Bitter melon (Momordica charantia L.) bioactive composition and health benefits: A review

References

• Habicht, S.D.; Kind, V.; Rudloff, S.; Borsch, C.; Mueller, A.S.; Pallauf, J.; Yang, R.Y.; Krawinkel, M.B. Quantification of antidiabetic extracts and compounds in bitter gourd varieties. Food Chem. 2011, 126, 172–176.
   Web of Science ®Google Scholar
• Grover, J.K.; Yadav, S.P. Pharmacological actions and potential uses of Momordica charantia: A review. J. Ethnopharmacol. 2004, 93, 123–132.
   PubMed Web of Science ®Google Scholar
• Aminah, A.; Anna, P.K. Influence of ripening stages on physicochemical characteristics and antioxidant properties of bitter gourd (Momordica charantia). Int. Food Res. J. 2011, 18, 895–900.
   Google Scholar
• Basch, E.; Gabardi, S.; Ulbricht, C. Bitter melon (Momordica charantia): A review of efficacy and safety. Am. J. Health Syst. Pharm. 2003, 60, 356–359.
   PubMed Web of Science ®Google Scholar
• Lucas, E.A.; Dumancas, G.G.; Smith, B.J.; Clarke, S.L.; Arjmandi, B.H. Health Benefits of Bitter Melon (Momordica charantia). In Bioactive Foods in Promoting Health; Watson, R.R., Preedy, V.R., Eds.; Academic Press: San Diego, 2010; pp 525–549.
   Google Scholar
• Celia, G.; Cummings, E.; David, A.P.; Jaipaul, S. Beneficial effect and mechanism of action of Momordica Charantia in the treatment of diabetes mellitus: A mini review. Int. J. Diabetes Metab. 2003, 11, 46–55.
   Google Scholar
• Scartezzini, P.; Speroni, E. Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 2000, 71, 23–43.
   PubMed Web of Science ®Google Scholar
• Nagasawa, H.; Watanabe, K.; Inatomi, H. Effects of bitter melon (Momordica charantia L.) or ginger rhizome (Zingiber offifinale rosc) on spontaneous mammary tumorigenesis in SHN mice. Am. J. Chin. Med. 2002, 30, 195–205.
   PubMed Web of Science ®Google Scholar
• Deep, G.; Dasgupta, T.; Rao, A.R.; Kale, R.K. Cancer preventive potential of Momordica charantia L. against benzo(a)pyrene induced fore-stomach tumourigenesis in murine model system. Indian J. Exp. Biol. 2004, 42, 319–322.
   PubMedGoogle Scholar
• Singh, A.; Singh, S.P.; Bamezai, R. Momordica charantia (Bitter Gourd) peel, pulp, seed and whole fruit extract inhibits mouse skin papillomagenesis. Toxicol. Lett. 1998, 94, 37–46.
   PubMed Web of Science ®Google Scholar
• Pongnikorn, S.; Fongmoon, D.; Kasinrerk, W.; Limtrakul, P.N. Effect of bitter melon (Momordica charantia Linn.) on level and function of natural killer cells in cervical cancer patients with radiotherapy. J. Med. Assoc. Thai. 2003, 86, 61–68.
   PubMedGoogle Scholar
• Konishi, T.; Satsu, H.; Hatsugai, Y.; Aizawa, K.; Inakuma, T.; Nagata, S.; Sakuda, S.H.; Nagasawa, H.; Shimizu, M. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br. J. Pharmacol. 2004, 143, 379–387.
   PubMed Web of Science ®Google Scholar
• Limtrakul, P.; Khantamat, O.; Pintha, K. Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract. Cancer Chemother. Pharmacol. 2004, 54, 525–530.
   PubMed Web of Science ®Google Scholar
• Yasui, Y.; Hosokawa, M.; Sahara, T.; Suzuki, R.; Ohgiya, S.; Kohno, H.; Tanaka, T.; Miyashita, K. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells. Prostaglandins Leukotrienes Essent. Fatty Acids 2005, 73, 113–119.
   PubMed Web of Science ®Google Scholar
• Ng, T.B.; Chan, W.Y.; Yeung, H.W. Proteins with abortifacient, ribosome inactivating, immunomodulatory, antitumor and anti-AIDS activities from Cucurbitaceae plants. Gen. Pharmacol. 1992, 23, 579–590.
   PubMedGoogle Scholar
• Beloin, N.; Gbeassor, M.; Akpagana, K.; Hudson, J.; de Soussa, K.; Koumaglo, K.; Arnason, J.T. Ethnomedicinal uses of Momordica charantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity. J. Ethnopharmacol. 2005, 96, 49–55.
   PubMed Web of Science ®Google Scholar
• Lin, J.; Tang, C. Strawberry, loquat, mulberry, and bitter melon juices exhibit prophylactic effects on LPS-induced inflammation using murine peritoneal macrophages. Food Chem. 2008, 107, 1587–1596.
   Web of Science ®Google Scholar
• Kobori, M.; Nakayama, H.; Fukushima, K.; Ohnishi-Kameyama, M.; Ono, H.; Fukushima, T.; Akimoto, Y.; Masumoto, S.; Yukizaki, C.; Hoshi, Y.; Deguchi, T.; Yoshida, M. Bitter gourd suppresses lipopolysaccharide-induced inflammatory responses. J. Agric. Food Chem. 2008, 56, 4004–4011.
   PubMed Web of Science ®Google Scholar
• Biswas, A.R.; Ramaswamy, S.; Bapna, J.S. Analgesic effect of Momordica charantia seed extract in mice and rats. J. Ethnopharmacol. 1991, 31, 115–118.
   PubMed Web of Science ®Google Scholar
• Choi, J.; Lee, K.T.; Jung, H.; Park, H.S.; Park, H.J. Anti-rheumatoid arthritis effect of the Kochia scoparia fruits and activity comparison of momordin lc, its prosapogenin and sapogenin. Arch. Pharmacol. Res. 2002, 25, 336–342.
   PubMed Web of Science ®Google Scholar
• Nerurkar, P.V.; Lee, Y.K.; Nerurkar, V.R. Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern. Med. 2010, 10, 34.
   PubMedGoogle Scholar
• Senanayake, G.V.; Maruyama, M.; Sakono, M.; Fukuda, N.; Morishita, T.; Yukizaki, C.; Kawano, M.; Ohta, H. The effects of bitter melon (Momordica charantia) extracts on serum and liver lipid parameters in hamsters fed cholesterol-free and cholesterol-enriched diets. J. Nutr. Sci. Vitaminol. (Tokyo) 2004, 50, 253–257.
   PubMed Web of Science ®Google Scholar
• Chan, L.L.Y.; Chen, Q.; Go, A.G.G.; Lam, E.K.Y.; Li, E.T.S. Reduced adiposity in bitter melon (Momordica charantia)–fed rats is associated with increased lipid oxidative enzyme activities and uncoupling protein expression. J. Nutr. 2005, 135, 2517–2523.
   PubMed Web of Science ®Google Scholar
• Fernandes, N.P.C.; Lagishetty, C.V.; Panda, V.S.; Naik, S.R. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern. Med. 2007, 7, 29–33.
   PubMedGoogle Scholar
• Gadang, V.; Gilbert, W.; Hettiararchchy, N.; Horax, R.; Katwa, L.; Devareddy, L. Dietary bitter melon seed increases peroxisome proliferator-activated receptor-gamma gene expression in adipose tissue, down-regulates the nuclear factor-kappaB expression, and alleviates the symptoms associated with metabolic syndrome. J. Med. Food. 2011, 14, 86–93.
   PubMed Web of Science ®Google Scholar
• Dans, A.M.L.; Villarruz, M.V.C.; Jimeno, C.A.; Javelosa, M.A.U.; Chua, J.; Bautista, R.; Velez, G.G.B. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J. Clin. Epidemiol. 2007, 60, 554–559.
   PubMed Web of Science ®Google Scholar
• Chen, Q.; Chan, L.; Li, E. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J. Nutr. 2003, 133, 1088–1093.
   PubMed Web of Science ®Google Scholar
• Chaturvedi, P.; George, S.; Milinganyo, M.; Tripathi, Y.B. Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats. Phytother. Res. 2004, 18, 954–956.
   PubMed Web of Science ®Google Scholar
• Welihinda, J.; Karunanayake, E.H. Extra-pancreatic effects of Momordica charantia in rats. J. Ethnopharmacol. 1986, 17, 247–255.
   PubMed Web of Science ®Google Scholar
• Sathishsekar, D.; Subramanian, S. Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol. Pharm. Bull. 2005, 28, 978–983.
   PubMed Web of Science ®Google Scholar
• Ali, L.; Khan, A.K.; Mamun, M.I.; Mosihuzzaman, M.; Nahar, N.; Nur-e-Alam, M.; Rokeya, B. Studies on hypoglycemic effects of fruit pulp, seed, and whole plant of Momordica charantia on normal and diabetic model rats. Planta Med. 1993, 59, 408–412.
   PubMed Web of Science ®Google Scholar
• Virdi, J.; Sivakami, S.; Shahani, S.; Suthar, A.C.; Banavalikar, M.M.; Biyani, M.K. Antihyperglycemic effects of three extracts from Momordica charantia. J. Ethnopharmacol. 2003, 88, 107–111.
   PubMed Web of Science ®Google Scholar
• Harinantenaina, L.; Tanaka, M.; Takaoka, S.; Oda, M.; Mogami, O.; Uchida, M.; Asakawa, Y. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem. Pharm. Bull. (Tokyo) 2006, 54, 1017–1021.
   PubMed Web of Science ®Google Scholar
• Morgan, W.; Midmore, D. Bitter Melon in Australia; Rural Industries Research and Development Corporation: Barton, Australia, 2002.
   Google Scholar
• Yang, S.L.; Walters, T.W. Ethnobotany and the economic role of the Cucurbitaceae of China. Econ. Bot. 1992, 46, 349–367.
   Web of Science ®Google Scholar
• Tran, T.L.H.; Raymundo, L.C. Biosynthesis of carotenoids in bittermelon at high temperature. Phytochemistry 1999, 52, 275–280.
   Web of Science ®Google Scholar
• Tuan, P.A.; Kim, J.K.; Park, N.I.; Lee, S.Y.; Park, S.U. Carotenoid content and expression of phytoene synthase and phytoene desaturase genes in bitter melon (Momordica charantia). Food Chem. 2011, 126, 1686–1692.
   PubMed Web of Science ®Google Scholar
• Kha, T.C.; Nguyen, M.H.; Roach, P.D.; Stathopoulos, C.E. Microencapsulation of gac oil by spray drying: Optimization of wall material concentration and oil load using response surface methodology. Dry. Technol. 2014, 32, 385–397.
   Web of Science ®Google Scholar
• Yasuda, M.; Iwamoto, M.; Okabe, H.; Yamauchi, T. Structures of momordicines I, II, and III, the bitter principles in the leaves and vines of Momordica charantia L. Chem. Pharm. Bull. (Tokyo) 1984, 32, 2044–2047.
   Web of Science ®Google Scholar
• Okabe, H.; Miyahara, Y.; Yamauchi, T. Studies on the constituents of Momordica charantia L. IV. Characterization of the new cucurbitacin glycosides of the immature fruits. (2). Structures of the bitterglycosides, momordicosides K and L. Chem. Pharm. Bull. (Tokyo) 1982, 30, 2753–2762.
   Google Scholar
• Horax, R.; Hettiarachchy, N.; Islam, S. Total phenolic contents and phenolic acid constituents in 4 varieties of bitter melons (Momordica charantia) and antioxidant activities of their extracts. J. Food Sci. 2005, 70, C275–C280.
   Web of Science ®Google Scholar
• Ikram, E.H.K.; Eng, K.H.; Jalil, A.M.M.; Ismail, A.; Idris, S.; Azlan, A.; Nazri, H.S.M.; Diton, N.A.M.; Mokhtar, R.A.M. Antioxidant capacity and total phenolic content of Malaysian underutilized fruits. J. Food Compos. Anal. 2009, 22, 388–393.
   Web of Science ®Google Scholar
• Tan, S.P.; Parks, S.E.; Stathopoulos, C.E.; Roach, P.D. Greenhouse-grown bitter melon: Production and quality characteristics. J. Sci. Food Agric. 2014, 94, 1896–1903.
   PubMed Web of Science ®Google Scholar
• Zhao, X.; Iwamoto, T.; Carey, E.E. Antioxidant capacity of leafy vegetables as affected by high tunnel environment, fertilisation and growth stage. J. Sci. Food Agric. 2007, 87, 2692–2699.
   PubMed Web of Science ®Google Scholar
• Pincemail, J.; Kevers, C.; Tabart, J.; Defraigne, J.-O.; Dommes, J. Cultivars, culture conditions, and harvest time influence phenolic and ascorbic acid contents and antioxidant capacity of strawberry (Fragaria × ananassa). J. Food Sci. 2012, 77, C205–C10.
   PubMed Web of Science ®Google Scholar
• Oh, M.; Carey, E.E.; Rajashekar, C.B. Antioxidant phytochemicals in lettuce grown in high tunnels and open field. Hortic. Environ. Biotechnol. 2011, 52, 133–139.
   Web of Science ®Google Scholar
• Dixon, R.A.; Paiva, N.L. Stress-induced phenylpropanoid metabolism. Plant Cell 1995, 7, 1085–1097.
   PubMed Web of Science ®Google Scholar
• Ibrahim, M.H.; Jaafar, H.Z.; Karimi, E.; Ghasemzadeh, A. Impact of organic and inorganic fertilizers application on the phytochemical and antioxidant activity of Kacip Fatimah (Labisia pumila Benth). Molecules 2013, 18, 10973–10988.
   PubMed Web of Science ®Google Scholar
• Horax, R.; Hettiarachchy, N.; Chen, P. Extraction, quantification, and antioxidant activities of phenolics from pericarp and seeds of bitter melons (Momordica charantia) harvested at three maturity stages (immature, mature, and ripe). J. Agric. Food Chem. 2010, 58, 4428–4433.
   PubMed Web of Science ®Google Scholar
• da Silva, F.L.; Escribano-Bailón, M.T.; Pérez Alonso, J.J.; Rivas-Gonzalo, J.C.; Santos-Buelga, C. Anthocyanin pigments in strawberry. LWT Food Sci. Technol. 2007, 40, 374–382.
   Web of Science ®Google Scholar
• Sridhar, M.G.; Vinayagamoorthi, R.; Arul, S.V.; Bobby, Z.; Selvaraj, N. Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br. J. Nutr. 2008, 99, 806–812.
   PubMed Web of Science ®Google Scholar
• Krawinkel, M.B.; Keding, G.B. Bitter gourd (Momordica charantia): A dietary approach to hyperglycemia. Nutr. Rev. 2006, 64, 331–337.
   PubMed Web of Science ®Google Scholar
• Snee, L.S.; Nerurkar, V.R.; Dooley, D.A.; Efird, J.T.; Shovic, A.C.; Nerurkar, P.V. Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): A vegetable commonly used for diabetes management. Nutr. J. 2011, 10, 78–88.
   PubMedGoogle Scholar
• Subtil, S.F.; Rocha-Selmi, G.A.; Thomazini, M.; Trindade, M.A.; Netto, F.M.; Favaro-Trindade, C.S. Effect of spray drying on the sensory and physical properties of hydrolysed casein using gum arabic as the carrier. J. Food Sci. Technol. 2012, 51, 1–8.
   Google Scholar
• Yang, S.; Mao, X.Y.; Li, F.F.; Zhang, D.; Leng, X.J.; Ren, F.Z.; Teng, G.X. The improving effect of spray-drying encapsulation process on the bitter taste and stability of whey protein hydrolysate. Eur. Food Res. Technol. 2012, 235, 91–97.
   Web of Science ®Google Scholar
• Tan, S.P.; Vuong, Q.V.; Stathopoulos, C.E.; Parks, S.E.; Roach, P.D. Optimized aqueous extraction of saponins from bitter melon for production of a saponin-enriched bitter melon powder. J. Food Sci. 2014, 79, E1372–E1381.
   PubMed Web of Science ®Google Scholar
• Tan, S.P.; Parks, S.E.; Stathopoulos, C.E.; Roach, P.D. An optimised aqueous extract of phenolic compounds from bitter melon with high antioxidant capacity. Antioxidants 2014, 3, 814–829.
   Google Scholar
• Budrat, P.; Shotipruk, A. Enhanced recovery of phenolic compounds from bitter melon (Momordica charantia) by subcritical water extraction. Sep. Purif. Technol. 2009, 66, 125–129.
   Web of Science ®Google Scholar
• Lin, J.-Y.; Tang, C.-Y. Determination of total phenolic and flavonoid contents in selected fruits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chem. 2007, 101, 140–147.
   Web of Science ®Google Scholar
• Wu, S.J.; Ng, L.T. Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) in Taiwan. LWT Food Sci. Technol. 2008, 41, 323–330.
   Web of Science ®Google Scholar
• Tan, S.P.; Parks, S.E.; Stathopoulos, C.E.; Roach, P.D. Extraction of flavonoids from bitter melon. Food Nutr. Sci. 2014, 5, 458–465.
   Google Scholar
• Kubola, J.; Siriamornpun, S. Phenolic contents and antioxidant activities of bitter gourd (Momordica charantia L.) leaf, stem and fruit fraction extracts in vitro. Food Chem. 2008, 110, 881–890.
   Google Scholar
• Fayos, J.; Belles, J.M.; Lopez-Gresa, M.P.; Primo, J.; Conejero, V. Induction of gentisic acid 5-O-beta-d-xylopyranoside in tomato and cucumber plants infected by different pathogens. Phytochemistry 2006, 67, 142–148.
   PubMed Web of Science ®Google Scholar
• Belles, J.M.; Garro, R.; Pallas, V.; Fayos, J.; Rodrigo, I.; Conejero, V. Accumulation of gentisic acid as associated with systemic infections but not with the hypersensitive response in plant-pathogen interactions. Planta 2006, 223, 500–511.
   PubMed Web of Science ®Google Scholar
• Harborne, J.B.; Williams, C.A. Advances in flavonoid research since 1992. Phytochemistry 2000, 55, 481–504.
   PubMed Web of Science ®Google Scholar
• Budrat, P.; Shotipruk, A. Extraction of phenolic compounds from fruits of bitter melon (Momordica charantia) with subcritical water extraction and antioxidant activities of these extracts. Chiang Mai J. Sci. 2008, 35, 123–130.
   Web of Science ®Google Scholar
• Mølgaard, P.; Ravn, H. Evolutionary aspects of caffeoyl ester distribution in dicotyledons. Phytochemistry 1988, 27, 2411–2421.
   Web of Science ®Google Scholar
• Oakenfull, D. Saponins in food—A review. Food Chem. 1981, 7, 19–40.
   Web of Science ®Google Scholar
• Guclu-Ustundag, Ö.; Mazza, G. Saponins: Properties, applications and processing. Crit. Rev. Food Sci. Nutr. 2007, 47, 231–258.
   PubMed Web of Science ®Google Scholar
• Lee, S.Y.; Eom, S.H.; Kim, Y.K.; Park, N.I.; Park, S.U. Cucurbitane-type triterpenoids in Momordica charantia Linn. J. Med. Plants Res. 2009, 3, 1264–1269.
   Google Scholar
• Wei-Min, Z. Saponins. In Introduction to Natural Products Chemistry; Xu, R., Ye, Y., Zhao, W., Eds.; CRC Press: Boca Raton, FL, 2011; pp 125–145.
   Google Scholar
• Alice, C.B.; Vargas, V.M.; Silva, G.A.; de Siqueira, N.C.; Schapoval, E.E.; Gleye, J.; Henriques, J.A.; Henriques, A.T. Screening of plants used in south Brazilian folk medicine. J. Ethnopharmacol. 1991, 35, 165–171.
   PubMed Web of Science ®Google Scholar
• Liu, J.; Henkel, T. Traditional Chinese medicine (TCM): Are polyphenols and saponins the key ingredients triggering biological activities? Curr. Med. Chem. 2002, 9, 1483–1485.
   Web of Science ®Google Scholar
• Raman, A.; Lau, C. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine 1996, 2, 349–362.
   PubMed Web of Science ®Google Scholar
• Tan, M.; Ye, J.; Turner, N.; Hohnen-Behrens, C.; Ke, C.; Tang, C.; Chen, T.; Weiss, H.; Gesing, E.; Rowland, A.; James, D.; Ye, Y. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem. Biol. 2008, 15, 263–273.
   PubMed Web of Science ®Google Scholar
• Murakami, T.; Emoto, A.; Matsuda, H.; Yoshikawa, M. Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L. Chem. Pharm. Bull. (Tokyo) 2001, 49, 54–63.
   PubMed Web of Science ®Google Scholar
• Ullah, M.; Chy, F.K.; Sarkar, S.K.; Islam, M.K.; Absar, A. Nutrient and phytochemical analysis of four varieties of bitter gourd (Momordica charantia) grown in Chittagong Hill Tracts, Bangladesh. Asian J. Agric. Res. 2011, 5, 186–193.
   Google Scholar
• Orlovskaya, T.; Chelombitko, V. Amino acid composition of Momordica charantia seeds and pericarp. Chem. Nat. Compd. 2007, 43, 237–238.
   Google Scholar
• Horax, R.; Hettiarachchy, N.; Kannan, A.; Chen, P. Proximate composition and amino acid and mineral contents of Mormordica charantia. L. pericarp and seeds at different maturity stages. Food Chem. 2010, 122, 1111–1115.
   Web of Science ®Google Scholar
• Yawai, K.E.; Rao, K.S.; Kaluwin, C.; Jones, G.P.; Rivett, D.E. Chemical composition of Momordica charantia L. fruits. J. Agric. Food Chem. 1991, 39, 1762–1763.
   Web of Science ®Google Scholar
• Khanna, P.; Jain, S.C.; Panagariya, A.; Dixit, V.P. Hypoglycemic activity of polypeptide-p from a plant source. J. Nat. Prod. 1981, 44, 648–655.
   PubMed Web of Science ®Google Scholar
• Yibchok-anun, S.; Adisakwattana, S.; Yao, C.Y.; Sangvanich, P.; Roengsumran, S.; Hsu, W.H. Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities. Biol. Pharm. Bull. 2006, 29, 1126–1131.
   PubMed Web of Science ®Google Scholar
• Sharma, V.N.; Sogani, R.K.; Arora, R.B. Some observations on hpoglycaemia activity in Momordica charantia. Indian J. Med. Res. 1960, 48, 471–477.
   Google Scholar
• Paul, A.; Raychaudhuri, S.S. Medicinal uses and molecular identification of two Momordica charantia varieties—A review. Electronic J. Biol. 2010, 6, 43–51.
   Google Scholar
• Zänker, K.S.; Mang, B.; Wolters, M.; Hahn, A. Personalized diabetes and cancer medicine: A rationale for anti-diabetic nutrition (Bitter Melon) in a supportive setting. Curr. Cancer Ther. Rev. 2012, 8, 66–77.
   Google Scholar
• Wang, Z.Q.; Zhang, X.H.; Yu, Y.; Poulev, A.; Ribnicky, D.; Floyd, Z.E.; Cefalu, W.T. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J. Nutr. Biochem. 2011, 22, 1064–1073.
   PubMed Web of Science ®Google Scholar
• Chang, C.; Tseng, H.; Liao, Y.; Yen, C.; Chen, T.; Lin, C.; Cheng, H. In vivo and in vitro studies to identify the hypoglycaemic constituents of Momordica charantia wild variant WB24. Food Chem. 2011, 125, 521–528.
   Web of Science ®Google Scholar
• Nivitabishekam, S.N.; Asad, M.; Prasad, V.S. Pharmacodynamic interaction of Momordica charantia with rosiglitazone in rats. Chem. Biol. Interact. 2009, 177, 247–253.
   PubMed Web of Science ®Google Scholar
• Shih, C.; Lin, C.; Lin, W.; Wu, J. Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats. J. Ethnopharmacol. 2009, 123, 82–90.
   PubMed Web of Science ®Google Scholar
• Ahmed, I.; Adeghate, E.; Sharma, A.K.; Pallot, D.J.; Singh, J. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Res. Clin Pract. 1998, 40, 145–151.
   PubMed Web of Science ®Google Scholar
• Higashino, H.; Suzuki, A.; Tanaka, Y.; Pootakham, K. Hypoglycemic effects of Siamese Momordica charantia and Phyllanthus urinaria extracts in streptozotocin-induced diabetic rats (the 1st report). Nihon Yakurigaku Zasshi 1992, 100, 415–421.
   PubMed Web of Science ®Google Scholar
• Sarkar, S.K.; Pranava, M.; Marita, R.A. Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes. Pharmacol. Res. 1996, 33, 1–4.
   PubMed Web of Science ®Google Scholar
• Miura, T.; Itoh, C.; Iwamoto, N.; Kato, M.; Kawai, M.; Park, S.R.; Suzuki, I. Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice. J. Nutr. Sci. Vitaminol. (Tokyo) 2001, 47, 340–344.
   PubMed Web of Science ®Google Scholar
• Matsuda, H.; Li, Y.; Murakami, T.; Matsumura, N.; Yamahara, J.; Yoshikawa, M. Antidiabetic principles of natural medicines. III. Structure-related inhibitory activity and action mode of oleanolic acid glycosides on hypoglycemic activity. Chem. Pharm. Bull. (Tokyo) 1998, 46, 1399–1403.
   Google Scholar
• Mahomoodally, M.F.; Fakim, A.G.; Subratty, A.H. Momordica charantia extracts inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in-vitro. Biol. Pharm. Bull. 2004, 27, 216–218.
   PubMed Web of Science ®Google Scholar
• Shibib, B.A.; Khan, L.A.; Rahman, R. Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: Depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem. J. 1993, 292, 267–270.
   PubMed Web of Science ®Google Scholar
• Masuzaki, H.; Paterson, J.; Shinyama, H.; Morton, N.M.; Mullins, J.J.; Seckl, J.R.; Flier, J.S. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001, 294, 2166–2170.
   PubMed Web of Science ®Google Scholar
• Blum, A.; Loerz, C.; Martin, H.J.; Staab-Weijnitz, C.A.; Maser, E. Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11β-hydroxysteroid dehydrogenase type 1 inhibitor. J. Steriod Biochem. Mol. Biol. 2012, 128, 51–55.
   PubMed Web of Science ®Google Scholar
• Keller, A.C.; Ma, J.; Kavalier, A.; He, K.; Brillantes, A.B.; Kennelly, E.J. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine 2011, 19, 32–37.
   PubMed Web of Science ®Google Scholar
• Marles, R.J.; Farnsworth, N.R. Antidiabetic plants and their active constituents. Phytomedicine 1995, 2, 137–189.
   PubMed Web of Science ®Google Scholar
• Fuangchan, A.; Sonthisombat, P.; Seubnukarn, T.; Chanouan, R.; Chotchaisuwat, P.; Sirigulsatien, V.; Ingkaninan, K.; Plianbangchang, P.; Haines, S.T. Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J. Ethnopharmacol. 2011, 134, 422–428.
   PubMed Web of Science ®Google Scholar
• Inayat-ur, R.; Malik, S.A.; Bashir, M.; Khan, R.; Iqbal, M. Serum sialic acid changes in non-insulin-dependant diabetes mellitus (NIDDM) patients following bitter melon (Momordica charantia) and rosiglitazone (Avandia) treatment. Phytomedicine 2009, 16, 401–405.
   PubMed Web of Science ®Google Scholar
• Baldwa, V.S.; Bhandari, C.M.; Pangaria, A.; Goyal, R.K. Clinical trial in patients with diabetes mellitus of an insulin like compound obtained from plant source. Upsala J. Med. Sci. 1977, 82, 39–41.
   PubMed Web of Science ®Google Scholar
• Leatherdale, B.A.; Panesan, R.K.; Singh, G.; Atkins, T.W.; Bailey, C.J.; Bignell, A.H. Improvement in glucose tolerance due to Momordica charantia (karela). Br. Med. J. (Clin. Res. Educ.) 1981, 282, 1823–1824.
   PubMed Web of Science ®Google Scholar
• Srivastava, Y.; Venkatakrishna-Bhatt, H.; Verma, Y. Antidiabetic and adaptogenic properties of Momordica charantia extract. An experimental and clinical evaluation. Phytother. Res. 1993, 7, 285–289.
   Web of Science ®Google Scholar
• Grover, J.K.; Gupta, S.R. Hypoglycemic activity of seeds of Momordica charantia. Eur. J. Pharm. 1990, 183, 1026–1027.
   Web of Science ®Google Scholar
• Ahmad, N.; Hassan, M.R.; Halder, H.; Bennoor, K.S. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients. Bangladesh Med. Res. Council Bull. 1999, 25, 11–13.
   PubMedGoogle Scholar
• Jayasooriya, A.P.; Sakono, M.; Yukizaki, C.; Kawano, M.; Yamamoto, K.; Fukuda, N. Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. J. Ethnopharmacol. 2000, 72, 331–336.
   PubMed Web of Science ®Google Scholar
• Avramoglu, R.K.; Basciano, H.; Adeli, K. Lipid and lipoprotein dysregulation in insulin resistant states. Clin. Chim. Acta 2006, 368, 1–19.
   PubMed Web of Science ®Google Scholar
• Nerurkar, P.V.; Pearson, L.; Efird, J.T.; Adeli, K.; Theriault, A.G.; Nerurkar, V.R. Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells. J. Nutr. 2005, 135, 702–706.
   PubMed Web of Science ®Google Scholar
• Nerurkar, P.V.; Lee, Y.K.; Motosue, M.; Adeli, K.; Nerurkar, V.R. Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions. Br. J. Nutr. 2008, 100, 751–759.
   PubMed Web of Science ®Google Scholar
• Lee, I.T.; Lee, W.; Tsai, C.; Su, I.; Yen, H.; Sheu, W.H.H. Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome. Nutr. Res. 2012, 32, 85–92.
   PubMed Web of Science ®Google Scholar
• Prasad, V.; Jain, V.; Girish, D.; Dorle, A.K. Wound-healing property of Momordica charantia L. fruit powder. J. Herb. Pharmacother. 2006, 6, 105–115.
   PubMedGoogle Scholar
• Ono, T.; Tsuji, T.; Sakai, M.; Yukizaki, C.; Ino, H.; Akagi, I.; Hiramatsu, K.; Matsumoto, Y.; Sugiura, Y.; Uto, H.; Tsubouchi, H.; Gohda, E. Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp. Cytokine 2009, 46, 119–126.
   PubMed Web of Science ®Google Scholar
• Roopashree, T.S.; Dang, R.; Shobha Rani, R.H.; Narendra, C. Antibacterial activity of antipsoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis. Int. J. Appl. Res. Nat. Prod. 2008, 1, 20–28.
   Google Scholar
• Braca, A.; Siciliano, T.; D’Arrigo, M.; Germanò, M.P. Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. Fitoterapia 2008, 79, 123–125.
   PubMed Web of Science ®Google Scholar
• Abalaka, M.E.; Inabo, H.I.; Onaolapo, J.A.; Olonitola, O.S. Antioxidant capabilities of extracts and antimicrobial activities of chromatographic fractions of Momordica charantia L. (Cucurbitaceae). Ferment. Technol. Bioeng. 2011, 1, 1–6.
   Google Scholar
• Meng, Y.; Liu, B.; Lei, N.; Zheng, J.; He, Q.; Li, D.; Zhao, X.; Shen, F. Alpha-momorcharin possessing high immunogenicity, immunotoxicity and hepatotoxicity in SD rats. J. Ethnopharmacol. 2012, 139, 590–598.
   PubMed Web of Science ®Google Scholar
• Kobori, M.; Ohnishi-Kameyama, M.; Akimoto, Y.; Yukizaki, C.; Yoshida, M. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J. Agric. Food Chem. 2008, 56, 10515–10520.
   PubMed Web of Science ®Google Scholar
• Semiz, A.; Sen, A. Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract. Afr. J. Biotechnol. 2007, 6, 273–277.
   Web of Science ®Google Scholar
• Fang, E.F.; Zhang, C.Z.; Fong, W.P.; Ng, T.B. RNase MC2: A new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways. Apoptosis 2012, 17, 377–387.
   PubMed Web of Science ®Google Scholar
• Fang, E.F.; Zhang, C.Z.; Zhang, L.; Fong, W.P.; Ng, T.B. In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells. Int. J. Biochem. Cell Biol. 2012, 44, 1351–1360.
   PubMed Web of Science ®Google Scholar