Prunetin alleviates dextran sulfate sodium-induced colitis via the regulation of inflammatory response based on network pharmacology and experimental evidence

References

• Ahn TG, Yang G, Lee HM, Kim MD, Choi HY, Park KS, Lee SD, Kook YB, An HJ. 2013. Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone. Biochem Pharmacol. 85(10):1525–1533. doi:10.1016/j.bcp.2013.02.020.
   PubMed Web of Science ®Google Scholar
• Aihaiti Y, Song Cai Y, Tuerhong X, Ni Yang Y, Ma Y, Shi Zheng H, Xu K, Xu P. 2021. Therapeutic effects of naringin in rheumatoid arthritis: network pharmacology and experimental validation. Front Pharmacol. 12:672054.
   PubMedGoogle Scholar
• Gong Y, Niu W, Tang Y, Zhang Q, Liu S, Liu X, Wang X, Xu Y. 2019. Aggravated mucosal and immune damage in a mouse model of ulcerative colitis with stress. Exp Ther Med. 17(3):2341–2348.
   PubMed Web of Science ®Google Scholar
• Griffiths OR, Landon J, Coxon RE, Morris K, James P, Adams R. 2020. Advances in protein chemistry and structural biology. Adv Protein Chem Struct Biol. 119:157–198. doi:10.1016/bs.apcsb.2019.08.009.
   PubMedGoogle Scholar
• Hu H, Li H. 2018. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 106:1469–1477. doi:10.1016/j.biopha.2018.07.093.
   PubMed Web of Science ®Google Scholar
• Huang C, Zheng C, Li Y, Wang Y, Lu A, Yang L. 2014. Systems pharmacology in drug discovery and therapeutic insight for herbal medicines. Brief Bioinform. 15(5):710–733. doi:10.1093/bib/bbt035.
   PubMed Web of Science ®Google Scholar
• Hung TV, Suzuki T. 2016. Dietary fermentable fiber reduces intestinal barrier defects and inflammation in colitic mice. J Nutr. 146(10):1970–1979. doi:10.3945/jn.116.232538.
   PubMed Web of Science ®Google Scholar
• Khan K, Pal S, Yadav M, Maurya R, Trivedi AK, Sanyal S, Chattopadhyay N. 2015. Prunetin signals via G-protein-coupled receptor, GPR30(GPER1): stimulation of adenylyl cyclase and cAMP-mediated activation of MAPK signaling induces Runx2 expression in osteoblasts to promote bone regeneration. J Nutr Biochem. 26(12):1491–1501.
   PubMed Web of Science ®Google Scholar
• Köksal Karayildirim Ç, Nalbantsoy A, Karabay Yavaşoğlu N. 2021. Prunetin inhibits nitric oxide activity and induces apoptosis in urinary bladder cancer cells via CASP3 and TNF-α genes. Mol Biol Rep. 48(11):7251–7259. doi:10.1007/s11033-021-06719-w.
   PubMed Web of Science ®Google Scholar
• Liu F, Yao Y, Lu Z, Zhang Q, Liu C, Zhu C, Lin C. 2021. 5-Hydroxy-4-methoxycanthin-6-one alleviates dextran sodium sulfate-induced colitis in rats via regulation of metabolic profiling and suppression of NF-κB/p65 signaling pathway. Phy Int J Phy Phyt. 82:153438.
   Google Scholar
• Liu W, Ye J, Yan H. 2019. Investigation of Key genes and pathways in inhibition of oxycodone on vincristine-induced microglia activation by using bioinformatics analysis. Dis Markers. 2019:3521746.
   PubMed Web of Science ®Google Scholar
• Mansoor TA, Ramalho RM, Luo X, Ramalhete C, Rodrigues CM, Ferreira MJ. 2011. Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells. Phytother Res. 25(12):1819–1824. doi:10.1002/ptr.3498.
   PubMed Web of Science ®Google Scholar
• Mayangsari Y, Suzuki T. 2018. Resveratrol ameliorates intestinal barrier defects and inflammation in colitic mice and intestinal cells. J Agric Food Chem. 66(48):12666–12674. doi:10.1021/acs.jafc.8b04138.
   PubMed Web of Science ®Google Scholar
• Murakami Y, Tanabe S, Suzuki T. 2016. High-fat diet-induced intestinal hyperpermeability is associated with increased bile acids in the large intestine of mice. J Food Sci. 81(1):H216–H222. doi:10.1111/1750-3841.13166.
   PubMed Web of Science ®Google Scholar
• Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, et al. 2017. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet (London, England). 390(10114):2769–2778.
   PubMed Web of Science ®Google Scholar
• Ogita T, Tanii Y, Morita H, Suzuki T, Tanabe S. 2011. Suppression of Th17 response by streptococcus thermophilus ST28 through induction of IFN-γ. Int J Mol Med. 28(5):817–822.
   PubMed Web of Science ®Google Scholar
• Packey CD, Sartor RB. 2008. Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases. J Intern Med. 263(6):597–606. doi:10.1111/j.1365-2796.2008.01962.x.
   PubMed Web of Science ®Google Scholar
• Piegholdt S, Pallauf K, Esatbeyoglu T, Speck N, Reiss K, Ruddigkeit L, Stocker A, Huebbe P, Rimbach G. 2014. Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation. Free Radical Biol Med. 70:255–264. doi:10.1016/j.freeradbiomed.2014.02.025.
   PubMed Web of Science ®Google Scholar
• Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N. 2008. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest. 118(2):560–570.
   PubMed Web of Science ®Google Scholar
• Ryu J, Lee HJ, Park SH, Sikder MA, Kim JO, Hong JH, Seok JH, Lee CJ. 2013. Effect of prunetin on TNF-α-induced MUC5AC mucin gene expression, production, degradation of IκB and translocation of NF-κB p65 in human airway epithelial cells. Tuberc Respir Dis (Seoul). 75(5):205–209.
   PubMedGoogle Scholar
• Statovci D, Aguilera M, MacSharry J, Melgar S. 2017. The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces. Front Immunol. 8:838.
   PubMed Web of Science ®Google Scholar
• Szigethy E, McLafferty L, Goyal A. 2010. Inflammatory bowel disease. Child Adolesc Psychiatr Clin N Am. 19(2):301–318. ix.
   PubMed Web of Science ®Google Scholar
• Takac B, Mihaljević S, Stefanić M, Glavas-Obrovac L, Kibel A, Samardzija M. 2014. Importance of interleukin 6 in pathogenesis of inflammatory bowel disease. Coll Antropol. 38(2):659–664.
   PubMedGoogle Scholar
• Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K. 2018. Immune response and inflammatory pathway of ulcerative colitis. J Basic Clin Physiol Pharmacol. 30(1):1–10. doi:10.1515/jbcpp-2018-0036.
   PubMedGoogle Scholar
• Vetrivel P, Kim SM, Ha SE, Kim HH, Bhosale PB, Senthil K, Kim GS. 2020. Compound prunetin induces cell death in gastric cancer cell with potent anti-proliferative properties: In vitro assay, molecular docking, dynamics, and ADMET studies. Biomolecules. 10(7):1086. doi:10.3390/biom10071086.
   PubMed Web of Science ®Google Scholar
• Xiao YT, Yan WH, Cao Y, Yan JK, Cai W. 2016. Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis. Cytokine. 83:189–192. doi:10.1016/j.cyto.2016.04.012.
   PubMed Web of Science ®Google Scholar
• Yang G, Ham I, Choi HY. 2013. Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway. Food Chem Toxicol. 58:124–132. doi:10.1016/j.fct.2013.03.039.
   PubMed Web of Science ®Google Scholar
• Yao D, Dong M, Dai C, Wu S. 2019. Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and Its associated cancer. Inflamm Bowel Dis. 25(10):1595–1602. doi:10.1093/ibd/izz149.
   PubMed Web of Science ®Google Scholar