Eicosapentaenoic Acid and Docosahexaenoic Acid from Fish Oil and Their Role in Cancer Research

References

• Ferlay, J.; Colombet, M.; Soerjomataram, I.; Mathers, C.; Parkin, D. M.; Pineros, M.; Znaor, A.; Bray, F. Estimating the Global Cancer Incidence and Mortality in 2018: GLOBOCAN Sources and Methods. Int. J. Cancer. 2019, 144, 1941–1953.
   Google Scholar
• Amaral, R. G.; Santos, S. A. D.; Andrade, L. N.; Severino, P.; Carvalho, A. A. Natural Products as Treatment against Cancer: A Historical and Current Vision. Clin. Oncol. 2019, 4, 1–5.
   Google Scholar
• Abiri, B.; Vafa, M. Dietary Omega-3 Polyunsaturated Fatty Acids and Treatment of Cancer. Adv. Obes Weight Manag. Control. 2018, 8, 198–201.
   Google Scholar
• Echeverria, F.; Ortiz, M.; Valenzuela, R.; Videla, A. L. Long-chain Polyunsaturated Fatty Acids Regulation of PPARs, Signaling: Relationshipto Tissue Development and Aging. Prostaglandins. Leukot. Essent. Fatty Acids. 2016, 114, 28–34. DOI: 10.1016/j.plefa.2016.10.001.
   Google Scholar
• Valenzulea, R.; Videla, A. L. The Importance of the Long-chain Polyunsaturated Fatty Acid n-6/n-3 Ratio in Development of Non-alcoholic Fatty Liver Associated with Obesity. Food Funct. 2011, 2, 644–648. DOI: 10.1039/c1fo10133a.
   Google Scholar
• Echeverria, F.; Valenzuela, R.; Herandez-Rodas, C. M.; Valenzuela, A. Docosahexaenoic Acid (DHA), a Fundamental Fatty Acid for the Brain: New Dietary Sources. Prostaglandins. Leukot. Essent. Fatty Acids. 2017, 124, 1–10. DOI: 10.1016/j.plefa.2017.08.001.
   Google Scholar
• Ciriminna, R.; Meneguzzo, F.; Delisi, R.; Mario, P. Enhancing and Improving the Extraction of Omega-3 from Fish Oil. Sustainable Chem. Pharm. 2017, 5, 54–59. DOI: 10.1016/j.scp.2017.03.001.
   Google Scholar
• Ivanovs, K.; Blumberga, D. Extraction of Fish Oil Using Green Extraction Methods: A Short Review. Energy Procedia. 2017, 128, 477–483. DOI: 10.1016/j.egypro.2017.09.033.
   Google Scholar
• Tocher, D.; Betancor, M.; Sprague, M.; Olsen, R.; Napier, J. Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand. Nutrients. 2019, 11, 89. DOI: 10.3390/nu11010089.
   Google Scholar
• Jaroslav, A. K.; Shuocheng, Z.; Wei, Z.; Colin, J. B. A Review of the Progress in Enzymatic Concentration and Microencapsulation of Omega-3 Rich Oil from Fish and Microbial Sources. Food Chem. 2012, 131, 639–644. DOI: 10.1016/j.foodchem.2011.08.085.
   Google Scholar
• Sahena, F.; Zaidul, I. S. M.; Jinap, S.; Yazid, A. M.; Khatib, A.; Norulaini, N. A. N. Fatty Acid Compositions of Fish Oil Extracted from Different Parts of Indian Mackerel (Rastrelliger kanagurta) Using Various Techniques of Supercritical CO2 Extraction. Food Chem. 2009, 120, 879–885. DOI: 10.1016/j.foodchem.2009.10.055.
   Google Scholar
• Nuria, -R.-R.; Sara, M. D. D.; Sagrario, B.; Isabel, J.; Maria, T. S.; Jordi, R. Supercritical Fluid Extraction of Fish Oil from Fish By-products: A Comparison with Other Extraction Methods. J. Food Eng. 2012, 109, 238–248. DOI: 10.1016/j.jfoodeng.2011.10.011.
   Google Scholar
• Darren, J. H.; Bruce, J. H. Omega-3 Fatty Acids from fish Oils and Cardiovascular Disease. Mol. Cell Biochem. 2004, 263, 217–225. DOI: 10.1023/B:MCBI.0000041863.11248.8d.
   Google Scholar
• Radford, Z.; Hyder, K.; Zarauz, L.; Mugerza, E.; Ferter, K.; Prellezo, R.; Strehlow, H. V.; Townhill, B.; Lewin, W.-C.; Weltersbach, M. S. The Impact of Marine Recreational Fishing on Key Fish Stocks in European Waters. PloS One. 2018, 13, e0201666. DOI: 10.1371/journal.pone.0201666.
   Google Scholar
• Ian, H. P.; Andrew, J. Fish Oil: Production and Use Now and in the Future. Lipid. Tech. 2010, 22, 59–61. DOI: 10.1002/lite.201000003.
   Google Scholar
• Mengelberg, A.; Leathem, J.; Podd, J. Fish Oil Supplement Use in New Zealand: A Cross-sectional Survey. Complement Ther. Clin. Pract. 2018, 33, 118–123. DOI: 10.1016/j.ctcp.2018.09.005.
   Google Scholar
• Lin, Z.; Chen, R.; Jiang, Y.; Xia, Y.; Niu, Y.; Wang, C.; Liu, C.; Chen, C.; Ge, Y.; Wang, W.; et al. Cardiovascular Benefits of Fish Oil Supplementation against Fine Particulate Air Pollution in China. J. Am. Coll. Cardiol. 2019, 73, 2076–2085. DOI: 10.1016/j.jacc.2018.12.093.
   Google Scholar
• Bird, J.; Calder, P.; Eggersdorfer, M. The Role of N-3 Long Chain Polyunsaturated Fatty Acids in Cardiovascular Disease Prevention, and Interactions with Statins. Nutrients. 2018, 10, 775. DOI: 10.3390/nu10060775.
   Google Scholar
• Mazaherioun, M.; Saedisomeolia, A.; Javanbakht, M. H.; Koohdani, F.; Zarei, M.; Ansari, S.; Bazargani, F. K.; Djalali, M. Long Chain N-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus. Iran. J. Public Health. 2018, 47, 575.
   Google Scholar
• Iizuka, Y.; Kim, H.; Izawa, T.; Sakurai, K.; Hirako, S.; Wada, M.; Matsumoto, A. Protective Effects of Fish Oil and Pioglitazone on Pancreatic Tissue in Obese KK Mice with Type 2 Diabetes. Prostaglandins, Leukotrienes Essent. Fatty Acids. 2016, 115, 53–59. DOI: 10.1016/j.plefa.2016.10.007.
   Google Scholar
• Sara, P.; Elena, P.; Carrie, R.; Elena, N. The Mediterranean Diet, Fish Oil Supplements and Rheumatoid Arthritis Outcomes: Evidence from Clinical Trials. Autoimmunity Rev. 2018, 1105–1114.
   Google Scholar
• Tortosa-Caparrós, E.; Navas-Carrillo, D.; Marín, F.; Orenes-Piñero, E. Anti-inflammatory Effects of Omega 3 and Omega 6 Polyunsaturated Fatty Acids in Cardiovascular Disease and Metabolic Syndrome. Crit. Rev. Food Sci. Nutr. 2017, 57, 3421–3429. DOI: 10.1080/10408398.2015.1126549.
   Google Scholar
• Xue, M.; Wang, Q.; Zhao, J.; Dong, L.; Ge, Y.; Hou, L.; Liu, Y.; Zheng, Z. Docosahexaenoic Acid Inhibited the Wnt/β-catenin Pathway and Suppressed Breast Cancer Cells in Vitro and in Vivo. J. Nutr. Biochem. 2014, 25, 104–110. DOI: 10.1016/j.jnutbio.2013.09.008.
   Google Scholar
• Fu, Y.-Q.; Zheng, J.-S.; Yang, B.; Li, D. Effect of Individual Omega-3 Fatty Acids on the Risk of Prostate Cancer: A Systematic Review and Dose-response Meta-analysis of Prospective Cohort Studies. J. Epidemiol. 2015, 25 (4): 261–274. JE20140120.
   Google Scholar
• Sheng, H.; Li, P.; Chen, X.; Liu, B.; Zhu, Z.; Cao, W. Omega-3 PUFAs Induce Apoptosis of Gastric Cancer Cells via ADORA1. Front. Biosci. (Landmark Ed). 2014, 19, 854–861. DOI: 10.2741/4252.
   Google Scholar
• Newell, M.; Baker, K.; Postovit, L.; Field, C. A Critical Review on the Effect of Docosahexaenoic Acid (DHA) on Cancer Cell Cycle Progression. Int. J. Mol. Sci. 2017, 18, 1784. DOI: 10.3390/ijms18081784.
   Google Scholar
• Geng, L.; Zhou, W.; Liu, B.; Wang, X.; Chen, B. DHA Induces Apoptosis of Human Malignant Breast Cancer Tissues by the TLR-4/PPAR-α Pathways. Oncol. Lett. 2018, 15, 2967–2977. DOI: 10.3892/ol.2017.7702.
   Google Scholar
• Hang, L.; Xiong, Z. R.; Stephen, H. P.; Ray, F.; Wint, Y. M.; David, C. W.; John, F. M.; Zac, V. EPA and DHA Reduce LPS-induced Inflammation Responses in HK-2 Cells: Evidence for a PPAR-gama-dependent Mechanism. Kidney Int. 2005, 67, 867–874. DOI: 10.1111/j.1523-1755.2005.00151.x.
   Google Scholar
• Zulfakar, M. H.; Abdeoluahab, N.; Heard, C. M. Enhanced Topical Delivery and Ex Vivo Anti-inflammatory Activity from a Betamethasone Dipropionate Formulation Containing Fish Oil. Inflam. Res. 2010, 59, 23–30. DOI: 10.1007/s00011-009-0065-z.
   Google Scholar
• Zulfakar, M. H.; Edwards, M.; Heard, C. M. Is There a Role for Topically Delivered Eicosapentaenoic Acid in the Treatment of Psoriasis? Eur. J. Dermatol. 2007, 17, 284–291. DOI: 10.1684/ejd.2007.0201.
   Google Scholar
• Khayel, G.; Young, J.; Burns-Whitmore, B.; Spalidng, T. Effects of Fish Oil Supplements on Inflammatory Acne. Lipids Health Dis. 2012, 11. DOI: 10.1186/476-511X-11-165.
   Google Scholar
• Dupuis, N.; Curatolo, N.; Benoist, J. F.; Auvin, S. Ketogenic Diet Exhibits Anti‐inflammatory Properties. Epilepsia. 2015, 56, e95–e8. DOI: 10.1111/epi.13038.
   Google Scholar
• Chu, C.;. Lipids: COX-2’s New Role in Inflammation. Nat. Chem. Biol. 2010, 6, 401–402. DOI: 10.1038/nchembio.375.
   Google Scholar
• Soon, A. L.; Hye, J. K.; Ki, C. C.; Jong, C. B.; Ji, K. P.; Jeong, K. S.; Won, J. C.; Lee, J. H.; Won, Y. P. DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-κB Activity in LPS-treated Human Umbilical Vein Endothelial Cells. Korean J. Physiol. Pharmacol. 2009, 13, 301–307. DOI: 10.4196/kjpp.2009.13.4.301.
   Google Scholar
• Leslie, G. C.; Michael, J. J.; Susanna, M. P. Fish Oil: What Prescriber Needs to Know. Arthiritis Res. Ther. 2006, 8, 202–211. DOI: 10.1186/ar1876.
   Google Scholar
• Isabelle, M. B.; Iris, J. E.; Yong, Q. C. Multi-targeted Therapy of Cancer by Omega-3 Fatty Acids. Cancer Lett. 2008, 269, 363–377. DOI: 10.1016/j.canlet.2008.03.044.
   Google Scholar
• Spencer, L.; Mann, C.; Metcalfe, M.; Webb, M.; Pollard, C.; Spencer, D.; Berry, D.; Steward, W.; Dennison, A. The Effect of Omega-3 FAs on Tumor Angiogenesis and Their Therapeutic Potential. Eur. J. Cancer. 2009, 45, 2077–2086. DOI: 10.1016/j.ejca.2009.04.026.
   Google Scholar
• Fetterman, J. W. J.; Zdanowicz, M. Therapeutic Potential of N-3 Polyunsaturated Fatty Acids in Disease. Am. J. Health Syst. Pharm. 2009, 66, 1169–1179. DOI: 10.2146/ajhp080411.
   Google Scholar
• Serini, S.; Piccioni, E.; Merendino, N.; Calviello, G. Dietary Polyunsaturated Fatty Acids as Inducers of Apoptosis: Implications for Cancer. Apoptosis. 2009, 14, 135–152. DOI: 10.1007/s10495-008-0298-2.
   Google Scholar
• D’Eliseo, D.; Velotti, F. Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-targeted Cancer Therapy. J. Clin. Med. 2016, 5, 15. DOI: 10.3390/jcm5020015.
   Google Scholar
• Yamagami, T.; Porada, C. D.; Pardini, R. S.; Zanjani, E. D.; Almedia-Porada, G. Docosahexaenoic Acid Induces Dose Dependent Cell Death in Early Undifferntiated Subtype Acute Myeloid Leukemia Cell Line. Cancer Biol. Ther. 2009, 8, 331–337. DOI: 10.4161/cbt.8.4.7334.
   Google Scholar
• Park, M.; Lim, J.; Kim, H. Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and Nf-κB. Nutrients. 2018, 10, 1621. DOI: 10.3390/nu10111621.
   Google Scholar
• Soyeon, S.; Kaipeng, J.; Soyeon, J.; Nayeong, K.; Kyoung-Sub, S.; Jun-Young, H.; Ji-Hoon, P.; Seo, K.-S.; Jeongsu, H.; Jong-Il, P.; et al. The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-mediatid AKt-m TOR Signaling in Prostate Cancer Cells Expressing Mutant P53. Biomed Res. Int. 2013. DOI: 10.1155/2013/568671.
   Google Scholar
• Fukui, M.; Kang, K. S.; Okada, K.; Zhu, B. T. EPA, an Omega-3 Fatty Acid, Induces Apoptosis in Human Pancreatic Cancer Cells: Role of ROS Accumulation, Caspase-8 Activation, and Autophagy Induction. J. Cell. Biochem. 2013, 114, 192–203. DOI: 10.1002/jcb.v114.1.
   Google Scholar
• Sun, S. N.; Jia, W. D.; Chen, H.; Ma, J. L.; Ge, Y. S.; Yu, J. H.; Li, J. S. Docosahexaenoic Acid (DHA) Inducs Apoptosis in Human Hepatocellular Carcinoma Cells. Int. Clin. Exp. Pathol. 2013, 6, 281–289.
   Google Scholar
• Tsai, C. H.; Shen, Y. C.; Chen, H. W.; Liu, K. L.; Chang, J. W.; Chen, P. Y.; Lin, C. Y.; Yao, H. T.; Li, C. C. Docosahexaenoic Acid Increases the Expression of Oxidative Stress-induced Growth Inhibitor 1 through the PI3K/Akt/Nrf2 Signaling Pathway in Breast Cancer Cells. Food Chem. Toxicol. 2017, 108, 276–288. DOI: 10.1016/j.fct.2017.08.010.
   Google Scholar
• Helena, G.; John, I. J.; Per, K. Omega-3 Fatty Acids in Cancer, the Protectors of Good and the Killers of Evil? Exp. Cell Res. 2010, 316, 1365–1373. DOI: 10.1016/j.yexcr.2010.02.039.
   Google Scholar
• Nita, M.; Grzybowski, A. The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults. Oxid. Med. Cell. Longev. 2016, 2016, 1–23. DOI: 10.1155/2016/3164734.
   Google Scholar
• Volpato, M.; Hull, M. A. Omega-3 Polyunsaturated Fatty Acids as Adjuvant Therapy of Colorectal Cancer. Cancer Metastasis Rev. 2018, 37, 545–555. DOI: 10.1007/s10555-018-9744-y.
   Google Scholar
• Lee, S. I.; Kang, K. S. Omega-3 Fatty Acids Modulate Cyclophosphamide Induced Markers of Immunosuppression and Oxidative Stress in Pigs. Sci. Rep. 2019, 9, 2684. DOI: 10.1038/s41598-019-39458-x.
   Google Scholar
• Echeverria, F.; Valenzuela, R.; Bustamante, A.; Alvarez, D.; Ortiz, M.; Soto-Alarcon, A. S.; Munoz, P.; Corbari, A.; Videla, A. L. Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT. Oxid. Med. Cell. Longev. 2018, 2018, 1–13. DOI: 10.1155/2018/5109503.
   Google Scholar
• Valenzuela, R.; Espinosa, R.; Gonzalez-Manan, D.; D’Espessailles, A.; Frenandez, V.; Videla, A. L.; Tapia, G. N-3 Long-chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis. PloS One. 2012, 7, 1–8. DOI: 10.1371/journal.pone.0046400.
   Google Scholar
• Albert, B. B.; Smith, D. C.; Hoffman, P. L.; Cutfield, W. S. Oxidation of Marine Omega-3 Supplements and Human Health. Biomed Res. Int. 2013, 2013, 1–8. DOI: 10.1155/2013/464921.
   Google Scholar
• Tapia, G.; Valenzuela, R.; Espinosa, A.; Romanque, P.; Dossi, C.; Gonzalez-Mañán, D.; Videla, L. A.; D’Espessailles, A. N-3 Long-chain PUFA Supplementation Prevents High Fat Diet Induced Mouse Liver Steatosis and Inflammation in Relation to PPAR-α Upregulation and NF-κB DNA Binding Abrogation. Mol. Nutr. Food Res. 2014, 58, 1333–1341. DOI: 10.1002/mnfr.201300458.
   Google Scholar
• Allam-Ndoul, B.; Guénard, F.; Barbier, O.; Vohl, M.-C. Effect of N-3 Fatty Acids on the Expression of Inflammatory Genes in THP-1 Macrophages. Lipids Health Dis. 2016, 15, 69. DOI: 10.1186/s12944-016-0241-4.
   Google Scholar
• Stephenson, J. A.; Al-Taan, O.; Arshad, A.; Morgan, B.; Metcalfe, M. S.; Dennison, A. The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer. J. Lipids. 2013, 2013, 1–13. DOI: 10.1155/2013/261247.
   Google Scholar
• Attiq, A.; Jalil, J.; Husain, K. B.; Ahmad, W. Raging the War against Inflammation with Natural Products. Front. Pharmacol. 2018, 9, 976. DOI: 10.3389/fphar.2018.00976.
   Google Scholar
• Baryawno, N.; Sveinbjornsson, B.; Eksborg, S.; Orrego, A.; Segerstrom, I.; Oqvist, C. O.; Holm, S.; Gustavsson, B.; Kagedal, B.; Kogner, P.; et al. Tumor-growth-promoting Cyclooxygenase-2 Prostaglandin E2 Pathway Provides Medulloblastoma Therapeutic Targets. Neuro. Oncol. 2008, 10, 661–674. DOI: 10.1215/15228517-2008-035.
   Google Scholar
• Ponthan, F.; Wickstrom, M.; Gleissman, H.; Fuskevag, O. M.; Segerstrom, I.; Sveinbjornsson, B.; Redfern, C. P.; Eksborg, S.; Kogner, P.; Johnsern, J. I. Celecoxib Prevents Neuroblastoma Tumor Development and Potentiates the Effect of Chemotherapeutic Drugs in Vitro and in Vivo. Clin. Cancer. Res. 2007, 13, 1036–1044. DOI: 10.1158/1078-0432.CCR-06-1908.
   Google Scholar
• Tilley, S. L.; Coffman, T. M.; Koller, B. H. Mixed Messages: Modulation of Inflammation and Immune Responses by Prostaglandins and Thromboxanes. J. Clin. Invest. 2001, 108, 15–23. DOI: 10.1172/JCI200113416.
   Google Scholar
• Grosso, G.; Galvano, F.; Marventano, S.; Malaguarnera, M.; Bucolo, C.; Drago, F.; Caraci, F. Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms. Oxid. Med. Cell. Longev. 2014, 2014, 16. DOI: 10.1155/2014/313570.
   Google Scholar
• Gajos, G.; Zalewski, J.; Mostowik, M.; Konduracka, E.; Nessler, J.; Undas, A. Polyunsaturated Omega-3 Fatty Acids Reduce Lipoprotein-associated Phospholipase A2 in Patients with Stable Angina. Nutr. Metab. Cardiovasc. Dis. 2014, 24, 434–439. DOI: 10.1016/j.numecd.2013.09.011.
   Google Scholar
• Rehman, K.; Mohd, A. M. C.; Yuen, N. P.; Zulfakar, M. H. Immunomodulatory Effectiveness of Fish Oil and Omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells. J. Oleo Sci. 2016, 65, 217–224. DOI: 10.5650/jos.ess15256.
   Google Scholar
• Rehman, K.; Zulfakar, M. H. Novel Fish Oil-based Bigel System for Controlled Drug Delivery and Its Influence on Immunomodulatory Activity of Imiquimod against Skin Cancer. Pharm. Res. 2017, 34, 36–48. DOI: 10.1007/s11095-016-2036-8.
   Google Scholar
• Sara, M. W.; David, A. C. Tumor Angiogenesis: Molecular Pathways and Therapeutic Targets. Nat. Med. 2011, 17, 1359–1370. DOI: 10.1038/nm.2537.
   Google Scholar
• Victory, R.; Saed, G. M.; Diamond, M. P. Antiadhesion Effects of Docosahexaenoic Acid on Normal Human Peritoneal and Adhesion Fibroblasts. Fertil. Steril. 2007, 88, 1657–1662. DOI: 10.1016/j.fertnstert.2007.01.123.
   Google Scholar
• Schaefer, M. B.; Wenzel, A.; Fischer, T.; Braun-Dullaeus, R. C.; Renner, F.; Seeger, W.; Mayer, K. Fattyacids Differntially Influence Phophatidylinositol 3-kinase Signal Transduction in Endothelial Cells: Impact on Adhesion and Apoptosis. Atherosclerosis. 2008, 197, 630–637. DOI: 10.1016/j.atherosclerosis.2007.09.004.
   Google Scholar
• Kamisawa, T.; Wood, L. D.; Itoi, T.; Takaori, K. Pancreatic Cancer. Lancet. 2016, 388, 73–85. DOI: 10.1016/S0140-6736(16)00141-0.
   Google Scholar
• Liam, D. C.; Siong-Seng, L.; Ashok, R. V. Chromosome Instability and Carcinogenesis: Insights from Murine Models of Human Pancreatic Cancer Associated with BRCA2 Inactivation. Mol. Oncol. 2014, 8, 161–168. DOI: 10.1016/j.molonc.2013.10.005.
   Google Scholar
• Gregor, J. I.; Heukamp, I.; Killian, M.; Kiewert, C.; Schimke, I.; Kristiansen, G.; Walz, M.; Jacob, C. A.; Wenger, F. A. Does Enteral Nutrition of Dietary Polyunsaturated Fatty Acids Promote Oxidative Stress and Tumour Growth in Ductal Pancreatic Cancer?: Experimental Trial in Syrian Hamster. Prostaglandins. Leukot. Essent. Fatty Acids. 2006, 74, 67–74. DOI: 10.1016/j.plefa.2005.08.007.
   Google Scholar
• Swamy, M. V.; Citineni, B.; Patlolla, J. M.; Mohammed, A.; Zhang, Y.; Rao, C. V. Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination with Omega-3 Fatty Acids. Nutr. Cancer. 2008, 60, 81–89. DOI: 10.1080/01635580802416703.
   Google Scholar
• Arshad, A.; Chung, W. Y.; Isherwood, J.; Mann, C. D.; Al-Leswas, D.; Steward, W. P.; Metcalfe, M. S.; Dennison, A. R. Cellular and Plasma Uptake of Parenteral Omega-3 Rich Lipid Emulsion Fatty Acids in Patients with Advanced Pancreatic Cancer. Clin. Nutr. 2013. DOI: 10.1016/j.clnu.2013.09.017.
   Google Scholar
• Park, M.; Kim, H. Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review. J. Cancer Prev. 2017, 22, 1. DOI: 10.15430/JCP.2017.22.1.1.
   Google Scholar
• Song, K. S.; Jing, K.; Kim, J. S.; Yun, E. J.; Shin, S.; Seo, K. S.; Park, J. H.; Heo, J. Y.; Kang, J. X.; Suh, K. S.; et al. Omega-3-polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in Vitro and in Vivo via Downregulation of Wnt/Beta-catenin Signaling. Pancreatology. 2011, 11, 574–584. DOI: 10.1159/000334468.
   Google Scholar
• Li, L; Leung, P. S. Pancreatic Cancer, Pancreatitis and Oxidative Stress. Gastrointestinal Tissue (Oxidative Stress and Dietary Antioxidants). 2017, Chapter 13, 173-186.
   Google Scholar
• Siegel, R.; Naishadham, D.; Jemal, A. Cancer Statistics, 2014. CA Cancer J. Clin. 2014, 63, 11–30. DOI: 10.3322/caac.21166.
   Google Scholar
• Charles, L. V.; Mary, A. J.; Christi, C.; Deborah, B. Toremifene for Breast Cancer: A Review of 20 Years of Data. Clin. Breast Cancer. 2014, 14, 1–9. DOI: 10.1016/j.clbc.2013.10.014.
   Google Scholar
• Philippe, B.; Nawale, H.; Karine, M.; Charles, C.; Stephan, C. Fatty Acids and Breast Cancer: Sensitization to Treatments and Prevention of Metastatic Re-growth. Prog. Lipid Res. 2010, 49, 76–86. DOI: 10.1016/j.plipres.2009.08.003.
   Google Scholar
• Neil, M. I.; Clifford, A. H.; Ayca, G. Omega-3 Fatty Acids for Prevention of Breast Cancer: An Update and the State of Science. Curr. Breast Cancer Rep. 2013, 5, 247–254. DOI: 10.1007/s12609-013-0112-1.
   Google Scholar
• McCarty, M. F.; DiNicolantonio, J. J. Minimizing Membrane Arachidonic Acid Content as A Strategy for Controlling Cancer: A Review. Nutr. Cancer. 2018, 70, 840–850. DOI: 10.1080/01635581.2018.1470657.
   Google Scholar
• Silva, P. D. E. M.; Oliveira, A. C. D. M.; Pizato, N.; Muniz-Junqueira, M. I.; Magalhaes, K. G.; Nakano, E. Y.; Ito, M. K. The Effects of EPA and DHA Enriched Fish Oil on Nutritional and Immunological Markers of Treatment Naïve Breast Cancer Patients: A Randomized Double-blind Controlled Trial. Nutr. J. 2017, 16,1–11.
   Google Scholar
• Fabian, J. C.; Kimler, F. B.; Hursting, D. S. Omega-3 Fatty Acids for Breast Cancer Prevention and Survivorship. Breast Cancer Res. 2015, 17. DOI: 10.1186/s13058-015-0571-6.
   Google Scholar
• Philippe, B.; Nawale, H.; Ferrasson, M. N.; Giraudeau, B.; Charles, C.; Le Floch, O. Improving Outcome of Chemotherapy of Metastatic Breast Cancer by Docosahexaenoic Acid: A Phase II Trial. Br. J. Cancer. 2009, 101, 1978–1985. DOI: 10.1038/sj.bjc.6605441.
   Google Scholar
• Sophie, V.; Caroline, G.; Philippe, B.; Jean-Paul, S.; Jacques, G.; Karine, M. Sensitization by Docosahexaenoic Acid (DHA) of Breast Cancer Cells to Anthracyclines through Loss of Glutathione Peroxidase (Gpx1) Response. Free Radic. Biol. Med. 2008, 44, 1483–1491. DOI: 10.1016/j.freeradbiomed.2008.01.009.
   Google Scholar
• Ruth, E. P.; Flatt, S. W.; Newman, V. A.; Loki, N.; Cheryl, L. R.; Cynthia, A. T.; Bette, J. C.; Barbara, A. P.; John, P. P. Marine Fatty Acid Intake Is Associated with Breast Cancer Prognosis. J. Nutr. 2011, 141, 201–206. DOI: 10.3945/jn.110.128777.
   Google Scholar
• Schley, P. D.; Jijon, H. B.; Robinson, L. E.; Field, C. J. Mechanisms of Omega-3 Fatty Acid-induced Growth Inhbition in MDA-MB-231 Human Breast Cancer Cells. Breast Cancer Res. Treat. 2005, 92, 187–195. DOI: 10.1007/s10549-005-2415-z.
   Google Scholar
• Fabian, J. C.; Kimler, F. B.; Phillips, A. T.; Box, A. J.; Kreutzjans, L. A.; Carlson, E. S.; Hidaka, H. B.; Metheny, T.; Zalles, M. C.; Mills, B. G.; et al. Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women. Cancer Prev. Res. 2015, 8, 912–921. DOI: 10.1158/1940-6207.CAPR-14-0335.
   Google Scholar
• Rahman, M. M.; Veigas, J. M.; Williams, P. J.; Fernandes, G. DHA Is a More Potent Inhibitor of Breast Cancer Metastasis to Bone and Related Osteolysis than EPA. Breast Cancer Res. Treat. 2013, 141, 341–352. DOI: 10.1007/s10549-013-2703-y.
   Google Scholar
• Fen, L. I.; Hasio, A.-C.; Hu, M.-C.; Yang, F.-M.; Su, H.-M. Docosahexaenoic Acid Induces Proteasome-dependent Degradation of Estrogen Receptor α and Inhibits the Downstream Signaling Target in MCF-7 Breast Cancer Cells. J. Nutr. Biochem. 2010, 21, 512–517. DOI: 10.1016/j.jnutbio.2009.02.009.
   Google Scholar
• Pizato, N.; Luzete, C. B.; Kiffer, V. M. F. L.; Correa, H. L.; Santos, O. D. I.; Assumpcao, F. A. J.; Ito, M. K.; Magalhaes, K. G. Omega-3 Docosahexaenoic Acid Induces Pyroptosis Cell Death in Triple-negative Breast Cancer Cells. Sci. Rep. 2018, 8, 1–12. DOI: 10.1038/s41598-017-17765-5.
   Google Scholar
• Molfino, A.; Amabile, M. I.; Mazzucco, S.; Biolo, G.; Farcomeni, A.; Ramaccini, C.; Antonaroli, S.; Monti, M.; Muscaritoli, M. Effect of Oral Docosahexaenoic Acid (DHA) Supplementation on DHA Levels and Omega-3 Index in Red Blood Cell Membranes of Breast Cancer Patients. Front. Physiol. 2017, 8, 1–7. DOI: 10.3389/fphys.2017.00549.
   Google Scholar
• Palaniselvam, K.; Mashitah, M. Y.; Gaanty, P. M.; Solachuddin, J. A. I.; Ilavenil, S.; Natanamurugaraj, G. Nutraceuticals as Potential Therapeutic Agents for Colon Caner: A Review. Acta. Pharmaceutica Sinica B. 2014, 4, 173–181. DOI: 10.1016/j.apsb.2014.04.002.
   Google Scholar
• Junjie, Z.; Lijian, Z.; Xiaoxia, Y.; Liyu, C.; Liangtao, Z.; Yihua, G.; Jing, X. K.; Chun, C. Characteristics of Fatty Acid Distribution Is Associated with Colorectal Cancer Prognosis. Prostaglandins. Leukot. Essent. Fatty Acids. 2013, 88, 355–360. DOI: 10.1016/j.plefa.2013.02.005.
   Google Scholar
• Cockbain, A. J.; Toogood, G. J.; Hull, M. A. Omega-3 Polyunsaturated Fatty Acids for the Treatment and Prevention of Colorectal Cancer. Gut. 2012, 61, 135–149.
   Google Scholar
• Eltweri, A. M.; Thomas, A. L.; Metcalfe, M.; Calder, P. C.; Dennison, A. R.; Bowrey, D. J. Potential Applications of Fish Oils Rich in Omega-3 Polyunsaturated Fatty Acids in the Management of Gastrointestinal Cancer. Clin. Nutr. 2017, 36, 65–78. DOI: 10.1016/j.clnu.2016.01.007.
   Google Scholar
• Song, M.; Zhang, X.; Meyerhardt, J. A.; Giovannucci, E. L.; Ogino, S.; Fuchs, C. S.; Chan, A. T. Marine ω-3 Polyunsaturated Fatty Acid Intake and Survival after Colorectal Cancer Diagnosis. Gut. 2017, 66, 1790–1796. DOI: 10.1136/gutjnl-2016-311990.
   Google Scholar
• Lee, J. Y.; Sim, T.-B.; Lee, J.-E.; Na, H.-Y. Chemopreventive and Chemotherapeutic Effects of Fish Oil Derived Omega-3 Polyunsaturated Fatty Acids on Colon Carcinogenesis. Clin. Nutr. Res. 2017, 6, 147–160. DOI: 10.7762/cnr.2017.6.3.147.
   Google Scholar
• Ting, Y.; Shi, F.; Hai-Xia, Z.; Li-Xiao, X.; Zhan-Qiang, Z.; Kai-Tao, Y.; Cong-Long, X.; Hong-Lan, Y.; Sheng, Z.; Han-Ping, S.; et al. N-3 PUFAs Have Antiproliferative and Apoptotic Effects on Human Colorectal Cancer Stem-like Cells in Vitro. J. Nutr. Biochem. 2013, 24, 744–753. DOI: 10.1016/j.jnutbio.2012.03.023.
   Google Scholar
• Carline, H. J.; Gro, L. S.; Svanhild, A. S. DHA Induces ER Stress and Growth Arrest in Human Colon Cancer Cells: Associations with Cholesterol and Calcim Homeostatis. J. Lipid Res. 2008, 49, 2089–2100. DOI: 10.1194/jlr.M700389-JLR200.
   Google Scholar
• Morin, C.; Rodriguez, E.; Blier, U. P.; Fortin, S. Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer. Mar. Drugs. 2017, 15, 1–13. DOI: 10.3390/md15090283.
   Google Scholar
• Pettersen, K.; Monsen, V. T.; Hakvag, P. C. H.; Overland, H. B.; Pettersen, G.; Samdai, H.; Tesfahun, A. N.; Lundemo, A. G.; Bjorkoy, G.; Schonberg, S. A. DHA-induced Stress Response in Human Colon Cancer Cells – Focus on Oxidative Stress and Autophagy. Free Radic. Biol. Med. 2016, 90, 158–172. DOI: 10.1016/j.freeradbiomed.2015.11.018.
   Google Scholar
• Elena, F.; Simona, S.; Elisabetta, P.; Amelia, T.; Giovanni, M.; Achille, R. C.; Franco, O. R.; Gabriella, C. DHA Induces Apoptosis by Altering the Expression and Cellular Location of GRP78 in Colon Cancer Cell Lines. Biochem. Biophys. Acta-Mol. Basis Dis. 2012, 1822, 1762–1772. DOI: 10.1016/j.bbadis.2012.08.003.
   Google Scholar
• Huang, Q.; Wen, J.; Chen, G.; Ge, M.; Gao, Y.; Ye, X.; Liu, C.; Cai, C. Omega-3 Polyunsaturated Fatty Acids Inhibited Tumor Growth via Preventing the Decrease of Genomic DNA Methylation in Colorectal Cancer Rats. Nutr. Cancer. 2016, 68, 113–119. DOI: 10.1080/01635581.2016.1115526.
   Google Scholar
• Wang, W.; Yang, J.; Nimiya, Y.; Lee, K. S. S.; Sanidad, K.; Qi, W.; Sukamtoh, E.; Park, Y.; Liu, Z.; Zhang, G. ω-3 Polyunsaturated Fatty Acids and Their Cytochrome P450-derived Metabolites Suppress Colorectal Tumor Development in Mice. J. Nutr. Biochem. 2017, 48, 29–35. DOI: 10.1016/j.jnutbio.2017.06.006.
   Google Scholar
• Patel, D.; Thevenet-Morrison, K. Wijingaarden V. E. Omega-3 Polyunsaturated Fatty Acid Intake through Fish Consupmtion and Prostate Specific Antigen Level: Results from the 2003-2010 Nahtional Health and Examination Survey. Prostaglandins. Leukot. Essent. Fatty Acids. 2014, 91, 155–160. DOI: 10.1016/j.plefa.2014.07.008.
   Google Scholar
• Williams, C. D.; Whitley, B. M.; Hoyo, C.; Grant, D. J.; Iraggi, J. D.; Newman, K. A.; Gerber, L.; Taylor, L. A.; McKeever, M. G.; SJ, F. A High Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Is Associated with Increased Risk of Prostate Cancer. Nutr. Res. 2011, 31, 1–8. DOI: 10.1016/j.nutres.2011.01.002.
   Google Scholar
• Martin, C. S.; Brett, L.; Fredrik, P.; Tommy, C.; Eric, O.; Peter, E.; Charles, B. A Comparative Study of Tissue W-6 and W-3 Polyunsaturated Fatty Acids (PUFA) in Benign and Malignant Pathological Stage pT2a Radical Prostatectomy Specimens. Urol. Oncol. 2013, 31, 318–324. DOI: 10.1016/j.urolonc.2011.01.014.
   Google Scholar
• Aucoin, M.; Cooley, K.; Knee, C.; Fritz, H.; Balneaves, L. G.; Breau, R.; Fergusson, D.; Skidmore, B.; Wong, R.; Seely, D. Fish-Derived Omega-3 Fatty Acids and Prostate Cancer: A Systematic Review. Integr. Cancer Ther. 2017, 16, 32–62. DOI: 10.1177/1534735416656052.
   Google Scholar
• Eswaramkunnath, J.; Kuriakose, A.; Abraham, L. Omega Fatty Acids in Prostate Cancer–A Review. Indian J. Pharm. Pract. 2018, 11, 65. DOI: 10.5530/ijopp.11.2.14.
   Google Scholar
• Berquin, I. M.; Min, Y.; Wu, R.; Wu, J.; Perry, D.; Cline, J. M.; Thomas, M. J.; Thornburg, T.; Kulik, G.; Smith, A. Modulation of Prostate Cancer Genetic Risk by Omega-3 and Omega-6 Fattyacids. J. Clin. Invest. 2007, 117, 1866–1875. DOI: 10.1172/JCI31494.
   Google Scholar
• Yungping, H.; Haiguo, S.; Rick, T. O.; Zhennan, G.; Jansheng, W.; Yong, Q. C.; Joseph, T. O. F.; Iris, J. E. Syndecan-1 Dependant Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer. Neoplasia. 2010, 12, 826–836. DOI: 10.1593/neo.10586.
   Google Scholar
• Uddhav, P. K.; Justin, H.; Rajiv, D.; Paul, K.; Kenneth, G. D. A.; Kevin, M. Prostate Tumor Growth and Recurrence Can Be Modulated by the W-6: W-3ratio Diet: Athymic Mouse Xenograft Model Simulating Radical Prostatectomy. Neoplasia. 2006, 8, 112–124. DOI: 10.1593/neo.05637.
   Google Scholar
• Istfan, N. W.; Person, K. S.; Holick, M. F.; Chen, T. C. 1a,25-dihydroxyvitamin D and Fish Oil Synergistically Inhibit G1/S-phase Transition in Prostate Cancer Cells. J. Steriod Biochem. Mol. Biol. 2007, 103, 726–730. DOI: 10.1016/j.jsbmb.2006.12.011.
   Google Scholar
• Kyu, L.; Chang, H.; Yifan, D.; Miaoda, S.; Tong, W. Omega-3 Polyunsaturated Fatty Acids Inhibit Hepatocellular Carcinoma Cell Growth Blocking Beta-catenin and Cyclooxygenase-2. Mol. Cancer Ther. 2009, 8, 3046–3055. DOI: 10.1158/1535-7163.MCT-09-0551.
   Google Scholar
• Ringehan, M.; McKeating, J. A.; Protzer, U. Viral Hepatitis and Liver Cancer. Philos. Trans. R. Soc. B. 2017, 372, 20160274. DOI: 10.1098/rstb.2016.0274.
   Google Scholar
• Norie, S.; Manami, I.; Motoki, I.; Shizuka, S.; Taichi, S.; Taiki, Y.; Ribeka, T.; Yasuhito, T.; Masashi, M.; Shoichiro, T. Consumption of N-3 Fatty Acis and Fish Reduces Risk of Hepatoceullar Carcinoma. Gastroenterology. 2012, 142, 1468–1475. DOI: 10.1053/j.gastro.2012.02.018.
   Google Scholar
• Zhengshan, W.; Jianjie, Q.; Liyong, P. Omega-3 Fatty Acids Improves the Clinical Outcome of Hepatacetomized Patients with Hepatitis B Virus (HBV)- Associated Hepatocellular Carcinoma. J. Biomed. Res. 2012, 26, 395–399. DOI: 10.7555/JBR.26.20120058.
   Google Scholar
• Helen, M. P.; Nathan, A. J.; Cartriona, A. B.; Jeffery, S. C.; Helen, T. O. C.; Jacob, G. Omega-3 Supplementation and Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. J. Hepatol. 2012, 56, 944–951. DOI: 10.1016/j.jhep.2011.08.018.
   Google Scholar
• Haim, S.; Miryam, T.; Joelle, A.-S.; Rafel, B.; Rachel, L.; Pierre, S. The Therapeutic Potential of Long Chain Omega-3 Fattyacids in Nonalcoholic Fatty Liver Disease. Clin. Nutr. 2011, 30, 6–19. DOI: 10.1016/j.clnu.2010.06.001.
   Google Scholar
• Stefania, B.; Valeria, R.; Laura, N.; Maria, D. B.; Manuela, M.; Oliviero, R.; Cristina, N.; Roberto, C.; Pasquale, P.; Franesco, V. Polyunsaturated Fatty Acids Balance Affects Platelets NOX2 Activity in the Patients with Liver Cirrhosis. Digestive Liver Dis. 2014, 46, 632–638. DOI: 10.1016/j.dld.2014.02.021.
   Google Scholar
• Valenzuela, R.; Ortiz, M.; Herandez-Rodas, C. M.; Echeverria, F.; Videla, A. L. Targeting N-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease. Curr. Med. Chem. 2019. DOI: 10.2174/0929867326666190410121716.
   Google Scholar
• de Castro, G.; Calder, P. C. Non-alcoholic Fatty Liver Disease and Its Treatment with N-3 Polyunsaturated Fatty Acids. Clin. Nutr. 2018, 37, 37–55. DOI: 10.1016/j.clnu.2017.01.006.
   Google Scholar
• Beardo, P.; Cacho, D. T.; Izquierdo, L.; Alcover-Garcia, J. B.; Alcaraz, A.; Extramiana, J.; Mallofré, C. Cancer-Specific Survival Stratification Derived from Tumor Expression of Tissue Inhibitor of Metalloproteinase-2 in Non-Metastatic Renal Cell Carcinoma. Pathol. Oncol. Res. 2019, 25, 289–299. DOI: 10.1007/s12253-017-0339-7.
   Google Scholar
• Liou, Y.-F.; Hsieh, Y.-S.; Hung, T.-W.; Chen, P.-N.; Chang, Y.-Z.; Kao, S.-H.; Lin, S.-W.; Chang, H.-R. Thymoquinone Inhibits Metastasis of Renal Cell Carcinoma Cell 786-O-SI3 Associating with Downregulation of MMP-2 and u-PA and Suppression of PI3K/Src Signaling. Int. J. Med. Sci. 2019, 16, 686–695. DOI: 10.7150/ijms.32763.
   Google Scholar
• Zhou, Y.; Tong, L.; Chu, X.; Deng, F.; Tang, J.; Tang, Y.; Dai, Y. The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma. Cell. Physiol. Biochem. 2017, 43, 733–742. DOI: 10.1159/000481557.
   Google Scholar
• Anthony, J. M.; Julie, M. W. W.; William, S. G.; Hugh, M.; Sean, J. S. Docosahexaenoic Acid Reduces in Vitro Invasion of Renal Cell Carcinoma by Elevated Levels of Tissue Inhibitor of Metalloproteinase-1. J. Nutr. Biochem. 2005, 16, 17–22. DOI: 10.1016/j.jnutbio.2004.07.006.
   Google Scholar
• Mariko, S.; Shinji, K.; Keiji, I.; Noako, T.; Shin-ichi, A.; Yuki, T.; Toshiro, S.; Masami, C.-K.; Yoshihiko, N.; Masakazu, H.; et al. Oleate and Eicosapenataenoic Acid Attenuate Palmitate-induced Inflammation and Apoptosis in Renal Proximal Tubular Cell. Biochem. Biophys. Res. Commun. 2010, 402,265–271.
   Google Scholar
• Tasaki, S.; Horiguchi, A.; Asano, T.; Ito, K.; Asano, T.; Asakura, H. Docosahexaenoic Acid Inhibits the Phosphorylation of STAT3 and the Growth and Invasion of Renal Cancer Cells. Exp. Ther. Med. 2017, 14, 1146–1152. DOI: 10.3892/etm.2017.4616.
   Google Scholar
• Johnson, K. A.;. The Standard of Perfection: Thoughts about the Laying Hen Model of Ovarian Cancer. Cancer Prev. Res. 2009, 2, 97–99. DOI: 10.1158/1940-6207.CAPR-08-0244.
   Google Scholar
• Urick, M. E.; Giles, J. R.; Johnson, P. A. Dietary Aspirin Decreases the Stage of Ovarian Cancer in the Hen. Gynecol. Oncol. 2009, 112, 166–170. DOI: 10.1016/j.ygyno.2008.09.032.
   Google Scholar
• Erfan, E.; Karen, H.; Yan, Z.; Kristine, A. F.; Rui, Y.; Richard, B. V. B.; Hales, D. B. Flaxseed Enriched Diet-mediated Reduction in Ovarian Cancer Severity Is Correlated to the Reduction of Prostaglandin E2 in Laying Hen Ovaries. Prostaglandins. Leukot. Essent. Fatty Acids. 2013, 89, 179–187. DOI: 10.1016/j.plefa.2013.08.001.
   Google Scholar
• Erfan, E.; Janice, M. B.; Dale, B. H. Long Term Consumption of Flaxseed Enriched Diet Decreased Ovarian Cancer Incidence and Prostaglandins E2 in Hens. Gynecologic Oncol. 2013, 130, 620–628. DOI: 10.1016/j.ygyno.2013.05.018.
   Google Scholar
• Erfan, E.; Carolynn, C. S.; Stacey, R. M.; Nawneet, K. K.; Dale, B. H. Anti-inflammatory Effects of Fish Oil in Ovaries of Laying Hens Targets Prostaglandin Pathway. Lipids Health Dis. 2013, 12, 152–164. DOI: 10.1186/1476-511X-12-152.
   Google Scholar
• Arun, S.; Jennifer, B.; Jennifer, L.; Jospeh, E.; Jean, A. H. The Effects of Omega-3 Fatty Acids on Growth Regulaion of Epithelial Ovarian Cancer Cell Lines. Gynecologic Oncol. 2005, 99, 58–64. DOI: 10.1016/j.ygyno.2005.05.024.
   Google Scholar
• Arun, S.; Jennifer, B.; Joseph, E.; Gustavo, R.; Vernon, T. C.; Jean, A. H. Effects of Omega-3 Fatty Acids on Components of the Transforming Growth Factor Beta-1 Pathway: Implication for Dietary Modification and Prevention in Ovarian Cancer. Am. J. Obstet. Gynecol. 2009, 200,1–6.
   Google Scholar
• Merritt, M. A.; Cramer, D. W.; Missmer, S. A.; Vitonis, A. F.; Titus, L. J.; Terry, K. L. Dietary Fat Intake and Risk of Epithelial Ovarian Cancer by Tumour Histology. Br. J. Cancer. 2014, 110, 1392–1401. DOI: 10.1038/bjc.2014.16.
   Google Scholar
• Jiang, P.-Y.; Jiang, Z.-B.; Shen, K.-X.; Yue, Y. Fish Intake and Ovarian Cancer Risk: A Meta-analysis of 15 Case-control and Cohort Studies. PloS One. 2014, 9, e96401.
   Google Scholar
• West, L.; Pierce, S. R.; Yin, Y.; Fang, Z.; Zhou, C.; Bae-Jump, V. L. Docosahexaenoic Acid (DHA), an Omega-3 Fatty Acid, Inhibits Ovarian Cancer Growth and Adhesion. Gynecol. Oncol. 2018, 149, 30420–30427.
   Google Scholar
• Cerchietti, L. C.; Navigante, A. H.; Castro, M. A. Effects of Eicosapentaenoic and Docosahexaenoic N-3 Fatty Acids from Fish Oil and Preferential Cox-2 Inhibition on Systemic Syndromes in Patients with Advanced Lung Cancer. Nutr. Cancer. 2007, 59, 14–20. DOI: 10.1080/01635580701365068.
   Google Scholar
• Finocchiaro, C.; Segre, O.; Fadda, M.; Monge, T.; Scigliano, M.; Schena, M.; Tinivella, M.; Tiozzo, E.; Catalano, M. G.; Pugliese, M.; et al. Effect of N-3 Fatty Acids on Patients with Advanced Lung Cancer: A Double-blind, Placebo-controlled Study. Br. J. Nutr. 2012, 108, 327–333. DOI: 10.1017/S0007114511005551.
   Google Scholar
• Nicolo, M.; Lara, C.; Laura, M.; Romina, M.; Donatella, D. E.; Francesca, V. Dietary W-3 Polyunasaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer. Biomed Res. Int. 2013. DOI: 10.1155/2013/310186.
   Google Scholar
• Yao, Q. H.; Zhang, X. C.; Fu, T.; Gu, J. Z.; Wang, L.; Wang, Y.; Lai, Y. B.; Wang, Y. Q.; Guo, Y. W-3 Polyunsaturated Fatty Acids Inhibit the Proliferation of the Lung Adenocarcinoma Cell Line A549 in Vitro. Mol. Med. Rep. 2014, 9, 401–406. DOI: 10.3892/mmr.2013.1829.
   Google Scholar
• Kikawa, K. D.; Herrick, J. S.; Tateo, R. E.; Mouradian, M.; Tay, J. S.; Pardini, R. S. Induced Oxidative Stress and Cell Death in the A549 Lung Adenocarcinoma Cell Line by Ionizing Radiation Is Enhanced by Supplementation with Docosahexaenoic Acid. Nutr. Cancer. 2010, 62, 1017–1024. DOI: 10.1080/01635581.2010.492084.
   Google Scholar
• Jin, W.; Jian-Chun, Y.; Wei-Ming, K.; Zhi-Qiang, M. Supperiority of A Fish Oil Enriched to Medium Chain Triacylglycerols/long Chain Triacylglycerols in Gastrointestinal Surgery Patients: A Randomized Clinical Trial. Nutrition. 2012, 28, 623–629. DOI: 10.1016/j.nut.2011.08.004.
   Google Scholar
• de Miranda Torrinhas, R. S. M.; Raquel, S.; Thais, G.; Maria, F. C.-B.; Maria, M. S.; Rui, C.; Dan, L. W. Parenteral Fish Oil as A Pharmacological Agent to Modulate Post Operative Immune Response: A Randomized, Double Blind and Controlled Clinical Trial in Patients with Gastrointestinal Cancer. Clin. Nutr. 2013, 32, 503–510. DOI: 10.1016/j.clnu.2012.12.008.
   Google Scholar
• Oluwakemi, O.; Kenneth, D. B.; Donald, J. M.; Rose, M. B.; Iian, G.; Brian, M. R. Differential Effects of Eicosapentaenoic and Docosahexaenoic Acids upon Oxidant-stimulated Release and Uptake of Arachidonic Acid in Human Lymphoma U937 Cells. Pharmacol. Res. 2006, 52, 183–191.
   Google Scholar
• Arthur, J.; Jacek, C.; Joanna, G.-A.; Anna, C.; Grayna, B.; Miroslaw, D.; William, P.; Jorge, J. C. Erythrocyte Membrane Fatty Acids in Multiple Myeloma Patients. Leukemia Res. 2014, 38, 1260–1265. DOI: 10.1016/j.leukres.2014.08.009.
   Google Scholar
• Gorjão, R.; Verlengia, R.; Lima, T. M.; Soriano, F. G.; Boaventura, M. F.; Kanunfre, C. C.; Peres, C. M.; Sampaio, S. C.; Otton, R.; Folador, A.; et al. Effect of Docosahexaenoic Acid-rich Fish Oil Supplementation on Human Leukocyte Function. Clin. Nutr. 2006, 25, 923–938. DOI: 10.1016/j.clnu.2006.03.004.
   Google Scholar