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Review

Is Probiotic and Synbiotic Supplementation Effective on Immune Cells? A Systematic Review and Meta-analysis of Clinical Trials

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References

  • Yan, F.; Polk, D. B. Probiotics and Immune Health. Curr. Opin. Gastroenterol. 2011, 27(6), 496–501. DOI: 10.1097/MOG.0b013e32834baa4d.
  • Galdeano, C. M.; de Moreno de LeBlanc, A.; Vinderola, G.; Bonet, M. E. B.; Perdigón, G. Proposed Model: Mechanisms of Immunomodulation Induced by Probiotic Bacteria. Clin. Vaccine Immunol. 2007, 14(5), 485–492. DOI: 10.1128/CVI.00406-06.
  • Perdigón, G.;. Immunomodulation of Mucosal Immune Response by Probiotics. Curr. Trends Immunol. 2005, 6, 69–85.
  • Perdigón, G.; Fuller, R.; Raya, R. Lactic Acid Bacteria and Their Effect on the Immune System. Curr. Issues Intestinal Microbiol. 2001, 2(1), 27–42.
  • Rumbo, M.; Anderle, P.; Didierlaurent, A.; Sierro, F.; Debard, N.; SIRARD, J. C.; Finke, D.; KRAEHENBUHL, J. P. How the Gut Links Innate and Adaptive Immunity. Ann. N.Y. Acad. Sci. 2004, 1029(1), 16–21. DOI: 10.1196/annals.1309.003.
  • Miller, L. E.; Lehtoranta, L.; Lehtinen, M. J. The Effect of Bifidobacterium animalis Ssp. Lactis HN019 on Cellular Immune Function in Healthy Elderly Subjects: Systematic Review and Meta-Analysis. Nutrients. 2017, 9(3), 191. DOI: 10.3390/nu9030191.
  • Liberati, A.; Altman, D. G.; Tetzlaff, J.; Mulrow, C.; Gøtzsche, P. C.; Ioannidis, J. P.; Clarke, M.; Devereaux, P. J.; Kleijnen, J.; Moher, D. The PRISMA Statement for Reporting Systematic Reviews and Meta-analyses of Studies that Evaluate Health Care Interventions: Explanation and Elaboration. Ann. Internal Med. 2009, 151(4), W-65-W-94. DOI: 10.7326/0003-4819-151-4-200908180-00136.
  • Higgins, J. P.; Altman, D. G.; Gøtzsche, P. C.; Jüni, P.; Moher, D.; Oxman, A. D.; Savović, J.; Schulz, K. F.; Weeks, L.; Sterne, J. A. The Cochrane Collaboration’s Tool for Assessing Risk of Bias in Randomised Trials. Bmj. 2011, 343, d5928. DOI: 10.1136/bmj.d5928.
  • Gotoh, M.; Sashihara, T.; Ikegami, S.; Yamaji, T.; Kino, K.; Orii, N.; Taketomo, N.; Okubo, K. Efficacy of Oral Administration of a Heat-killed Lactobacillus Gasseri OLL2809 on Patients of Japanese Cedar Pollinosis with High Japanese-cedar Pollen-specific IgE. Biosci. Biotechnol. Biochem. 2009, 73(9), 1971–1977. DOI: 10.1271/bbb.90144.
  • Xiao, J. Z.;. Effect of Probiotic Bifidobacterium Longum BBS36 in Relieving Clinical Symptoms and Modulating Plasma Cytokine Levels in Japanase Cedar Pollinosis during the Pollen Season. A Randomized Double-blind, Placebo-controlled Trial. J. Invest. Allergol. Clin. Immunol. 2006, 16(4), 273.
  • Kimoto-Nira, H.; Nagakura, Y.; Kodama, C.; Shimizu, T.; Okuta, M.; Sasaki, K.; Koikawa, N.; Sakuraba, K.; Suzuki, C.; Suzuki, Y. Effects of Ingesting Milk Fermented by Lactococcus Lactis H61 on Skin Health in Young Women: A Randomized Double-blind Study. J. Dairy Sci. 2014, 97(9), 5898–5903. DOI: 10.3168/jds.2014-7980.
  • Nishihira, J.; Kagami-Katsuyama, H.; Tanaka, A.; Nishimura, M.; Kobayashi, T.; Kawasaki, Y. Elevation of Natural Killer Cell Activity and Alleviation of Mental Stress by the Consumption of Yogurt Containing Lactobacillus Gasseri SBT2055 and Bifidobacterium Longum SBT2928 in a Double-blind, Placebo-controlled Clinical Trial. J. Funct. Foods. 2014, 11(C), 261–268. DOI: 10.1016/j.jff.2014.09.002.
  • Hummelen, R.; Changalucha, J.; Butamanya, N. L.; Koyama, T. E.; Cook, A.; Habbema, J. D.; Reid, G. Effect of 25 Weeks Probiotic Supplementation on Immune Function of HIV Patients. Gut Microbes. 2011, 2(2), 80–85. DOI: 10.4161/gmic.2.2.15787.
  • Ivory, K.; Chambers, S. J.; Pin, C.; Prieto, E.; Arques, J. L.; Nicoletti, C. Oral Delivery of Lactobacillus Casei Shirota Modifies Allergen-induced Immune Responses in Allergic Rhinitis. Clin. Exp. Allergy. 2008, 38(8), 1282–1289. DOI: 10.1111/j.1365-2222.2008.03025.x.
  • Horvath, A.; Leber, B.; Schmerboeck, B.; Tawdrous, M.; Zettel, G.; Hartl, A.; Madl, T.; Stryeck, S.; Fuchs, D.; Lemesch, S.; et al. Randomised Clinical Trial: The Effects of a Multispecies Probiotic Vs. Placebo on Innate Immune Function, Bacterial Translocation and Gut Permeability in Patients with Cirrhosis. Aliment. Pharmacol. Ther.2016, 44(9), 926–935. DOI: 10.1111/apt.13788.
  • Childs, C. E.; Roytio, H.; Alhoniemi, E.; Fekete, A. A.; Forssten, S. D.; Hudjec, N.; Lim, Y. N.; Steger, C. J.; Yaqoob, P.; Tuohy, K. M.; et al. Xylo-oligosaccharides Alone or in Synbiotic Combination with Bifidobacterium animalis Subsp. Lactis Induce Bifidogenesis and Modulate Markers of Immune Function in Healthy Adults: A Double-blind, Placebo-controlled, Randomised, Factorial Cross-over Study. Br. J. Nutr.2014, 111(11), 1945–1956. DOI: 10.1017/s0007114513004261.
  • Burton, J. P.; Cowley, S.; Simon, R. R.; McKinney, J.; Wescombe, P. A.; Tagg, J. R. Evaluation of Safety and Human Tolerance of the Oral Probiotic Streptococcus Salivarius K12: A Randomized, Placebo-controlled, Double-blind Study. Food Chem. Toxicol. 2011, 49(9), 2356–2364. DOI: 10.1016/j.fct.2011.06.038.
  • Cox, A. J.; West, N. P.; Horn, P. L.; Lehtinen, M. J.; Koerbin, G.; Pyne, D. B.; Lahtinen, S. J.; Fricker, P. A.; Cripps, A. W. Effects of Probiotic Supplementation over 5 Months on Routine Haematology and Clinical Chemistry Measures in Healthy Active Adults. Eur. J. Clin. Nutr. 2014, 68(11), 1255–1257. DOI: 10.1038/ejcn.2014.137.
  • de Vrese, M.; Winkler, P.; Rautenberg, P.; Harder, T.; Noah, C.; Laue, C.; Ott, S.; Hampe, J.; Schreiber, S.; Heller, K.; et al. Effect of Lactobacillus Gasseri PA 16/8, Bifidobacterium Longum SP 07/3, B. Bifidum MF 20/5 on Common Cold Episodes: A Double Blind, Randomized, Controlled Trial. Clin. Nutr.2005, 24(4), 481–491. DOI: 10.1016/j.clnu.2005.02.006.
  • Gleeson, M.; Bishop, N. C.; Oliveira, M.; McCauley, T.; Tauler, P.; Lawrence, C. Effects of a Lactobacillus Salivarius Probiotic Intervention on Infection, Cold Symptom Duration and Severity, and Mucosal Immunity in Endurance Athletes. Int. J. Sport Nutr. Exerc. Metab. 2012, 22(4), 235–242. DOI: 10.1123/ijsnem.22.4.235.
  • Guillemard, E.; Tanguy, J.; Flavigny, A. L.; De la Motte, S.; Schrezenmeir, J. Effects of Consumption of a Fermented Dairy Product Containing the Probiotic Lactobacillus Casei DN-114 001 on Common Respiratory and Gastrointestinal Infections in Shift Workers in a Randomized Controlled Trial. J. Am. Coll. Nutr. 2010, 29(5), 455–468. DOI: 10.1080/07315724.2010.10719882.
  • Majeed, M.; Nagabhushanam, K.; Natarajan, S.; Sivakumar, A.; Ali, F.; Pande, A.; Majeed, S.; Karri, S. K. Bacillus Coagulans MTCC 5856 Supplementation in the Management of Diarrhea Predominant Irritable Bowel Syndrome: A Double Blind Randomized Placebo Controlled Pilot Clinical Study. Nutr. J. 2016, 15. DOI: 10.1186/s12937-016-0140-6.
  • Lee, C. Y.; Shih, H. C.; Yu, M. C.; Lee, M. Y.; Chang, Y. L.; Lai, Y. Y.; Lee, Y. C.; Kuan, Y. H.; Lin, C. C. Evaluation of the Potential Inhibitory Activity of A Combination of L. Acidophilus, L. Rhamnosus and L. Sporogenes on Helicobacter Pylori: A Randomized Double-blind Placebo-controlled Clinical Trial. Chin. J. Integr. Med. 2017, 23(3), 176–182. DOI: 10.1007/s11655-016-2531-0.
  • Stadlbauer, V.; Mookerjee, R. P.; Hodges, S.; Wright, G. A.; Davies, N. A.; Jalan, R. Effect of Probiotic Treatment on Deranged Neutrophil Function and Cytokine Responses in Patients with Compensated Alcoholic Cirrhosis. J. Hepatol. 2008, 48(6), 945–951. DOI: 10.1016/j.jhep.2008.02.015.
  • Gleeson, M.; Bishop, N. C.; Struszczak, L. Effects of Lactobacillus Casei Shirota Ingestion on Common Cold Infection and Herpes Virus Antibodies in Endurance Athletes: A Placebo-controlled, Randomized Trial. Eur. J. Appl. Physiol. 2016, 116(8), 1555–1563. DOI: 10.1007/s00421-016-3415-x.
  • Ishida, Y.; Nakamura, F.; Kanzato, H.; Sawada, D.; Hirata, H.; Nishimura, A.; Kajimoto, O.; Fujiwara, S. Clinical Effects of Lactobacillus Acidophilus Strain L-92 on Perennial Allergic Rhinitis: A Double-blind, Placebo-controlled Study. J. Dairy Sci. 2005, 88(2), 527–533. DOI: 10.3168/jds.S0022-0302(05)72714-4.
  • Ibrahim, N. S.; Ooi, F. K.; Chen, C. K.; Muhamad, A. S. Effects of Probiotics Supplementation and Circuit Training on Immune Responses among Sedentary Young Males. J. Sports Med. Phys. Fitness. 2017. DOI: 10.23736/s0022-4707.17.07742-8.
  • Yoshida, Y.; Seki, T.; Matsunaka, H.; Watanabe, T.; Shindo, M.; Yamada, N.; Yamamoto, O. Clinical Effects of Probiotic Bifidobacterium Breve Supplementation in Adult Patients with Atopic Dermatitis. Yonago Acta Med. 2010, 53(2), 37–45.
  • Ishida, Y.; Nakamura, F.; Kanzato, H.; Sawada, D.; Yamamoto, N.; Kagata, H.; Oh-Ida, M.; Takeuchi, H.;Fujiwara, S. Effect of Milk Fermented with Lactobacillus Acidophilus Strain L-92 on Symptoms of Japanese Cedar Pollen Allergy: A Randomized Placebo-controlled Trial. Bioscience, Biotechnology and Biochemistry. 2005, 69, 1652–1660.
  • Jones, M. L.; Martoni, C. J.; Di Pietro, E.; Simon, R. R.; Prakash, S. Evaluation of Clinical Safety and Tolerance of A Lactobacillus Reuteri NCIMB 30242 Supplement Capsule: A Randomized Control Trial. Regul. Toxicol. Pharmacol. 2012, 63(2), 313–320. DOI: 10.1016/j.yrtph.2012.04.003.
  • Tamura, M.; Shikina, T.; Morihana, T.; Hayama, M.; Kajimoto, O.; Sakamoto, A.; Kajimoto, Y.; Watanabe, O.; Nonaka, C.; Shida, K.; et al. Effects of Probiotics on Allergic Rhinitis Induced by Japanese Cedar Pollen: Randomized Double-blind, Placebo-controlled Clinical Trial. Int. Arch. Allergy Immunol.2007, 143(1), 75–82. DOI: 10.1159/000098318.
  • Meyer, A. L.; Micksche, M.; Herbacek, I.; Elmadfa, I. Daily Intake of Probiotic as Well as Conventional Yogurt Has a Stimulating Effect on Cellular Immunity in Young Healthy Women. Ann. Nutr. Metab. 2006, 50(3), 282–289. DOI: 10.1159/000091687.
  • Moreira, A.; Kekkonen, R.; Korpela, R.; Delgado, L.; Haahtela, T. Allergy in Marathon Runners and Effect of Lactobacillus GG Supplementation on Allergic Inflammatory Markers. Respir. Med. 2007, 101(6), 1123–1131. DOI: 10.1016/j.rmed.2006.11.015.
  • Marteau, P.; Vaerman, J. P.; Dehennin, J. P.; Bord, S.; Brassart, D.; Pochart, P.; Desjeux, J. F.; Rambaud, J. C. Effects of Intrajejunal Perfusion and Chronic Ingestion of Lactobacillus Johnsonii Strain La1 on Serum Concentrations and Jejunal Secretions of Immunoglobulins and Serum Proteins in Healthy Humans. Gastroenterologie Clinique et Biologique. 1997, 21, 293–298.
  • Miyazawa, K.; Kawase, M.; Kubota, A.; Yoda, K.; Harata, G.; Hosoda, M.; He, F. Heat-killed Lactobacillus Gasseri Can Enhance Immunity in the Elderly in a Double-blind, Placebo-controlled Clinical Study. Beneficial Microbes. 2015, 6(4), 441–449. DOI: 10.3920/BM2014.0108.
  • Minami, J.; Iwabuchi, N.; Tanaka, M.; Yamauchi, K.; Xiao, J. Z.; Abe, F.; Sakane, N. Effects of Bifidobacterium Breve B-3 on Body Fat Reductions in Pre-obese Adults: A Randomized, Double-blind, Placebo-controlled Trial. Biosci. Microbiota Food Health. 2018, 37(3), 67–75. DOI: 10.12938/bmfh.18-001.
  • Mansouri-Tehrani, H. A.; Rabbani-Khorasgani, M.; Hosseini, S. M.; Mokarian, F.; Mahdavi, H.; Roayaei, M. Effect of Supplements: Probiotics and Probiotic Plus Honey on Blood Cell Counts and Serum IgA in Patients Receiving Pelvic Radiotherapy. J. Res. Med. Sci. 2015, 20(7), 679–683. DOI: 10.4103/1735-1995.166224.
  • Marcos, A.; Warnberg, J.; Nova, E.; Gomez, S.; Alvarez, A.; Alvarez, R.; Mateos, J. A.; Cobo, J. M. The Effect of Milk Fermented by Yogurt Cultures Plus Lactobacillus Casei DN-114001 on the Immune Response of Subjects under Academic Examination Stress. Eur. J. Nutr. 2004, 43(6), 381–389. DOI: 10.1007/s00394-004-0517-8.
  • Mangalat, N.; Liu, Y.; Fatheree, N. Y.; Ferris, M. J.; van Arsdall, M. R.; Chen, Z.; Rahbar, M. H.; Gleason, W. A.; Norori, J.; Tran, D. Q.; et al. Safety and Tolerability of Lactobacillus Reuteri DSM 17938 and Effects on Biomarkers in Healthy Adults: Results from a Randomized Masked Trial. PLoS ONE.2012, 7(9), e43910. DOI: 10.1371/journal.pone.0043910.
  • Yonekura, S.; Okamoto, Y.; Okawa, T.; Hisamitsu, M.; Chazono, H.; Kobayashi, K.; Sakurai, D.; Horiguchi, S.; Hanazawa, T. Effects of Daily Intake of Lactobacillus Paracasei Strain KW3110 on Japanese Cedar Pollinosis. Allergy Asthma Proc. 2009, 30(4), 397–405. DOI: 10.2500/aap.2009.30.3256.
  • Nova, E.; Toro, O.; Varela, P.; Lopez-Vidriero, I.; Morande, G.; Marcos, A. Effects of a Nutritional Intervention with Yogurt on Lymphocyte Subsets and Cytokine Production Capacity in Anorexia Nervosa Patients. Eur. J. Nutr. 2006, 45(4), 225–233. DOI: 10.1007/s00394-006-0589-8.
  • Drago, L.; Toscano, M.; De Vecchi, E.; Piconi, S.; Iemoli, E. Changing of Fecal Flora and Clinical Effect of L. Salivarius LS01 in Adults with Atopic Dermatitis. J. Clin. Gastroenterol. 2012, 46(SUPPL. 1), S56–S63. DOI: 10.1097/MCG.0b013e318265ef38.
  • Hirose, Y.; Murosaki, S.; Yamamoto, Y.; Yoshikai, Y.; Tsuru, T. Daily Intake of Heat-killed Lactobacillus Plantarum L-137 Augments Acquired Immunity in Healthy Adults. J. Nutr. 2006, 136(12), 3069–3073. DOI: 10.1093/jn/136.12.3069.
  • Sashihara, T.; Nagata, M.; Mori, T.; Ikegami, S.; Gotoh, M.; Okubo, K.; Uchida, M.; Itoh, H. Effects of Lactobacillus Gasseri OLL2809 and Alpha-lactalbumin on University-student Athletes: A Randomized, Double-blind, Placebo-controlled Clinical Trial. Appl. Physiol. Nutr. Metab = Physiologie Appliquee, Nutrition Et Metabolisme. 2013, 38(12), 1228–1235. DOI: 10.1139/apnm-2012-0490.
  • Yokoyama, Y.; Nishigaki, E.; Abe, T.; Fukaya, M.; Asahara, T.; Nomoto, K.; Nagino, M. Randomized Clinical Trial of the Effect of Perioperative Synbiotics versus No Synbiotics on Bacterial Translocation after Oesophagectomy. Br. J. Surg. 2014, 101(3), 189–199. DOI: 10.1002/bjs.9385.
  • Snel, J.; Vissers, Y. M.; Smit, B. A.; Jongen, J. M.; van der Meulen, E. T.; Zwijsen, R.; Ruinemans-Koerts, J.; Jansen, A. P.; Kleerebezem, M.; Savelkoul, H. F. Strain-specific Immunomodulatory Effects of Lactobacillus Plantarum Strains on Birch-pollen-allergic Subjects Out of Season. Clin. Exp. Allergy. 2011, 41(2), 232–242. DOI: 10.1111/j.1365-2222.2010.03650.x.
  • Xavier-Santos, D.; Lima, E. D.; Simão, A. N. C.; Bedani, R.; Saad, S. M. I. Effect of the Consumption of A Synbiotic Diet Mousse Containing Lactobacillus Acidophilus La-5 by Individuals with Metabolic Syndrome: A Randomized Controlled Trial. J. Funct. Foods. 2018, 41, 55–61. DOI: 10.1016/j.jff.2017.12.041.
  • Schoen, C.; Schulz, A.; Schweikart, J.; Schutt, S.; von Baehr, V. Regulatory Effects of a Fermented Food Concentrate on Immune Function Parameters in Healthy Volunteers. Nutrition (Burbank, Los Angeles County, Calif). 2009, 25(5), 499–505. DOI: 10.1016/j.nut.2008.10.022.
  • Giamarellos-Bourboulis, E. J.; Bengmark, S.; Kanellakopoulou, K.; Kotzampassi, K. Pro- and Synbiotics to Control Inflammation and Infection in Patients with Multiple Injuries. J. Trauma - Injury Infect. Crit. Care. 2009, 67(4), 815–821. DOI: 10.1097/TA.0b013e31819d979e.
  • Takii, Y.; Nishimura, S.; Yoshida-Yamamoto, S.; Kobayashi, Y.; Nagayoshi, E. Effects of Intake of Pickles Containing Lactobacillus Brevis on Immune Activity and Bowel Symptoms in Female Students. J. Nutr. Sci. Vitaminol. 2013, 59(5), 402–411. DOI: 10.3177/jnsv.59.402.
  • Dong, H.; Rowland, I.; Thomas, L. V.; Yaqoob, P. Immunomodulatory Effects of a Probiotic Drink Containing Lactobacillus Casei Shirota in Healthy Older Volunteers. Eur. J. Nutr. 2013, 52(8), 1853–1863. DOI: 10.1007/s00394-012-0487-1.
  • Mane, J.; Pedrosa, E.; Loren, V.; Gassull, M. A.; Espadaler, J.; Cune, J.; Audivert, S.; Bonachera, M. A.; Cabre, E. A Mixture of Lactobacillus Plantarum CECT 7315 and CECT 7316 Enhances Systemic Immunity in Elderly Subjects. A Dose-response, Double-blind, Placebo-controlled, Randomized Pilot Trial. Nutr. Hospitalaria. 2011, 26(1), 228–235.
  • Ogawa, T.; Hashikawa, S.; Asai, Y.; Sakamoto, H.; Yasuda, K.; Makimura, Y. A New Synbiotic, Lactobacillus Casei Subsp. Casei Together with Dextran, Reduces Murine and Human Allergic Reaction. FEMS Immunol. Med. Microbiol. 2006, 46(3), 400–409. DOI: 10.1111/j.1574-695X.2006.00046.x.
  • Hasegawa, T.; Hirakawa, K.; Matsumoto, T.; Toki, S.; Maeyama, Y.; Morimatsu, F. Efficacy of Lactobacillus Plantarum Strain HSK201 in Relief from Japanese Cedar Pollinosis. Biosci. Biotechnol. Biochem. 2009, 73(12), 2626–2631. DOI: 10.1271/bbb.90465.
  • Kotani, Y.; Shinkai, S.; Okamatsu, H.; Toba, M.; Ogawa, K.; Yoshida, H.; Fukaya, T.; Fujiwara, Y.; Chaves, P. H. M.; Kakumoto, K.; et al. Oral Intake of Lactobacillus Pentosus Strain B240 Accelerates Salivary Immunoglobulin A Secretion in the Elderly: A Randomized, Placebo-controlled, Double-blind Trial. Immun. Ageing. 2010, 7. DOI: 10.1186/1742-4933-7-11.
  • Pu, F.; Guo, Y.; Li, M.; Zhu, H.; Wang, S.; Shen, X.; He, M.; Huang, C.; He, F. Yogurt Supplemented with Probiotics Can Protect the Healthy Elderly from Respiratory Infections: A Randomized Controlled Open-label Trial. Clin. Interventions Aging. 2017, 12, 1223–1231. DOI: 10.2147/CIA.S141518.
  • Yamamoto, K.; Yokoyama, K.; Matsukawa, T.; Kato, S.; Kato, S.; Yamada, K.; Hirota, T. Efficacy of Prolonged Ingestion of Lactobacillus Acidophilus L-92 in Adult Patients with Atopic Dermatitis. J. Dairy Sci. 2016, 99(7), 5039–5046. DOI: 10.3168/jds.2015-10605.
  • Hatakka, K.; Martio, J.; Korpela, M.; Herranen, M.; Poussa, T.; Laasanen, T.; Saxelin, M.; Vapaatalo, H.; Moilanen, E.; Korpela, R. Effects of Probiotic Therapy on the Activity and Activation of Mild Rheumatoid Arthritis - A Pilot Study. Scand. J. Rheumatol. 2003, 32(4), 211–215. DOI: 10.1080/03009740310003695.
  • Gilbey, P.; Livshits, L.; Sharabi-Nov, A.; Avraham, Y.; Miron, D. Probiotics in Addition to Antibiotics for the Treatment of Acute Tonsillitis: A Randomized, Placebo-controlled Study. Eur. J. Clin. Microbiol. Infect. Dis. 2015, 34(5), 1011–1015. DOI: 10.1007/s10096-015-2315-z.
  • Sierra, S.; Lara-Villoslada, F.; Sempere, L.; Olivares, M.; Boza, J.; Xaus, J. Intestinal and Immunological Effects of Daily Oral Administration of Lactobacillus Salivarius CECT5713 to Healthy Adults. Anaerobe. 2010, 16(3), 195–200. DOI: 10.1016/j.anaerobe.2010.02.001.
  • Villar-García, J.; Hernàndez, J. J.; Güerri-Fernàndez, R.; Gonzàlez, A.; Lerma, E.; Guelar, A.; Saenz, D.; Sorlí, L.; Montero, M.; Horcajada, J. P.; et al. Effect of Probiotics (Saccharomyces Boulardii) on Microbial Translocation and Inflammation in HIV-treated Patients: A Double-blind, Randomized, Placebo-controlled Trial. J. Acquired Immune Deficiency Syndromes.2015, 68(3), 256–263. DOI: 10.1097/QAI.0000000000000468.
  • Zhu, D.; Chen, X.; Wu, J.; Ju, Y.; Feng, J.; Lu, G.; Ouyang, M.; Ren, B.; Li, Y. Effect of Perioperative Intestinal Probiotics on Intestinal Flora and Immune Function in Patients with Colorectal Cancer. Nan Fang Yi Ke Da Xue Xue Bao = J. South. Med. Univ. 2012, 32(8), 1190–1193.
  • Maruyama, M.; Abe, R.; Shimono, T.; Iwabuchi, N.; Abe, F.; Xiao, J. Z. The Effects of Non-viable Lactobacillus on Immune Function in the Elderly: A Randomised, Double-blind, Placebo-controlled Study. Int. J. Food Sci. Nutr. 2016, 67(1), 67–73. DOI: 10.3109/09637486.2015.1126564.
  • Costanza, A. C.; Moscavitch, S. D.; Faria Neto, H. C.; Mesquita, E. T. Probiotic Therapy with Saccharomyces Boulardii for Heart Failure Patients: A Randomized, Double-blind, Placebo-controlled Pilot Trial. Int. J. Cardiol. 2015, 179, 348–350. DOI: 10.1016/j.ijcard.2014.11.034.
  • Fujii, T.; Jounai, K.; Horie, A.; Takahashi, H.; Suzuki, H.; Ohshio, K.; Fujiwara, D.; Yamamoto, N. Effects of Heat-killed Lactococcus lactis Subsp. Lactis JCM 5805 on Mucosal and Systemic Immune Parameters, and Antiviral Reactions to Influenza Virus in Healthy Adults; a Randomized Controlled Double-blind Study. J. Funct. Foods. 2017, 35, 513–521. DOI: 10.1016/j.jff.2017.06.011.
  • Fujimori, S.; Gudis, K.; Mitsui, K.; Seo, T.; Yonezawa, M.; Tanaka, S.; Tatsuguchi, A.;Sakamoto, C. A Randomized Controlled Trial on the Efficacy of Synbiotic Versus Probiotic or Prebiotic Treatment to Improve the Quality of Life in Patients with Ulcerative Colitis. Nutrition. 2009, 25, 520–525.
  • Marcial, G. E.; Ford, A. L.; Haller, M. J.; Gezan, S. A.; Harrison, N. A.; Cai, D.; Meyer, J. L.; Perry, D. J.; Atkinson, M. A.; Wasserfall, C. H.;, et al. Lactobacillus Johnsonii N6.2 Modulates the Host Immune Responses: A Double-blind, Randomized Trial in Healthy Adults. Front. Immunol. 2017, 8(JUN). DOI:10.3389/fimmu.2017.00655.
  • Xiao, J. Z.; Kondo, S.; Yanagisawa, N.; Takahashi, N.; Odamaki, T.; Iwabuchi, N.; Miyaji, K.; Iwatsuki, K.; Togashi, H.; Enomoto, K.; et al. Probiotics in The Treatment of Japanese Cedar Pollinosis: A Double-Plind Placebo-controlled Trial. Clinical and Experimental Allergy. 2006, 36, 1425–1435.
  • Shang, X. J. Effect of Treatment with Compound Lactobacillus Acidophilus on Complements and T Lymphocyte Subsets in Patients with Compensated Liver Cirrhosis. World Chin. J. Digestol. 2013, 21(24), 2446–2450. DOI: 10.11569/wcjd.v21.i24.2446.
  • Rammohan, A.; Sathyanesan, J.; Rajendran, K.; Pitchaimuthu, A.; Perumal, S. K.; Balaraman, K.; Ramasamy, R.; Palaniappan, R.; Govindan, M. Synbiotics in Surgery for Chronic Pancreatitis: Are They Truly Effective? A Single-blind Prospective Randomized Control Trial. Ann. Surg. 2015, 262(1), 31–37. DOI: 10.1097/sla.0000000000001077.
  • Nyangale, E. P.; Farmer, S.; Cash, H. A.; Keller, D.; Chernoff, D.; Gibson, G. R. Bacillus Coagulans GBI-30, 6086 Modulates Faecalibacterium Prausnitzii in Older Men and Women. J. Nutr. 2015, 145(7), 1446–1452. DOI: 10.3945/jn.114.199802.
  • Kim, H. S.; Park, H.; Cho, I. Y.; Paik, H. D.; Park, E. Dietary Supplementation of Probiotic Bacillus Polyfermenticus, Bispan Strain, Modulates Natural Killer Cell and T Cell Subset Populations and Immunoglobulin G Levels in Human Subjects. J. Med. Food. 2006, 9(3), 321–327. DOI: 10.1089/jmf.2006.9.321.
  • Natarajan, R.; Pechenyak, B.; Vyas, U.; Ranganathan, P.; Weinberg, A.; Liang, P.; Mallappallil, M. C.; Norin, A. J.; Friedman, E. A.; Saggi, S. J. Randomized Controlled Trial of Strain-Specific Probiotic Formulation (Renadyl) in Dialysis Patients. Biomed Res. Int. 2014, 2014, 1–9. DOI: 10.1155/2014/568571.
  • Macfarlane, S.; Cleary, S.; Bahrami, B.; Reynolds, N.; Macfarlane, G. T. Synbiotic Consumption Changes the Metabolism and Composition of the Gut Microbiota in Older People and Modifies Inflammatory Processes: A Randomised, Double-blind, Placebo-controlled Crossover Study. Aliment. Pharmacol. Ther. 2013, 38(7), 804–816. DOI: 10.1111/apt.12453.
  • Olivares, M.; Diaz-Ropero, M. P.; Gomez, N.; Lara-Villoslada, F.; Sierra, S.; Maldonado, J. A.; Martin, R.; Rodriguez, J. M.; Xaus, J. The Consumption of Two New Probiotic Strains, Lactobacillus Gasseri CECT 5714 and Lactobacillus Coryniformis CECT 5711, Boosts the Immune System of Healthy Humans. Int. Microbiol. 2006, 9(1), 47–52.
  • Russolillo, N.; Ferrero, A.; Vigano, L.; Langella, S.; Briozzo, A.; Ferlini, M.; Migliardi, M.; Capussotti, L. Impact of Perioperative Symbiotic Therapy on Infectious Morbidity after Hpb Surgery in Jaundiced Patients: A Randomized Controlled Trial. Updates Surg. 2014, 66(3), 203–210. DOI: 10.1007/s13304-014-0259-y.
  • Rayes, N.; Hansen, S.; Seehofer, D.; Muller, A. R.; Serke, S.; Bengmark, S.; Neuhaus, P. Early Enteral Supply of Fiber and Lactobacilli versus Conventional Nutrition: A Controlled Trial in Patients with Major Abdominal Surgery. Nutrition (Burbank, Los Angeles County, Calif). 2002, 18(7–8), 609–615. DOI: 10.1016/S0899-9007(02)00811-0.
  • Saito, Y.; Fujii, M.; Watanabe, T.; Maruyama, K.; Kowatari, Y.; Ogata, H.; Kumagai, T. Randomized, Double-blind, Placebo-controlled, Parallel-group Study of the Effect of Lactobacillus Paracasei K71 Intake on Salivary Release of Secretory Immunoglobulin A. Biosci. Microbiota Food Health. 2017, 36(2), 55–63. DOI: 10.12938/bmfh.16-022.
  • Wind, R. D.; Tolboom, H.; Klare, I.; Huys, G.; Knol, J. Tolerance and Safety of the Potentially Probiotic Strain Lactobacillus Rhamnosus PRSF-L477: A Randomised, Double-blind Placebo-controlled Trial in Healthy Volunteers. Br. J. Nutr. 2010, 104(12), 1806–1816. DOI: 10.1017/S0007114510002746.
  • West, N. P.; Horn, P. L.; Barrett, S.; Warren, H. S.; Lehtinen, M. J.; Koerbin, G.; Brun, M.; Pyne, D. B.; Lahtinen, S. J.; Fricker, P. A.; et al. Supplementation with a Single and Double Strain Probiotic on the Innate Immune System for Respiratory Illness. e-SPEN J.2014, 9(5), e178–e84. DOI: 10.1016/j.clnme.2014.06.003.
  • Wolf, B. W.; Wheeler, K. B.; Ataya, D. G.; Garleb, K. A. Safety and Tolerance of Lactobacillus Reuteri Supplementation to a Population Infected with the Human Immunodeficiency Virus. Food Chem. Toxicol. 1998, 36(12), 1085–1094. DOI: 10.1016/S0278-6915(98)00090-8.
  • Seifert, S.; Bub, A.; Franz, C. M.; Watzl, B. Probiotic Lactobacillus Casei Shirota Supplementation Does Not Modulate Immunity in Healthy Men with Reduced Natural Killer Cell Activity. J. Nutr. 2011, 141(5), 978–984. DOI: 10.3945/jn.110.136440.
  • Parra, M. D.; de Morentin, B. E. M.; Cobo, J. M.; Mateos, A.; Martinez, J. A. Daily Ingestion of Fermented Milk Containing Lactobacillus Casei DN114001 Improves Innate-defense Capacity in Healthy Middle-aged People. J. Physiol. Biochem. 2004, 60(2), 85–91. DOI: 10.1007/bf03168444.
  • Kanazawa, H.; Nagino, M.; Kamiya, S.; Komatsu, S.; Mayumi, T.; Takagi, K.; Asahara, T.; Nomoto, K.; Tanaka, R.; Nimura, Y. Synbiotics Reduce Postoperative Infectious Complications: A Randomized Controlled Trial in Biliary Cancer Patients Undergoing Hepatectomy. Langenbeck’s Arch. Surg. 2005, 390(2), 104–113. DOI: 10.1007/s00423-004-0536-1.
  • Reale, M.; Boscolo, P.; Bellante, V.; Tarantelli, C.; Di Nicola, M.; Forcella, L.; Li, Q.; Morimoto, K.; Muraro, R. Daily Intake of Lactobacillus Casei Shirota Increases Natural Killer Cell Activity in Smokers. Br. J. Nutr. 2012, 108(2), 308–314. DOI: 10.1017/S0007114511005630.
  • Krebs, B. Prebiotic and Synbiotic Treatment before Colorectal Surgery - Randomised Double Blind Trial. Collegium Antropologicum. 2016, 40, 35–40.
  • Yang, Y.; Xia, Y.; Chen, H.; Hong, L.; Feng, J.; Yang, J.; Yang, Z.; Shi, C.; Wu, W.; Gao, R.;, et al. The Effect of Perioperative Probiotics Treatment for Colorectal Cancer: Short-term Outcomes of a Randomized Controlled Trial. Oncotarget.2016, 7(7), 8432–8440. DOI: 10.18632/oncotarget.7045.
  • Anukam, K. C.; Osazuwa, E. O.; Osadolor, H. B.; Bruce, A. W.; Reid, G. Yogurt Containing Probiotic Lactobacillus Rhamnosus GR-1 and L. Reuteri RC-14 Helps Resolve Moderate Diarrhea and Increases CD4 Count in HIV/AIDS Patients. J. Clin. Gastroenterol. 2008, 42(3), 239–243. DOI: 10.1097/MCG.0b013e31802c7465.
  • Shing, C. M.; Peake, J. M.; Lim, C. L.; Briskey, D.; Walsh, N. P.; Fortes, M. B.; Ahuja, K. D.; Vitetta, L. Effects of Probiotics Supplementation on Gastrointestinal Permeability, Inflammation and Exercise Performance in the Heat. Eur. J. Appl. Physiol. 2014, 114(1), 93–103. DOI: 10.1007/s00421-013-2748-y.
  • Rayes, N.; Seehofer, D.; Müller, A. R.; Hansen, S.; Bengmark, S.; Neuhaus, P. Influence of Probiotics and Fibre on the Incidence of Bacterial Infections following Major Abdominal Surgery - Results of a Prospective Trial. Z. Gastroenterologie. 2002, 40(10), 869–876. DOI: 10.1055/s-2002-35259.
  • Jung, S. P.; Lee, K. M.; Kang, J. H.; Yun, S. I.; Park, H. O.; Moon, Y.; Kim, J. Y. Effect of Lactobacillus Gasseri BNR17 on Overweight and Obese Adults: A Randomized, Double-blind Clinical Trial. Korean Journal of Family Medicine. 2013, 34, 80–89.
  • Usami, M.; Miyoshi, M.; Kanbara, Y.; Aoyama, M.; Sakaki, H.; Shuno, K.; Hirata, K.; Takahashi, M.; Ueno, K.; Tabata, S.; et al. Effects of Perioperative Synbiotic Treatment on Infectious Complications, Intestinal Integrity, and Fecal Flora and Organic Acids in Hepatic Surgery with or without Cirrhosis. J. Parenteral Enteral Nutr.2011, 35(3), 317–328. DOI: 10.1177/0148607110379813.
  • Shimizu, K.; Sato, H.; Suga, Y.; Yamahira, S.; Toba, M.; Hamuro, K.; Kakumoto, K.; Kohda, N.; Akama, T.; Kono, I.; et al. The Effects of Lactobacillus Pentosus Strain B240 and Appropriate Physical Training on Salivary Secretory IgA Levels in Elderly Adults with Low Physical Fitness: A Randomized, Double-blind, Placebo-controlled Trial. J. Clin. Biochem. Nutr.2014, 54(1), 61–66. DOI: 10.3164/jcbn.13-62.
  • Shida, K.; Sato, T.; Iizuka, R.; Hoshi, R.; Watanabe, O.; Igarashi, T.; Miyazaki, K.; Nanno, M.; Ishikawa, F. Daily Intake of Fermented Milk with Lactobacillus Casei Strain Shirota Reduces the Incidence and Duration of Upper Respiratory Tract Infections in Healthy Middle-aged Office Workers. Eur. J. Nutr. 2017, 56(1), 45–53. DOI: 10.1007/s00394-015-1056-1.
  • Michalickova, D.; Minic, R.; Dikic, N.; Andjelkovic, M.; Kostic-Vucicevic, M.; Stojmenovic, T.; Nikolic, I.; Djordjevic, B. Lactobacillus Helveticus Lafti L10 Supplementation Reduces Respiratory Infection Duration in A Cohort of Elite Athletes: A Randomized, Double-blind, Placebo-controlled Trial. Appl. Physiol. Nutr. Metab. 2016, 41(7), 782–789. DOI: 10.1139/apnm-2015-0541.
  • Valentini, L.; Pinto, A.; Bourdel-Marchasson, I.; Ostan, R.; Brigidi, P.; Turroni, S.; Hrelia, S.; Hrelia, P.; Bereswill, S.; Fischer, A.; et al. Impact of Personalized Diet and Probiotic Supplementation on Inflammation, Nutritional Parameters and Intestinal Microbiota - the “RISTOMED Project”: Randomized Controlled Trial in Healthy Older People. Clin. Nutr.2015, 34(4), 593–602. DOI: 10.1016/j.clnu.2014.09.023.
  • Nova, E.; Viadel, B.; Warnberg, J.; Carreres, J. E.; Marcos, A. Beneficial Effects of a Synbiotic Supplement on Self-perceived Gastrointestinal Well-being and Immunoinflammatory Status of Healthy Adults. J. Med. Food. 2011, 14(1–2), 79–85. DOI: 10.1089/jmf.2008.0328.
  • Kawase, M.; He, F.; Kubota, A.; Hiramatsu, M.; Saito, H.; Ishii, T.; Yasueda, H.; Akiyama, K. Effect of Fermented Milk Prepared with Two Probiotic Strains on Japanese Cedar Pollinosis in a Double-blind Placebo-controlled Clinical Study. Int. J. Food Microbiol. 2009, 128(3), 429–434. DOI: 10.1016/j.ijfoodmicro.2008.09.017.
  • Kato-Kataoka, A.; Nishida, K.; Takada, M.; Kawai, M.; Kikuchi-Hayakawa, H.; Suda, K.; Ishikawa, H.; Gondo, Y.; Shimizu, K.; Matsuki, T.; et al. Fermented Milk Containing Lactobacillus Casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress. Appl. Environ. Microbiol.2016, 82(12), 3649–3658. DOI: 10.1128/AEM.04134-15.
  • Gleeson, M.; Bishop, N. C.; Oliveira, M.; Tauler, P. Daily Probiotic’s (Lactobacillus Casei Shirota) Reduction of Infection Incidence in Athletes. Int. J. Sport Nutr. Exerc. Metab. 2011, 21(1), 55–64. DOI: 10.1123/ijsnem.21.1.55.
  • Hirose, Y.; Yamamoto, Y.; Yoshikai, Y.; Murosaki, S. Oral Intake of Heat-killed Lactobacillus Plantarum L-137 Decreases the Incidence of Upper Respiratory Tract Infection in Healthy Subjects with High Levels of Psychological Stress. J. Nutr. Sci. 2013, 2, 1–8. DOI: 10.1017/jns.2013.35.
  • de Vos, P.; Mujagic, Z.; de Haan, B. J.; Siezen, R. J.; Bron, P. A.; Meijerink, M.; Wells, J. M.; Masclee, A. A. M.; Boekschoten, M. V.; Faas, M. M., et al. Lactobacillus Plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells. Front. Immunol. 2017, 8(AUG). DOI:10.3389/fimmu.2017.01000.
  • Lee, A.; Lee, Y. J.; Yoo, H. J.; Kim, M.; Chang, Y.; Lee, D. S.; Lee, J. H. Consumption of Dairy Yogurt Containing Lactobacillus paracasei Ssp. Paracasei, Bifidobacterium pnimalis Ssp. Lactis and Heat-Treated Lactobacillus Plantarum Improves Immune Function Including Natural Killer Cell Activity. Nutrients. 2017, 9(6). DOI: 10.3390/nu9060558.
  • Stiksrud, B.; Nowak, P.; Nwosu, F. C.; Kvale, D.; Thalme, A.; Sonnerborg, A.; Ueland, P. M.; Holm, K.; Birkeland, S.-E.; Dahm, A. E. Reduced Levels of D-dimer and Changes in Gut Microbiota Composition after Probiotic Intervention in HIV-infected Individuals on Stable ART. JAIDS J. Acquired Immune Deficiency Syndromes. 2015, 70(4), 329–337. DOI: 10.1097/QAI.0000000000000784.
  • Bolnick, D. I.; Snowberg, L. K.; Hirsch, P. E.; Lauber, C. L.; Org, E.; Parks, B.; Lusis, A. J.; Knight, R.; Caporaso, J. G.; Svanback, R. Individual Diet Has Sex-dependent Effects on Vertebrate Gut Microbiota. Nat. Commun. 2014, 5, 4500. DOI: 10.1038/ncomms5500.
  • Upadhyaya, S.; Banerjee, G. Enhancement of Natural Killer Cell Activity in Immuno-compromised Elderly Subjects by Bacillus Coagulans. Int. J. Probiotics Prebiotics. 2011, 6(3–4), 141–146.
  • Villar-Garcia, J.; Guerri-Fernandez, R.; Moya, A.; Gonzalez, A.; Hernandez, J. J.; Lerma, E.; Guelar, A.; Sorli, L.; Horcajada, J. P.; Artacho, A.; et al. Impact of Probiotic Saccharomyces Boulardii on the Gut Microbiome Composition in HIVtreated Patients: A Double-blind, Randomised, Placebo-controlled Trial. Plos One.2017, 12(4), e0173802. DOI: 10.1371/journal.pone.0173802.
  • Roller, M.; Clune, Y.; Collins, K.; Rechkemmer, G.; Watzl, B. Consumption of Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus rhamnosus and Bifidobacterium Lactis Has Minor Effects on Selected Immune Parameters in Polypectomised and Colon Cancer Patients. Br. J. Nutr. 2007, 97(4), 676–684. DOI: 10.1017/S0007114507450292.
  • Yang, O. O.; Kelesidis, T.; Cordova, R.; Khanlou, H. Immunomodulation of Antiretroviral Drug-suppressed Chronic HIV-1 Infection in an Oral Probiotic Double-blind Placebo-controlled Trial. AIDS Res. Hum. Retroviruses. 2014, 30(10), 988–995. DOI: 10.1089/aid.2014.0181.
  • Heiser, C. R.; Ernst, J. A.; Barrett, J. T.; French, N.; Schutz, M.; Dube, M. P. Probiotics, Soluble Fiber, and L-glutamine (GLN) Reduce Nelfinavir (NFV) or Lopinavir/ritonavir (Lpv/r)-related Diarrhea. J. Int. Assoc. Phys. AIDS Care. 2004, 3(4), 121–129. DOI: 10.1177/154510970400300403.
  • Berggren, A.; Lazou Ahren, I.; Larsson, N.; Onning, G. Randomised, Double-blind and Placebo-controlled Study Using New Probiotic Lactobacilli for Strengthening the Body Immune Defence against Viral Infections. Eur. J. Nutr. 2011, 50(3), 203–210. DOI: 10.1007/s00394-010-0127-6.
  • Meyer, A. L.; Elmadfa, I.; Herbacek, I.; Micksche, M. Probiotic, as Well as Conventional Yogurt, Can Enhance the Stimulated Production of Proinflammatory Cytokines. J. Human Nutr. Diet. 2007, 20(6), 590–598. DOI: 10.1111/j.1365-277X.2007.00807.x.
  • Emara, M. H.; Mohamed, S. Y.; Abdel Aziz, H. R. Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients: A Double-blind Placebo-controlled Randomized Clinical Trial. Ther. Adv. Gastroenterol. 2014, 7(1), 4–13. DOI: 10.1177/1756283X13503514.
  • Nishimura, M.; Ohkawara, T.; Tetsuka, K.; Kawasaki, Y.; Nakagawa, R.; Satoh, H.; Sato, Y.; Nishihira, J. Effects of Yogurt Containing Lactobacillus Plantarum HOKKAIDO on Immune Function and Stress Markers. J. Traditional Complementary Med. 2016, 6(3), 275–280. DOI: 10.1016/j.jtcme.2015.07.003.
  • Perrin, Y.; Nutten, S.; Audran, R.; Berger, B.; Bibiloni, R.; Wassenberg, J.; Barbier, N.; Aubert, V.; Moulin, J.; Singh, A.; et al. Comparison of Two Oral Probiotic Preparations in a Randomized Crossover Trial Highlights a Potentially Beneficial Effect of Lactobacillus Paracasei NCC2461 in Patients with Allergic Rhinitis. Clin. Transl. Allergy.2014, 4(1), 1. DOI: 10.1186/2045-7022-4-1.
  • Akelma, A. Z.; Topçu, Z. İ. K. Probiotics and Allergic Diseases. World J. Immunol. 2016, 6(1), 75–82. DOI: 10.5411/wji.v6.i1.75.
  • Zhao, R.; Wang, Y.; Huang, Y.; Cui, Y.; Xia, L.; Rao, Z.; Zhou, Y.; Wu, X. Effects of Fiber and Probiotics on Diarrhea Associated with Enteral Nutrition in Gastric Cancer Patients. Medicine (USA). 2017, 96(43). DOI: 10.1097/MD.0000000000008418.
  • Sperry, M. F.; Silva, H. L. A.; Balthazar, C. F.; Esmerino, E. A.; Verruck, S.; Prudencio, E. S.; Neto, R. P. C.; Tavares, M. I. B.; Peixoto, J. C.; Nazzaro, F.; et al. Probiotic Minas Frescal Cheese Added with L-casei 01: Physicochemical and Bioactivity Characterization and Effects on Hematological/biochemical Parameters of Hypertensive Overweighted Women - A Randomized Double-blind Pilot Trial. J. Funct. Foods. 2018, 45, 435–443. DOI: 10.1016/j.jff.2018.04.015.
  • Jung, S.; Lee, Y. J.; Kim, M.; Kim, M.; Kwak, J. H.; Lee, J. W.; Ahn, Y. T.; Sim, J. H.; Lee, J. H. Supplementation with Two Probiotic Strains, Lactobacillus Curvatus HY7601 and Lactobacillus Plantarum KY1032, Reduced Body Adiposity and Lp-PLA2 Activity in Overweight Subjects. J. Funct. Foods. 2015, 19, 744–752. DOI: 10.1016/j.jff.2015.10.006.
  • Mizuta, M.; Endo, I.; Yamamoto, S.; Inokawa, H.; Kubo, M.; Udaka, T.; Sogabe, O.; Maeda, H.; Shirakawa, K.; Okazaki, E.; et al. Perioperative Supplementation with Bifidobacteria Improves Postoperative Nutritional Recovery, Inflammatory Response, and Fecal Microbiota in Patients Undergoing Colorectal Surgery: A Prospective, Randomized Clinical Trial. Biosci. Microbiota Food Health.2016, 35(2), 77–87. DOI: 10.12938/bmfh.2015-017.
  • Santana Porben, S.;. Influence of a Combination of Lactobacilli and Bifidobacteria upon Disease Activity, Stool Pattern and Nutritional Status of Ulcerative Colitis Patients. Nutr. Hospitalaria. 2010, 25(6), 971–983.
  • Tiollier, E.; Chennaoui, M.; Gomez-Merino, D.; Drogou, C.; Filaire, E.; Guezennec, C. Y. Effect of a Probiotics Supplementation on Respiratory Infections and Immune and Hormonal Parameters during Intense Military Training. Mil. Med. 2007, 172(9), 1006–1011. DOI: 10.7205/MILMED.172.9.1006.
  • Spanhaak, S.; Havenaar, R.; Schaafsma, G. The Effect of Consumption of Milk Fermented by Lactobacillus Casei Strain Shirota on the Intestinal Microflora and Immune Parameters in Humans. Eur. J. Clin. Nutr. 1998, 52(12), 899–907. DOI: 10.1038/sj.ejcn.1600663.
  • Nishimura, I.; Igarashi, T.; Enomoto, T.; Dake, Y.; Okuno, Y.; Obata, A. Clinical Efficacy of Halophilic Lactic Acid Bacterium Tetragenococcus Halophilus Th221 from Soy Sauce Moromi for Perennial Allergic Rhinitis. Allergol. Int. 2009, 58(2), 179–185. DOI: 10.2332/allergolint.O-08-548.
  • Takeda, K.; Okumura, K. Effects of a Fermented Milk Drink Containing Lactobacillus Casei Strain Shirota on the Human NK-cell Activity. J. Nutr. 2007, 137(3 Suppl 2), 791S–3S. DOI: 10.1093/jn/137.3.791S.
  • Nagata, Y.; Yoshida, M.; Kitazawa, H.; Araki, E.; Gomyo, T. Improvements in Seasonal Allergic Disease with Lactobacillus Plantarum No. 14. Biosci. Biotechnol. Biochem. 2010, 74(9), 1869–1877. DOI: 10.1271/bbb.100270.
  • Inoue, Y.; Kambara, T.; Murata, N.; Komori-Yamaguchi, J.; Matsukura, S.; Takahashi, Y.; Ikezawa, Z.; Aihara, M. Effects of Oral Administration of Lactobacillus Acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-blind, Randomized, Clinical Trial. Int. Arch. Allergy Immunol. 2014, 165(4), 247–254. DOI: 10.1159/000369806.
  • Moro-Garcia, M. A.; Alonso-Arias, R.; Baltadjieva, M.; Benitez, C. F.; Barrial, M. A. F.; Ruisánchez, E. D.; Santos, R. A.; Sánchez, M. A.; Miján, J. S.; López-Larrea, C. Oral Supplementation with Lactobacillus delbrueckii Subsp. Bulgaricus 8481 Enhances Systemic Immunity in Elderly Subjects. Age. 2013, 35(4), 1311–1326. DOI: 10.1007/s11357-012-9434-6.
  • González-Hernández, L. A.; Jave-Suarez, L. F.; Fafutis-Morris, M.; Montes-Salcedo, K. E.; Valle-Gutierrez, L. G.; Campos-Loza, A. E.; Enciso-Gómez, L. F.; Andrade-Villanueva, J. F. Synbiotic Therapy Decreases Microbial Translocation and Inflammation and Improves Immunological Status in HIV-infected Patients: A Double-blind Randomized Controlled Pilot Trial. Nutr. J. 2012, 11(1), 90. DOI: 10.1186/1475-2891-11-90.
  • Schunter, M.; Chu, H.; Hayes, T. L.; McConnell, D.; Crawford, S. S.; Luciw, P. A.; Bengmark, S.; Asmuth, D. M.; Brown, J.; Bevins, C. L.;, et al. Randomized Pilot Trial of a Synbiotic Dietary Supplement in Chronic HIV-1 Infection. BMC Complementary Altern. Med. 2012, 12. DOI: 10.1186/1472-6882-12-84.
  • Hummelen, R.; Hemsworth, J.; Changalucha, J.; Butamanya, N. L.; Hekmat, S.; Habbema, J. D.; Reid, G. Effect of Micronutrient and Probiotic Fortified Yogurt on Immune-function of Anti-retroviral Therapy Naive HIV Patients. Nutrients. 2011, 3(10), 897–909. DOI: 10.3390/nu3100897.
  • Klein, S. L.; Flanagan, K. L. Sex Differences in Immune Responses. Nat. Rev. Immunol. 2016, 16(10), 626. DOI: 10.1038/nri.2016.90.
  • Markle, J. G.; Frank, D. N.; Mortin-Toth, S.; Robertson, C. E.; Feazel, L. M.; Rolle-Kampczyk, U.; von Bergen, M.; McCoy, K. D.; Macpherson, A. J.; Danska, J. S. Sex Differences in the Gut Microbiome Drive Hormone-dependent Regulation of Autoimmunity. Science (New York, NY). 2013, 339(6123), 1084–1088. DOI: 10.1126/science.1233521.
  • Mueller, S.; Saunier, K.; Hanisch, C.; Norin, E.; Alm, L.; Midtvedt, T.; Cresci, A.; Silvi, S.; Orpianesi, C.; Verdenelli, M. C.; et al. Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: A Cross-sectional Study. Appl. Environ. Microbiol.2006, 72(2), 1027–1033. DOI: 10.1128/aem.72.2.1027-1033.2006.
  • Suzuki, Y.; Ikeda, K.; Sakuma, K.; Kawai, S.; Sawaki, K.; Asahara, T.; Takahashi, T.; Tsuji, H.; Nomoto, K.; Nagpal, R.; et al. Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender. Front. Microbiol. 2017, 8, 847. DOI: 10.3389/fmicb.2017.00847.
  • Grover, S.; Rashmi, H. M.; Srivastava, A. K.; Batish, V. K. Probiotics for Human Health -new Innovations and Emerging Trends. Gut Pathog. 2012, 4(1), 15. DOI: 10.1186/1757-4749-4-15.

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