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Research Article

Dendritic Cells Under Investigation in Autoimmune Disease

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Pages 1-21 | Published online: 29 Sep 2008

References

  • http://www.aarda.orgquestions_ and_answers.html; http://www.nature. com/ni/special_focus /autoimmunity/wel-come/html
  • Stoll, M. L. and Gavalchin, J. 2000. Sys-temic lupus erythematosus-messages from experimental models. Rheumatology 39:18—27.
  • Theofilopoulos, A.N. and Dixon, F.J. 1985. Murine models of systemic lupus erythe-matosus. Adv Immunol 37:269—390.
  • Matzinger, P. 1994. Tolerance, danger and the extended family. Annu Rev Immunol 12:991—1045.
  • Martin, R., Gran, B., Zhao, Y., Markovic-Plese, S., Bielekova, B., Marques, A., Sung, M.H., Hemmer, B., Simon, R., McFarland, H.F., and Pinilla, C. 2001. Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease. J Autoimmun 16:187—92.
  • Joshi, S.K., Suresh, P.R., and Chauhan, V.S. 2001. Flexibility in MHC and TCR recognition: degenerate specificity at the T cell level in the recognition of promis-cuous Th epitopes exhibiting no primary sequence homology. J Immunol 166:6693- 703.
  • Anderton, S.M. and Wraith, D.C. 2002. Selection and fine-tuning of the autoim-mune T-cell repertoire. Nat Rev Immunol 2:487—98.
  • Ermann, J. and Fathman C.G. 2001. Au-toimmune diseases: genes, bugs and failed regulation. Nat Immunol 2:759- 61.
  • Anderson, A.C., Nicholson L.B., and Kuchroo V.K. 2001. The origin and regulation of autopathogenic T cells. J Clin Immunol 21:74—80.
  • Yan, J. and Mamula, M.J. 2002. Autoreactive T cells revealed in the normal repertoire: escape from negative selection and periph-eral tolerance. J Immunol 168:3188—3194.
  • Banchereau, J. and Steinman, R.M. 1998. Dendritic cells and the control of immu-nity. Nature 392:245—252.
  • Brenner, B., Koppenhoefer, U., Grassme, H., Kun, J., Lang, F., and Gulbins, E. 1997. Evidence for a novel function of the CD40 ligand as a signalling mol ecule in T-lymphocytes. FEBS Lett 417:301—6.
  • Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzaveccia, A., and Alber, G. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of Interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184:747—752.
  • Dubois, B., Bridon, J.M., Fayette, J., Barthelemy, C., Banchereau J., Caux, C., and Briere, F. 1999. Dendritic cells di-rectly modulate B cell growth and differ-entiation. J Leukoc Biol 66:224—30.
  • Ridge, J.P., Di Rosa, F., and Matzinger, P. 1998. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393:474—478.
  • Anderson, G., Moore, N.C., Owen, J.J., and Jenkinson, E.J. 1996. Cellular interactions in thymocyte development. Ann Rev Immunol 14:73—99
  • Steinbrink, K., Wolfl, M., Jonuleit, H., Knop, J., and Enk, A.H. 1997. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159:4772—4780.
  • Enk, A.H., Angeloni, V.L., Udey, M.C., and Katz, S.I. 1993. Inhibition of Langer-hans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 151:2390—2398.
  • Beissert, S., Hosoi, J., Grabbe, S., Asahina, A., and Granstein, R.D. 1995. IL-10 in-hibits tumor antigen presentation by epi-dermal antigen-presenting cells. J Immunol 154:1280—1286.
  • Jonuleit, H., Schmitt, E., Schuler, G., Knop, J., and Enk, A.H. 2000. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192:1213—22.
  • Adler, A.J., Marsh, D.W., Yochum, G.S., Guzzo, J.L., Nigam, A., Nelson, W.G., and Pardoll, D.M. 1998. CD4+ T cell tolerance to parenchymal self-antigens re-quires presentation by bone marrow-de-rived antigen-presenting cells. J Exp Med 187:1555—64.
  • Kurts, C, Heath, W.R., Kosaka, H., Miller, J.F., and Carbone, F.R. 1998. The periph-eral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J Exp Med 188:415—20.
  • Menges, M., Rossner, S., Voigtlander, C, Schindler, H., Kukutsch, N.A., Bogdan, C, Erb, K., Schuler, G., and Lutz, M.B. 2002. Repetitive injections of dendritic cells matured with tumor necrosis factor a induce antigen-specific protection of mice from autoimmunity. J Exp Med 195:15–21.
  • Dhodapkar, M.V., Steinman, R.M., Krasovsky, J., Munz, C, and Bhardwaj, N. 2001. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193: 233—238.
  • Dhodapkar, M.V. and Steinman, R.M. 2002. Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans. Blood 100: 174—177.
  • Steinman, R.M. and Nussenzweig, M.C. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 99:351—358.
  • Sauter, B., Albert, M.L., Francisco, L., Larsson, M., Somersan, S., and Bhardwaj, N. 2000. Consequences of cell death: expo-sure to necrotic tumor cells, but not pri-mary tissue cells or apoptotic cells, induces the maturation of immunostimulatory den-dritic cells. J Exp Med 191:423—434.
  • Rosen, A. and Casciola-Rosen, L. 1999. Autoantigens as substrates for apoptotic proteases: implications for the pathogen-esis of systemic autoimmune disease. Cell Death Differ 6:6—12.
  • Casciola-Rosen, L., Rosen, A., Petri, M., and Schlissel, M. 1996. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 93:1624—1629.
  • Rovere, P., Vallinoto, C., Bondanza, A., Crosti, M.C., Rescigno, M., Ricciardi-Castagnoli, P., Rugarli, C., and Manfredi, A.A. 1998. Bystander apoptosis triggers dendritic cell maturation and antigen-pre-senting function. J Immunol 161:4467–4471.
  • Benoist, C. and Mathis, D. 2001. Autoim-munity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2:797—801.
  • Ludewig, B., McCoy, K., Pericin, M., Ochsenbein, A.F., Dumrese, T., Odermatt, B., Toes, R.E., Melief, C.J., Hengartner, H., and Zinkernagel, R.M. 2001. Rapid peptide turnover and inefficient presentation of exogenous antigen critically limit the activation of self-reactive CTL by den-dritic cells. J Immunol 166:3678—87
  • Cella, M., Engering, A., Pinet, V., Pieters, J., and Lanzavecchia, A. 1997. Inflamma-tory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388:782—787.
  • Yi, Y., McNerney, M., and Datta, S. K. 2000. Regulatory defects in Cbl and mito-gen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. J Immunol 165:6627–6634.
  • Scheinecker, C., Zwolfer, B., Koller, M., Manner, G., and Smolen, J.S. 2001. Alterations of dendritic cells in systemic lupus erythematosus: phenotypic and functional deficiencies. Arthritis Rheum 44:856—865.
  • Lettesjo, H., Burd, G.P., and Mageed, R.A. 2000. CD4+ T lymphocytes with constitutive CD40 ligand in preautoimmune (NZB x NZW)F1 lupus-prone mice: phenotype and possible role in autoreactivity. J Immunol 165:4095—4104.
  • Kalled, S.L., Cutler, A.H., and Burkly, L.C. 2001. Apoptosis and altered dendritic cell homeostasis in lupus nephritis are limited by anti-CD154 treatment. J Immunol 167:1740—7.
  • Blanco, P., Palucka, A.K., Gill, M., Pascual, V., and Banchereau J. 2001. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythemato-sus. Science 294:1540—1543.
  • Maddison, P.J. 2000. Mixed connective tis-sue disease: overlap syndromes. Baillieres Best Pract Res Clin Rheumatol 14:111- 124.
  • Roell, N.R. and M.J.D. Goodfield. 1998. The connective tissue diseases. In Rook/ Wilkinson/Ebling Textbook of Dermatol-ogy, R.H. Champion, J.L. Burton, D.A. Burns, S.M. Breathnach, Eds. 6th edition, Blackwell Science Ltd. pp. 2545—2547.
  • Jablonska, S. and Blaszczyk, M. 1999. Scleroderma overlap syndromes. Adv Exp Med Biol 455:85—92.
  • Mehling, A., Loser, K., Varga, G., Metze, D., Luger, T.A., Schwarz, T., Grabbe, S., and Beissert, S. 2001. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med 194:615—628.
  • Garza, K.M., Chan, S.M, Suri, R., Nguyen, L.T., Odermatt, B., Schoenberger, S.P., and Ohashi, P.S. 2000. Role of antigen-presenting cells in mediating tolerance and autoimmunity. J Exp Med 191:2021—7.
  • Green, E.A., Eynon, E.E., and Flavell, R.A. 1998. Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 9:733—743.
  • Kweon, M.N. and Kiyono, H. 2002. CD40L in autoimmunity and mucosally induced tolerance. J Clin Invest 109:171–3.
  • Hanninen, A., Martinez, N.R., Davey, G.M., Heath, W.R., and Harrison, L.C. 2002. Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity. J Clin Invest 109: 261—7.
  • van Dinther-Janssen, A.C., Pals, S.T., Scheper, R., Breedveld, F., and Meijer, C.J. 1990. Dendritic cells and high endot-helial venules in the rheumatoid synovial membrane. J Rheumatol 17:11—17.
  • de Vere Tyndall, A., Knight, S.C., Edwards, A.J., and Clarke, J.B. 1983. Veiled (dendritic) cells in synovial fluid. Lancet 1:472—3.
  • Harding, B. and Knight, S.C. 1986. The distribution of dendritic cells in the synovial fluids of patients with arthritis. Clin Exp Immunol 63:594—600.
  • Pettit, A.R., Ahern, M.J., Zehntner, S., Smith, M.D., and Thomas, R. 2001. Com-parison of differentiated dendritic cell infiltration of autoimmune and osteoarthri-tis synovial tissue. Arthritis Rheum 44:105—110.
  • Takemura, S., Braun, A., Crowson, C., Kurtin, P.J., Cofield, R.H., O'Fallon, W.M., Goronzy, J.J., and Weyand, CM. 2001. Lymphoid neogenesis in rheuma-toid synovitis. J Immunol 167:1072—1080.
  • Weyand, CM., Braun, A., Takemura, S., and Goronzy, J.J. 2001. Lymphoid microstructures in rheumatoid synovitis. Curr Dir Autoimmun 3:168—87.
  • Thomas, R., MacDonald, K.P., Pettit, A.R., Cavanaugh, L.L., Padmanabha, J., and Zehnter, S. 1999. Dendritic cells and the pathogenesis of rheumatoid arthritis. J Leukoc Biol 66:286—292.
  • Huang, Y.M., Xiao, B.G., Ozenci, V., Kouwenhoven, M., Teleshova, N., Fredrikson, S., and Link, H. 1999 Multiple sclerosis is associated with high levels of circulating dendritic cells secreting proinflammatory cytokines. J Neuroimmunol 99:82—90.
  • Dittel, B.N., Visintin, I., Merchant, R.M., and Janeway, C.A., Jr. 2000. Presentation of the self-antigen myelin basic protein by dendritic cells leads to experimental au-toimmune encephalomyelitis. J Immunol 163:32—39.
  • Lehmann, P.V., Forsthuber, T., Miller, A., and Sercarz, E.E. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155—157.
  • Dittel, B.N., Urbania, T.H., and Janeway, C.A., Jr. 2000. Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice. J Autoimmun 14:311—318.
  • van Blokland, S.C., van Helden-Meeuwsen, C.G., Wierenga-Wolf, A.F., Drexhage, H.A., Hooijkaas, H., van de Merwe, J.P., and Versnel, M.A. 2000. Two different types of sialoadenitis in the NOD- and MRL/lpr mouse models for Sjogren's syndrome: a differential role for dendritic cells in the initiation of sialoadenitis? Lab Invest. 80:575—585.
  • van Blokland, S.C, Wierenga-Wolf, A.F., van Helden-Meeuwsen, C.G., Drexhage, H.A., Hooijkaas, H., van de Merwe, J.P., and Versnel, M.A. 2000. Professional an-tigen presenting cells in minor salivary glands in Sjogren's syndrome: potential contribution to the histopathological diag-nosis? Lab Invest 80:1935—1941.
  • Ikeda, Y., Akbar, F., Matsui, H., and Onji, M. 2001. Characterization of antigen-presenting dendritic cells in the peripheral blood and colonic mucosa of patients with ulcerative colitis. Eur J Gastroenterol Hepatol 13:841—850.
  • Vuckovic, S., Florin, T.H., Khalil, D., Zhang, M.F., Patel, K., Hamilton, I., and Hart, D.N. 2001. CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel dis-eases. Am J Gastroenterol 96:2946—2956.
  • Biondo, M., Nasa, Z., Marshall, A., Toh, B.H., and Alderuccio, F. 2001. Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity. J Immunol 166:2090—2099.
  • Leithauser, F., Trobonjaca, Z., Moller, P., and Reimann, J. 2001. Clustering of colonic lamina propria CD4(+) T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a mu-rine adoptive transfer model. Lab Invest 81:1339—1349.
  • Malmstrom, V., Shipton, D., Singh, B., Al-Shamkhani, A., Puklavec, M.J., Barclay, A.N., and Powrie, F. 2001. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J Immunol 166:6972—6981.
  • Binks, M., Jones, G.E., Brickell, P.M., Kinnon, C, Katz, D.R., and Thrasher, A.J. 1998. Intrinsic dendritic cell abnormali-ties in Wiskott-Aldrich syndrome. Eur J Immunol 28:3259—67.
  • Wang, J., Zheng, L., Lobito, A., Chan, F.K., Dale, J., Sneller, M., Yao, X., Puck, J.M., Straus, S.E., and Lenardo, M.J. 1999. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 98:47—58.
  • Mentzer, S.J. 2000. Dendritic cells in the pathophysiology of sarcoidal reactions. In Vivo 14:209—212.
  • Whitacre, CC. 2001. Sex differences in autoimmune disease. Nat Immunol 2:777- 780.
  • Matera, L., Mori, M., and Galetto, A. 2001. Effect of prolactin on the antigen present-ing function of monocyte-derived dendritic cells. Lupus 10:728—734.
  • Komi, J. and Lassila, O. 2000. Nonsteroi-dal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells. Blood 95:2875—2882.
  • Sthoeger, Z.M., Bentwich, Z., Zinger, H., and Mozes, E. 1994. The beneficial effect of the estrogen antagonist, tamoxifen, on experimental systemic lupus erythemato-sus. J Rheumatol 21:2231—2238.
  • Dayan, M., Zinger, H., Kalush, F., Mor, G., Amir-Zaltzman, Y., Kohen, F., Sthoeger, Z., and Mozes, E. 1997. The beneficial effects of treatment with tamoxifen and anti-estradiol antibody on experimental systemic lupus erythemato-sus are associated with cytokine modulations. Immunology 90:101—108.
  • Grainger, D.J. and Metcalfe, J.C. 1996. Tamoxifen: teaching an old drug new tricks? Nat Med 2:381—385.
  • Komi, J., Mottonen, M., Luukkainen, R., and Lassila, O. 2001. Non-steroidal anti-oestrogens inhibit the differentiation of synovial macrophages into dendritic cells. Rheumatology (Oxford) 40:185—91.
  • Early, G.S., Zhao, W., and Burns, C.M. 1996. Anti-CD40 ligand antibody treat-ment prevents the development of lupus-like nephritis in a subset of New Zealand black New Zealand white mice. Response correlates with the absence of an anti-an-tibody response. J Immunol 157:3159–3164.
  • Huang, W., Sinha, J., Newman, J., Reddy, B., Budhai, L., Furie, R., Vaishnaw, A., and Davidson, A. 2002 The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus. Arthritis Rheum 46:1554—1562.
  • Mehling, A., Grabbe, S., Voskort, M., Schwarz, T., Luger, T.A., and Beissert, S. 2000. Mycophenolate mofetil impairs the maturation and function of murine den-dritic cells. J Immunol 165:2374—2381.
  • Moser, M., De Smedt, T., Sornasse, T., Tielemans, F., Chentoufi, A.A., Muraille, E., Van Mechelen, M., Urbain, J., and Leo, O. 1995. Glucocorticoids down-regu-late dendritic cell function in vitro and in vivo. Eur J Immunol. 25:2818—2824.
  • Dam, T.N., Moller, B., Hindkjaer, J., and Kragballe, K. 1996. The vitamin D3 analog calcipotriol suppresses the num-ber and antigen-presenting function of Langerhans cells in normal human skin. J Investig Dermatol Symp Proc 1:72- 77.
  • Griffin, M.D., Lutz, W.H., Phan, V.A., Bachman, L.A., McKean, D.J., Kumar, R. 2000 Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. Biochem Biophys Res Commun 270:701—8.
  • Gregori, S., Casorati, M., Amuchastegui, S., Smiroldo, S., Davalli, A.M., and Adorini, L. 2001. Regulatory T cells in-duced by 1alpha,25-dihydroxyvitamin D(3) and mycophenolate mofetil treat-ment mediate transplantation tolerance. J Immunol 167:1945—1953.
  • Canning, M.O., Grotenhuis, K., de Wit, H., Ruwhof, C., and Drexhage, H.A. 2001. 1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the matura tion of fully active immature dendritic cells from monocytes. Eur J Endocrinol 145:351—7.
  • Huisman, A.M., White, K.P., Algra, A., Harth, M., Vieth, R., Jacobs, J.W., Bijlsma, J.W., and Bell, D.A. 2001. Vitamin D lev-els in women with systemic lupus erythe-matosus and fibromyalgia. J Rheumatol 28:2535—9.
  • Mackay, F., Woodcock, S.A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J., and Browning, J.L. 1999. Mice transgenic for BAFF develop lym-phocytic disorders along with autoimmune manifestations. J Exp Med 190:1697—710
  • Strasser, A., Whittingham, S., Vaux, D.L., Bath, M.L., Adams, J.M., Cory, S., and Harris, A.W. 1991. Enforced bcl-2 expression in B-lymphoid cells prolongs anti-body responses and elicits autoimmune disease. Proc Natl Acad Sci U S A 88:8661–8665.
  • Lopez-Hoyos, M., Carrio, R., Merino, R., Buelta, L., Izui, S., Nunez, G., and Me-rino, J. 1996. Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H-2b alloan-tigens. J Exp Med 183:2523—2531.
  • Zhou, L.J., Smith, H.M., Waldschmidt, T.J., Schwarting, R., Daley, J., and Tedder, T.F. 1994. Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lympho-cyte development. Mol Cell Biol 14:3884–3894.
  • Sato, S., Hasegawa, M., Fujimoto, M., Tedder, T.F., and Takehara, K. 2000. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 165:6635—6643.
  • Ogueta, S., Olazabal, I., Santos, I., Delgado-Baeza, E., and Garcia-Ruiz, J.P. 2000. Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies. J Endocrinol 165:321—328.
  • Seery, J.P., Carroll, J.M., Cattell, V., and Watt, F.M. 1997. Antinuclear autoantibod-ies and lupus nephritis in transgenic mice expressing interferon gamma in the epi-dermis. J Exp Med 186:1451—1459.
  • Niki, Y., Yamada, H., Seki, S., Kikuchi, T., Takaishi, H., Toyama, Y., Fujikawa, K., and Tada, N. 2001. Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice. J Clin Invest 107:1127—1135.
  • Erb, K.J., Ruger, B., von Brevern, M., Ryffel, B., Schimpl, A., and Rivett, K. 1997. Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice. J Exp Med 185:329—339.
  • Turksen, K., Kupper, T.S., Degenstein, L., Williams, I., and Fuchs, E. 1992. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A 89:5068—5072.
  • Ohashi, P.S., Oehen, S., Buerki, K., Pircher, H., Ohashi, C.T., Odermatt, B., Malissen, B., Zinkernagel, R.M., and Hengartner H. 1991. Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305—17.
  • Khare, S.D., Sarosi, I., Xia, X.Z., McCabe, S., Miner, K., Solovyev, I., Hawkins, N., Kelley, M., Chang, D., Van, G., Ross, L., Delaney, J., Wang, L., Lacey, D., Boyle, W.J., and Hsu, H. 2000. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc Natl Acad Sci U S A 97:3370—3375.
  • Vassar, R. and Fuchs, E. 1991. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev 5:714—727.
  • Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D., and Kollias, G. 1991. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025—4031.
  • Gross, J.A., Johnston, J., Mudri, S., Enselman, R., Dillon, S.R, Madden, K., Xu, W., Parrish-Novak, J., Foster, D., Lofton-Day, C., Moore, M., Littau, A., Grossman, A., Haugen, H., Foley, K., Blumberg, H., Harrison, K., Kindsvogel, W., and Clegg, C.H. 2000. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404:995—999.
  • Salvador, J.M., Hollander, C.M., Nguyen, A.T., Kopp, J.B., Barisoni, l., Moore, J.K., Ashwell, J.D., and Fornace, A.J., Jr. 2002. Mice lacking the p53 effector gene GADD45a develop a lupus-like syndrome. Immunity 16:499—508.
  • Bolland, S., Yim, Y.-S., Tus, K., Wakeland, E.K., and Ravetch, J.V. 2002. Genetic modi-fiers of systemic lupus erythemotosus in FcgRII-/- mice. J Exp Med 195: 1167—1174.
  • Bouillet, P., Metcalf, D., Huang, D.C., Tarlinton, D.M., Kay, T.W., Kontgen, F., Adams, J.M., and Strasser, A. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmu-nity. Science 286:1735—1738.
  • Horak, I., Lohler, J., Ma, A., and Smith, K.A. 1995. Interleukin-2-deficient mice: a new model to study autoimmunity and self-tolerance. Immunol Rev 148:35—44.
  • Nishizumi, H., Taniuchi, I., Yamanashi, Y., Kitamura, D., Ilic, D., Mori. S., and Watanabe, T., and Yamamoto, T. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3:549—560.
  • Hibbs, M.L., Tarlinton, D.M., Armes, J., Grail, D., Hodgson, G., Maglitto, R., Stacker, S.A., and Dunn, A.R. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301—311.
  • Nishimura, H., Nose, M., Hiai, H., Minato, N., and Honjo, T. 1999. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11:141—151.
  • Yan, M., Wang, H., Chan, B., Roose-Girma, M., Erickson, S., Baker, T., Tumas, D., Grewal, I.S., and Dixit, V.M. 2001. Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2:638–43.
  • Kulkarni, A.B., Huh, C.-G., Becker, D., Geiser, A., Lyght, M., Flanders, K.C., Roberts, A.B., Sporn, M.B., Ward, J.M., and Karlsson, S. 1993. Transforming growth factor beta1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90:770—774.
  • Taylor, G.A., Carballo, E., Lee, D.M., Lai, W.S., Thompson, M.J., Patel, D.D., Schenkman, D.I., Gilkeson, G.S., Broxmeyer, H.E., Haynes, B.F., and Blackshear, P.J. 1996. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity re-sulting from tristetraprolin (TTP) defi-ciency. Immunity 4:445—454.
  • Zhou, T., Edwards, C.K., 3rd, Yang, P., Wang, Z., Bluethmann, H., and Mountz, J.D. 1996. Greatly accelerated lymphad-enopathy and autoimmune disease in lpr mice lacking tumor necrosis factor recep-tor I. J Immunol. 156:2661—2665.
  • DesJardin, L.E., Butfiloski, E.J., Sobel, E.S., and Schiffenbauer, J. 1996. Hyperproliferation of BXSB B cells is linked to the Yaa allele. Clin Immunol Immunopathol 81:145—152.
  • HogenEsch, H., Gijbels, M.J., Offerman, E., van Hooft, J., van Bekkum, D.W., and Zurcher, C. 1993. A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol 143:972—982.
  • Pelsue, S.C., Schweitzer, P.A., Schweitzer, I.B., Christianson, S.W., Gott, B., Sundberg, J.P., Beamer, W.G., and Shultz, L.D. 1998. Lymphadenopathy, elevated serum IgE lev-els, autoimmunity, and mast cell accumulation in flaky skin mutant mice. Eur J Immunol 28: 1379—1388.
  • Peng, S.L., Madaio, M.P., and Craft, J. 1996. Systemic autoimmunity in LG/J mice. Immunol Lett 53:153—155.
  • Tsui, F.W., and Tsui, H.W. 1994. Molecu-lar basis of the motheaten phenotype. Immunol Rev 138:185—206.
  • Wang, Y., Nose, M., Kamoto, T., Nishimura, M., and Hiai, H. 1997. Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol 151: 1791—1798.
  • Theofilopoulos, A.N., Balderas, R.S., Shawler, D.L., Lee, S., and Dixon, F.J. 1981. Influence of thymic genotype on the systemic lupus erythematosus-like dis-ease and T cell proliferation of MRL/ Mp-lpr/lpr mice. J Exp Med 153:1405–1414.
  • Rozzo, S. J., Vyse, T. J., Menze, K., Izui, S., and Kotzin, B. L. 2000. Enhanced sus-ceptibility to lupus contributed from the nonautoimmune C57BL/10, but not C57BL/6, Genome. J Immunol 164: 5515- 5521.
  • Walker, S.E., Gray, R.H., Fulton, M., Wigley, R.D., and Schnitzer, B. 1978. Palmerston North mice, a new animal model of systemic lupus erythematosus. J Lab Clin Med 92:932—945.
  • Green, M.C., Sweet, H.O., and Bunker, L.E. 1976. Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. Am J Pathol 82:493—512.
  • Siracusa, L.D., McGrath, R., Ma, Q., Moskow, J.J., Manne, J., Christner, P.J., Buchberg, A.M., and Jiminez, S.A. 1996. A tandem dublication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res 10:505—517.
  • Peters, J. and Ball, S.T. 1986. Tight skin-2 (TSK-2). Mouse Newslett 74: 91—92.
  • Christner, P.J., Peters, J., Hawkins, D., Siracusa, L.D., and Jiminez, S.A. 1995. The tight skin 2 mouse: an animal model of scleroderma displaying cutaneous fi-brosis and mononuclear cell infiltration. Arthritis Rheum 38:1791—1799.
  • Koch, P.J., Mahoney, M.G., Ishikawa, H., Pulkkinen, L., Uitto, J., Shultz, L., Murphy, G.F., Whitaker-Menezes, D., and Stanley, J.R. 1997. Targeted dis-ruption of the pemphigus vulgaris anti-gen (desmoglein 3) gene in mice causes loss of keratinocyte adhesion with a phe-notype similar to pemphigus vulgaris. J Cell Biol 137:1091—1102.

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