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Research Article

Biogenic Amines and Polyamines: Similar Biochemistry for Different Physiological Missions and Biomedical Applications

Pages 23-59 | Published online: 29 Sep 2008

References

  • Aghajanian, G. K. and Marek, G. J. 2000. Serotonin model of schizophrenia: emergingrole of glutamate mechanisms. Brain Res Rev 31:302—312.
  • Almrud, J. J., Oliveira, M. A., Kern, A. D., Grishin, N. V., Phillips, M. A., and Hackert, M. L. 2000. Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structuralinsights to antizyme binding. J Mol Biol 295:7—16.
  • Al-shabanah, O. A. and Raza, M. 1999. Effect of ulceration on rat gastric tissue polyamine contents in response to different procedures; inhibition of these effects by cimetidine. Pharmacol Res 40:75—82.
  • Andreasson, B., Nordenskiold, L., Braunlin, W.H., Schultz, J., and Stilbs, P. 1993. Localised interaction of the polyamine methylspermidine with double-helical DNA as monitored by 1H NMR self-diffusion measurements. Bio-chemistry 32:961—967.
  • Andreasson, B., Nordenskiold, L., and Schultz, J. 1996. Interactions of spermidine and methylspermidine with DNA studied by nuclear magnetic resonance self-diffusion measurements. Biophys J 70:2847—2856.
  • Araki, M., Nakamura, M., Takenoshita, S., Shoda, H., Nagamachi, Y., and Matsuzaki, S. 1991. Effects of dexamethasone on the activity of histidine decarboxylase, ornithine decarboxylase, and dopa decarboxy-lase in rat oxyntic mucosa. Can J Physiol Pharmacol 69:37—42.
  • Aziz, S. M., Yatin, M., Worthen, D. R., Lipke, D. W., and Crooks, P. A. 1998. A novel technique for visualizing the intracellular localization and distribution of transported polyamines in cultured pulmonary artery smooth muscle cells. J Pharm Biomed Anal 17:307—320.
  • Babal, P., Ruchko, M., Campbell, C. C, Gilmour, S. P., Mitchell, J. L., Olson, J. W., and Gillespie, M. N. 2001. Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells. J Pharmacol Exp Ther 296:372—377.
  • Baldwin, D. and Rudge, S. 1995. The role of serotonin in depression and anxiety. Int Clin Psychopharmacol 9:41—45.
  • Bartholeyns, J. 1983. Treatment of metastatic Lewis lung carcinoma with DL-alpha-difluoromethylornithine. Eur J Cancer Clin Oncol 19:567—572.
  • Bartholeyns, J. and Bouclier, M. 1984. Involve-ment of histamine in growth of mouse and rat tumors: antitumoralproperties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Cancer Res 44:639—645.
  • Bengtsson, F. 1999. Brain tryptophan/serotonin perturbations in metabolic encephalopa-thy and the hazards involved in the use of psychoactive drugs. Adv Exp Med Biol 467:139—154
  • Berk, M. 2000. Selective serotonin reuptake inhibitors in mixed anxiety-depression. Int Clin Psychopharmacol 15:S41–S45.
  • Bernstein, H. G. and Muller, M. 1999. The cel-lular localization of the L-ornithine decar-boxylase/polyamine system in normal and diseased central nervous systems. Prog Neurobiol 57:485—505.
  • Betoldi, M., Castellani, S., and Volttatorni, C. B. 2001. Mutation of residues in the coen-zyme binding pocket of dopa decarboxy-lase. Effects on catalytic properties. Eur J Biochem 268:2975—2981.
  • Binda, C., Mattevi, A., and Edmondson, D. E. 2002. Structure-function relationships in flavoenzyme-dependent amine oxidations. J Biol Chem 277:23973—23976.
  • Brooks, H. B. and Phillips, M. A. 1997. Charac-terization of the reaction mechanism for Trypanosoma brucei ornithine decarboxy-lase by multiwavelength stopped-flow spectroscopy. Biochemistry 36:15147–15155.
  • Brown, R. E., Stevens, D. R., and Haas, H. L. 2001. The physiology of brain histamine. Prog Neurobiol 63:637—672.
  • Bruun, L., Hlgdall, E. V., Vuust, J., and Houen, G. 1998. Polyamine-stimulated binding of diamine oxidase to DNA. Acta Chem Scand 52:921—929.
  • Burkhard, P., Dominici, P., Borri-Voltattorni, C., Jansonius, J. N., and Malashkevich, V. N. 2001. Structural insight into Parkinson's dis-ease treatment from drug-inhibited DOPA decarboxylase. Nat Struct Biol 8:963—967.
  • Byk, G., Soto, J., Matter, C., Frederic, M., and Scherman, D. 1998. Novel non-viral vectors for gene delivery: synthesis of a second-generation library of mono-functionalized poly-(guanidinium) amines and their introduction into cationic lipids. Biotechnol Bioeng 1998:81—87.
  • Casero, R. A., Jr. and Pegg, A. E. 1993. Spermi-dine/spermine N1-acetyltransferase-the turning point in polyamine metabolism. FASEB J 7:653—661.
  • Chen, Y., Kramer, D. L., Diegelman, P., Vujcic, S., and Porter, C. W. 2001. Apoptotic sig-naling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res 61:6437—6444.
  • Cohen, S.S. 1998. A Guide to the Polyamines. Oxford Univ. Press, New York.
  • Coleman, C. S. and Pegg, A. E. 1997. Proteasomal degradation of spermidine/ spermine N 1-acetyltransferase requires the carboxyl-terminal glutamic acid residues. J Biol Chem 272:12164—12169.
  • Coleman, C. S., Stanley, B. A., Viswanath, R., and Pegg, A. E. 1994. Rapid exchange of subunits of mammalian ornithine decarboxylase. J Biol Chem 269:3155—3158.
  • Cullis, P. M., Green, R. E., Merson-Davies, L., and Travis, N. 1999. Probing the mecha-nism of transport and compartmentalisation of polyamines in mammalian cells. Chem Biol 6:717—729.
  • Daeffler, L., Nadra, K., Eichwald, V., Ohresser, S., and Landry, Y. 1999. Effect of NMDA receptor ligands on mast cell histamine re-lease, a reappraisal. Naunyn Schmiedebergs Arch Pharmacol 359:512—528.
  • D'Amore, P. A., Hechtman, H. B., and Shepro, D. 1978. Ornithine decarboxylase activity in cultured endothelial cells stimulated by serum, thrombin and serotonin. Thromb Haemost 39:496—503.
  • Dartsch, C., Chen, D., and Persson, L. 1998. Multiple forms of rat stomach histidine decarboxylase may reflect posttranslational activation of the enzyme. Regul Pept 77:33—41.
  • Dartsch, C., Chen, D., Hakanson, R., and Persson, L. 1999. Histidine decarboxylase in rat stomach ECL cells: relationshipbe-tween enzyme activity and different mo-lecular forms. Regul Pept 81:41—48.
  • Davidson, N. E., Hahm, H. A., McCloskey, D. E., Woster, P. M., and Casero, R. A., Jr. 1999. Clinical aspects of cell death in breast cancer: thepolyamine pathway as a new target for treatment. Endocr Relat Cancer 6:69—73.
  • Deakin, J. F. 1998. The role of serotonin in panic, anxiety and depression Int Clin Psychopharmacol 13:S1–S5.
  • Del Valle, J. and Gantz, I. 1997. Novel insights into histamine H2 receptor biology. Am J Physiol 273:G987–G996.
  • Deng, H., Bloomfield, V.A., Benevides, J.M., and Thomas, G.J., Jr. 2000. Structural ba-sis of polyamine-DNA recognition: sper-midineand spermine interactions with genomic B-DNAs of different GC content probed by Raman spectrocopy. Nucleic Acid Res 28:3379—3385.
  • Ding, X. Q., Chen, D., Rosengren, E., Persson, L., and Hakanson, R. 1996. Comparison between activation of ornithine decarboxy-lase and histidine decarboxylase in rat stomach. Am J Physiol 270:G476–G486.
  • Drew, H.R. and Dickerson, R.E. 1981. Structure of a B-DNA dodecamer. III. Geometry of hydration. J. Mol Biol 151:535—556.
  • Drew, H.R., Takano, T., Tanaka, S., Itakura, K., and Dickerson, R.E. 1980. High-salt d(CpGpCpG), a left-handed Z' DNA double helix. Nature 286:567—573.
  • Efange, S. M. 2000. In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter. FASEB J 14:2401—2413.
  • Egli, M., Williams, L.D., Gao, Q., and Rich, A. 1991. Structure of the pure-spermine form of Z-DNA (magnesium free) at 1-A resolution. Biochemistry 30:11388—11402.
  • Eiden, L. E. 2000. The vesicular neurotransmit-ter transporters: current perspectives and future prospects. FASEB J 14:2396—2400.
  • Ekker, M. and Sourkes, T. L. 1987. Decreased activity of adrenal S-adenosylmethionine decarboxylase in rats subjected to dopam-ine agonists, metabolic stress, or bodily immobilization. Endocrinology 120:1299—1307.
  • Endo, Y. 1989. Induction of histidine and orni-thine decarboxylase activities in mouse tissues by recombinant interleukin-1 and tumor necrosis factor. Biochem Pharmacol 38:1287—1292.
  • Engel, N., Olmo, M. T., Coleman, C. S., Medina, M. A., Pegg, A. E., and Sanchez-Jimenez, F. 1996. Experimental evidence for struc-ture-activity features in common between mammalian histidine decarboxylase and ornithine decarboxylase. Biochem J 320:365—368.
  • Erwin, B. G. and Pegg, A. E. 1986. Regulation of spermidine/spermine N 1-acetyltransferase in L6 cells by polyamines and related com-pounds. Biochem J 238:581—587.
  • Facchiano, F., D'Arcangelo, D., Riccomi, A., Lentini, A., Beninati, S., and Capogrossi, M. C. 2001. Transglutaminase activity is involved in polyamine-induced pro-grammed cell death. Exp Cell Res 271:118—129.
  • Fajardo, I., Urdiales, J. L., Medina, M. A., and Sanchez-Jimenez, F. 2001a. Effects of phorbol ester and dexamethasone treat-ment on histidine decarboxylase and ornithine decarboxylase in basophilic cells. Biochem Pharmacol 61:1101—1106.
  • Fajardo, I., Urdiales, J. L., Paz, J. C, Chavarra, T., Sanchez-Jimenez, F., and Medina, M. A. 2001b. Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures. Eur J Biochem 268:768—773.
  • Fajardo, I., Urdiales, J. L., Sanchez-Jimenez, F., and Medina, M. A. 2000. An experiment on apoptosis induced by polyamine ad-ducts produced in the presence of serum amine oxidase. Biochem Educ 28:110—112.
  • Fell, D. 1997. Understanding the Control of Metabolism, Portland Press, London.
  • Feuerstein, B.G., Pattabiraman, N., and Marton, L.J. 1986. Spermine-DNA interactions: a theoretical study. Proc Natl Acad Sci USA 83:5948—5992.
  • Feuerstein, B.G., Pattabiraman, N., and Marton, L.J. 1990. Molecular mechanics of the interactions of spermine with DNA:DNA bending as a result of ligand binding. Nucleic Acid Res 18:1271—1282.
  • Feuerstein, B.G., Williams, L.D., Basu, H.S. and Marton, L.J., 1991. Implications and concepts of polyamine-nucleic acid interactions. J Cell Biochem 46:37—47.
  • Fleming, J. V. and Wang, T. C. 2000. Amino-and carboxy-terminal PEST domains mediate gastrin stabilization of rat L-histidine decarboxylase iso forms. Mol Cell Biol 20:4932—4947.
  • Friedman, J. I., Adler, D. N., and Davis, K. L. 1999. The role of norepinephrine in the pathophysi-ology of cognitive disorders: potential applications to the treatment of cognitive dysfunc-tion in schizophrenia and Alzheimer's disease. Biol Psychiatry 46:1243—1252.
  • Fuhr, N. and Kownatzki, E. 1986. Inhibition of rat kidney histamine N-methyltransferase by biogenic amines. Pharmacology 32:114—120.
  • Galea, E., Regunathan, S., Eliopoulos, V., Feinstein, D.L., and Reis, D.J. 1996. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 316:247—249.
  • Ghoda, L., Sidney, D., Macrae, M., and Coffino, P. 1992. Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation. Mol Cell Biol 12:2178—2185.
  • Gibson, W. and Roizman, B. 1971. Compart-mentalization of spermine and spermidine in the herpes simplex virion. Proc Natl Acad Sci USA 68:2818—2821.
  • Girard, B., Otterness, D. M., Wood, T. C., Honchel, R., Wieben, E. D., and Weinhshilboum, R. M. 1994. Human his-tamine N-methyltransferase pharmaco-genetics: cloning and expression of kid-ney cDNA. Mol Pharmacol 45:461—468.
  • Graff, L., Frungieri, M., Zanner, R., Pohlinger, A., Prinz, C., and Gratzl, M. 2002. Expression of histidine decarboxylase and synthe-sis of histamine by human small cell lung carcinoma. Am J Pathol 160:1561—1565.
  • Grishin, N. V., Phillips, M. A., and Goldsmith, E. J. 1995. Modeling of the spatial structure of eukaryotic ornithine decarboxy-lases. Protein Sci 4:1291—1304.
  • Grosberg, A.Y. and Zhestkov, A.V. 1986. On the compact form of linear duplex DNA: globular states of the uniform elastic (persistent) macromolecule. J Biomol Struct Dynam 3:859—872.
  • Ha H.C., Yager, J.D., Woster, P.A., and Casero, Jr., R.A. 1998. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun 244:298- 303.
  • Haroon, Z. A., Lai, T. S., Hettasch, J. M., Lindberg, R. A., Dewhirst, M. W., and Greenberg, C. S. 1999. Tissue transglutaminase is expressed as a host response to tumor invasion and inhibits tumor growth. Lab Invest 79:1679–1686.
  • Hart, P. H., Grimbaldeston, M. A., and Finlay-Jones, J. J. 2001. Sunlight, immunosup-pression and skin cancer: roleof histamine and mast cells. Clin Exp Pharmacol Physiol 28:1—8.
  • Hasan, R., Alam, K., and Ali, R., 1995. Polyamine induced Z-conformation of native calf-thymus DNA. FEBS Lett 368:27—30.
  • Hayashi, H. 1995. Pyridoxal enzymes: mecha-nisticdiversity and uniformity. J Biochem 118:463—473.
  • Hayashi, S., Murakami, Y., and Matsufuji, S. 1996. Ornithine decarboxylase antizyme: anovel type of regulatory protein. Trends Biochem Sci 21:27—30.
  • Heby, O. and Persson, L. 1990. Molecular ge-netics of polyamine synthesis in eukary-otic cells. Trends Biochem Sci 15:153- 158.
  • Heleniak, E. and O'Desky, I. 1999. Histamine and prostaglandins in schizophrenia: revis-ited. Med Hypotheses 52:37—42.
  • Hellstrand, K. 2002. Histamine in cancer immu-notherapy: a preclinical background. Semin Oncol 29:35—40.
  • Hellstrand, K., Brune, M., Naredi, P., Mellqvist, U. H., Hansson, M., Gehlsen, K. R., and Hermodsson, S. 2000. Histamine: a novel approach to cancer immunotherapy. Can-cer Invest 18:347—355
  • Hirsch, S. R., Richardson-Andrews, R., Costall, B., Kelly, M. E., de Belleroche, J., and Naylor, R. J. 1987. The effects of some polyamines on putative behavioural indices of mesolimbic versus striatal dopam-inergic function. Psychopharmacology 93:101—104.
  • Horton, J. R., Sawada, K., Nishibori, M., Zhang, X., and Cheng, X. 2001. Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure 9:837—849.
  • Igarashi, K. and Kashiwagi, K. 1999. Polyamine transport in bacteria and yeast. Biochem J 344:633—642.
  • Igarashi, K. and Kashiwagi, K. 2000. Polyamines:mysteriousmodulators of cellular functions. Biochem Biophys Res Commun 271:559—564.
  • Ingi, T., Worley, P. F., and Lanahan, A. A. 2001. Regulation of SSAT expression by synaptic activity. Eur J Neurosci 13:1459–1463.
  • Iqbal, N. and van Praag, H. M. 1995. The role of serotonin in schizophrenia. Eur Neuropsychopharmacol 5:11—23.
  • Iversen, L. 2000. Neurotransmitter transporters: fruit-ful targets for CNS drug discovery. Mol Psy-chiatry 5:357—362.
  • Jackson, L. K., Brooks, H. B., Osterman, A. L., Goldsmith, E. J., and Phillips, M. A. 2000. Altering the reaction specificity of eukary-otic ornithine decarboxylase. Biochemis-try 39:11247—11257.
  • Jain, S., Zon, G., and Sundaralingam, M. 1989. Base only binding of spermine in the deep groove of the A-DNA octamer d(GTGTACAC). Biochemistry 28:2360–2364.
  • Jalkanen, S. and Salmi, M. 2001. Cell surface monoamine oxidases: enzymes in search of a function. Embo J 20:3893—3901.
  • Kapur, S. and Remington, G. 1996. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 153:466–476.
  • Kern, A. D., Oliveira, M. A., Coffino, P., and Hackert, M. L. 1999. Structure of mam-malian ornithine decarboxylase at 1.6-A resolution: stereochemical implications of PLP-dependent amino acid decarboxy-lases. Structure Fold Des 7:567—581.
  • Kitanaka, J., Kitanaka, N., Tsujimura, T., Kakihana, M., Terada, N., and Takemura, M. 2001. Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution. Jpn J Pharmacol 85:105—108.
  • Korolev, N., Lyubartsev, A.P., Nordenskiold, L., and Laaksonen, A. 2001. Spermine:an“invisible” component in the crystals of B-DNA. A gran canonical Monte Carlo and molecular dynamics simulation study. J Mol Biol 308:907—917.
  • Kuhl, D. E., Minoshima, S., Fessler, J. A., Frey, K. A., Foster, N. L., Ficaro, E. P., Wieland, D. M., and Koeppe, R. A. 1996. In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease. Ann Neurol 40:399—410.
  • Lecklin, A., Eriksson, L., Leppaluoto, J., Tarhanen, J., and Tuomisto, L. 1999. Metoprine-induced thirst and diuresis in Wistar rats. Acta Physiol Scand 165:325—333.
  • Lesort, M., Tucholski, J., Miller, M. L., and Johnson, G. V. 2000. Tissue transglutaminase: apossible role in neurodegenerative diseases. Prog Neurobiol 61:439—463.
  • Leurs, R., Blandina, P., Tedford, C, and Timmerman, H. 1998. Therapeutic poten-tial of histamine H3 receptor agonists and antagonists. Trends Pharmacol Sci 19:177—183.
  • Li, S., Regunathan, S., Barrow, C.J., Eshraghi, J., Cooper, R., and Reis, D.J. 1994. Agma-tine:anendogenous clonidine-displacing substance in the brain. Science 263:966—969.
  • Li, G., Regunathan, S., and Reis, D.J. 1995. Agmatine is synthesized by a mitochon-drial arginine decarboxylase in rat brain. Ann N Y Acad Sci. 763:325—329.
  • Liquori, A.M., Constantino, L., Crescenzi, V., Elia, V., Giglio, E., Puliti, R., De Santis-Savino, M., and Vitagliano, V. 1967. Complexes between DNA and polyamines: a molecular model. J Mol Biol 24:113—122.
  • Lortie, M.J., Novotny, W.F., Peterson, O.W., Vallon, V., Malvey, K., Mendonca, M., Satriano, J., Insel, P., Thompson, S.C., and Blantz, R.C. 1996. Agmatine, a bioactive metabolite of arginine. Production, degradation and functional effects in the kidney of the rat. J Clin Invest 97:413—420.
  • Lundstrom, K., Tenhunen, J., Tilgmann, C, Karhunen, T., Panula, P., and Ulmanen, I. 1995. Cloning, expression and structure of catechol-O-methyltransferase. Biochim Biophys Acta 1251:1—10.
  • Mannisto, P. T. and Kaakkola, S. 1999. Cat-echol-O-methyltransferase (COMT): bio-chemistry, molecular biology, pharmacol-ogy, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51:593—628.
  • Marquet, R. and Houssier, C. 1988. Different binding modes of spermine to A-T and G-C base pairs modulate the bending and stiffening of the DNA double helix. J Biomol Struct Dynamics 6:235—246.
  • Mates, J. M., Sanchez-Jimenez, F., Lopez-Herrera, J., and Nunez de Castro, I. 1991. Regulation by 1,4-diamines of the orni-thine decarboxylase activity induced by ornithine in perifused tumor cells. Biochem Pharmacol 42:1045—1052.
  • Mathew, N. T. 1997. Serotonin 1D (5-HT1D) agonists and other agents in acute migraine. Neurol Clin 15:61—83.
  • Medina, M. A., Garcia de Veas, R., Morata, P., Lozano, J., and Sanchez-Jimenez, F. 1995. Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat 35:187—194.
  • Medina, M. A., Quesada, A. R., Nunez de Castro, I., and Sanchez-Jimenez, F. 1999. Hista-mine, polyamines, and cancer. Biochem Pharmacol 57:1341—1344.
  • Medina, M. A., Ramfrez, F. J., Ruiz-Chica, J., Chavarria, T., Lopez-Navarrete, J. T., and Sanchez-Jimenez, F. 1998. DNA-chlorpheniramine interaction studied by spectroscopic techniques. Biochim Biophys Acta 1379:129—133.
  • Medina, M. A. and Schwille, P. 2002. Fluorescence correlation spectroscopy for the detection and study of single molecules in biology. Bioessays, in press.
  • Medina, M. A., Urdiales, J. L., Nunez de Castro, I., and Sanchez-Jimenez, F. 1991. Di-amines interfere with the transport of L-ornithine in Ehrlich-cell plasma-membrane vesicles. Biochem J 280:825—827.
  • Mefford, I. N. and Potter, W. Z. 1989. A neu-roanatomical and biochemical basis for attention deficit disorder with hyperactiv-ity in children: a defect in tonic adrenaline mediated inhibition of locus coeruleus stimulation. Med Hypotheses 29:33—42.
  • Mehta, P. K. and Christen, P. 2000. The molecular evolution of pyridoxal-5'-phos-phate-dependent enzymes. Adv Enzymol Relat Areas Mol Biol 74:129—184.
  • Melino, G. and Piacentini, M. 1998. 'Tissue' transglutaminase in cell death: a down-stream or a multifunctional upstream ef-fector? FEBS Lett 430:59—63.
  • Meyer, J. L., Hall, A. C, and Harrington, M. E. 1998. Histamine phase shifts the hamster cir-cadian pacemaker via an NMDA-dependent mechanism. J Biol Rhythms 13:288—295.
  • Miller, G. M., Yatin, S. M., De La Garza, R., 2nd, Goulet, M., and Madras, B. K. 2001. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevanceto cocaine sensitivity. Brain Res Mol Brain Res 87:124—143.
  • Mistri, S.K., Burwell, T.J., Chambers, R.M., Rudolph-Owen, L., Spaltmann, F., Cook, W.J., and Morris, S.M., Jr. 2002. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. Am J Physiol 282:G375–G381.
  • Miyawaki, E., Meah, Y., and Koller, W. C. 1997. Serotonin, dopamine, and motor effects in Parkinson's disease. Clin Neuropharmacol 20:300—310.
  • Molderings, G.J., Burian, M., Menzel, S., Donecker, K., Homann, J., Nihius, M., and Gothert, M. 1999. Imidazoline recognition sites and stomach function. Ann N Y Acad Sci 881:332—343.
  • Momany, C, Ghosh, R., and Hackert, M. L. 1995. Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxy-lase. Protein Sci 4:849—854.
  • Morrissey, J., McCracken, R., Ishidoya, S., and Klahr, S. 1996. Partial cloning and char-acterization of an arginine decarboxylase in the kidney. Kidney Int 47:1458—1461.
  • Mossner, R., Schmitt, A., Syagailo, Y., Gerlach, M., Riederer, P., and Lesch, K. P. 2000. The serotonin transporter in Alzheimer's and Parkinson's disease. J Neural Transm Suppl 60:345—350
  • Nair, G. V., Gurbel, P. A., O'Connor, C. M., Gattis, W. A., Murugesan, S. R., and Serebruany, V. L. 1999. Depression, coro-nary events, platelet inhibition, and serotonin reuptake inhibitors. Am J Cardiol 84:321—328.
  • Oh, S. J., Ha, H. J., Chi, D. Y., and Lee, H. K. 2001. Serotonin receptor and transporter ligands- current status. Curr Med Chem 8:999—1034.
  • Olmo, M. T., Rodriguez-Agudo, D., Medina, M. A., and Sanchez-Jimenez, F. 1999. The PEST-regions containing C-termini of mammalian ornithine decarboxylase and histidine decarboxylase play different roles in protein degradation. Biochem Biophys Res Commun 257:269—272.
  • Olmo, M. T., Sanchez-Jimenez, F., Medina, M. A., and Hayashi, H. 2002. Spectro-scopic analysis of recombinant rat histidine decarboxylase. J. Biochem. 132: 433—439.
  • Olmo, M. T., Urdiales, J. L., Pegg, A. E., Medina, M. A., and Sanchez-Jimenez, F. 2000. In vitro study of proteolytic degradation of rat histidine decarboxylase. Eur J Biochem 267:1527—1531.
  • Ostrowski, J., Wojciechowski, K., Konturek, S. J., and Butruk, E. 1993. Inhibitory effect of EGF on secretory response of rat parietal cells is associated with an induction of ODC. Am J Physiol 264:C1428–C1433.
  • Pang, Y. P., Zheng, X. E., and Weinshilboum, R. M. 2001. Theoretical 3D model of hista-mine N-methyltransferase: insights into the effects of a genetic polymorphism on enzy-matic activity and thermal stability. Biochem Biophys Res Commun 287:204—208.
  • Paz, J. C, Sanchez-Jimenez, F., and Medina, M. A. 2001. Characterization of spermine uptake by Ehrlich tumour cells in culture. Amino Acids 21:271—279
  • Pegg, A. E. 1986. Recent advances in the bio-chemistry of polyamines in eukaryotes. Biochem J 234:249—62.
  • Pegg, A. E. and Erwin, B. G. 1985. Induction of spermidine/spermine N 1-acetyltransferase in rat tissues by polyamines. Biochem J 231:285—289.
  • Penner, S.B. and Smyth, D.D. 1996. Natriuresis following central and peripheral administration of agmatine in the rat. Pharmacol-ogy 53:160—169.
  • Persson, L. and Rosengren, E. 1987. Dopamin-ergic regulation of polyamine synthesis in the rat pituitary gland. Mol Cell Endocrinol 51:219—225.
  • Piacentini, M., Rodolfo, C, Farrace, M. G., and Autuori, F. 2000. “Tissue” transglutaminase in animal development. Int J Dev Biol 44:655—662.
  • Porter, C.W. and Bergeron, R. J. 1988. Enzyme regulation as an approach to interference with polyamine biosynthesis- an alternative to enzyme inhibition. Adv Enzyme Reg 27:57—79.
  • Premont, R. T., Gainetdinov, R. R., and Caron, M. G. 2001. Following the trace of elusive amines. Proc Natl Acad Sci U S A 98:9474–9475.
  • Preuss, C. V., Wood, T. C., Szumlanski, C. L., Raftogianis, R. B., Otterness, D. M., Girard, B., Scott, M. C., and Weinshilboum, R. M. 1998. Human histamine N-methyltransferase pharmacogenetics: common genetic poly-morphisms that alter activity. Mol Pharmacol53:708—717.
  • Purcell, W. M., Doyle, K. M., Westgate, C., and Atterwill, C. K. 1996. Characterization of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex. J Neuroimmunol 65:49- 53.
  • Raasch, W., Regunathan, S., Li, G., and Reis, D.J. 1995. Agmatine, the bacterial amine, is widely distributed in mammalian tis-sues. Life Sci 56:2319—2330.
  • Regunathan, S., Feinstein, D.L., Raasch, W., and Reis, D.J. 1995. Agmatine, the decar-boxylated arginine, is localized and syn-thesized in glial cells. Neuroreport 6:1897- 1900.
  • Regunathan, S., Feinstein, D.L., and Reis, D.J. 1999. Antiproliferative and anti-inflamma-tory actions of imidazoline agents: are imidazoline receptors involved? Ann N Y Acad Sci 881:410—419.
  • Regunathan, S. and Reis, D.J. 1997. Stimulation of imidazoline receptors inhibits proliferation of human coronary artery vascular smooth muscle cells. Hypertension 30:295—300.
  • Regunathan, S. and Reis, D. J. 2000. Character-ization of arginine decarboxylase in rat brain and liver: distinction from ornithine decarboxylase. J Neurochem 74:2201–2208.
  • Regunathan, S., Youngson, C., Raasch, W., Wang, H., and Reis, D.J. 1996. Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation. J Pharmacol Exp Ther 276:1272—1282
  • Reich, Z., Levin-Zaidman, S., Gutman, S.B., Arad, T., and Minsky, A. 1994. Supercoil-ing-regulated liquid-crystalline packaging of topologically constrained, nucleosome-free DNA molecules. Biochemistry 33:14177—14184.
  • Ritz, M. C, Mantione, C. R., and London, E. D. 1994. Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology (Berlin) 114:47—52.
  • Rodriguez-Agudo, D., Olmo, M. T., Sanchez-Jimenez, F., and Medina, M. A. 2000. Rat histidine decarboxylase is a substrate for m-calpain in vitro. Biochem Biophys Res Commun 271:777—781.
  • Rogers, S., Wells, R., and Rechsteiner, M. 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234:364—368.
  • Rudolph, C, Lausier, J., Naundorf, S., Muller, R. H., and Rosenecker, J. 2000. In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers. J Gene Med 2:269—278.
  • Ruiz-Chica, J., Medina, M.A., Sanchez-Jimenez, F., and Ramirez, F.J. 1999. Raman study of the effects of polyamines on DNA: spermine and histamine. J Mol Struct 480—481:455—458.
  • Ruiz-Chica, J., Medina, M.A., Sanchez-Jimenez, F., and Ramirez, F.J. 2001a. Fourier trans-form Raman study of the structural speci-ficities on the interaction between DNA and biogenic polyamines. Biophys J 80:443—454.
  • Ruiz-Chica, J., Medina, M.A., Sanchez-Jimenez, F., and Ramirez, F.J. 2001b. Characteriza-tion of polyamine-induced aggregates of oligodeoxyribonucleotides by Raman spec-troscopy. J Mol Struct 565—566:141—146.
  • Ruiz-Chica, J., Medina, M.A., Sanchez-Jimenez, F., and Ramirez, F.J. 2001c. Raman study of the interaction between polyamines and a GC oligonucleotide. Biochem Biophys Res Commun 285:437—446.
  • Russell, D. H. 1983. Clinical relevance of polyamines. Crit Rev Clin Lab Sci 18:261–311
  • Sandmeier, E., Hale, T. I., and Christen, P. 1994. Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decar-boxylases. Eur J Biochem 221:997—1002.
  • Sastre, M., Galea, E., Reis, D.J., and Regunathan, S. 1998. Metabolism of agmatine in macrophages: modulation by lipopolysacharides and inhibitory cytokines. Biochem J 330:1405—1409.
  • Sastre, M., Regunathan, S., Galea, E., and Reis, D.J. 1996. Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatine. J Neurochem 67:1761—1765.
  • Satriano, J., Matsufuji, S., Murakami, Y., Lortie, M.J., Schwartz, D., Kelly, C.J., Hayashi, S., and Blantz, R. 1998. Agmatine sup-presses proliferation by frameshift induction of antizyme and attenuation of cellu-lar polyamine levels. J Biol Chem 273:15313—15316.
  • Schellman, J.A. and Parthasarathy, N. 1984. X-ray diffraction studies on cation-col-lapsed DNA. J Mol Biol 175:313—329.
  • Seiler, N. and Douaund, F. 1998. Polyamine metabolism and transport in the mamma-lian organism. In: COST 917 Biogenically active amines in food. Metabolic effect of biogenically active amines in foods. II. European Commission publications. Lux-emburg, 19—38.
  • Seiler, N., Atanassov, C. L., and Raul, F. 1998. Polyamine metabolism as target for cancer chemoprevention (review). Int J Oncol 13:993—1006.
  • Seiler, N., Delcros, J. G., and Moulinoux, J. P. 1996. Polyamine transport in mammalian cells. An update. Int J Biochem Cell Biol 28:843—861.
  • Sener, A., Lebrun, F., Blaicher, F., and Malaisse, W.J. 1989. Stimulus-secretion coupling of arginine-induced insulin release. Insulinitropic action of agmatine. Biochem Pharmacol 38:327—330.
  • Shappell, N. W., Fogel-Petrovic, M. F., and Porter, C. W. 1993. Regulation of spermi-dine/spermine N1-acetyltransferase by in-tracellular polyamine pools. Evidence for a functional role in polyamine homeosta-sis. FEBS Lett 321:179—183.
  • Sharmin, S., Sakata, K., Kashiwagi, K., Ueda, S., Iwasaki, S., Shirahata, A., and Igarashi, K. 2001. Polyamine cytotoxicity in the presence of bovine serum amine oxidase. Biochem Biophys Res Commun 282:228–235.
  • Solai, L. K., Mulsant, B. H., and Pollock, B. G. 2001. Selective serotonin reuptake inhibi-tors for late-life depression: a comparative review. Drugs Aging 18:355—368
  • Southwick, S. M., Bremner, J. D., Rasmusson, A., Morgan, C. A., 3rd, Arnsten, A., and Charney, D. S. 1999. Role of norepineph-rine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psy-chiatry 46:1192—1204.
  • Stark, H., Arrang, J. M., Ligneau, X., Garbarg, M., Ganellin, C. R., Schwartz, J. C., and Schunack, W. 2001. The histamine H3 receptor and its ligands. Prog Med Chem 38:279—308.
  • Stickle, D., Bohrer, A., Berger, R., Morrisey, J., Klahr, S., and Turk, J. 1996. Quantitation of the putative neurotransmitter agmatine as the hexafluoroacetylacetonate deriva-tive by stable isotope dilution gas chroma-tography and negative-ion chemical ion-ization mass spectrometry. Anal Biochem 238:129—136.
  • Suwalsky, M., Traub, W., Shmueli, U., and Subirana, J.A. 1969. An X-ray study of the interaction of DNA with spermine. J Mol Biol 42:363—373.
  • Suzuki, S., Tanaka, S., Nemoto, K., and Ichikawa, A. 1998. Membrane targeting and binding of the 74-kDa form of mouse L-histidine decarboxylase via its carboxyl-terminal sequence. FEBS Lett 437:44—48.
  • Svensson, F., Ceriani, C., Wallstrom, E. L., Kockum, I., Algranati, I. D., Heby, O., and Persson, L. 1997. Cloning of a trypanosomatid gene coding for an orni-thine decarboxylase that is metabolically unstable even though it lacks the C-termi-nal degradation domain. Proc Natl Acad Sci USA 94:397—402.
  • Sy, D., Hugot S., Savoye, C., Ruiz, S., Charlier, M., and Spotheim-Maurizot, M. 1999. Radioprotection of DNA by spermine: a molecular modelling approach. Int J Radiat Biol 75:953—961.
  • Tabor, H. 1962. The protective effect of sper-mine and polyamines against heat dena-turation of deoxyribonuclei acid. Biochem-istry 1:496—501.
  • Tabor, H. and Tabor, C.W. 1984. Polyamines. Annu Rev Biochem 53:749—790.
  • Takemura, M., Tanaka, T., Taguchi, Y., Imamura, I., Mizuguchi, H., Kuroda, M., Fukui, H., Yamatodani, A., and Wada, H. 1992. Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells. J Biol Chem 267:15687–15691.
  • Tanaka, S., Nemoto, K., Yamamura, E., Ohmura, S., and Ichikawa, A. 1997. Degradation of the 74 kDa form of L-histidine decarboxy-lase via the ubiquitin-proteasome pathway in a rat basophilic/mast cell line (RBL-2H3). FEBS Lett 417:203—207.
  • Thomas, T., Shah, N., Klinge, C.M., Faaland, C.A., Adihkarakunnathu, S., Gallo, M.A., and Thomas, T.J. 1999. Polyamine biosyn-thesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells. J Mol Endocrinol 22:131—139.
  • Thomas, T.J. and Messner, R.P. 1986. A left-handed (Z) conformation of poly(dA-dC).poly(dG-dT) induced by polyamines. Nucleic Acid Res 14:6721—6733.
  • Thomas, T.J., Kulkarni, G.D., Greenfield, N., Shirahata, A., and Thomas, T. 1996. Structural specificity effects of trivalent polyamine analogues on the stabilization and conformational plasticity of triplex DNA. Biochem J 319:591—599.
  • Thomas,T., Kulkarni, G.D., Gallo, M.A., Greenfield, N., Lewis, J.S., Shirahata, A., and Thomas, T.J. 1997. Effects of natural and synthetic polyamines on the conformation of an oligodeoxyribonucleotide with the estrogen response element. Nucleic Acid Res 25:2396—2402.
  • Tomasi, S., Le-Roch, M., Renault, J., Corbei, J. C., Uriac, P., Carbone, B., Moncoq, D., Martin, B., and Delcros, J. G. 1998. Solid phase organic synthesis of polyamine de-rivatives and initial biological evaluation of their antitumoral activity. Bioorg Med Chem Lett 8:635—640.
  • Tomitori, H., Kashiwagi, K., Asakawa, T., Kakinuma, Y., Michael, A. J., and Igarashi, K. 2001. Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem J 353:681—688.
  • Tomitori, H., Kashiwagi, K., Sakata, K., Kakinuma, Y., and Igarashi, K. 1999. Iden-tification of a gene for a polyamine transport protein in yeast. J Biol Chem 274:3265—3267.
  • Toninello, A., Dalla Via, L., Siliprandi, D., and Garlid, K. D. 1992. Evidence that sper-mine, spermidine, and putrescine are trans-ported electrophoretically in mitochondria by a specific polyamine uniporter. J Biol Chem 267:18393—18397.
  • Townsend, C. M., Jr., Ishizuka, J., and Thompson, J. C. 1993. Studies of growth regulation in a neuroendocrine cell line. Acta Oncol 32:125—130
  • Tsuboi, M. 1964. On the melting temperature of nucleic acid in solution. Bull Chem Soc Jpn 37:1514—1522.
  • Tsutsumi, J., Takayama, S., and Nimura, H. 1998. Biochemical and immunohistological changes in the gastric mucosa of rats with long-term administration of histamine H2- receptor antagonist. Nippon Shokakibyo Gakkai Zasshi 95:1333—1342.
  • van der Goot, H. and Timmerman, H. 2000. Selective ligands as tools to study hista-mine receptors. Eur J Med Chem 35:5—20.
  • van Veelen, N. M. and Kahn, R. S. 1999. Dopam-ine, serotonin, and schizophrenia. Adv Neurol 80:425—429.
  • Vargiu, C., Cabella, C., Belliardo, S., Cravanzola, C., Grillo, M.A., and Colombatto, S. 1999. Agmatine modulates polyamine content in hepatocytes by inducing spermidine/sper-mine acetyltransferase. Eur J Biochem 259:933—938.
  • Viguera, E., Trelles, O., Urdiales, J. L., Mates, J. M. and Sanchez-Jimenez, F. 1994. Mam-malian L-amino acid decarboxylases pro-ducing 1,4-diamines: analogies among dif-ferences. Trends Biochem Sci 19:318—319.
  • Wang, A.H.-J., Quigley, G.J., Kolpak, F.J., van Boom, J.H., van der Marel, G., and Rich, A. 1981. Left-handed double helical DNA: variations in the backbone conformation. Science 211:171—176.
  • Wang, L., Yan, L., McGuire, C., Kozak, C. A., Wang, M., Kim, U. J., Siciliano, M., and Weinshilboum, R. M. 2001. Mouse hista-mine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflamm Res 50:300—308.
  • Wang, Y., Devereux, W., Stewart, T. M., and Casero, R. A., Jr. 1999. Cloning and char-acterization of human polyamine-modu-lated factor-1, a transcriptional cofactor that regulates the transcription of the sper-midine/spermine N1-acetyltransferase gene. J Biol Chem 274:22095—22101.
  • Wang, Y., Xiao, L., Thiagalingam, A., Nelkin, B.D., and Casero, R. A., Jr. 1998. The identification of a cis-element and a transacting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/ spermine N1-acetyltransferase gene transcription. J Biol Chem 273:34623—34630.
  • Weihe, E. and Eiden, L. E. 2000. Chemical neuroanatomy of the vesicular amine trans-porters. FASEB J 14:2435—2449.
  • Welker, P., Grabbe, J., Grutzkau, A., and Henz, B. M. 1998. Effects of nerve growth factor (NGF) and other fibro-blast-derived growth factors on immature human mast cells (HMC-1). Immu-nology 94:310—317.
  • Wemmer, D.E., Srivenugopal, K.S., Reid, B.R., and Morris, D.R. 1985. Nuclear magnetic resonance studies of polyamine binding to a defined DNA sequence. J Mol Biol 185:457—459.
  • Williams, K. 1997. Modulation and block of ion channels: a new biology of polyamines. Cell Signal 9:1—13.
  • Wu, W.H. and Morris, D.R. 1973. Biosynthetic arginine decarboxylase from Escherichia coli. J Biol Chem 248:1687—1695.
  • Wu, G. and Morris, S.M., Jr. 1998. Arginine metabolism: nitric oxide and beyond. Biochem J 336:1—17.
  • Wurtman, R. J. and Wurtman, J. J. 1996. Brain serotonin, carbohydrate-craving, obesity and depression. Adv Exp Med Biol 398:35—41
  • Yamakura, T. and Shimoji, K. 1999. Subunit-and site-specific pharmacology of the NMDA receptor channel. Prog Neurobiol 59:279—298.
  • Yamamoto, J., Fukui, T., Suzuki, K., Tanaka, S., Yatsunami, K., and Ichikawa, A. 1993. Expression and characterization of recombinant mouse mastocytoma histidine de-carboxylase. Biochim Biophys Acta 1216:431—440.
  • Yamamoto, J., Yatsunami, K., Ohmori, E., Sugimoto, Y., Fukui, T., Katayama, T., and Ichikawa, A. 1990. cDNA-derived amino acid sequence of L-histidine decar-boxylase from mouse mastocytoma P-815 cells. FEBS Lett 276:214—218.
  • Yang, X.C. and Reis, D. J. 1999. Agmatine selectively blocks the N-methyl-D-as-partate subclass of glutamate recep-tor channels in rat hippocampal neurons. J Pharmacol Exp Ther 288:544- 549.
  • Yatsunami, K., Tsuchikawa, M., Kamada, M., Hori, K., and Higuchi, T. 1995. Comparative studies of human recombinant 74- and 54-kDa L-histidine decarboxylases. J Biol Chem 270:30813—30817.

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