54
Views
13
CrossRef citations to date
0
Altmetric
Original Articles

Determination of Dermal Absorption Qsar/Qsprs by Brute Force Regression: Multiparameter Model Development with Molsuite 2000

&
Pages 1927-1942 | Published online: 02 Feb 2011

References

  • Vecchia , B. E. and Bunge , A. L. 2002c . “ Partitioning of chemicals into skin: Results and predictions ” . In Transdermal drug delivery systems , 2nd , Edited by: Guy , R. H. and Hadgraft , J. 143 – 198 . New York : Marcel Dekker .
  • Weast , R. C. and Astle , M. J. 1979 . CRC handbook of chemistry and physics , F44 – F48 . Boca Raton, FL : CRC Press .
  • Wiechers , J. W. 1989 . The barrier function of the skin in relation to percutaneous absorption of drugs . Pharm. Weekbl. (Sci.) , 11 : 185 – 198 .
  • Wilschut , A. , ten Berge , W. F. , Robinson , P. J. and McKone , T. E. 1995 . Estimating skin permeation--The validation of 5 mathematical skin permeation models . Chemosphere , 30 : 1275 – 1296 .
  • Degim , I. T. , Pugh , W. J. and Hadgraft , J. 1998 . Skin permeability data: Anomolous results . Int. J. Pharm. , 170 : 129 – 133 .
  • Flynn , C. L. 1990 . “ Physicochemical determinants of skin absorption ” . In Principles of route-to-route extrapolations for risk assessment , Edited by: Cerrity , T. R. and Henry , C. J. 93 – 127 . New York : Elsevier Science .
  • Frasch , H. F. 2002 . A random walk model of skin permeation . Risk Anal. , 22 : 265 – 276 .
  • Frasch , H. F. and Landsittel , D. P. 2002 . Regarding the sources of data analyzed with quantitative structureskin permeability relationship methods [Commentary on "Investigation of the mechanism of flux across human skin in vitro by quantitative structure permeability relationships"], Eur . J. Pharmaceut. Sci. , 15 : 399 – 403 .
  • Johnson , M. E. , Blankschtein , D. and Langer , R. 1995 . Permeation of steroids through human skin . J. Pharmaceut. Sci. , 84 : 1144 – 1146 .
  • Kier , L B. and Hall , L. H. 1986 . Molecular connectivity in structure-activity analysis , New York : John Wiley and Sons .
  • Abraham , M. H. , Chadha , H. S. and Mitchell , R. C . 1995 . The factors that influence skin penetration of solutes . J. Pharm. Pharmaool. , 47 : 8 – 16 .
  • Barratt , M. D. 1995 . Quantitative structure activity relationships for skin permeability . Toxicol. In Vitro , 9 : 27 – 37 .
  • Bronaugh , R. L. , Stewart , R. F. and Simon , M. 1986 . Methods for in vitro percutaneous absorption studies. VII. Use of excised human skin . 7. Pharm. Sci. , 75 : 1094 – 1097 .
  • Burden , F. R. 1997 . Chemically intuitive molecular index based on the eigenvalues of a modified adjacency matrix . Quant. Struct.-Act.Relat. , 16 : 309 – 314 .
  • Cronin , M. T. D. , Dearden , J. C. , Moss , C. P. and Murray-Dickson , C. 1999 . Investigation of the mechanism of flux across human skin in vitro by quantitative structure-permeability relationships, fur . J. Pharm. Sei. , 7 : 325 – 330 .
  • Dearden , J. C. , Cronin , M. T. D. , Patel , H. and Raevsky , O. A. 2000 . QSAR prediction of human skin permeability coefficients . J. Pharm. Pharmacol. , 52 ( suppl. ) : 221
  • Kirchner , L. A. , Moody , R. P. , Doyle , E. , Bose , R. , Jeffery , J. and Chu , I. 1997 . The prediction of skin permeability using physicochemical data . ATLA , 25 : 359 – 370 .
  • Lohninger , H. , eds. 1999 . Teach/me data analysis , 111 – 126 . Berlin : Springer Verlag .
  • Moody , R. P. 1999 . “ Dermal penetration ” . In Occupational hazards of pesticide exposure. Sampling, monitoring, measuring , Edited by: Ecobichon , D. 81 – 105 . Philadelphia : Taylor & Francis .
  • Moss , C. P. , Dearden , J. C. , Patel , H. and Cronin , M. T. D. 2002 . Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption . Toxicol. In Vitro , 16 : 299 – 317 .
  • Patel , H. , ten Berge , W. and Cronin , M. T. D. 2002 . Quantitative structure-activity relationships (QSARs) for the prediction of skin permeation of exogenous chemicals . Chemosphere , 48 : 603 – 613 .
  • Poda , C. I. , Landsittel , D. P. , Brumbaugh , K. , Sharp , D. S. , Frasch , H. F. and Demchuk , E. 2001 . Random sampling or "random" model in skin flux measurements? [Commentary on "Investigation of the mechanism of flux across human skin in vitro by quantitative structure-permeability relationships"], fur . 7. Pharmaceut. Sci. , 14 : 197 – 200 .
  • Potts , R. O. and Guy , R. H. 1992 . Predicting skin permeability . Pharm. Res. , 9 : 663 – 669 .
  • Roberts , M. S. , Cross , S. E. and Pelleft , M. A. 2002 . “ Skin transport ” . In Dermatological and transdermal formulations , Edited by: Walters , K. A. 89 – 195 . New York : Marcel Dekker .
  • Vecchia , B. E. and Bunge , A. L. 2002a . “ Evaluating the transdermal permeability of chemicals ” . In Transdermal drug delivery systems , 2nd , Edited by: Guy , R. H. and Hadgraft , J. 25 – 55 . New York : Marcel Dekker .
  • Vecchia , B. E. and Bunge , A. L. 2002b . “ Skin absorption databases and predictive equations ” . In Transdermal drug delivery systems , 2nd , Edited by: Guy , R. H. and Hadgraft , J. 57 – 141 . New York : Marcel Dekker .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.