46
Views
65
CrossRef citations to date
0
Altmetric
Original Article

Oxidative Inactivation of Paraoxonase1, an Antioxidant Protein and its Effect on Antioxidant Action

&
Pages 1319-1330 | Received 09 Apr 2003, Published online: 07 Jul 2009

References

  • La Du, B.N. (1996) "Structural and functional diversity of paraoxonase", Nat. Med. 2, 1186–1187.
  • Berliner, J.A., Navab, M., Fogelman, AM., Frank, J.S., Demer, L.L., Edwards, PA., Watson, AD. and Lusis, A.J. (1995) "Atherosclerosis: basic mechanism, oxidation, inflammation and genetics", Circulation 91, 2488–2496.
  • Mackness, MI., Mackness, B., Durrington, P.A., Connelly, P.W. and Hegele, R.A. (1996) "Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins", Curr. Opin. Lipidol. 7, 69–76.
  • Davies, HG., Richter, R.J., Keifer, M., Broomfield, CA., Sowalla, J. and Furlong, C.E. (1996) "The effect of the human serum paraoxonase polymorphism is reversed with dia-zoxon, soman and sarin", Nat. Genet. 14, 334–336.
  • Gan, K.N., Smolen, A., Eckerson, H.W. and La Du, B.N. (1991) "Purification of human serum paraoxonase/arylesterase", Drug Metab. Dispos. 19, 100–106.
  • Jakubowski, H. (2000) "Calcium-dependent human serum homocysteine thiolactone hydrolase: a protective mechanism against protein N-homocysteinylation", J. Biol. Chem. 275, 3957–3962.
  • Josse, D., Loduidge, 0., Xie, W., Bartels, C.F., Schopfer, L.M. and Masson, P. (2001) "The active site of human paraoxonase (PON1)", J. Appl. Toxicol. 21, S7—S11.
  • Shih, D.M., Cu, L., Xia, Y-R., Navab, M., Li, W.-F., Hama, S., Castellani, LW., Furlong, CE., Costa, L.G., Fogelman, AM. and Lusis, A.J. (1998) "Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis", Nature 394, 284–287.
  • Ferguson, E., Parthasarathy, S., Joseph, J. and Kalyanaraman, B. (1998) "Generation and initial characterization of a novel polyclonal antibody directed against homocysteine thiolactone-modified low density lipoprotein", J. Lipid Res. 39, 925–933.
  • Watson, AD., Berliner, J.A., Hama, S.Y., La Du, B.N., Fauli, K.F., Fogelman, A.M. and Mohamad, N. (1995) "Protective effect of high density lipoprotein associated paraoxnase: inhibition of the biological activity of minimally oxidized low density lipoprotein", J. Clin. Investig. 96, 2882–2891.
  • Aviram, M., Rosenblat, M., Billecke, S., Erogul, J., Sorenson, R., Bisgaier, CI., Newton, R.S. and La Du, B.N. (1999) "Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by anti-oxidants", Free Radic. Biol. Med. 26, 892–904.
  • Ahmed, Z., Ravandi, A., Maguire, C.F., Emili, A., Draganov, D., La Du, B.N., Kuksis, A. and Connelly, P.W. (2001) "Apolipoprotein A-I promotes the formation of phospha-tidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor", J. Biol. Chem. 276, 24473–24481.
  • Aviram, M., Hardak, E., Vaya, J., Mahmood, S., Milo, S., Hoffman, A., Billicke, S., Draganov, D. and Rosenblat, M. (2000) "Human serum paraoxnase (PON 1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and pero)d-dase-like activities", Circlulation 101, 2510–2517.
  • Ahmed, Z., Ravandi, A., Maguire, C.F., Emili, A., Draganov, D., La Du, B.N., Kuksis, A. and Connelly, P.W. (2002) "Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite", Biochem. Biophys. Res. Commun. 290, 391–396.
  • Aviram, M., Billecke, S., Sorenson, R., Bisgaier, C., Newton, R., Rosenblat, M., Erogut J., Hsu, C., Dunlop, C. and La Du, B.N. (1998) "Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/para-oxonase activities", Arterioscler. Thromb. Vasc. Biol. 18, 1617–1624.
  • Shih, D.M., Cu, L., Hama, S., Xia, Y.-R., Navab, M., Fogelman, A.M. and Lusis, A.J. (1996) "Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model", J. Clin. Investig. 97, 1630–1639.
  • Ruiz, J., Blanche, H., James, R.W., Garin, MC., Vaisse, C., Charpentier, G., Cohen, N., Morabia, A., Passa, P and Froguel, P. (1995) "Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes", Lancet 30, 869–872.
  • Mackness, B., Davies, G.K., Turkie, W., Lee, E., Roberts, D.H., Hill, E., Roberts, C., Durrington, P.N. and Mackness, MI. (2001) "Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?", Arterioscler. Thromb. Vasc. Biol. 21, 1451–1457.
  • Mackness, B., Durrington, P.N. and Mackness, M.I. (2002) "The paraoxonase gene family and coronary heart disease", Curr. Opin. Lipidol. 13, 357–362.
  • Furlong, CE., Cole, TB., Jarvik, G.P. and Costa, L.G. (2002) "Pharmacogenomic considerations of the paraoxonase poly-morphisms", Pharmacogenomics 3, 341–348.
  • Rodrigo, L., Mackness, B., Durrington, P.N., Hernandez, A. and Mackness, MI. (2001) "Hydrolysis of platelet-activating factor by human serum paraoxonase", Biochem. J. 354, 1–7.
  • Marathe, G.K., Zimmerman, GA. and McIntyre, T.M. (2003) "PAF acetylhydrolase, and not paraoxonase-1, is the oxidized phospholipid hydrolase of high density lipoprotein par-ticles", J. Biol. Chem. 278, 3937–3947.
  • Berliner, J.A. and Heinecke, J.W. (1996) "The role of oxidized lipoproteins in atherogenesis", Free Radic. Biol. Med. 20, 707–727.
  • Burkitt, M.J.A. (2001) "Critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: roles of lipid hydropermddes, alpha-tocopherol, thiols, and cerulo-plasmin", Arch. Biochem. Biophys. 394, 117–135.
  • Ferretti, G., Bacchetli, T., Marchionni, C., Caldarelli, L. and Curatola, G. (2001) "Effect of glycation of high density lipoproteins on their physicochemical properties and on paraoxonase activity", Acta Diabetol. 38, 163–169.
  • McCall, M.R., Tang, J.Y., Bielicki, J.K. and Forte, T.M. (1995) "Inhibition of lecithin-cholesterol acyltransferase and modi-fication of HDL apolipoproteins by aldehydes", Art erioscler. Thromb. Vasc. Biol. 15, 1599–1606.
  • Bub, A., Barth, S., Watzl, B., Briviba, K., Herbert, B.M., Luhrmann, P.M., Neuhauser-Berthold, M. and Rechkemmer, G. (2002) "Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid permddation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet", Fur. J. Nutr. 41, 237–243.
  • Liu, T.-Y. and Chang, Y.H. (1971) "Hydrolysis of proteins with p-toluenesulfonic acid", J. Biol. Chem. 246, 2842–2848.
  • Tarr, G.E. (1986) In: Shively, J.E., ed, Methods of protein microcharacterization (Humana Press, Clifton, NJ), pp 155–194.
  • Ellman, GI. (1958) "A colorimetric method for determining low concentrations of mercaptans", Arch. Biochem. Biophys. 74, 443–450.
  • Halliwell, B., Gutteridge, J.M. and Aruoma, 0.1. (1987) "The deoxyribose method: a simple test-tube assay for determi-nation of rate constants for ractions od hydroxyl radicals", Anal. Biochem. 165, 215–219.
  • Puppo, A. and Halliwell, B. (1989) "Oxidation of dimethyl-sulphoxide to formaldehyde by oxyhaemoglobin and oxyleghaemoglobin in the presence of hydrogen peroxide is not mediated by free hydroxyl radicals", Free Radic. Res. Commun. 5, 277–281.
  • Bray, T.M. and Bettger, W.J. (1990) "The physiological role of zinc as an antioxidant", Free Radic. Biol. Med. 8, 281–291.
  • Sok, D.-E. (1998) "Ascorbate-induced oxidative inactivation of Zn2±-glycerophos-phocholine cholinephosphodiesterase", J. Neurochem. 70, 1167–1174.
  • Esterbauer, H., Schaur, R. and Zollner, H. (1991) "Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes", Free Radic. Biol. Med. 11, 81–128.
  • Uchida, K. and Stadtman, KR. (1992) "Selective cleavage of thioester linkage in proteins modified with 4-hydroxynone-nal", Proc. Natl. Acad. Sci. USA 89, 5611–5615.
  • Levine, R.L., Oliver, C.N., Fulko, R.M. and Stadtman, E.R. (1981) "Turnover of bacterial glutamine synthetase: oxidative inactivation proceeds proteolysis", Proc. Natl. Acad. Sci. USA 78, 2120–2124.
  • Halliwell, B. and Gutteridge, J.M. (1984) "Oxygen toxicity, oxygen radicals, transition metals and disease", Biochem. J. 219, 1–14.
  • Stadtman, E.R. and Oliver, C.N. (1991) "Metal-catalyzed oxidation of proteins", J. Biol. Chem. 266, 2005–2008.
  • Swain, J. and Gutteridge, J.M.C. (1995) "Prooxidant iron and copper with ferroxidase and xanthine mddase activities in human atherosclerosis", FEBS Lett. 368, 513–515.
  • Jialal, I., Vega, G.L. and Grundy, S.M. (1990) "Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein", Atherosclerosis 82, 185–191.
  • Minqin, R., Watt, F., Huat, B.T. and Halliwell, B. (2003) "Correlation of iron and zinc levels with lesion depth in newly formed atherosclerotic lesions", Free Radic. Biol. Med. 34, 746–752.
  • Doom, J.A., Sorenson, R.C., Billecke, S.S., Hsu, C. and La Du, B.N. (1999) "Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase /arylesterase", Chem.-Biol. Interact. 119–120, 235–241.
  • Uchida, K. and Kawakishi, S. (1990) "Site-specific oxidation of angiotensin I by copper(II) and L-ascorbate: conversion of histidine residues to 2-imidazolones", Arch. Biochem. Biophys. 283, 20–26.
  • Uchida, K. and Kawakishi, S. (1993) "2-0xo-histidine as a novel biological marker for mddatively modified proteins", FEBS Lett. 332, 208–210.
  • Josse, D., Xie, W., Renault, F., Rochu, D., Schopfer, L.M., Masson, P. and Lockridge, 0. (1999) "Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphate activities", Biochemistry 38,2816–2825.
  • Benedetti, A., Comporti, M. and Esterbauer, H. (1980) "Identification of 4-hydroxynonenal as a cytotoxic product originating from the permddation of liver microsomal lipids", Biochim. Biophys. Acta 620, 281–296.
  • Draganov, DJ., Stetson, Pi., Watson, CE., Billecke, S.S. and La Du, B.N. (2000) "Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation", J. Biol. Chem. 275, 33435–33442.
  • Maor, L., Hayek, T., Coleman, R. and Aviram, M. (1997) "Plasma LDL oxidation leads to its aggregation in the atherosclerotic apolipoprotein E-deficient mice", Art erioscler. Thromb. Vasc. Biol. 17, 2995–3005.
  • Rozenberg, 0., Rosenblat, M., Coleman, R., Shih, D.M. and Aviram, M. (2003) "Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice", Free Radic. Biol. Med. 15, 774–784.
  • Jaouad, L., Milochevitch, C. and Khalil, A. (2003) "PON1 paraoxonase activity is reduced during HDL oxidation and is an indicator of HDL antioxidant capacity", Free Radic. Res. 37, 77–83.
  • Kuremoto, K., Watanabe, Y, Ohmura, H., Shimada, K., Mokuno, H. and Daida, H. (2003) "R/R Genotype of human paraoxonase (PON1) is more protective against lipoprotein oxidation and coronary artery disease in Japanese subjects", J. Atheroscler. Thromb. 10, 85–92.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.