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Evaluation of Ginger (Zingiber Officinale Roscoe) on Energy Metabolism and Obesity: Systematic Review and Meta-Analysis

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References

  • Ali, B. H.; Blunden, G.; Tanira, M. O.; Nemmar, A. Some Phytochemical, Pharmacological and Toxicological Properties of Ginger (Zingiber Officinale Roscoe): A Review of Recent Research. Food. Chem. Toxicol. 2008, 46, 409–420. DOI: 10.1016/j.fct.2007.09.085.
  • Kaplan, H.; Growing and Plant Characteristics of Ginger (Zingiber Officinale Roscoe). DERIM. 2014, 22(2), 1–9. http://www.derim.com.tr/issue/4559/62571 (accessed May 21, 2017)).
  • Chaiyakunapruk, N.; Kitikannakorn, N.; Nathisuwan, S.; Leeprakobboon, K.; Leelasettagool, C. The Efficacy of Ginger for the Prevention of Postoperative Nausea and Vomiting: A Meta Analysis. Am. J. Obstet. Gynecol. 2006, 194, 95–99. DOI: 10.1016/j.ajog.2005.06.046.
  • Li, Y.; Tran, V. H.; Duke, C. C.; Roufogalis, B. D. Preventive and Protective Properties of Zingiber Officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Evid. Based. Complement. Altern. Med. 2012, 2012 (Article ID516870).
  • Schwertner, H. A.; Rios, D. C. High-Performance Liquid Chromatographic Analysis of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol in Ginger Containing Dietary Supplements, Spices, Teas, and Beverages. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 856(1–2), 41–47. DOI: 10.1016/j.jchromb.2007.05.011.
  • Palatty, P. L.; Haniadka, R.; Valder, B.; Arora, R.; Baliga, M. S. Ginger in the Prevention of Nausea and Vomiting: A Review. Crit. Rev. Food Sci. Nutr. 2013, 53(7), 659–669. DOI: 10.1080/10408398.2011.553751.
  • Mashhadi, N. S.; Ghiasvand, R.; Askari, G.; Hariri, M.; Darvishi, L.; Mofid, M. R. Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. Int. J. Prev. Med. 2013, 4(S1), 36–42.
  • Mansour, M. S.; Ni, Y. M.; Roberts, A. L.; Kelleman, M.; Roychoudhury, A.; St-Onge, M. P. Ginger Consumption Enhances the Thermic Effect of Food and Promotes Feelings of Satiety without Affecting Metabolic and Hormonal Parameters in Overweight Men: A Pilot Study. Metabolism. 2012, 61(10), 1347–1352. DOI: 10.1016/j.metabol.2012.03.016.
  • Jeena, K.; Liju, V. B.; Viswanathan, R.; Kuttan, R. Antimutagenic Potential and Modulation of Carcinogen-Metabolizing Enzymes by Ginger Essential Oil. Phytother Res. 2014, 28(6), 849–855. DOI: 10.1002/ptr.v28.6.
  • Saravanan, G.; Ponmurugan, P.; Deepa, M. A.; Senthilkumar, B. Anti-Obesity Action of Gingerol: Effect on Lipid Profile, Insulin, Leptin, Amylase and Lipase in Male Obese Rats Induced by a High-Fat Diet. J. Sci. Food Agric. 2014, 94(14), 2972–2977. DOI: 10.1002/jsfa.2014.94.issue-14.
  • Ahn, E. K.; Oh, J. S. Inhibitory Effect of Galanolactone Isolated from Zingiber Officinale Roscoe Extract on Adipogenesis in 3T3-L1 Cells. J. Korean Soc. Appl. Biol. Chem. 2012, 55, 63–68. DOI: 10.1007/s13765-012-0011-6.
  • Suk, S.; Kwon, G. T.; Lee, E.; Jang, W. J.; Yang, H.; Kim, J. H.; Kim, J. K.; Gingerenone, A. A Polyphenol Present in Ginger, Suppresses Obesity and Adipose Tissue Inflammation in High‐Fat Diet‐Fed Mice. Mol. Nutr. Food Res. 2017, 61, 1700139. DOI: 10.1002/mnfr.201700139.
  • Mattes, R. D.;. Spices and Energy Balance. Physiol. Behav. 2012, 107(4), 584–590. DOI: 10.1016/j.physbeh.2011.10.028.
  • Lazzini, S.; Polinelli, W.; Riva, A.; Morazzoni, P.; Bombardelli, E. The Effect of Ginger (Zingiber Officinalis) and Artichoke (Cynara Cardunculus) Extract Supplementation on Gastric Motility: A Pilot Randomized Study in Healthy Volunteers. Eu.R Rev. Med. Pharmacol. Sci. 2016, 20(1), 146–149.
  • Hu, M. L.; Rayner, C. K.; Wu, K. L.; Chuah, S. K.; Tai, W. C.; Chou, Y. P.; Chiu, Y. C.; Chiu, K. W.; Hu, T. H. Effect of Ginger on Gastric Motility and Symptoms of Functional Dyspepsia. World J. Gastroenterol. 2011, 17, 105–110. DOI: 10.3748/wjg.v17.i1.105.
  • Eldershaw, T. P.; Colquhoun, E. Q.; Dora, K. A.; Peng, Z. C.; Clark, M. G. Pungent Principles of Ginger (Zingiber Officinale) are Thermogenic in the Perfused Rat Hindlimb. Int. J. Obes. Relat. Metab. Disord. 1992, 16, 755–763.
  • Henry, C. J.; Piggotti, S. M. Effect of Ginger on Metabolic Rate. Hum. Nutr. Clin. Nutr. 1987, 41, 89–92.
  • Iwami, M.; Mahmoud, F. A.; Shiina, T.; Hirayama, H.; Shima, T.; Sugita, J.; Shimizu, Y. Extract of Grains of Paradise and Its Active Principle 6-Paradol Trigger Thermogenesis of Brown Adipose Tissue in Rats. Auton Neurosci. 2011, 161(1), 63–67. DOI: 10.1016/j.autneu.2010.11.012.
  • Wang, J. K. W.; Bao, R.; Hu, X.; Chen, F. Beneficial Effects of Ginger Zingiber Officinale Roscoe on Obesity and Metabolic Syndrome: A Review. Ann. N Y Acad. Sci. 2017, 1398(1), 83–98. DOI: 10.1111/nyas.13375.
  • Zhu, J.; Chen, H.; Song, Z.; Wang, X.; Sun, Z. Effects of Ginger (Zingiber Officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid. Based Complement. Altern. Med. 2018. DOI: 10.1155/2018/5692962.
  • Goyal, R. K.; Kadnur, S. V. Beneficial Effects of Zingiber Officinale on Goldthioglucose Induced Obesity. Fitoterapia. 2006, 77, 160–163. DOI: 10.1016/j.fitote.2006.02.010.
  • Brahma Naidu, P.; Uddandrao, V. V.; Ravindar Naik, R.; Suresh, P.; Meriga, B.; Begum, M. S.; Pandiyan, R.; Saravanan, G. Ameliorative Potential of Gingerol: Promising Modulation of Inflammatory Factors and Lipid Marker Enzymes Expressions in HFD Induced Obesity in Rats. Mol. Cell. Endocrinol. 2016, 419, 139–147. DOI: 10.1016/j.mce.2015.10.007.
  • Misawa, K.; Hashizume, K.; Yamamoto, M.; Minegishi, Y.; Hase, T. Shimotoyodome A Ginger Extract Prevents High-Fat Diet-Induced Obesity in Mice via Activation of the Peroxisome Proliferator-Activated Receptor δ Pathway. J. Nutr. Biochem. 2015, 26, 1058–1067. DOI: 10.1016/j.jnutbio.2015.04.014.
  • Malik, Z. A.; Sharma, P. I. Attenuation of High Fat Diet Induced Body Weight Gain Adiposity and Biochemical Anomalies after Cronic Administration of Ginger (Zingiberofficinale) in Wistar Rats. Int. J. Pharm. 2011, 7(8), 801–812. DOI: 10.3923/ijp.2011.801.812.
  • Shalaby, M. A.; Saifna, H. Y. Some Pharmacological Effects of Cinnamon and Ginger Herbs in Obese Diabetic Rats. J. Intercult. Ethnopharmacol. 2014, 3(4), 144–149. DOI: 10.5455/jice.20140818050741.
  • Lee, D. H.; Ahn, J.; Jang, Y. J.; Ha, T. Y.; Jung, C. H. Zingiber Mioga Reduces Weight Gain, Insulin Resistance and Hepatic Gluconeogenesis in Diet‑Induced Obese Mice. Exp. Ther. Med. 2016, 12, 369–376. DOI: 10.3892/etm.2016.3331.
  • Mahmoud, R. H.; Elnour, W. A. Comparative Evaluation of the Efficacy of Ginger and Orlistat on Obesity Management, Pancreatic Lipase and Liver Peroxisomal Catalase Enzyme in Male Albino Rats. Eu.R Rev. Med. Pharmacol. Sci. 2013, 17(1), 75–83.
  • Ueki, S.; Miyoshi, M.; Shido, O.; Hasegawa, J.; Watanabe, T. Systemic Administration of [6]-Gingerol, a Pungent Constituent of Ginger, Induces Hypothermia in Rats via an Inhibitory Effect on Metabolic Rate. Eur. J. Pharmacol. 2008, 584(1), 87–92. DOI: 10.1016/j.ejphar.2008.01.031.
  • Kim, K.; Lee, M. S.; Jung, S.; Son, H. Y.; Park, S.; Kang, B.; Kim, S. Y.; Kim, I. W.; Kim, C. T.; Kim, Y. Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue. Nutrients. 2018, 10, 1567. DOI: 10.3390/nu10111567.
  • Abdel Raoof, G. F.; Mohamed, K. Y.; Mohammed, H. M. Phytochemical Evaluation, Anti-Obesity and Antihyperlipidemic Effects of Combined Administration of Green Coffee, Cinnamon and Ginger. Plant. 2017, 5(5), 80–84. DOI: 10.11648/j.plant.20170505.12.
  • Atashak, S.; Peeri, M.; Azarbayjani, M. A.; Stannard, S. R. Effects of Ginger (Zingiber Officinale Roscoe) Supplementation and Resistance Training on Some Blood Oxidative Stress Markers in Obese Men. J. Exerc. Sci. Fit. 2014, 12(1), 26–30. DOI: 10.1016/j.jesf.2014.01.002.
  • Sugita, J.; Yoneshiro, T.; Sugishima, Y.; Ikemoto, T.; Uchiwa, H.; Suzuki, I.; Saito, M. Daily Ingestion of Grains of Paradise (Aframomum Melegueta) Extract Increases Whole-Body Energy Expenditure and Decreases Visceral Fat in Humans. J. Nutr. Sci. Vitaminol. 2014, 60(1), 22–27.
  • Gregersen, N. T.; Belza, A.; Jensen, M. G.; Ritz, C.; Bitz, C.; Hels, O.; Frandsen, E.; Mela, D. J.; Astrup, A. Acute Effects of Mustard, Horseradish, Black Pepper and Ginger on Energy Expenditure, Appetite, Ad Libitum Energy Intake and Energy Balance in Human Subjects. Br. J. Nutr. 2013, 109(03), 556–563. DOI: 10.1017/S0007114512001201.
  • Attari, V. E.; Ostadrahimi, A.; Jafarabadi, M. A.; Mehralizadeh, S.; Mahluji, S. Changes of Serum Adipocytokines and Body Weight following Zingiber Officinale Supplementation in Obese Women: A RCT. Eur. J. Nutr. 2016, 55(6), 2129–2136. DOI: 10.1007/s00394-015-1027-6.
  • Miyamoto, M.; Matsuzaki, K.; Katakura, M.; Hara, T.; Tanabe, Y.; Shido, O. Oral Intake of Encapsulated Dried Ginger Root Powder Hardly Affects Human Thermoregulatory Function, but Appears to Facilitate Fat Utilization. Int. J. Biometeorol. 2015, 59(10), 1461–1474. DOI: 10.1007/s00484-015-0957-2.
  • Attari, V. E.; Asghari Jafarabadi, M.; Zemestani, M.; Ostadrahimi, A. Effect of Zingiber Officinale Supplementation on Obesity Management with respect to the Uncoupling Protein 1‐3826A>G and ß3‐Adrenergic Receptor Trp64Arg Polymorphism. Phytother Res. 2015, 29(7), 1032–1039. DOI: 10.1002/ptr.5343.
  • Sugita, J.; Yoneshiro, T.; Hatano, T.; Aita, S.; Ikemoto, T.; Uchiwa, H.; Saito, M. Grains of Paradise (Aframomum Melegueta) Extract Activates Brown Adipose Tissue and Increases Whole-Body Energy Expenditure in Men. Br. J. Nutr. 2013, 110(04), 733–738. DOI: 10.1017/S0007114512005715.
  • Tzeng, T. F.; Liu, I. M. 6-Gingerol Prevents Adipogenesis and the Accumulation of Cytoplasmic Lipid Droplets in 3T3-L1 Cells. Phytomed. 2013, 20(6), 481–487. DOI: 10.1016/j.phymed.2012.12.006.
  • Suk, S., Seo, S.G., Yu J.G.; Yang, H.; Jeong, E.; Jang, Y. J. et al. A Bioactive Constituent of Ginger, 6-Shogaol, Prevents Adipogenesis and Stimulates Lipolysis in 3t3-L1 Adipocytes. J. Food Biochem. 2016, 40, 84–90. DOI: 10.1111/jfbc.12191.
  • Pulbutr, P.; Thunchomnang, K.; Lawa, K.; Mangkhalathon, A.; Saenubol, P. Lipolytic Effects of Zingerone in Adipocytes Isolated from Normal Diet Fed Rats and High Fat Diet Fed Rats. Int. J. Pharmacol. 2011, 7, 629–634. DOI: 10.3923/ijp.2011.629.634.
  • Fujisawa, F.; Nadamoto, T.; Fushiki, T. Effect of Intake of Ginger on Peripheral Body Temperature. J. Jpn. Soc. Nutr. Food Sci. 2005, 58(1), 3–9. DOI: 10.4327/jsnfs.58.3.
  • Iwasaki, Y.; Morita, A.; Iwasawa, T.; Kobata, K.; Sekiwa, Y.; Morimitsu, Y.; Kubota, K.; Watanabe, T. A Nonpungent Component of Steamed Ginger—(10)-Shogaol—Increases Adrenaline Secretion via the Activation of TRPV1. Nutr. Neurosci. 2006, 9(3–4), 169–178.
  • Riera, C. E.; Menozzi‐Smarrito, C.; Affolter, M.; Michlig, S.; Munari, C.; Robert, F.; Vogel, H.; Simon, S. A.; le Coutre, J. Compounds from Sichuan and Melegueta Peppers Activate, Covalently and Non‐Covalently, TRPA1 and TRPV1 Channels. Br. J. Pharmacol. 2009, 157(8), 1398–1409. DOI: 10.1111/j.1476-5381.2009.00307.x.
  • Morera, E.; De Petrocellis, L.; Morera, L.; Moriello, A. S.; Nalli, M.; Di Marzo, V.; Ortar, G. Synthesis and Biological Evaluation of [6]-Gingerol Analogues as Transient Receptor Potential Channel TRPV1 and TRPA1 Modulators. Bioorg. Med. Chem. Lett. 2012, 22(4), 1674–1677. DOI: 10.1016/j.bmcl.2011.12.113.
  • Toda, K.; Takeda, S.; Hitoe, S.; Nakamura, S.; Matsuda, H.; Shimoda, H. Enhancement of Energy Production by Black Ginger Extract Containing Polymethoxy Flavonoids in Myocytes through Improving Glucose, Lactic Acid and Lipid Metabolism. J. Nat. Med. 2016, 70(2), 163–172. DOI: 10.1007/s11418-015-0948-y.
  • Yu, Y.; Zick, S.; Li, X.; Zou, P.; Wright, B.; Sun, D. Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans. Aaps J. 2011, 13, 417–426. DOI: 10.1208/s12248-011-9295-4.
  • Tornio, A.; Filppula, A. M.; Kailari, O.; Neuvonen, M.; Nyrönen, T. H.; Tapaninen, T.; Neuvonen, P. J.; Niemi, M.; Backman, J. T. Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions. Clin. Pharmacol. Ther. 2014, 96, 498–507. DOI: 10.1038/clpt.2014.97.
  • Platel, K.; Srinivasan, K. Digestive Stimulant Action of Spices: A Myth or Reality? Indian J. Med. Res. 2004, 119(5), 167–179.

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