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Research Articles

Efficacy of a Proprietary Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst®) in Women with Polycystic Ovary Syndrome (PCOS): a Randomized, Double-Blind, Placebo-Controlled Study

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Pages 651-659 | Received 17 Aug 2022, Accepted 15 Sep 2022, Published online: 11 Oct 2022

References

  • Evans TN, Riley GM. Polycystic ovarian disease (Stein-Leventhal syndrome); etiology and rationale for surgical treatment. Obstet Gynecol. 1958;12(2):168–79.
  • Deswal R, Narwal V, Dang A, Pundir CS. The prevalence of polycystic ovary syndrome: A brief systematic review. J Hum Reprod Sci. 2020;13(4):261–71. doi:10.4103/jhrs.JHRS_95_18.
  • Balen A, Rajkowha M. Polycystic ovary syndrome–a systemic disorder? Best Pract Res Clin Obstet Gynaecol. 2003;17(2):263–74. doi:10.1016/S1521-6934(02)00119-0.
  • Witchel SF, Oberfield S, Peña AS. Polycystic ovary syndrome: Pathophysiology, presentation, and treatment with emphasis on adolescent girls. J Endocr Soc. 2019;3(8):1545–73. doi:10.1210/js.2019-00078.
  • Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health. 2011;3:25–35. doi:10.2147/IJWH.S11304.
  • Johnson NP. Metformin use in women with polycystic ovary syndrome. Ann Transl Med. 2014;2(6):56. doi:10.3978/j.issn.2305-5839.2014.04.15.
  • Ozturk ZA, Kadayifci A. Insulin sensitizers for the treatment of non-alcoholic fatty liver disease. World J Hepatol. 2014;6(4):199–206. doi:10.4254/wjh.v6.i4.199.
  • Kumarendran B, O’Reilly MW, Subramanian A, Sumilo D, Toulis K, Gokhale KM, Wijeratne CN, Coomarasamy A, Tahrani AA, Azoulay L, et al. Polycystic ovary syndrome, combined oral contraceptives, and the risk of dysglycemia: A population-based cohort study with a nested pharmacoepidemiological case-control study. Diabetes Care. 2021;44(12):2758–66. doi:10.2337/dc21-0437.
  • Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C. Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2018;5(5):CD010287. doi:10.1002/14651858.CD010287.pub3.
  • Lunny CA, Fraser SN. The use of complementary and alternative medicines among a sample of canadian menopausal–aged women. J Midwifery Womens Health. 2010;55(4):335–43. doi:10.1016/j.jmwh.2009.10.015.
  • Smith CA, Bateson DJ, Weisberg E. A survey describing the use of complementary therapies and medicines by women attending a family planning clinic. BMC Complement Altern Med. 2013;13(1):224. doi:10.1186/1472-6882-13-224.
  • Ren MQ, Kuhn G, Wegner J, Chen J. Isoflavones, substances with multi-biological and clinical properties. Eur J Nutr. 2001;40(4):135–46. doi:10.1007/pl00007388.
  • Whitten PL, Naftolin F. Reproductive actions of phytoestrogens. Baillieres Clin Endocrinol Metab. 1998;12(4):667–90. doi:10.1016/S0950-351X(98)80010-4.
  • Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, Kushi LH, Erdmann C, Hiatt RA, Rybak ME, Breast Cancer and Environment Research Centers, et al. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect. 2010;118(7):1039–46. doi:10.1289/ehp.0901690.
  • Arentz S, Abbott JA, Smith CA, Bensoussan A. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement Altern Med. 2014;14:511. doi:10.1186/1472-6882-14-511.
  • Kwon CY, Cho IH, Park KS. Therapeutic effects and mechanisms of herbal medicines for treating polycystic ovary syndrome: A review. Front Pharmacol. 2020;11:1192. doi:10.3389/fphar.2020.01192.
  • Jia LY, Feng JX, Li JL, Liu FY, Xie LZ, Luo SJ, Han FJ. The complementary and alternative medicine for polycystic ovary syndrome: A review of clinical application and mechanism. Evid Based Complement Alternat Med. 2021;2021:5555315. doi:10.1155/2021/5555315.
  • Prabhu YD, Gopalakrishnan AV, Roopan SM. Medicinal plants and polycystic ovary syndrome. In: Chauhan DN, Shah K, editors. Phytopharmaceutical: Potential therapeutic applications. 1st ed. Beverly, MA: Scrivener Publishing; 2021. p. 287–299.
  • Ben Hameid AS, Al-Sindi TA, Allow AK, Nafie EM, Alahmad BE, Faisal GG. Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model. OMJ. 2019;34(3):238–43. doi:10.5001/omj.2019.45.
  • Khanna A, John F, Das S, Thomas J, Rao J, Maliakel B, Im K. Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled study. J Food Biochem. 2020;44(12):e13507. doi:10.1111/jfbc.13507.
  • Swaroop A, Jaipuriar AS, Gupta SK, Bagchi M, Kumar P, Preuss HG, Bagchi D. Efficacy of a novel Fenugreek seed extract (Trigonella foenum-graecum, FurocystTM) in polycystic ovary syndrome (PCOS). Int J Med Sci. 2015;12(10):825–31. doi:10.7150/ijms.13024.
  • Azziz R. Diagnosis of polycystic ovarian syndrome: The Rotterdam criteria are premature. J Clin Endocrinol Metab. 2006;91(3):781–5. doi:10.1210/jc.2005-2153.
  • Gayoso-Diz P, Otero-González A, Rodriguez-Alvarez MX, Gude F, Garcia F, De Francisco A, Quintela AG. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 2013;13:47. doi:10.1186/1472-6823-13-47.
  • Wani AA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci. 2018;17(2):97–106. doi:10.1016/j.jssas.2016.01.007.
  • Mayo JL. Black cohosh and chasteberry: herbs valued by women for centuries. Clin Nutr Insights. 1998;6(15):1–4.
  • Younesy S, Amiraliakbari S, Esmaeili S, Alavimajd H, Nouraei S. Effects of fenugreek seed on the severity and systemic symptoms of dysmenorrhea. J Reprod Infertil. 2014;15(1):41–8.
  • Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, Depriest P, Doubilet PM, Goldstein SR, et al. Management of asymptomatic ovarian and other adnexal cysts imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2010;256(3):943–54954. doi:10.1148/radiol.10100213.
  • Alsamarai S, Adams JM, Murphy MK, Post MD, Hayden DL, Hall JE, Welt CK. Criteria for polycystic ovarian morphology in polycystic ovary syndrome as a function of age. J Clin Endocrinol Metab. 2009;94(12):4961–70. doi:10.1210/jc.2009-0839.
  • Wang F, Zhang ZH, Xiao KZ, Wang ZC. Roles of hypothalamic-pituitary-adrenal axis and hypothalamus-pituitary-ovary axis in the abnormal endocrine functions in patients with polycystic ovary syndrome. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017;39(5):699–704. doi:10.3881/j.issn.1000-503X.2017.05.017.
  • Diamanti-Kandarakis E, Kandarakis H, Legro RS. The role of genes and environment in the etiology of PCOS. Endocrine. 2006;30(1):19–26. doi:10.1385/ENDO:30:1:19.
  • Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61–73. doi:10.1056/NEJMra0708473.
  • Prior J. Perimenopause and menopause as oestrogen deficiency while ignoring progesterone. Nat Rev Dis Primers. 2015;1(1):15031. doi:10.1038/nrdp.2015.31.
  • Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J Endocrinol Metab. 2013;17(1):138–45. doi:10.4103/2230-8210.107858.
  • Sharma N, Lugani Y, Kaur A, Ahuja VK. Effect of metformin on insulin levels, blood sugar, and body mass index in polycystic ovarian syndrome cases. J Family Med Prim Care. 2019;8(8):2691–5. doi:10.4103/jfmpc.jfmpc_490_19.
  • Pellatt L, Rice S, Mason HD. Anti-Müllerian hormone and polycystic ovary syndrome: A mountain too high? Reproduction. 2010;139(5):825–33. doi:10.1530/REP-09-0415.
  • Hiraoka T, Wada-Hiraike O, Hirota Y, Hirata T, Koga K, Osuga Y, Fujii T. The impact of elevated thyroid stimulating hormone on female subfertility. Reprod Med Biol. 2016;15(2):121–6. doi:10.1007/s12522-015-0221-9.
  • Davoudi Z, Araghi F, Vahedi M, Mokhtari N, Gheisari M. Prolactin level in polycystic ovary syndrome (PCOS): An approach to the diagnosis and management. Acta Biomed. 2021;92(5):e2021291. doi:10.23750/abm.v92i5.9866.
  • Dewis P, Newman M, Ratcliffe WA, Anderson DC. Does testosterone affect the normal menstrual cycle? Clin Endocrinol (Oxf). 1986;24(5):515–21. doi:10.1111/j.1365-2265.1986.tb03280.x.
  • Newman CB, Blaha MJ, Boord JB, Cariou B, Chait A, Fein HJ, Ginsberg HN, Goldberg IJ, Murad MH, Subramanian S, et al. Lipid management in patients with endocrine disorders: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2020;105(12):3613–82. doi:10.1210/clinem/dgaa674.
  • Liu Q, Xie Y-J, Qu LH, Zhang M-X, Mo Z-C. Dyslipidemia involvement in the development of polycystic ovary syndrome. Taiwan J Obstet Gynecol. 2019;58(4):447–53. doi:10.1016/j.tjog.2019.05.003.
  • Marshall JC, Dunaif A. Should all women with PCOS be treated for insulin resistance? Fertil Steril. 2012;97(1):18–22. doi:10.1016/j.fertnstert.2011.11.036.
  • Luotola K, Piltonen TT, Puurunen J, Morin-Papunen LC, Tapanainen JS. Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome. Gynecol Endocrinol. 2018;34(1):40–4. doi:10.1080/09513590.2017.1342793.
  • Ng NYH, Jiang G, Cheung LP, Zhang Y, Tam CHT, Luk AOY, Quan J, Lau ESH, Yau TSL, Chan MHM, et al. Progression of glucose intolerance and cardiometabolic risk factors over a decade in Chinese women with polycystic ovary syndrome: A case-control study. PLoS Med. 2019;16(10):e1002953. doi:10.1371/journal.pmed.1002953.
  • Sewalt V, Shanahan D, Gregg L, La Marta J, Carrillo R. The generally recognized as safe (GRAS) process for industrial microbial enzymes. Industrial Biotechnol. 2016;12(5):295–302. doi:10.1089/ind.2016.0011.
  • Vassilatou E. Nonalcoholic fatty liver disease and polycystic ovary syndrome. World J Gastroenterol. 2014;20(26):8351–63. doi:10.3748/wjg.v20.i26.8351.

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