K, Lin C, Lee J. 2020. STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis. Oncogene. 40:791–805.
   PubMed Web of Science ®Google Scholar
• Liu S, Liu F, Zhou Y, Jin B, Sun Q, Guo S. 2020. Immunosuppressive property of MSCs mediated by cell surface receptors. Front Immunol. 11:1076.
   PubMed Web of Science ®Google Scholar
• Liu Y, Marin A, Ejlerskov P, Rasmussen LM, Prinz M, Issazadeh-Navikas S. 2017. Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)Treg cells. Nat Commun. 8:14709.
   PubMed Web of Science ®Google Scholar
• Lu M, Xie K, Lu X, Lu L, Shi Y, Tang YJ. 2020. Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2/STAT3 signaling. Invest New Drugs. 39:416–425.
   PubMed Web of Science ®Google Scholar
• Mu L, Wang Y, Su H, Lin Y, Sui W, Yu X, Lv Z. 2021. HIF1A-AS2 promotes the proliferation and metastasis of gastric cancer cells through miR-429/PD-L1 axis. Dig Dis Sci. 66:4314–4325.
   PubMed Web of Science ®Google Scholar
• Pan C, Wang Y, Liu Q, Hu Y, Fu J, Xie X, Zhang S, Xi M, Wen J. 2021. Phenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinoma. Oncoimmunology. 10:1883890.
   PubMed Web of Science ®Google Scholar
• Sharma S, Alharbi M, Kobayashi M, Lai A, Guanzon D, Zuniga F, Ormazabal V, Palma C, Scholz-Romero K, Rice GE, et al. 2018. Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration in vitro. Clin Sci. 132:2029–2044.
   Web of Science ®Google Scholar
• Shen Y, Xue C, Li X, Ba L, Gu J, Sun Z, Han Q, Zhao RC. 2019. Effects of gastric cancer cell-derived exosomes on the immune regulation of mesenchymal stem cells by the NF-kB signaling pathway. Stem Cells Dev. 28:464–476.
   PubMed Web of Science ®Google Scholar
• Shirinbak S, Chan RY, Shahani S, Muthugounder S, Kennedy R, Hung LT, Fernandez GE, Hadjidaniel MD, Moghimi B, Sheard MA, et al. 2020. Combined immune checkpoint blockade increases CD8+CD28+PD-1+effector T cells and provides a therapeutic strategy for patients with neuroblastoma. Oncoimmunology. 10:1838140.
   Web of Science ®Google Scholar
• So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, et al. 2021. Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population. Gut. 70:829–837.
   PubMed Web of Science ®Google Scholar
• Sun L, Huang C, Zhu M, Guo S, Gao Q, Wang Q, Chen B, Li R, Zhao Y, Wang M, et al. 2020. Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis. Theranostics. 10:11950–11962.
   PubMed Web of Science ®Google Scholar
• Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang H, Xu J, Zhu M, Zhao X, Xu C, et al. 2018. Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis. Cell Death Dis. 9:928.
   PubMed Web of Science ®Google Scholar
• Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Di Magliano M P, Welling TH, et al. 2016. GM-CSF mediates mesenchymal-epithelial cross-talk in pancreatic cancer. Cancer Discov. 6:886–899.
   PubMed Web of Science ®Google Scholar
• Wang G, Zhang S, Wang F, Li G, Zhang L, Luan X. 2013. Expression and biological function of programmed death ligands in human placenta mesenchymal stem cells. Cell Biol Int. 37:137–148.
   PubMed Web of Science ®Google Scholar
• Wang S, Wang G, Zhang L, Li F, Liu K, Wang Y, Shi Y, Cao K. 2020. Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells. Cell Biosci. 10:73.
   PubMed Web of Science ®Google Scholar
• Whiteside TL. 2018. Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. Semin Immunol. 35:69–79.
   PubMed Web of Science ®Google Scholar
• Wu L, Cai S, Deng Y, Zhang Z, Zhou X, Su Y, Xu D. 2021. PD-1/PD-L1 enhanced cisplatin resistance in gastric cancer through PI3 K/AKT mediated P-gp expression. Int Immunopharmacol. 94:107443.
   PubMed Web of Science ®Google Scholar
• Xu F, Fei Z, Dai H, Xu J, Fan Q, Shen S, Zhang Y, Ma Q, Chu J, Peng F, et al. 2022. Mesenchymal stem cell-derived extracellular vesicles with high PD-L1 expression for autoimmune diseases treatment. Adv Mater. 34:e2106265.
   PubMed Web of Science ®Google Scholar
• Yang Y, Li CW, Chan LC, Wei Y, Hsu JM, Xia W, Cha JH, Hou J, Hsu JL, Sun L, et al. 2018. Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res. 28:862–864.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wu Q, Li B, Wang D, Wang L, Zhou YL. 2020. m(6)A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer. Mol Cancer. 19:53.
   PubMed Web of Science ®Google Scholar
• Zhou K, Guo S, Li F, Sun Q, Liang G. 2020. Exosomal PD-L1: new insights into tumor immune escape mechanisms and therapeutic strategies. Front Cell Dev Biol. 8:569219.
   PubMed Web of Science ®Google Scholar