Virgin Coconut Oil Alleviates Dextran Sulphate–Induced Inflammatory Bowel Disease and Modulates Inflammation and Immune Response in Mice

References

• Ahuja V, Tandon RK. Inflammatory bowel disease in the Asia–Pacific area: a comparison with developed countries and regional differences. J Dig Dis. 2010;11(3):134–47. doi:10.1111/j.1751-2980.2010.00429.x.
   PubMed Web of Science ®Google Scholar
• Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014;14(5):329–42. doi:10.1038/nri3661.
   PubMed Web of Science ®Google Scholar
• Ebru P. Immunomodulatory effects of selected medicinal herbs and their essential oils: a comprehensive review. J Funct Foods. 2022;94:105108.
   Web of Science ®Google Scholar
• Noviello D, Mager R, Roda G, Borroni RG, Fiorino G, Vetrano S. The IL23-IL17 immune axis in the treatment of ulcerative colitis: successes, defeats, and ongoing challenges. Front Immunol. 2021;12:611256. doi:10.3389/fimmu.2021.611256.
   PubMed Web of Science ®Google Scholar
• Nair SS, Manalil JJ, Ramavarma SK, Suseela IM, Thekkepatt A, Raghavamenon AC. Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice. Hum Exp Toxicol. 2016;35(2):205–12. doi:10.1177/0960327115578867.
   PubMed Web of Science ®Google Scholar
• Illam SP, Kandiyil SP, Narayanankutty A, Veetil SV, Babu TD, Uppu RM, Raghavamenon AC. Virgin coconut oil complements with its polyphenol components mitigate sodium fluoride toxicity in vitro and in vivo. Drug Chem Toxicol. 2022;45(6):2528–34. doi:10.1080/01480545.2021.1962691.
   PubMed Web of Science ®Google Scholar
• Jose SP, I.m K, M R, S A, S S, V R. Polyphenolic fraction of virgin coconut oil inhibits the inflammatory response in oxidized LDL activated human peripheral blood mononuclear cells by modulating TLR/NF-κB signaling pathways. Eur J Integr Med. 2017;10:59–65. 2017/02/01/doi:10.1016/j.eujim.2017.01.004.
   Web of Science ®Google Scholar
• Vysakh A, Ratheesh M, Rajmohanan TP, Pramod C, Premlal S, Girish Kumar B, Sibi PI. Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action. Int Immunopharmacol. 2014;20(1):124–30. doi:10.1016/j.intimp.2014.02.026.
   PubMed Web of Science ®Google Scholar
• Narayanankutty A, Mukesh RK, Ayoob SK, Ramavarma SK, Suseela IM, Manalil JJ, Kuzhivelil BT, Raghavamenon AC. Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats. J Food Sci Technol. 2016;53(1):895–901. doi:10.1007/s13197-015-2040-8.
   PubMed Web of Science ®Google Scholar
• Ding S, Jiang H, Fang J. Regulation of immune function by polyphenols. J Immunol Res. 2018;2018:1264074–8. doi:10.1155/2018/1264074.
   PubMed Web of Science ®Google Scholar
• Ainsworth EA, Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent. Nat Protoc. 2007;2(4):875–7. doi:10.1038/nprot.2007.102.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Canales M, Jimenez-Rivas R, Canales-Martinez MM, Garcia-Lopez AJ, Rivera-Yañez N, Nieto-Yañez O, Ledesma-Soto Y, Sanchez-Torres LE, Rodriguez-Sosa M, Terrazas LI, et al. Protective effect of Amphipterygium adstringens extract on dextran sulphate sodium-induced ulcerative colitis in mice. Mediators Inflamm. 2016;2016:8543561. doi:10.1155/2016/8543561.
   PubMed Web of Science ®Google Scholar
• Quade MJ, Roth JA. A rapid, direct assay to measure degranulation of bovine neutrophil primary granules. Vet Immunol Immunopathol. 1997;58(3–4):239–48. 1997/09/19/doi:10.1016/s0165-2427(97)00048-2.
   PubMed Web of Science ®Google Scholar
• Mehara E, Vaidya MC. Handbook of pratical and clinical immunology. New Delhi: CBS Publishers; 1984.
   Google Scholar
• Bancroff JD, Cook HF. A manual of histologic technique. London: Churchill Livingston; 1984.
   Google Scholar
• Illam SP, Narayanankutty A, Raghavamenon AC. Polyphenols of virgin coconut oil prevent pro-oxidant mediated cell death. Toxicol Mech Methods. 2017;27(6):442–50. doi:10.1080/15376516.2017.1320458.
   PubMed Web of Science ®Google Scholar
• Illam SP, Narayanankutty A, Kandiyil SP, Raghavamenon AC. Variations in natural polyphenols determine the anti-inflammatory potential of virgin coconut oils. J Food Sci. 2021;86(5):1620–8. doi:10.1111/1750-3841.15705.
   PubMed Web of Science ®Google Scholar
• Li C, Wu G, Zhao H, Dong N, Wu B, Chen Y, Lu Q. Natural-derived polysaccharides from plants, mushrooms, and seaweeds for the treatment of inflammatory bowel disease. Front Pharmacol. 2021;12:651813. doi:10.3389/fphar.2021.651813.
   PubMed Web of Science ®Google Scholar
• Chassaing B, Aitken JD, Malleshappa M, et al. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol. 2014;104(15):1–15.
   Google Scholar
• Hwang S, Hwang S, Jo M, Lee CG, Rhee K-J. Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice. Int J Med Sci. 2020;17(13):1984–91. doi:10.7150/ijms.44834.
   PubMed Web of Science ®Google Scholar
• Jeon Y-D, Lee J-H, Lee Y-M, Kim D-K. Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. Biomed Pharmacother. 2020;124:109847. 2020/04/01/doi:10.1016/j.biopha.2020.109847.
   PubMed Web of Science ®Google Scholar
• Nguyen TQC, Duy Binh T, Pham TLA, et al. Anti-Inflammatory effects of Lasia spinosa leaf extract in lipopolysaccharide-induced RAW 264.7 macrophages. Int J Mol Sci. 2020;21(10):3439.
   Web of Science ®Google Scholar
• Valle D, Kim-Schulze S, Huang H-H, et al. An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat Med. 2020;26:1–8.
   PubMed Web of Science ®Google Scholar
• Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011;22(4):189–95. doi:10.1016/j.cytogfr.2011.10.001.
   PubMed Web of Science ®Google Scholar
• Zhou X, Dong Q, Kan X, Peng L, Xu X, Fang Y, Yang J. Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide. PLoS One. 2018;13(10):e0204152. doi:10.1371/journal.pone.0204152.
   PubMed Web of Science ®Google Scholar
• Castro F, Cardoso AP, Gonçalves RM, Serre K, Oliveira MJ. Interferon-gamma at the crossroads of tumor immune surveillance or evasion. Front Immunol. 2018;9(847):847. doi:10.3389/fimmu.2018.00847.
   PubMedGoogle Scholar
• Sunil MA, Sunitha VS, Santhakumaran P, Mohan MC, Jose MS, Radhakrishnan EK, Mathew J. Protective effect of (+)-catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-κB and p38 MAPK. Inflammopharmacology. 2021;29(4):1139–55. doi:10.1007/s10787-021-00827-6.
   PubMed Web of Science ®Google Scholar
• Cai L, Wei Z, Zhao X, Li Y, Li X, Jiang X. Gallic acid mitigates LPS-induced inflammatory response via suppressing NF-κB signalling pathway in IPEC-J2 cells. J Anim Physiol Anim Nutr (Berl). 2022;106(5):1000–8. doi:10.1111/jpn.13612.
   PubMed Web of Science ®Google Scholar
• Basu Mallik S, Mudgal J, Nampoothiri M, Hall S, Dukie SAnoopkumar, Grant G, Rao CM, Arora D. Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice. Neurosci Lett. 2016;632:218–23. doi:10.1016/j.neulet.2016.08.044.
   PubMed Web of Science ®Google Scholar
• Chen L-L, Song C, Zhang Y, Li Y, Zhao Y-H, Lin F-Y, Han D-D, Dai M-H, Li W, Pan P-H, et al. Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation. Eur J Pharmacol. 2022;936:175352. 2022/12/05/doi:10.1016/j.ejphar.2022.175352.
   PubMed Web of Science ®Google Scholar
• Zhang H, Deng A, Zhang Z, Yu Z, Liu Y, Peng S, Wu L, Qin H, Wang W. The protective effect of epicatechin on experimental ulcerative colitis in mice is mediated by increasing antioxidation and by the inhibition of NF-κB pathway. Pharmacol Rep. 2016;68(3):514–20. 2016/06/01/doi:10.1016/j.pharep.2015.12.011.
   PubMed Web of Science ®Google Scholar
• Lin R, Piao M, Song Y. Dietary quercetin increases colonic microbial diversity and attenuates colitis severity in Citrobacter rodentium-infected mice. Front Microbiol. 2019;10:1092. doi:10.3389/fmicb.2019.01092.
   PubMed Web of Science ®Google Scholar
• Pandurangan AK, Norhaizan M, Mohebali N, Yeng LC. Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice. Drug Des Dev Ther. 2015;9:3923–34. doi:10.2147/DDDT.S86345.
   PubMed Web of Science ®Google Scholar
• Wan F, Zhong R, Wang M, Zhou Y, Chen Y, Yi B, Hou F, Liu L, Zhao Y, Chen L, et al. Caffeic acid supplement alleviates colonic inflammation and oxidative stress potentially through improved gut microbiota community in mice. Front Microbiol. 2021;12:784211. (doi:10.3389/fmicb.2021.784211.
   PubMed Web of Science ®Google Scholar