A Blend of Tamarindus Indica and Curcuma Longa Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats

References

• Bae KJ, Jeong JW, Choi CH, Won JY, Kim TG, Kim YR, Na CS, Kim SJ. Antiosteoarthritic effects of ChondroT in a rat model of monosodium iodoacetate-induced osteoarthritis. Evid Based Complement Alternat Med. 2018;2018:8565132. doi:10.1155/2018/8565132.
   PubMed Web of Science ®Google Scholar
• Na HS, Kwon JY, Lee SY, Lee SH, Lee AR, Woo JS, Jung KA, Cho KH, Choi JW, Lee DH, et al. Metformin attenuates monosodium-iodoacetate-induced osteoarthritis via regulation of pain mediators and the autophagy–lysosomal pathway. Cells. 2021;10(3):681. doi:10.3390/cells10030681.
   PubMed Web of Science ®Google Scholar
• Zhang P, Li K, Kamali A, Ziadlou R, Ahmad P, Wang X, Geoff Richards R, Alini M, Basoli V, Li Z, et al. Small molecules of herbal origin for treatment of osteoarthritis: in vitro and in vivo evidence. Arthritis Res Ther. 2022;24(1):105. doi:10.1186/s13075-022-02785-y.
   PubMed Web of Science ®Google Scholar
• Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMed. 2020;29–30:100587. doi:10.1016/j.eclinm.2020.100587.
   PubMedGoogle Scholar
• Wallace IJ, Worthington S, Felson DT, Jurmain RD, Wren KT, Maijanen H, Woods RJ, Lieberman DE. Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci USA. 2017;114(35):9332–6. doi:10.1073/pnas.1703856114.
   PubMed Web of Science ®Google Scholar
• Abdel-Rahman RF, Abd-Elsalam RM, Amer MS, El-Desoky AM, Mohamed SO. Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis. Food Funct. 2020;11(9):7960–72. doi:10.1039/d0fo01297a.
   PubMed Web of Science ®Google Scholar
• Lee M, Kim D, Park SJ, Yun JM, Oh DH, Lee J. Antarctic Krill oil ameliorates monosodium iodoacetate-induced irregularities in articular cartilage and inflammatory response in the rat models of osteoarthritis. Nutrients. 2020;12(11):3550. doi:10.3390/nu12113550.
   PubMed Web of Science ®Google Scholar
• Ängeby Möller K, Klein S, Seeliger F, Finn A, Stenfors C, Svensson CI. Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats. Neurobiol Pain. 2019;6:100036. doi:10.1016/j.ynpai.2019.100036.
   PubMedGoogle Scholar
• Karlapudi V, Mungara AVVP, Sengupta K, Davis BA, Raychaudhuri SP. A placebo-controlled double-blind study demonstrates the clinical efficacy of a novel herbal formulation for relieving joint discomfort in human subjects with osteoarthritis of knee. J Med Food. 2018;21(5):511–20. doi:10.1089/jmf.2017.0065.
   PubMed Web of Science ®Google Scholar
• Gök S, Ulker S, Hüseyinov A, Hatip FB, Cinar MG, Evinç A. Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000;60(1):41–6. doi:10.1159/000028345.
   PubMed Web of Science ®Google Scholar
• Kim HL, Lee HJ, Lee DR, Choi BK, Yang SH. Herbal composition LI73014F2 alleviates articular cartilage damage and inflammatory response in monosodium iodoacetate-induced osteoarthritis in rats. Molecules. 2020;25(22):5467. doi:10.3390/molecules25225467.
   PubMed Web of Science ®Google Scholar
• Wang Z, Huang J, Zhou S, Luo F, Xu W, Wang Q, Tan Q, Chen L, Wang J, Chen H, et al. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway. J Cell Mol Med. 2017;21(12):3231–43. doi:10.1111/jcmm.13227.
   PubMed Web of Science ®Google Scholar
• Steinmeyer J, Bock F, Stove J, Jerosch J, Flechtenmacher J. Pharmacological treatment of knee osteoarthritis: special considerations of the new German guideline. Orthop Rev (Pavia). 2018;10(4):7782. doi:10.4081/or.2018.7782.
   PubMed Web of Science ®Google Scholar
• De Caluwé E, Halamouá K, Van Damme P. Tamarindus indica L. – A review of traditional uses, phytochemistry and pharmacology. AFOC. 2010;23(1):53–83. doi:10.1163/2031356X-02301006.
   Google Scholar
• Komakech R, Kim Y-G, Matsabisa GM, Kang Y. Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review. Integr Med Res. 2019;8(3):181–6. doi:10.1016/j.imr.2019.07.002.
   PubMed Web of Science ®Google Scholar
• Sundaram MS, Hemshekhar M, Santhosh MS, Paul M, Sunitha K, Thushara RM, NaveenKumar SK, Naveen S, Devaraja S, Rangappa KS, et al. Tamarind seed (Tamarindus indica) extract ameliorates adjuvant-induced arthritis via regulating the mediators of cartilage/bone degeneration, inflammation and oxidative stress. Sci Rep. 2015;5:11117. doi:10.1038/srep11117.
   PubMed Web of Science ®Google Scholar
• Martinez-Micaelo N, González-Abuín N, Ardèvol A, Pinent M, Blay MT. Procyanidins and inflammation: molecular targets and health implications. Biofactors. 2012;38(4):257–65. doi:10.1002/biof.1019.
   PubMed Web of Science ®Google Scholar
• Ray SD, Kumar MA, Bagchi D. A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-Xl expression and prevents acetaminophen-Induced programmed and unprogrammed cell death in mouse liver. Arch Biochem Biophys. 1999;369(1):42–58. doi:10.1006/abbi.1999.1333.
   PubMed Web of Science ®Google Scholar
• Derosa G, Maffioli P, Simental-Mendía LE, Bo S, Sahebkar A. Effect of curcumin on circulating interleukin-6 concentrations: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2016;111:394–404. doi:10.1016/j.phrs.2016.07.004.
   PubMed Web of Science ®Google Scholar
• Rahmani AH, Alsahli MA, Aly SM, Khan MA, Aldebasi YH. Role of curcumin in disease prevention and treatment. Adv Biomed Res. 2018;7:38. doi:10.4103/abr.abr_147_16.
   PubMedGoogle Scholar
• Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717–29. doi:10.1089/jmf.2016.3705.
   PubMed Web of Science ®Google Scholar
• Park HJ, Lee CK, Song SH, Yun JH, Lee A, Park HJ. Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis. Food Sci Biotechnol. 2020;29(2):251–63. doi:10.1007/s10068-019-00679-5.
   PubMed Web of Science ®Google Scholar
• Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A combination of Tamarindus indica seeds and Curcuma longa rhizome extracts improves knee joint function and alleviates pain in non-arthritic adults following physical activity. Int J Med Sci. 2019;16(6):845–53. doi:10.7150/ijms.32505.
   PubMed Web of Science ®Google Scholar
• Kare SK, Vinay V, Maresz K, Prisk V, Vik H. Tamarindus indica seed extract-based botanical compositions alleviate knee pain and improve joint function in mild-to-moderate osteoarthritis: a randomized, double-blind, placebo-controlled clinical study. Evid Based Complement Alternat Med. 2022;2022:2226139. doi:10.1155/2022/2226139.
   PubMed Web of Science ®Google Scholar
• Choudhary D, Kothari P, Tripathi AK, Singh S, Adhikary S, Ahmad N, Kumar S, Dev K, Mishra VK, Shukla S, et al. Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats. BMC Complement Altern Med. 2018;18(1):69. doi:10.1186/s12906-018-2117-9.
   PubMedGoogle Scholar
• Kim SH, Choi HJ, Yang WK, Lee JE, Cho JH, Park IJ, Park S, Park BK, Jin M. Suppressive effect of the n-Hexane extract of Litsea japonica fruit flesh on monosodium-iodoacetate-induced osteoarthritis in rats. Evid Based Complement Alternat Med. 2017;2017:1791403. doi:10.1155/2017/1791403.
   PubMed Web of Science ®Google Scholar
• Flowers SA, Zieba A, Örnros J, Jin C, Rolfson O, Björkman LI, Eisler T, Kalamajski S, Kamali-Moghaddam M, Karlsson NG. Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface. Sci Rep. 2017;7(1):13149. doi:10.1038/s41598-017-13558-y.
   PubMed Web of Science ®Google Scholar
• Charan J, Kantharia ND. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4(4):303–6. doi:10.4103/0976-500X.119726.
   PubMedGoogle Scholar
• Ameye LG, Chee WSS. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther. 2006;8(4):R127. doi:10.1186/ar2016.
   PubMed Web of Science ®Google Scholar
• Badmaev V, Vik H, Stohs SJ, Galluzzo F. Safety and toxicological evaluation of NXT15906F6 (TamaFlex®): a food-derived botanical composition containing standardized extracts of Tamarindus indica seeds and Curcuma longa rhizomes. Tox Res Appl. 2018;2:1–14. doi:10.1177/2397847317749240.
   Google Scholar
• Jeong J-W, Lee HH, Kim J, Choi E-O, Hwang-Bo H, Kim HJ, Kim MY, Ahn KI, Kim G-Y, Lee KW, et al. Mori folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate-induced osteoarthritis rats. Mol Med Rep. 2017;16(4):3841–8. doi:10.3892/mmr.2017.7075.
   PubMed Web of Science ®Google Scholar
• van der Kraan PM, Vitters EL, van de Putte LB, van den Berg WB. Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. Am J Pathol. 1989;135(6):1001–14.
   PubMed Web of Science ®Google Scholar
• Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, Im HJ. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013;527(2):440–7. doi:10.1016/j.gene.2013.05.069.
   PubMed Web of Science ®Google Scholar
• Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, Schrier DJ, Kilgore KS. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthr Cartil. 2003;11(11):821–30. doi:10.1016/S1063-4584(03)00163-8.
   PubMed Web of Science ®Google Scholar
• Miller RE, Miller RJ, Malfait AM. Osteoarthritis joint pain: the cytokine connection. Cytokine. 2014;70(2):185–93. doi:10.1016/j.cyto.2014.06.019.
   PubMed Web of Science ®Google Scholar
• Molnar V, Matišić V, Kodvanj I, Bjelica R, Jeleč Ž, Hudetz D, Rod E, Čukelj F, Vrdoljak T, Vidović D, et al. Cytokines and chemokines involved in osteoarthritis pathogenesis. IJMS. 2021;22(17):9208. doi:10.3390/ijms22179208.
   Google Scholar
• Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, Sokolove J. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(10):580–92. doi:10.1038/nrrheum.2016.136.
   PubMed Web of Science ®Google Scholar
• Clancy RM, Amin AR, Abramson SB. The role of nitric oxide in inflammation and immunity. Arthritis Rheum. 1998;41(7):1141–51. doi:10.1002/1529-0131.
   PubMedGoogle Scholar
• Abramson SB. Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Res Ther. 2008;10(Suppl 2):S2. doi:10.1186/ar2463.
   PubMedGoogle Scholar
• Ahmad N, Ansari MY, Haqqi TM. Role of iNOS in osteoarthritis: pathological and therapeutic aspects. J Cell Physiol. 2020;235(10):6366–76. doi:10.1002/jcp.29607.
   PubMed Web of Science ®Google Scholar
• Choi MC, Jo J, Park J, Kang HK, Park Y. NF-κB signaling pathways in osteoarthritic cartilage destruction. Cells. 2019;8(7):734. doi:10.3390/cells8070734.
   PubMed Web of Science ®Google Scholar
• Murahashi Y, Yano F, Kobayashi H, Makii Y, Iba K, Yamashita T, Tanaka S, Saito T. Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis. Sci Rep. 2018;8(1):16475. doi:10.1038/s41598-018-34830-9.
   PubMedGoogle Scholar
• Laronha H, Caldeira J. Structure and function of human matrix metalloproteinases. Cells. 2020;9(5):1076. doi:10.3390/cells9051076.
   PubMed Web of Science ®Google Scholar
• Arunrukthavon P, Heebthamai D, Benchasiriluck P, Chaluay S, Chotanaphuti T, Khuangsirikul S. Can urinary CTX-II be a biomarker for knee osteoarthritis? Arthroplasty. 2020;2(1):6. doi:10.1186/s42836-020-0024-2.
   PubMedGoogle Scholar
• Cheng H, Hao B, Sun J, Yin M. C-terminal cross-linked telopeptides of type II collagen as biomarker for radiological knee osteoarthritis: a meta-analysis. Cartilage. 2020;11(4):512–20. doi:10.1177/1947603518798884.
   PubMed Web of Science ®Google Scholar