Antimicrobial Peptides of Dairy Proteins: From Fundamental to Applications

References

• Park, Y.W. Overview of bioactive components in milk and dairy products. In Bioactive Components in Milk and Dairy Products; Wiley-Blackwell: Hoboken, NJ, 2009; pp 1–12.
   Google Scholar
• Yeaman, M.R.; Yount, N.Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol. Rev. 2003, 55, 27–55.
   PubMed Web of Science ®Google Scholar
• Théolier, J.; Fliss, I.; Jean, J.; Hammami, R. MilkAMP: A comprehensive database of antimicrobial peptides of dairy origin. Dairy Sci. Technol. 2014, 94, 181–193.
   Google Scholar
• Théolier, J.; Hammami, R.; Labelle, P.; Fliss, I.; Jean, J. Isolation and identification of antimicrobial peptides derived by peptic cleavage of whey protein isolate. J. Funct. Foods 2013, 5, 706–714.
   Web of Science ®Google Scholar
• Jenssen, H.; Hamill, P.; Hancock, R.E.W. Peptide antimicrobial agents. Clin. Microbiol. Rev. 2006, 19, 491–511.
   PubMed Web of Science ®Google Scholar
• Brogden, K.A. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 2005, 3, 238–250.
   Google Scholar
• Yamauchi, K.; Tomita, M.; Giehl, T.J.; Ellison, R.T. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect. Immun. 1993, 61, 719–728.
   PubMed Web of Science ®Google Scholar
• Muñoz, A.; Marcos, J. Activity and mode of action against fungal phytopathogens of bovine lactoferricin-derived peptides. J. Appl. Microbiol. 2006, 101, 1199–1207.
   PubMed Web of Science ®Google Scholar
• Chapple, D.S.; Mason, D.J.; Joannou, C.L.; Odell, E.W.; Gant, V.; Evans, R.W. Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111. Infect. Immun. 1998, 66, 2434–2440.
   PubMed Web of Science ®Google Scholar
• Aguilera, O.; Ostolaza, H.; Quirós, L.M.; Fierro, J.F. Permeabilizing action of an antimicrobial lactoferricin-derived peptide on bacterial and artificial membranes. FEBS Lett. 1999, 462, 273–277.
   PubMed Web of Science ®Google Scholar
• López-Expósito, I.; Amigo, L.; Recio, I. Identification of the initial binding sites of αs2-casein f(183–207) and effect on bacterial membranes and cell morphology. Biochim. Biophys. Acta Biomembr. 2008, 1778, 2444–2449.
   PubMed Web of Science ®Google Scholar
• Ulvatne, H.; Haukland, H.H.; Olsvik, Ø.; Vorland, L.H. Lactoferricin B causes depolarization of the cytoplasmic membrane of Escherichia coli ATCC 25922 and fusion of negatively charged liposomes. FEBS Lett. 2001, 492, 62–65.
   PubMed Web of Science ®Google Scholar
• van der Kraan, M.I.A.; van Marle, J.; Nazmi, K.; Groenink, J.; van ’t Hof, W.; Veerman, E.C.I.; Bolscher, J.G.M.; Amerongen, A.V.N. Ultrastructural effects of antimicrobial peptides from bovine lactoferrin on the membranes of Candida albicans and Escherichia coli. Peptides 2005, 26, 1537–1542.
   Google Scholar
• Wakabayashi, H.; Hiratani, T.; Uchida, K.; Yamaguchi, H. Antifungal spectrum and fungicidal mechanism of an N-terminal peptide of bovine lactoferrin. J. Infect. Chemother. 1996, 1, 185–189.
   PubMedGoogle Scholar
• Bellamy, W.; Wakabayashi, H.; Takase, M.; Kawase, K.; Shimamura, S.; Tomita, M. Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin. Med Microbiol. Immunol. 1993, 182, 97–105.
   PubMed Web of Science ®Google Scholar
• Bellamy, W.; Yamauchi, K.; Wakabayashi, H.; Takase, M.; Takakura, N.; Shimamura, S.; Tomita, M. Antifungal properties of lactoferricin B, a peptide derived from the N-terminal region of bovine lactoferrin. Lett. Appl. Microbiol. 1994, 18, 230–233.
   Web of Science ®Google Scholar
• Andrä, J.; Lohner, K.; Blondelle, S.E.; Jerala, R.; Moriyon, I.; Koch, M.H.J.; Garidel, P.; Brandenburg, K. Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem. J. 2005, 385, 135–143.
   PubMed Web of Science ®Google Scholar
• Sinha, M.; Kaushik, S.; Kaur, P.; Sharma, S.; Singh, T.P. Antimicrobial lactoferrin peptides: The hidden players in the protective function of a multifunctional protein. Int. J. Pept. 2013, 2013, 390230.
   PubMedGoogle Scholar
• Farnaud, S.; Spiller, C.; Moriarty, L.C.; Patel, A.; Gant, V.; Odell, E.W.; Evans, R.W. Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity. FEMS Microbiol. Lett. 2004, 233, 193–199.
   PubMed Web of Science ®Google Scholar
• Dashper, S.G.; O’Brien-Simpson, N.M.; Cross, K.J.; Paolini, R.A.; Hoffmann, B.; Catmull, D.V.; Malkoski, M.; Reynolds, E.C. Divalent metal cations increase the activity of the antimicrobial peptide kappacin. Antimicrob. Agents Chemother. 2005, 49, 2322–2328.
   PubMed Web of Science ®Google Scholar
• Malkoski, M.; Dashper, S.G.; O’Brien-Simpson, N.M.; Talbo, G.H.; Macris, M.; Cross, K.J.; Reynolds, E.C. Kappacin, a novel antibacterial peptide from bovine milk. Antimicrob. Agents Chemother. 2001, 45, 2309–2315.
   PubMed Web of Science ®Google Scholar
• Harris, F.; Dennison, S.R.; Phoenix, D.A. Anionic antimicrobial peptides from eukaryotic organisms. Curr. Protein Pept. Sci. 2009, 10, 585–606.
   PubMed Web of Science ®Google Scholar
• Campagna, S.; Cosette, P.; Molle, G.; Gaillard, J.L. Evidence for membrane affinity of the C-terminal domain of bovine milk PP3 component. Biochim. Biophys. Acta Biomembr. 2001, 1513, 217–222.
   PubMed Web of Science ®Google Scholar
• Park, T.-J.; Kim, J.-S.; Ahn, H.-C.; Kim, Y. Solution and solid-state NMR structural studies of antimicrobial peptides LPcin-I and LPcin-II. Biophys. J. 2011, 101, 1193–1201.
   PubMed Web of Science ®Google Scholar
• Pedersen, L.R.L.; Hansted, J.G.; Nielsen, S.B.; Petersen, T.E.; Sørensen, U.S.; Otzen, D.; Sørensen, E.S. Proteolytic activation of proteose peptone component 3 by release of a C-terminal peptide with antibacterial properties. J. Dairy Sci. 2012, 95, 2819–2829.
   PubMed Web of Science ®Google Scholar
• Haney, E.F.; Lau, F.; Vogel, H.J. Solution structures and model membrane interactions of lactoferrampin, an antimicrobial peptide derived from bovine lactoferrin. Biochim. Biophys. Acta Biomembr. 2007, 1768, 2355–2364.
   PubMed Web of Science ®Google Scholar
• Haney, E.F.; Nazmi, K.; Lau, F.; Bolscher, J.G.M.; Vogel, H.J. Novel lactoferrampin antimicrobial peptides derived from human lactoferrin. Biochimie 2009, 91, 141–154.
   PubMed Web of Science ®Google Scholar
• Boman, H.G.; Agerberth, B.; Boman, A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect. Immun. 1993, 61, 2978–2984.
   PubMed Web of Science ®Google Scholar
• Ho, Y.-H.; Sung, T.-C.; Chen, C.-S. Lactoferricin B inhibits the phosphorylation of the two-component system response regulators BasR and CreB. Mol. Cell. Proteomics 2012, 11, M111.014720.
   Google Scholar
• Tu, Y.-H.; Ho, Y.-H.; Chuang, Y.-C.; Chen, P.-C.; Chen, C.-S. Identification of lactoferricin B intracellular targets using an Escherichia coli proteome chip. PLoS ONE 2011, 6, e28197.
   PubMed Web of Science ®Google Scholar
• Viejo-Diaz, M.; Andrés, M.T.; Pérez-Gil, J.; Sánchez, M.; Fierro, J.F. Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane. Biochemistry (Moscow) 2003, 68, 217–227.
   PubMed Web of Science ®Google Scholar
• Viejo-Díaz, M.; Andrés, M.T.; Fierro, J.F. Different anti-Candida activities of two human lactoferrin-derived peptides, lfpep and kaliocin-1. Antimicrob. Agents Chemother. 2005, 49, 2583–2588.
   PubMed Web of Science ®Google Scholar
• Lahov, E.; Regelson, W. Antibacterial and immunostimulating casein-derived substances from milk: Casecidin, isracidin peptides. Food Chem. Toxicol. 1996, 34, 131–145.
   PubMed Web of Science ®Google Scholar
• Nibbering, P.H.; Ravensbergen, E.; Welling, M.M.; van Berkel, L.A.; van Berkel, P.H.C.; Pauwels, E.K.J.; Nuijens, J.H. Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria. Infect. Immun. 2001, 69, 1469–1476.
   PubMed Web of Science ®Google Scholar
• Dashper, S.G.; Liu, S.; Reynolds, E.C. Antimicrobial peptides and their potential as oral therapeutic agents. Int. J. Pept. Res. Ther. 2007, 13, 505–516.
   Web of Science ®Google Scholar
• Flores-Villaseñor, H.; Canizalez-Román, A.; Reyes-Lopez, M.; Nazmi, K.; de la Garza, M.; Zazueta-Beltrán, J.; León-Sicairos, N.; Bolscher, J. Bactericidal effect of bovine lactoferrin, LFcin, LFampin and LFchimera on antibiotic-resistant Staphylococcus aureus and Escherichia coli. BioMetals 2010, 23, 569–578.
   PubMed Web of Science ®Google Scholar
• Liu, Y.; Han, F.; Xie, Y.; Wang, Y. Comparative antimicrobial activity and mechanism of action of bovine lactoferricin-derived synthetic peptides. BioMetals 2011, 24, 1069–1078.
   PubMed Web of Science ®Google Scholar
• Longhi, C.; Marazzato, M.; Conte, M.P.; Iebba, V.; Schippa, S.; Seganti, L.; Comanducci, A. Effect of lactoferricin on fluoroquinolone susceptibility of uropathogenic Escherichia coli. J. Antibiot. 2009, 62, 109–111.
   PubMed Web of Science ®Google Scholar
• Oo, T.Z.; Cole, N.; Garthwaite, L.; Willcox, M.D.P.; Zhu, H. Evaluation of synergistic activity of bovine lactoferricin with antibiotics in corneal infection. J. Antimicrob. Chemother. 2010, 65, 1243–1251.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, H.; Teraguchi, S.; Tamura, Y. Increased Staphylococcus-killing activity of an antimicrobial peptide, lactoferricin B, with minocycline and monoacylglycerol. Biosci. Biotechnol. Biochem. 2002, 66, 2161–2167.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, H.; Abe, S.; Okutomi, T.; Tansho, S.; Kawase, K.; Yamaguchi, H. Cooperative anti-Candida effects of lactoferrin or its peptides in combination with azole antifungal agents. Microbiol. Immunol. 1996, 40, 821–825.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, H.; Abe, S.; Teraguchi, S.; Hayasawa, H.; Yamaguchi, H. Inhibition of hyphal growth of azole-resistant strains of Candida albicans by triazole antifungal agents in the presence of lactoferrin-related compounds. Antimicrob. Agents Chemother. 1998, 42, 1587–1591.
   PubMed Web of Science ®Google Scholar
• Lupetti, A.; Paulusma-Annema, A.; Welling, M.M.; Dogterom-Ballering, H.; Brouwer, C.P.J.M.; Senesi, S.; van Dissel, J.T.; Nibbering, P.H. Synergistic activity of the N-terminal peptide of human lactoferrin and fluconazole against Candida species. Antimicrob. Agents Chemother. 2003, 47, 262–267.
   PubMed Web of Science ®Google Scholar
• Tanida, T.; Okamoto, T.; Ueta, E.; Yamamoto, T.; Osaki, T. Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from Candida cells. J. Antimicrob. Chemother. 2006, 57, 94–103.
   PubMed Web of Science ®Google Scholar
• Leon-Sicairos, N.; Reyes-Lopez, M.; Ordaz-Pichardo, C.; de la Garza, M. Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolytica. Biochem. Cell Biol. 2006, 84, 327–336.
   PubMed Web of Science ®Google Scholar
• López-Expósito, I.; Pellegrini, A.; Amigo, L.; Recio, I. Synergistic effect between different milk-derived peptides and proteins. J. Dairy Sci. 2008, 91, 2184–2189.
   PubMed Web of Science ®Google Scholar
• Facon, M.J.; Skura, B.J. Antibacterial activity of lactoferricin, lysozyme and EDTA against Salmonella enteritidis. Int. Dairy J. 1996, 6, 303–313.
   Web of Science ®Google Scholar
• Masschalck, B.; Van Houdt, R.; Michiels, C.W. High pressure increases bactericidal activity and spectrum of lactoferrin, lactoferricin and nisin. Int. J. Food Microbiol. 2001, 64, 325–332.
   PubMed Web of Science ®Google Scholar
• Sánchez-Gómez, S.; Japelj, B.; Jerala, R.; Moriyón, I.; Fernández Alonso, M.; Leiva, J.; Blondelle, S.E.; Andrä, J.; Brandenburg, K.; Lohner, K.; Martínez de Tejada, G. Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo. Antimicrob. Agents Chemother. 2011, 55, 218–228.
   PubMed Web of Science ®Google Scholar
• Vorland, L.H.; Osbakk, S.A.; Perstolen, T.; Ulvatne, H.; Rekdal, Ø.; Svendsen, J.S.; Gutteberg, T.J. Interference of the antimicrobial peptide lactoferricin B with the action of various antibiotics against Escherichia coli and Staphylococcus aureus. Scand. J. Infect. Dis. 1999, 31, 173–177.
   PubMed Web of Science ®Google Scholar
• Vorland, L.H.; Ulvatne, H.; Andersen, J.; Haukland, H.H.; Rekdal, Ø.; Svendsen, J.S.; Gutteberg, T.J. Antibacterial effects of lactoferricin B. Scand. J. Infect. Dis. 1999, 31, 179–184.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, H.; Matsumoto, H.; Hashimoto, K.; Teraguchi, S.; Takase, M.; Hayasawa, H. N-acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity. Antimicrob. Agents Chemother. 1999, 43, 1267–1269.
   PubMed Web of Science ®Google Scholar
• Strøm, M.B.; Rekdal, Ø.; Svendsen, J.S. The effects of charge and lipophilicity on the antibacterial activity of undecapeptides derived from bovine lactoferricin. J. Pept. Sci. 2002, 8, 36–43.
   PubMed Web of Science ®Google Scholar
• Majerle, A.; Kidrič, J.; Jerala, R. Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain. J. Antimicrob. Chemother. 2003, 51, 1159–1165.
   PubMed Web of Science ®Google Scholar
• Haug, B.E.; Andersen, J.; Rekdal, Ø.; Svendsen, J.S. Synthesis of a 2-arylsulphonylated tryptophan: The antibacterial activity of bovine lactoferricin peptides containing Trp(2-Pmc). J. Pept. Sci. 2002, 8, 307–313.
   PubMed Web of Science ®Google Scholar
• Haug, B.E.; Skar, M.L.; Svendsen, J.S. Bulky aromatic amino acids increase the antibacterial activity of 15-residue bovine lactoferricin derivatives. J. Pept. Sci. 2001, 7, 425–432.
   PubMed Web of Science ®Google Scholar
• Haug, B.E.; Svendsen, J.S. The role of tryptophan in the antibacterial activity of a 15-residue bovine lactoferricin peptide. J. Pept. Sci. 2001, 7, 190–196.
   PubMed Web of Science ®Google Scholar
• Strøm, M.B.; Stensen, W.; Svendsen, J.S.; Rekdal, Ø. Increased antibacterial activity of 15-residue murine lactoferricin derivatives. J. Pept. Res. 2001, 57, 127–139.
   PubMedGoogle Scholar
• Strøm, M.B.; Svendsen, J.S.; Rekdal, Ø. Antibacterial activity of 15-residue lactoferricin derivatives. J. Pept. Res. 2000, 56, 265–274.
   PubMedGoogle Scholar
• Strøm, M.B.; Haug, B.E.; Rekdal, Ø.; Skar, M.L.; Stensen, W.; Svendsen, J.S. Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity. Biochem. Cell Biol. 2002, 80, 65–74.
   PubMed Web of Science ®Google Scholar
• Haug, B.E.; Strom, M.B.; M. Svendsen, J.S. The medicinal chemistry of short lactoferricin-based antibacterial peptides. Curr. Med. Chem. 2007, 14, 1–18.
   PubMed Web of Science ®Google Scholar
• Håversen, L.; Kondori, N.; Baltzer, L.; Hanson, L.Å.; Dolphin, G.T.; Dunér, K.; Mattsby-Baltzer, I. Structure-microbicidal activity relationship of synthetic fragments derived from the antibacterial α-helix of human lactoferrin. Antimicrob. Agents Chemother. 2010, 54, 418–425.
   PubMed Web of Science ®Google Scholar
• Rekdal, Ø.; Andersen, J.; Vorland, L.H.; Svendsen, J.S. Construction and synthesis of lactoferricin derivatives with enhanced antibacterial activity. J. Pept. Sci. 1999, 5, 32–45.
   Web of Science ®Google Scholar
• Ramos de Armas, R.; Díaz, H.G.; Molina, R.; Uriarte, E. Stochastic-based descriptors studying biopolymers biological properties: Extended MARCH-INSIDE methodology describing antibacterial activity of lactoferricin derivatives. Biopolymers 2005, 77, 247–256.
   PubMed Web of Science ®Google Scholar
• Bolscher, J.G.M.; Adão, R.; Nazmi, K.; van den Keybus, P.A.M.; van ’t Hof, W.; Nieuw Amerongen, A.V.; Bastos, M.; Veerman, E.C.I. Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides. Biochimie 2009, 91, 123–132.
   PubMed Web of Science ®Google Scholar
• Flores-Villaseñor, H.; Canizalez-Román, A.; Velazquez-Roman, J.; Nazmi, K.; Bolscher, J.G.M.; Leon-Sicairos, N. Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic Escherichia coli O157: H7 infection. Biochem. Cell Biol. 2012, 90, 405–411.
   PubMed Web of Science ®Google Scholar
• López-Soto, F.; León-Sicairos, N.; Nazmi, K.; Bolscher, J.; de la Garza, M. Microbicidal effect of the lactoferrin peptides lactoferricin17–30, lactoferrampin265–284, and lactoferrin chimera on the parasite Entamoeba histolytica. BioMetals 2010, 23, 563–568.
   PubMed Web of Science ®Google Scholar
• Xu, G.; Xiong, W.; Hu, Q.; Zuo, P.; Shao, B.; Lan, F.; Lu, X.; Xu, Y.; Xiong, S. Lactoferrin-derived peptides and Lactoferricin chimera inhibit virulence factor production and biofilm formation in Pseudomonas aeruginosa. J. Appl. Microbiol. 2010, 109, 1311–1318.
   PubMed Web of Science ®Google Scholar
• Azuma, M.; Del Carpio, C.A.; Kojima, T.; Yokoyama, I.; Tajiri, H.; Yoshikawa, K.; Saga, S. Antibacterial activity of multiple antigen peptides homologous to a loop region in human lactoferrin. J. Pept. Res. 1999, 54, 237–241.
   PubMedGoogle Scholar
• Reynolds, E.C.; Dashper, S.G.; Paolini, R.A. Antimicrobial composition. In A61K38/00 edn: Dairy Australia Limited, 2012.
   Google Scholar
• Reynolds, E.C.; Dashper, S.G.; O’Brien-Simpson, N.M.; Talbo, G.H.; Malkoski, M. Antimicrobial peptides. In. A61Q11/00; A23J3/10; A61K35/20 edn: The University of Melbourne: Melbourne; 2009.
   Google Scholar
• Teraguchi, S.; Shin, K.; Ozawa, K.; Nakamura, S.; Fukuwatari, Y.; Tsuyuki, S.; Namihira, H.; Shimamura, S. Bacteriostatic effect of orally administered bovine lactoferrin on proliferation of Clostridium species in the gut of mice fed bovine milk. Appl. Environ. Microbiol. 1995, 61, 501–506.
   PubMed Web of Science ®Google Scholar
• Håversen, L.; Engberg, I.; Baltzer, L.; Dolphin, G.; Hanson, L.Å.; Mattsby-Baltzer, I. Human lactoferrin and peptides derived from a surface-exposed helical region reduce experimental Escherichia coli urinary tract infection in mice. Infect. Immun. 2000, 68, 5816–5823.
   PubMed Web of Science ®Google Scholar
• Li, S.-S.; Tsai, H.-J. Transgenic microalgae as a non-antibiotic bactericide producer to defend against bacterial pathogen infection in the fish digestive tract. Fish Shellfish Immunol. 2009, 26, 316–325.
   PubMed Web of Science ®Google Scholar
• Lin, C.-Y.; Yang, P.-H.; Kao, C.-L.; Huang, H.-I.; Tsai, H.-J. Transgenic zebrafish eggs containing bactericidal peptide is a novel food supplement enhancing resistance to pathogenic infection of fish. Fish Shellfish Immunol. 2010, 28, 419–427.
   PubMed Web of Science ®Google Scholar
• Halasa, T.; Huijps, K.; Osterás, O.; Hogeveen, H. Economic effects of bovine mastitis and mastitis management: A review. Vet. Q. 2007, 29, 18–31.
   PubMed Web of Science ®Google Scholar
• Kawai, K.; Nagahata, H.; Lee, N.Y.; Anri, A.; Shimazaki, K. Effect of infusing lactoferrin hydrolysate into bovine mammary glands with subclinical mastitis. Vet. Res. Commun. 2003, 27, 539–548.
   PubMed Web of Science ®Google Scholar
• Kawai, K.; Shimazaki, K.; Higuchi, H.; Nagahata, H. Antibacterial activity of bovine lactoferrin hydrolysate against mastitis pathogens and its effect on superoxide production of bovine neutrophils. Zoonoses Public Health 2007, 54, 160–164.
   PubMed Web of Science ®Google Scholar
• Zhang, J.X.; Zhang, S.F.; Wang, T.D.; Guo, X.J.; Hu, R.L. Mammary gland expression of antibacterial peptide genes to inhibit bacterial pathogens causing mastitis. J. Dairy Sci. 2007, 90, 5218–5225.
   PubMed Web of Science ®Google Scholar
• Lupetti, A.; Brouwer, C.P.J.M.; Bogaards, S.J.P.; Welling, M.M.; de Heer, E.; Campa, M.; van Dissel, J.T.; Friesen, R.H.E.; Nibbering, P.H. Human lactoferrin-derived peptide’s antifungal activities against disseminated Candida albicans infection. J. Infect. Dis. 2007, 196, 1416–1424.
   PubMed Web of Science ®Google Scholar
• Stallmann, H.P.; Roo, R.d.; Faber, C.; Amerongen, A.V.N.; Wuisman, P.I.J.M. In vivo release of the antimicrobial peptide hLF1-11 from calcium phosphate cement. J. Orthop. Res. 2008, 26, 531–538.
   PubMed Web of Science ®Google Scholar
• Stallmann, H.P.; Faber, C.; Slotema, E.T.; Lyaruu, D.M.; Bronckers, A.L.J.J.; Amerongen, A.V.N.; Wuisman, P.I.J.M. Continuous-release or burst-release of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11) from calcium phosphate bone substitutes. J. Antimicrob. Chemother. 2003, 52, 853–855.
   PubMed Web of Science ®Google Scholar
• Stallmann, H.P.; Faber, C.; Bronckers, A.L.J.J.; Nieuw Amerongen, A.V.; Wuisman, P.I.J.M. Osteomyelitis prevention in rabbits using antimicrobial peptide hLF1-11- or gentamicin-containing calcium phosphate cement. J. Antimicrob. Chemother. 2004, 54, 472–476.
   PubMed Web of Science ®Google Scholar
• Faber, C.; Stallmann, H.P.; Lyaruu, D.M.; Joosten, U.; von Eiff, C.; van Nieuw Amerongen, A.; Wuisman, P.I.J.M. Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. Antimicrob. Agents Chemother. 2005, 49, 2438–2444.
   PubMed Web of Science ®Google Scholar
• Nibbering, P.H.; Welling, M.M.; Paulusma-Annema, A.; Brouwer, C.P.J.M.; Lupetti, A.; Pauwels, E.K.J. 99mTc-labeled UBI 29-41 peptide for monitoring the efficacy of antibacterial agents in mice infected with Staphylococcus aureus. J. Nucl. Med. 2004, 45, 321–326.
   PubMed Web of Science ®Google Scholar
• Dijkshoorn, L.; Brouwer, C.P.J.M.; Bogaards, S.J.P.; Nemec, A.; van den Broek, P.J.; Nibbering, P.H. The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 2004, 48, 4919–4921.
   PubMed Web of Science ®Google Scholar
• Brouwer, C.P.J.M.; Welling, M.M. Various routes of administration of 99mTc-labeled synthetic lactoferrin antimicrobial peptide hLF 1–11 enables monitoring and effective killing of multidrug-resistant Staphylococcus aureus infections in mice. Peptides 2008, 29, 1109–1117.
   PubMed Web of Science ®Google Scholar
• Brouwer, C.P.J.M.; Jonk, L.J.C.; Velders, M.P.; Wulferink, M.B.F. Mutants of lactoferrin. In. AA61K3808FI edn: AM-Pharma B.V.; 2009.
   Google Scholar
• van der Velden, W.; van Iersel, T.; Blijlevens, N.; Donnelly, J. Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11). BMC Med. 2009, 7, doi: 10.1186/1741-7015-7-44.
   Web of Science ®Google Scholar
• Brouwer, C.P.J.M.; Rahman, M.; Welling, M.M. Discovery and development of a synthetic peptide derived from lactoferrin for clinical use. Peptides 2011, 32, 1953–1963.
   PubMed Web of Science ®Google Scholar
• Omata, Y.; Satake, M.; Maeda, R.; Saito, A.; Shimazaki, K.; Yamauchi, K.; Uzuka, Y.; Tanabe, S.; Sarashina, T.; Mikami, T. Reduction of the infectivity of Toxoplasma gondii and Eimeria stiedai sporozoites by treatment with bovine lactoferricin. J. Vet. Med. Sci. 2001, 63, 187–190.
   PubMed Web of Science ®Google Scholar
• López-Expósito, I.; Recio, I. Antibacterial activity of peptides and folding variants from milk proteins. Int. Dairy J. 2006, 16, 1294–1305.
   Web of Science ®Google Scholar
• López-Expósito, I.; Recio, I. Protective effect of milk peptides: Antibacterial and antitumor properties. In Bioactive Components of Milk; Edited by Bösze, Z., Ed.; Springer: New York, 2008; Vol. 606, pp 271–294.
   Google Scholar
• Murdock, C.A.; Matthews, K.R. Antibacterial activity of pepsin-digested lactoferrin on foodborne pathogens in buffered broth systems and ultra-high temperature milk with EDTA. J. Appl. Microbiol. 2002, 93, 850–856.
   PubMed Web of Science ®Google Scholar
• Quintieri, L.; Caputo, L.; Monaci, L.; Deserio, D.; Morea, M.; Baruzzi, F. Antimicrobial efficacy of pepsin-digested bovine lactoferrin on spoilage bacteria contaminating traditional Mozzarella cheese. Food Microbiol. 2012, 31, 64–71.
   PubMed Web of Science ®Google Scholar
• Rizzello, C.G.; Losito, I.; Gobbetti, M.; Carbonara, T.; De Bari, M.D.; Zambonin, P.G. Antibacterial activities of peptides from the water-soluble extracts of Italian cheese varieties. J. Dairy Sci. 2005, 88, 2348–2360.
   PubMed Web of Science ®Google Scholar
• Paul, M.; Somkuti, G.A. Degradation of milk-based bioactive peptides by yogurt fermentation bacteria. Lett. Appl. Microbiol. 2009, 49, 345–350.
   PubMed Web of Science ®Google Scholar
• Paul, M.; Somkuti, G.A. Hydrolytic breakdown of lactoferricin by lactic acid bacteria. J. Ind. Microbiol. Biotechnol. 2010, 37, 173–178.
   PubMed Web of Science ®Google Scholar
• Somkuti, G.A.; Paul, M. Enzymatic fragmentation of the antimicrobial peptides casocidin and isracidin by Streptococcus thermophilus and Lactobacillus delbrueckii sp. bulgaricus. Appl. Microbiol. Biotechnol. 2010, 87, 235–242.
   PubMed Web of Science ®Google Scholar
• Venkitanarayanan, K.S.; Zhao, T.; Doyle, M.P. Antibacterial effect of lactoferricin B on Escherichia coli O157: H7 in ground beef. J. Food Prot. 1999, 62, 747–750.
   PubMed Web of Science ®Google Scholar
• Ransom, J.R.; Belk, K.E.; Sofos, J.N.; Stopforth, J.D.; Scanga, J.A.; Smith, G.C. Comparison of intervention technologies for reducing Escherichia coli O157: H7 on beef cuts and trimmings. Food Prot. Trends 2003, 23, 24–34.
   Google Scholar
• Del Olmo, A.; Calzada, J.; Nuñez, M. Effect of lactoferrin and its derivatives, high hydrostatic pressure, and their combinations, on Escherichia coli O157: H7 and Pseudomonas fluorescens in chicken filets. Innov. Food Sci. Emerg. Technol. 2012, 13, 51–56.
   Web of Science ®Google Scholar
• Del Olmo, A.; Calzada, J.; Nuñez, M. Effect of lactoferrin and its derivatives against gram-positive bacteria in vitro and, combined with high pressure, in chicken breast fillets. Meat Sci. 2012, 90, 71–76.
   PubMed Web of Science ®Google Scholar
• Al-Nabulsi, A.A.; Holley, R.A. Effects on Escherichia coli O157: H7 and meat starter cultures of bovine lactoferrin in broth and microencapsulated lactoferrin in dry sausage batters. Int. J. Food Microbiol. 2007, 113, 84–91.
   PubMed Web of Science ®Google Scholar
• Al-Nabulsi, A.A.; Han, J.H.; Liu, Z.; Rodrigues-Vieira, E.T.; Holley, R.A. Temperature-sensitive microcapsules containing lactoferrin and their action against Carnobacterium viridans on bologna. J. Food Sci. 2006, 71, M208–M214.
   Web of Science ®Google Scholar
• Del Olmo, A.; Morales, P.; Nuñez, M. Bactericidal activity of lactoferrin and its amidated and pepsin-digested derivatives against Pseudomonas fluorescens in ground beef and meat fractions. J. Food Prot. 2009, 72, 760–765.
   PubMed Web of Science ®Google Scholar
• Chantaysakorn, P.; Richter, R.L. Antimicrobial properties of pepsin-digested lactoferrin added to carrot juice and filtrates of carrot juice. J. Food Prot. 2000, 63, 376–380.
   PubMed Web of Science ®Google Scholar
• Bellamy, W.; Takase, M.; Yamauchi, K.; Wakabayashi, H.; Kawase, K.; Tomita, M. Identification of the bactericidal domain of lactoferrin. Biochim. Biophys. Acta Protein Struct. Mol. Enzymol. 1992, 1121, 130–136.
   PubMed Web of Science ®Google Scholar
• Enrique, M.; Manzanares, P.; Yuste, M.; Martínez, M.; Vallés, S.; Marcos, J.F. Selectivity and antimicrobial action of bovine lactoferrin derived peptides against wine lactic acid bacteria. Food Microbiol. 2009, 26, 340–346.
   PubMed Web of Science ®Google Scholar
• Enrique, M.; Marcos, J.F.; Yuste, M.; Martínez, M.; Vallés, S.; Manzanares, P. Antimicrobial action of synthetic peptides towards wine spoilage yeasts. Int. J. Food Microbiol. 2007, 118, 318–325.
   PubMed Web of Science ®Google Scholar
• Enrique, M.; Marcos, J.F.; Yuste, M.; Martínez, M.; Vallés, S.; Manzanares, P. Inhibition of the wine spoilage yeast Dekkera bruxellensis by bovine lactoferrin-derived peptides. International J. Food Microbiol. 2008, 127, 229–234.
   PubMed Web of Science ®Google Scholar
• Tomita, M.; Takase, M.; Bellamy, W.; Shimamura, S. A review: The active peptide of lactoferrin. Pediatr. Int. 1994, 36, 585–591.
   Google Scholar
• Lejon, T.; Stiberg, T.; Strøm, M.B.; Svendsen, J.S. Prediction of antibiotic activity and synthesis of new pentadecapeptides based on lactoferricins. J. Peptide Sci. 2004, 10, 329–335.
   PubMed Web of Science ®Google Scholar