Wheat Bran Proteins: A Review of Their Uses and Potential

References

• United States Department of Agriculture (USDA). National Nutrient Database for Standard Reference Release 26. 2013. http://ndb.nal.usda.gov/ndb/foods/show/6419?fg=&man=&lfacet=&count=&max=25&sort=&qlookup=wheat+bran&offset=&format=Full&new=&measureby= ( accessed January 21, 2014).
   Google Scholar
• Heuzé, V.; Tran, G.; Baumont, R.; Lebas, F.; Lessire, M.; Noblet, J.; Renaudeau, D. 2013. Wheat bran. Feedipedia.org. A programme by INRA, CIRAD, AFZ and FAO. http://www.feedipedia.org/node/726 ( accessed February 5, 2014).
   Google Scholar
• Prückler, M.; Siebenhandl-Ehn, S.; Apprich, S.; Höltinger, S.; Haas, C.; Schmid, E.; Kneifel, W. Wheat bran-based biorefinery 1: Composition of wheat bran and strategies of functionalization. Food Sci. Technol. 2014, 56, 211–221.
   Google Scholar
• Curti, E.; Carini, E.; Bonacini, G.; Tribuzio, G.; Vittadini, E. Effect of the addition of bran fractions on bread properties. J. Cereal Sci. 2013, 57, 325–332.
   Web of Science ®Google Scholar
• Noort, M.W.J.; van Haaster, D.; Hemery, Y.; Schols, H.A.; Hamer, R.J. The effect of particle size of wheat bran fractions on bread quality—Evidence for fibre–protein interactions. J. Cereal Sci. 2010, 52, 59–64.
   Web of Science ®Google Scholar
• Reddy, N.; Sathe, S. Food Phytates; CRC Press: Boca Raton, FL, 2002.
   Google Scholar
• Sandberg, A.; Hasselblad, C.; Hasselblad, K. The effect of wheat bran on the absorption of minerals in the small intestine. Br. J. Nutr. 1982, 48, 185–191.
   PubMed Web of Science ®Google Scholar
• Weaver, C.; Kannan, S. Phytate and mineral bioavailability. In Food Phytates; Reddy, N., Sathe, S., Eds.; CRC Press: Boca Raton, FL, 2002; pp 211–220.
   Google Scholar
• Bean, M. Utilization of high-protein flours in aid programs: On site evaluation. In Proceedings of the 9th National Conference on Wheat Utilization Research, Seattle, WA, October 8–10, 1975; Agricultural Research Service: United States Department of Agriculture, 1976; pp 23–30.
   Google Scholar
• Idris, W.; Babiker, E.; El Tinay, A. Fractionation, solubility and functional properties of wheat bran proteins as influenced by pH and/or salt concentration. Nahrung/Food 2003, 47, 425–429.
   PubMedGoogle Scholar
• Saunders, R.; Betschart, A.; Edwards, R.; Kohler, G. In Nutritive assessment and potential food applications of protein concentrates prepared by alkaline extraction of wheat millfeeds. In Proceedings of the 9th National Conference on Wheat Utilization Research, Seattle, WA, October 8–10, 1975; Agricultural Research Service: United States Department of Agriculture, 1976; pp 9–22.
   Google Scholar
• Jerkovic, A.; Kriegel, A.; Bradner, J.; Atwell, B.; Roberts, T.; Willows, R. Strategic distribution of protective proteins within bran layers of wheat protects the nutrient-rich endosperm. Plant Physiol. 2010, 152, 1459–1470.
   PubMed Web of Science ®Google Scholar
• Grundas, S.; Wrigley, C. Wheat/ultrastructure of the grain, flour, and dough. In Encyclopedia of Grain Science; Wrigley, C., Corke, H., Walker, C., Eds.; Academic Press: New York, 2004; Vol. 3, pp 391–400.
   Google Scholar
• Dexter, J.; Sarkar, A. Wheat/dry milling. In Encyclopedia of Grain Science; Wrigley, C., Corke, H., Walker, C., Eds.; Academic Press: New York, 2004; Vol. 3, pp 363–375.
   Google Scholar
• Corke, H. Grain, morphology of internal structure. In Encyclopedia of Grain Science; Wrigley, C., Corke, H., Walker, C., Eds.; Elsevier: New York, 2004; Vol. 2, pp 30–38.
   Google Scholar
• Parker, M.L.; Ng, A.; Waldron, K.W. The phenolic acid and polysaccharide composition of cell walls of bran layers of mature wheat (Triticum aestivum L. cv. Avalon) grains. J. Sci. Food Agric. 2005, 85, 2539–2547.
   Google Scholar
• Xiong, F.; Yu, X. R.; Zhou, L.; Wang, Z.; Wang, F.; Xiong, A. S. Structural development of aleurone and its function in common wheat. Mol. Biol. Rep. 2013, 40, 6785–6792.
   PubMed Web of Science ®Google Scholar
• Belobrajdic, D. P.; Bird, A. R. The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes. Nutr. J. 2013, 12.
   PubMed Web of Science ®Google Scholar
• Björck, I.; Östman, E.; Kristensen, M.; Mateo Anson, N.; Price, R. K.; Haenen, G. R. M. M.; Havenaar, R.; Bach Knudsen, K. E.; Frid, A.; Mykkänen, H.; Welch, R. W.; Riccardi, G. Cereal grains for nutrition and health benefits: Overview of results from in vitro, animal and human studies in the HEALTHGRAIN project. Trends Food Sci. Technol. 2012, 25, 87–100.
   Web of Science ®Google Scholar
• Ferguson, L. R.; Harris, P. J.; Kestell, P.; Zhu, S.; Munday, R.; Munday, C. M. Comparative effects in rats of intact wheat bran and two wheat bran fractions on the disposition of the mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. Mutat. Res. 2011, 716, 59–65.
   PubMed Web of Science ®Google Scholar
• Gelinas, P. Preventing constipation: A review of the laxative potential of food ingredients. Int. J. Food Sci. Technol. 2013, 48, 445–467.
   Web of Science ®Google Scholar
• Liu, L.; Winter, K. M.; Stevenson, L.; Morris, C.; Leach, D. N. Wheat bran lipophilic compounds with in vitro anticancer effects. Food Chem. 2012, 130, 156–164.
   Web of Science ®Google Scholar
• Zhu, Y.; Conklin, D. R.; Chen, H.; Wang, L.; Sang, S. 5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth. Bioorg. Med. Chem. 2011, 19, 3973–3982.
   PubMed Web of Science ®Google Scholar
• Zhu, Y.; Soroka, D. N.; Sang, S. Structure elucidation and chemical profile of sphingolipids in wheat bran and their cytotoxic effects against human colon cancer cells. J. Agric. Food Chem. 2013, 61, 866–874.
   PubMed Web of Science ®Google Scholar
• Apprich, S.; Tirpanalan, Ö.; Hell, J.; Reisinger, M.; Böhmdorfer, S.; Siebenhandl-Ehn, S.; Novalin, S.; Kneifel, W. Wheat bran-based biorefinery 2: Valorization of products. Food Sci. Technol. 2013, 56, 222–231.
   Google Scholar
• Fardet, A. New hypotheses for the health-protective mechanisms of whole-grain cereals: What is beyond fibre? Nutr. Res. Rev. 2010, 23, 65–134.
   Google Scholar
• Truswell, A. Cereal grains and coronary heart disease. Eur. J. Clin. Nutr. 2002, 56, 1–14.
   PubMed Web of Science ®Google Scholar
• Graf, E.; Eaton, J. W. Antioxidant functions of phytic acid. Free Radic. Biol. Med. 1990, 8, 61–69.
   PubMed Web of Science ®Google Scholar
• Brindzová, L.; Zalibera, M.; Jakubík, T.; Mikulášová, M.; Takácsová, M.; Mošovská, S.; Rapta, P. Antimutagenic and radical scavenging activity of wheat bran. Cereal Res. Commun. 2009, 37, 45–55.
   Web of Science ®Google Scholar
• François, I.; Lescroart, O.; Veraverbeke, W.; Kubaszky, R.; Hargitai, J.; Esdaile, D.; Beres, E.; Soni, M.; Cockburn, A.; Broekaert, W. Safety assessment of a wheat bran extract containing arabinoxylan-oligosaccharides: Mutagenicity, clastogenicity, and 90-day rat-feeding studies. Int. J. Toxicol. 2010, 29, 479–495.
   PubMed Web of Science ®Google Scholar
• Eswaran, S.; Muir, J.; Chey, W. D. Fiber and functional gastrointestinal disorders. Am. J. Gastroenterol. 2013, 108, 718–727.
   PubMed Web of Science ®Google Scholar
• Moonmoon, M.; Shelly, N. J.; Khan, M. A.; Uddin, M. N.; Hossain, K.; Tania, M.; Ahmed, S. Effects of different levels of wheat bran, rice bran and maize powder supplementation with saw dust on the production of shiitake mushroom (Lentinus edodes (Berk.) Singer). Saudi J. Biol. Sci. 2011, 18, 323–328.
   PubMed Web of Science ®Google Scholar
• Locci, E.; Laconi, S.; Pompei, R.; Scano, P.; Lai, A.; Marincola, F. C. Wheat bran biodegradation by Pleurotus ostreatus: A solid-state Carbon-13 NMR study. Bioresour. Technol. 2008, 99, 4279–4284.
   PubMed Web of Science ®Google Scholar
• Du, C.; Campbell, G.M.; Misailidis, N.; Mateos-Salvador, F.; Sadhukhan, J.; Mustafa, M.; Weightman, R.M. Evaluating the feasibility of commercial arabinoxylan production in the context of a wheat biorefinery principally producing ethanol. Part 1. Experimental studies of arabinoxylan extraction from wheat bran. Chem. Eng. Res. Des. 2009, 87, 1232–1238.
   Google Scholar
• Favaro, L.; Basaglia, M.; Casella, S. Processing wheat bran into ethanol using mild treatments and highly fermentative yeasts. Biomass Bioenerg. 2012, 46, 605–617.
   Web of Science ®Google Scholar
• Favaro, L.; Basaglia, M.; van Zyl, W.H.; Casella, S. Using an efficient fermenting yeast enhances ethanol production from unfiltered wheat bran hydrolysates. Appl. Energ. 2013, 102, 170–178.
   Web of Science ®Google Scholar
• Nogata, Y.; Saito, T.; Abe, D.; Yoshida, A.; Ohta, H. Storage stability of wheat bran proteases for producing angiotensin I-converting enzyme inhibitory peptides. Food Sci. Technol. Res. 2013, 19, 313–317.
   Web of Science ®Google Scholar
• Ueno, T.; Nogata, Y.; Nakamura, A.; Nakamura, T.; Koga, H.; Torimura, T.; Suetsugu, M.; Yano, T.; Baba, S.; Taguchi, J.; Kajiwara, M.; Ishii, K.; Morita, Y.; Nagata, E.; Sata, M. 1304. Peptides produced by autolysis reactions from wheat bran have therapeutic effects in nonalcoholic steatohepatitis. J. Hepatol. 2013, 58, (Suppl. 1), S526–S527.
   Google Scholar
• El-Mekawy, A.; Diels, L.; De Wever, H.; Pant, D. Valorization of cereal based biorefinery byproducts: Reality and expectations. Environ. Sci. Technol. 2013, 47, 9014–9027.
   PubMed Web of Science ®Google Scholar
• Reisinger, M.; Tirpanalan, Ö.; Prückler, M.; Huber, F.; Kneifel, W.; Novalin, S. Wheat bran biorefinery—A detailed investigation on hydrothermal and enzymatic treatment. Bioresour. Technol. 2013, 144, 179–185.
   PubMed Web of Science ®Google Scholar
• Fama, L.; Bittante, A. M. B. Q.; Sobral, P. J. A.; Goyanes, S.; Gerschenson, L. N. Garlic powder and wheat bran as fillers: Their effect on the physicochemical properties of edible biocomposites. Mater. Sci. Eng. C 2010, 30, 853–859.
   Web of Science ®Google Scholar
• Fama, L.; Gerschenson, L.; Goyanes, S. Starch-vegetable fibre composites to protect food products. Carbohydr. Polym. 2009, 75, 230–235.
   Web of Science ®Google Scholar
• Kanwal, F.; Rehman, R.; Anwar, J.; Saeed, M. Removal of lead(II) from water by adsorption on novel composites of polyaniline with maize bran, wheat bran and rice bran. Asian J. Chem. 2013, 25, 2399–2404.
   Web of Science ®Google Scholar
• Singh, K.K.; Hasan, S.H.; Talat, M.; Singh, V.K.; Gangwar, S.K. Removal of Cr (VI) from aqueous solutions using wheat bran. Chem. Eng. J. 2009, 151, 113–121.
   Web of Science ®Google Scholar
• Shewry, P.R.; D’Ovidio, R.; Lafiandra, D.; Jenkins, J.A.; Mills, E.N.C.; Békés, F. Wheat grain proteins. In Wheat: Chemistry and Technology; 4th ed.; Khan, K., Shewry, P.R., Eds.; AACC International: St. Paul, MN, 2009; pp 223–298.
   Google Scholar
• Meziani, S.; Nadaud, I.; Gaillard-Martinie, B.; Chambon, C.; Benali, M.; Branlard, G. Proteomic analysis of the mature kernel aleurone layer in common and durum wheat. J. Cereal Sci. 2012, 55, 323–330.
   Web of Science ®Google Scholar
• Jones, D. B.; Gersdorf, C. Proteins of wheat bran: I. Isolation and elementary analyses of a globulin, albumin, and prolamine. J. Biol. Chem. 1923, 58, 117–131.
   Google Scholar
• Fellers, D. A.; Sinkey, V.; Shepherd, A. D.; Pence, J. W. Solubilization and recovery of protein from wheat millfeeds. Cereal Chem. 1966, 43, 1–13.
   Web of Science ®Google Scholar
• Woerman, J.; Satterlee, L. Extraction and nutritive quality of wheat protein concentrate. Food Technol. Chicago 1974, 28, 50–52.
   Google Scholar
• Hansmeyer, W.; Satterlee, L.; Mattern, P. Characterization of products from wet fractionation of wheat bran. J. Food Sci. 1976, 41, 505–508.
   Web of Science ®Google Scholar
• Roberts, P. J.; Simmonds, D. H.; Wootton, M.; Wrigley, C. W. Extraction of protein and solids from wheat bran. J. Sci. Food Agric. 1985, 36, 5–10.
   Web of Science ®Google Scholar
• Nogata, Y.; Nagamine, T. Production of free amino acids and γ-aminobutyric acid by autolysis reactions from wheat bran. J. Agric. Food Chem. 2009, 57, 1331–1336.
   PubMed Web of Science ®Google Scholar
• Jin, W.; Kim, M.; Kim, K. Utilization of barley or wheat bran to bioconvert glutamate to γ-aminobutyric acid (GABA). J. Food Sci. 2013, 78, C1376–C1382.
   Google Scholar
• Möller, N.; Scholz-Ahrens, K.; Roos, N.; Schrezenmeir, J. Bioactive peptides and proteins from foods: Indication for health effects. Eur. J. Nutr. 2008, 47, 171–182.
   PubMed Web of Science ®Google Scholar
• Nogata, Y.; Nagamine, T.; Yanaka, M.; Ohta, H. Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem. 2009, 57, 6618–6622.
   PubMed Web of Science ®Google Scholar
• Whelton, P.K.; He, J.; Muntner, P. Prevelance, awareness, treatment and control of hypertension in North America, North Africa and Asia. J. Hum. Hypertens. 2004, 18, 545–551.
   PubMed Web of Science ®Google Scholar
• Campas-Ríos, M.; Mercado-Ruiz, J.; Valdéz-Covarrubias, M.; Islas-Rubio, A.; Mendoza-Wilson, A.; Balandrán-Quintana, R. Hydrolysates from wheat bran albumin as color-adding agents and inhibitors of apple polyphenol oxidase. J. Food Biochem. 2012, 36, 470–478.
   Web of Science ®Google Scholar
• Ramírez, E.; Whitaker, J.; Mirador, V. Polyphenol oxidase. In Handbook of Food Enzymology; Whitaker, J., Voragen, A., Wong, D., Eds.; Marcel Deckker: New York, 2003; pp 509–523.
   Google Scholar
• Ates, S.; Pekyardimci, S.; Cokmus, C. Partial characterization of a peptide from honey that inhibits mushroom polyphenol oxidase. J. Food Biochem. 2001, 25, 127–137.
   Web of Science ®Google Scholar
• Ortíz-Estrada, A.; Mercado-Ruiz, J.; García-Robles, J.; Islas-Rubio, A.; Mendoza-Wilson, A.; Balandrán-Quintana, R. Wheat bran globulins: Competitive inhibitors of mushroom tyrosinase. Food Sci. Biotechnol. 2012, 21, 633–635.
   Web of Science ®Google Scholar
• Koh-Banerjee, P.; Franz, M.; Sampson, L.; Liu, Simin.; Jacobs, D.R., Jr.; Spiegelman, D.; Willett, W.; Rimm, E. Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men. Am. J. Clin. Nutr. 2004, 80, 1237–1245.
   PubMed Web of Science ®Google Scholar
• Borel, P.; Lairon, D.; Termine, E.; Grataroli, R.; Lafont, H. Isolation and properties of lipolysis inhibitory proteins from wheat germ and wheat bran. Plant Foods Hum. Nutr. 1989, 39, 339–348.
   PubMed Web of Science ®Google Scholar
• O’connor, C.; Sun, D.; Smith, B.; Melton, L. The inhibitory effects of brans and their aqueous extracts on the lipolysis of tributyrin catalyzed by calf pregastric lipase. J. Food Sci. 2003, 68, 1818–1825.
   Web of Science ®Google Scholar
• Neethirajan, S.; Jayas, D.S. Nanotechnology for the food and bioprocessing industries. Food Bioprocess Technol. 2011, 4, 39–47.
   PubMed Web of Science ®Google Scholar
• Scanlon, S.; Aggeli, A. Self-assembling peptide nanotubes. Nanotoday 2008, 3, 22–30.
   PubMed Web of Science ®Google Scholar
• Zhang, S. Fabrication of novel biomaterials through molecular self assembly. Nat. Biotechnol. 2003, 21, 1171–1178.
   PubMed Web of Science ®Google Scholar
• Zhang, S.; Davide, M.M.; Hwang, W.; Santoso, S. Design of nanostructured biological materials through self-assembly of peptides and proteins. Curr. Opin. Chem. Biol. 2002, 6, 865–871.
   PubMed Web of Science ®Google Scholar
• Lu, G.; Komatsu, T.; Tsuchida, E. Artificial hemoprotein nanotubes. Chem. Commun. 2007, 2980–2982.
   Google Scholar
• Mackintosh, S.H.; Meade, S.J.; Healy, J.P.; Sutton, K.H.; Larsen, N.G.; Squires, A. M.; Gerrard, J. A. Wheat glutenin proteins assemble into a nanostructure with unusual structural features. J. Cereal Sci. 2009, 49, 157–162.
   Web of Science ®Google Scholar
• Graveland-Bikker, J.; deKruif, C. Unique milk protein based nanotubes: Food and nanotechnology meet. Trends Food Sci. Technol. 2006, 17, 196–203.
   Web of Science ®Google Scholar
• Ezpeleta, I.; Irache, J.M.; Stainmesse, S.; Chabenat, C.; Gueguen, J.; Popineau, Y.; Orecchioni, A.-M. Gliadin nanoparticles for the controlled release of all-trans-retinoic acid. Int. J. Pharm. 1996, 131, 191–200.
   Web of Science ®Google Scholar
• Arangoa, M.A.; Ponchel, G.; Orecchioni, A.M.; Renedo, M.J.; Duchêne, D.; Irache, J.M. Bioadhesive potential of gliadin nanoparticulate systems. Eur. J. Pharm. Sci. 2000, 11, 333–341.
   PubMed Web of Science ®Google Scholar
• Paliwal, R.; Palakurthi, S. Zein in controlled drug delivery and tissue engineering. J. Control. Release 2014, 189, 108–122.
   PubMed Web of Science ®Google Scholar