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Review

Anti-Inflammatory Influences of Culinary Spices and Their Bioactives

References

  • Gupta, S. C.; Kunnumakkara, A. B.; Aggarwal, S.; Aggarwal, B. B. Inflammation, a Double-edge Sword for Cancer and Other Age-related Diseases. Front. Immunol. 2018, 9, 2160. DOI: 10.3389/fimmu.2018.02160.
  • Surh, Y. J.; Kundu, J. K.; Na, H. K.; Lee, J. S. Redox-sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-inflammatory and Antioxidative Phytochemicals. J. Nutr. 2005, 135(Suppl.), 2993S−3001S. DOI: 10.1093/jn/135.12.2993S.
  • Balkwill, F.; Charles, K. A.; Mantovani, A. Smoldering and Polarized Inflammation in the Initiation and Promotion of Malignant Disease. Cancer Cell. 2005, 7, 211–217. DOI: 10.1016/j.ccr.2005.02.013.
  • Agah, S.; Akbari, A.; Heshmati, J.; Sepidarkish, M.; Morvaridzadeh, M.; Adibi, P.; Mazidi, M; Farsia, F.; Ofori-Asenso, R.; Talley, N.J.; et al. Systematic Review with Meta-analysis: Effects of Probiotic Supplementation on Symptoms in Functional Dyspepsia. J. Funct. Foods. 2020, 68, 103902. DOI: 10.1016/j.jff.2020.103902.
  • Huerta, C.; Castellsague, J.; Varas-Lorenzo, C.; García-Rodríguez, L. A. Nonsteroidal Anti-Inflammatory Drugs and Risk of ARF in the General Population. Am. J. Kidney Dis. 2002, 45, 531–539. DOI: 10.1053/j.ajkd.2004.12.005.
  • Wallace, J. L.;. Pathogenesis of NSAID Induced Gastroduodenalmucosal Injury. Best Practice Res. Clin. Gastroenterol. 2001, 15, 691–703. DOI: 10.1053/bega.2001.0229.
  • Pilotto, A.; Sancarlo, D.; Addante, F.; Scarcelli, C.; Franceschi, M. Nonsteroidal Anti-inflammatory Drug Use in the Elderly. Surg. Oncol. 2010, 19, 167–172. DOI: 10.1016/j.suronc.2009.11.014.
  • Quiñonez-Flores, C. M.; González-Chávez, S. A.; Nájera, D. D. R.; Pacheco-Tena, C. Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review. Biomed. Res. Int. 2016, 2016, 6097417. DOI: 10.1155/2016/6097417.
  • Salehi, B.; Martorell, M.; Arbiser, J. L.; Sureda, A.; Martins, N.; Maurya, P. K.; Sharifi-Rad, M.; Kumar, P.; Sharifi-Rad, J.Antioxidants: Positive or Negative Actors? Biomolecules. 2018, 8, 124. DOI: 10.3390/biom8040124.
  • Kunnumakkara, A. B.; Shabnam, B.; Girisa, S.; Harsha, C.; Banik, K.; Devi, T. B.; Choudhury, R.; Sahu, H.; Parama, D.; Sailo, B. L.;, et al. Inflammation, NF-κB, and Chronic Diseases: How are They Linked? Crit. Rev. Immunol 2020, 40, 1–39. DOI: 10.1615/CritRevImmunol.2020033210.
  • Lin, J. Y.; Tang, C. Y. Strawberry, Loquat, Mulberry, and Bitter Melon Juices Exhibit Prophylactic Effects on LPS-induced Inflammation Using Murine Peritoneal Macrophages. Food Chem. 2008, 107, 1587–1596. DOI: 10.1016/j.foodchem.2007.10.025.
  • Sohrab, G.; Nasrollahzadeh, J.; Zand, H.; Amiri, Z.; Tohidi, M.; Kimiagar, M. Effects of Pomegranate Juice Consumption on Inflammatory Markers in Patients with Type 2 Diabetes: A Randomized, Placebo-controlled Trial. J. Res. Med. Sci. 2014, 19, 215–220.
  • Ghoochani, N.; Karandish, M.; Mowla, K.; Haghighizadeh, M. H.; Jalali, M. T. The Effect of Pomegranate Juice on Clinical Signs, Matrix Metalloproteinases and Antioxidant Status in Patients with Knee Osteoarthritis. J. Sci. Food Agric. 2016, 96, 4377–4381. DOI: 10.1002/jsfa.7647.
  • Ghavipour, M.; Sotoudeh, G.; Tavakoli, E.; Mowla, K.; Hasanzadeh, J.; Mazloom, Z. Pomegranate Extract Alleviates Disease Activity and Some Blood Biomarkers of Inflammation and Oxidative Stress in Rheumatoid Arthritis Patients. Eur. J. Clin. Nutr. 2017, 71, 92–96. DOI: 10.1038/ejcn.2016.151.
  • Yoon, J. H.; Baek, S. J. Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties. Yonsei Med. J. 2005, 46, 585–596. DOI: 10.3349/ymj.2005.46.5.585.
  • Srinivasan, K.;. Role of Spices beyond Food Flavouring: Nutraceuticals with Multiple Health Effects. Food Rev. Int. 2005, 21, 167–188. DOI: 10.1081/FRI-200051872.
  • Srinivasan, K.;. Dietary Spices as Beneficial Modulators of Lipid Profile in Conditions of Metabolic Disorders and Diseases. Food Funct. 2013, 4, 503–521. DOI: 10.1039/c2fo30249g.
  • Srinivasan, K.;. Anti-mutagenic and Cancer Preventive Potential of Spices and Their Bioactive Compounds. PharmaNutrition. 2017, 5, 89–102. DOI: 10.1016/j.phanu.2017.06.001.
  • Srinivasan, K.;. Antioxidant Potential of Spices and Their Active Constituents. Crit. Rev. Food Sci. Nutr. 2014, 54, 352–372. DOI: 10.1080/10408398.2011.585525.
  • Surh, Y.-J.;. Cancer Chemoprevention with Dietary Phytochemicals. Nature Rev. 2003, 3, 768–780.
  • Mueller, M.; Hobiger, S.; Jungbauer, A. Anti-inflammatory Activity of Extracts from Fruits, Herbs and Spices. Food Chem. 2010, 122, 987–996. DOI: 10.1016/j.foodchem.2010.03.041.
  • Sharifi-Rad, J.; Rayess, Y. E.; Rizk, A. A.; Sadaka, C.; Zgheib, R.; Zam, W.; Sesito, S.; Rapposelli, S.; Neffe-Skoinska, K.; Zielinska, D; et al. Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Front. Pharmacol. 2020, EPub. DOI: 10.3389/fphar.2020.01021.
  • Srinivasan, K.;. Nutraceutical Activities of Turmeric (Curcuma Longa) and Its Bioactive Constituent Curcumin. In Chapter 3. Science of Spices & Culinary Herbs;Eds., Atta-ur-Rahman, M., Chaudhary, I., Yousuf, S.; Bentham Science Publishers, Sharjah, UAE, 2019; Vol. 1, pp. 55–73.
  • Wal, P.; Saraswat, N.; Pal, R. S.; Wal, A.; Chaubey, M. A Detailed Insight of the Anti-inflammatory Effects of Curcumin with the Assessment of Parameters, Sources of ROS and Associated Mechanisms. Open Medicine Journal. 2019, 6(1), 64–76. DOI: 10.2174/1874220301906010064.
  • Salehi, B.; Calina, D.; Docea, A. O.; Koirala, N.; Arya, S.; Lombardo, D.; Pasqua, L.; Taheri, Y.; Marina Salgado Castillo, C.; Martorell, M.; et al. Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases. J. Clin. Med. 2020, 9, 430. DOI: 10.3390/jcm9020430.
  • Salehi, B.; Prado-Audelo, M. L. D.; Cortés, H.; Leyva-Gómez, G.; Stojanovi´c-Radi´c, Z.; Singh, Y. D.; Patra, J. K.; Das, G.; Martins, N.; Martorell, M.; et al. Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases. J. Clin. Med. 2020, 9, 746. DOI: 10.3390/jcm9030746.
  • Srimal, R. C.;. Turmeric: A Brief Review of Medicinal Properties. Fitoterapia. 1997, LXVIII, 483–490.
  • Mukhopadyay, A.; Basu, N.; Ghatak, N.; Gujral, P. K. Anti-inflammatory and Irritant Activities of Curcumin Analogs in Rats. Agents Action. 1982, 12, 508–515. DOI: 10.1007/BF01965935.
  • Rao, T. S.; Basu, N.; Siddiqui, H. H. Anti-inflammatory Activity of Curcumin Analogs. Indian J. Med. Res. 1982, 75, 574–578.
  • Srivastava, V.;. Effect of Curcumin on Platelet Aggregation and Vascular Prostacyclin Synthesis. Arznei Forch. 1986, 36, 715–717.
  • Satoskar, R. R.; Shah, S. J.; Shenoy, S. G. Evaluation of Anti-inflammatory Property of Curcumin (Diferuloylmethane) in Patients with Post-operative Inflammation. Int. J. Clin. Pharmacol. Therap. Toxicol. 1986, 24, 651–654.
  • Deodhar, S. D.; Sethi, R.; Srimal, R. C. Preliminary Studies on Anti-rheumatic Activity of Curcumin. Indian J. Med. Res. 1980, 71, 632–634.
  • Reddy, A. C. P.; Lokesh, B. R. Studies on Anti-inflammatory Activity of Spice Principles and Dietary N-3 Polyunsaturated Fatty Acids on Carrageenan Induced Inflammation in Rats. Ann. Nutr. Metab. 1994, 38, 349–358. DOI: 10.1159/000177833.
  • Joe, B.; Lokesh, B. R. Prophylactic and Therapeutic Effects of N-3 PUFA, Capsaicin and Curcumin on Adjuvant Induced Arthritis in Rats. J. Nutr. Biochem. 1997, 8, 397–407. DOI: 10.1016/S0955-2863(97)00047-8.
  • Joe, B.; Lokesh, B. R. Effect of Curcumin and Capsaicin on Arachidonic Acid Metabolism and Lysosomal Enzyme Secretion by Rat Peritoneal Macrophages. Lipids. 1997, 32, 1173–1180. DOI: 10.1007/s11745-997-0151-8.
  • Kwon, Y.; Malik, M.; Magnuson, B. A. Inhibition of Colonic Aberrant Crypt Foci by Curcumin in Rats Is Affected by Age. Nutr. Cancer. 2004, 48, 37–43. DOI: 10.1207/s15327914nc4801_6.
  • Edwards, R. L.; Luis, P. B.; Varuzza, P. V.; Joseph, A. I.; Presley, S. H.; Chaturvedi, R.; Schneider, C. The Anti-inflammatory Activity of Curcumin Is Mediated by Its Oxidative Metabolites. J. Biol. Chem. 2017, 292, 21243–21252. DOI: 10.1074/jbc.RA117.000123.
  • Kunnumakkara, A. B.; Harsha, C.; Banik, K.; Vikkurthi, R.; Sailo, B. L.; Bordoloi, D.; Gupta, S. C.; Aggarwal, B. B.Is Curcumin Bioavailability a Problem in Humans: Lessons from Clinical Trials. Expert Opin. Drug Metab. Toxicol. 2019, 15, 705–733. DOI: 10.1080/17425255.2019.1650914.
  • Kim, C.-S.; Kawada, T.; Kim, B.-S.; Han, I.-S.; Choe, S.-Y.; Kurata, T.; Yu, R. Capsaicin Exhibits Anti-inflammatory Property by Inhibiting IkB-a Degradation in LPS-stimulated Peritoneal Macrophages. Cell. Signal. 2003, 15, 299–306. DOI: 10.1016/S0898-6568(02)00086-4.
  • Lee, I. O.; Lee, K. H.; Pyo, J. H.; Kim, J. H.; Choi, Y. J.; Lee, Y. C. Antiinflammatory Effect of Capsaicin in Helicobacter Pylori-infected Gastric Epithelial Cells. Helicobacter. 2007, 12, 510–517. DOI: 10.1111/j.1523-5378.2007.00521.x.
  • Toyoda, T.; Shi, L.; Takasu, S.; Cho, Y. M.; Kiriyama, Y.; Nishikawa, A.; Ogawa, K.; Tatematsu, M.; Tsukamoto, T. Anti-inflammatory Effects of Capsaicin and Piperine on Helicobacter Pylori ‐ Induced Chronic Gastritis in Mongolian Gerbils. Helicobacter. 2015, 21, 131–142. DOI: 10.1111/hel.12243.
  • Park, J. Y.; Kawada, T.; Han, I. S.; Kim, B. S.; Goto, T.; Takahashi, N.; Fushiki, T.; Kurata, T.; Yu, R. Capsaicin Inhibits the Production of Tumor Necrosis Factor? By LPS-stimulated Murine Macrophages, RAW 264.7: A PPAR Ligand-like Action as A Novel Mechanism. FEBS Lett. 2004, 572, 266–270. DOI: 10.1016/j.febslet.2004.06.084.
  • Wang, J.; Tian, W.; Wang, S.; Wei, W.; Wu, D.; Wang, H.; Wang, L.; Yang, R.; Ji, A.; Li, Y.Antiinflammatory and Retinal Protective Effects of Capsaicin on Ischaemia ‐induced Injuries through the Release of Endogenous Somatostatin. Clin. Exp. Pharmacol. Physiol. 2017, 44, 803–814. DOI: 10.1111/1440-1681.12769.
  • Srinivasan, M. P.; Roy, A.; Thangavelu, L. The Effect of Capsicum Oleoresin on Nitric Oxide Production and Nitric Oxide Synthase Gene Expression in Macrophage Cell Line. Pharmacogn. Res. 2018, 10, 343–346. DOI: 10.4103/pr.pr_46_18.
  • Srinivasan, K.;. Biological Activities of Red Pepper (Capsicum Annuum) and Its Pungent Alkaloid - Capsaicin: A Review. Crit. Rev. Food Sci. Nutr. 2016, 56, 1488–1500. DOI: 10.1080/10408398.2013.772090.
  • Deal, C. L.; Schnitzer, T. J.; Lipstein, E.; Seibold, J. R.; Stevens, R. M.; Levy, M. D.; Albert, D.; Renold, F. Treatment of Arthritis with Topical Capsaicin: A Double-blind Trial. Clin. Ther. 1991, 13, 383–395.
  • McCarthy, G. M.; McCarthy, D. J. Effect of Topical Capsaicin in the Therapy of Painful Osteoarthritis of the Hand. J. Rheumatol. 1991, 19, 604–607.
  • Bernstein, J. E.; Korman, N. J.; Bickers, D. R.; Dahl, M. V.; Millikan, L. E. Treatment of Chronic Post-herpetic Neuralgia with Topical Capsaicin. Am. J. Dermatol. 1989, 21, 265–270. DOI: 10.1016/S0190-9622(89)70171-7.
  • Mustafa, T.; Srivastava, K. C.; Jensen, K. B. Pharmacology of Ginger (Zingiber Officinale). J. Drug Dev. 1993, 6, 25–39.
  • Kiuchi, F.; Iwakami, S.; Shibuya, M.; Hanaoka, F.; Sankawa, U. Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids. Chem. Pharm. Bull. (Tokyo). 1992, 40, 387–391. DOI: 10.1248/cpb.40.387.
  • Altman, R. D.; Marcussen, K. C. Effects of a Ginger Extract on Knee Pain in Patients with Osteoarthritis. Arthritis Rheum. 2001, 44, 2531–2538.
  • Wigler, I.; Grotto, I.; Caspi, D.; Yaron, M. The Effects of Zintona EC (A Ginger Extract) on Symptomatic Gonarthritis. Osteoarthritis Cartilage. 2003, 11, 783–789. DOI: 10.1016/S1063-4584(03)00169-9.
  • Parker, J.;. Culinary Herbs. In The New Crop Industries Handbook. RIRDC Publication No.04/125; Salvin, S., Bourke, M., Byrne, T., Eds.; Rural Industries Research and Development Corporation: Canberra, 2004; pp 236–243.
  • Morvaridzadeh, M.; Fazelian, S.; Agah, S.; Khazdouz, M.; Rahimlou, M.; Agah, F.; Potter, E.; Heshmati, S.; Heshmati, J. Effect of Ginger (Zingiber Officinale) on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Cytokine. 2020, 135, 155224. DOI: 10.1016/j.cyto.2020.155224.
  • Hsiang, C. Y.; Cheng, H. M.; Lo, H. Y.; Li, C. C.; Chou, P. C.; Lee, Y. C.; Ho, T-Y.Ginger and Zingerone Ameliorate Lipopolysaccharide-induced Acute Systemic Inflammation in Mice, Assessed by Nuclear factor-κB Bioluminescent Imaging. J. Agric. Food Chem. 2015, 63, 6051–6058. DOI: 10.1021/acs.jafc.5b01801.
  • Lantz, R. C.; Chen, G. J.; Sarihan, M.; Sólyom, A. M.; Jolad, S. D.; Timmermann, B. N. The Effect of Extracts from Ginger Rhizome on Inflammatory Mediator Production. Phytomedicine. 2007, 14, 123–128. DOI: 10.1016/j.phymed.2006.03.003.
  • Justo, O. R.; Simioni, P. U.; Gabriel, D. L.; Tamashiro, W. M. S. C.; Rosa, P. T. V.; Moraes, A. M. Evaluation of in Vitro Anti-inflammatory Effects of Crude Ginger and Rosemary Extracts Obtained through Supercritical CO2 Extraction on Macrophage and Tumor Cell Line: The Influence of Vehicle Type. BMC Compl. Altern. Med. 2015, 15, 390. DOI: 10.1186/s12906-015-0896-9.
  • Penna, S. C.; Medeiros, M. V.; Aimbire, F. S.; Faria-Neto, H. C.; Sertié, J. A.; Lopes-Martins, R. A. Anti-inflammatory Effect of the Hydralcoholic Extract of Zingiber Officinale Rhizomes on Rat Paw and Skin Edema. Phytomedicine. 2003, 10, 381–385. DOI: 10.1078/0944-7113-00271.
  • Ramadan, G.; Al-Kahtani, M. A.; El-Sayed, W. M. Anti-inflammatory and Antioxidant Properties of Curcuma Longa (Turmeric) versus Zingiber Officinale (Ginger) Rhizomes in Rat Adjuvant-induced Arthritis. Inflammation. 2011, 34, 291–301. DOI: 10.1007/s10753-010-9278-0.
  • Shimoda, H.; Shan, S. J.; Tanaka, J.; Seki, A.; Seo, J. W.; Kasajima, N.; Tamura, S.; Ke, Y.; Murakami, N. Anti-inflammatory Properties of Red Ginger (Zingiber Officinale Var. Rubra) Extract and Suppression of Nitric Oxide Production by Its Constituents. J. Med. Food. 2010, 13, 156–162. DOI: 10.1089/jmf.2009.1084.
  • Cortés-Rojas, D. F.; de Souza, C. R. F.; Oliveira, W. P. Clove (Syzygium Aromaticum): A Precious Spice. Asian Pac. J. Trop. Biomed. 2014, 4, 90–96. DOI: 10.1016/S2221-1691(14)60215-X.
  • Han, X.; Parker, T. L. Anti-inflammatory Activity of Clove (Eugenia Caryophyllata) Essential Oil in Human Dermal Fibroblasts. Pharm. Biol. 2017, 55, 1619–1622. DOI: 10.1080/13880209.2017.1314513.
  • Kim, S. S.; Oh, O. J.; Min, H. Y.; Park, E. J.; Kim, Y.; Park, H. J.; Nam Han, Y.; Lee, S. K. Eugenol Suppresses Cyclooxygenase-2 Expression in Lipopolysaccharide-stimulated Mouse Macrophage RAW264.7 Cells. Life Sci. 2003, 73, 337–348. DOI: 10.1016/S0024-3205(03)00288-1.
  • Bachiega, T. F.; de Sousa, J. P.; Bastos, J. K.; Sforcin, J. M. Clove and Eugenol in Noncytotoxic Concentrations Exert Immunomodulatory/anti-inflammatory Action on Cytokine Production by Murine Macrophages. J. Pharm. Pharmacol. 2012, 64, 610–616. DOI: 10.1111/j.2042-7158.2011.01440.x.
  • Tsai, T. H.; Huang, W. C.; Lien, T. J.; Huang, Y. H.; Chang, H.; Yu, C. H.; Tsai, P. J. Clove Extract and Eugenol Suppress Inflammatory Responses Elicited by Propionibacterium Acnes in Vitro and in Vivo. Food Agric. Immunol. 2017, 28, 916–931. DOI: 10.1080/09540105.2017.1320357.
  • Daniel, A. N.; Sartoretto, S. M.; Schmidt, G.; Caparroz-Assef, S. M.; Bersani-Amado, C. A.; Cuma, R. K. N. Anti-inflammatory and Antinociceptive Activities A of Eugenol Essential Oil in Experimental Animal Models. Rev. Bras. Farmacogn. 2009, 19, #1b. DOI: 10.1590/S0102-695X2009000200006.
  • Amin, B.; Hosseinzadeh, H. Black Cumin (Nigella Sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects. Planta Med. 2016, 82, 8–16.
  • Taka, E.; Mazzio, E. A.; Goodman, C. B.; Redmon, N.; Flores-Rozas, H.; Reams, R.; Darling-Reed, S.; Soliman, K. F. A. Anti-inflammatory Effects of Thymoquinone in Activated BV-2 Microglial Cells. J. Neuroimmunol. 2015, 286, 5–12. DOI: 10.1016/j.jneuroim.2015.06.011.
  • Hajhashemi, V.; Ghannadi, A.; Jafarabadi, H. Black Cumin Seed Essential Oil, as a Potent Analgesic and Anti-inflammatory Drug. Phytother. Res. 2004, 18, 195–199. DOI: 10.1002/ptr.1390.
  • Shuid, A. N.; Mohamed, N.; Mohamed, I. N.; Othman, F.; Suhaimi, F.; Mohd-Ramli, E. S.; Muhammad, N.; Soelaiman, I. N. Nigella Sativa: A Potential Antiosteoporotic Agent. Evid. Based Compl. Altern. Med. 2012, 2012, 696230.
  • Chehl, N.; Chipitsyna, G.; Gong, Q.; Yeo, C. J.; Arafat, H. A. Anti-inflammatory Effects of the Nigella Sativa Seed Extract, Thymoquinone, in Pancreatic Cancer Cells. HPB (Oxford). 2009, 11, 373–381. DOI: 10.1111/j.1477-2574.2009.00059.x.
  • Nikakhlagh, S.; Rahim, F.; Aryani, F. H.; Syahpoush, A.; Brougerdnya, M. G.; Saki, N. Herbal Treatment of Allergic Rhinitis: The Use of Nigella Sativa. Am. J. Otolaryngol. 2011, 32, 402–407. DOI: 10.1016/j.amjoto.2010.07.019.
  • Umar, S.; Zargan, J.; Umar, K.; Ahmad, S.; Katiyar, C. K.; Khan, H. A. Modulation of the Oxidative Stress and Inflammatory Cytokine Response by Thymoquinone in the Collagen Induced Arthritis in Wistar Rats. Chem. Biol. Interact. 2012, 197, 40–46. DOI: 10.1016/j.cbi.2012.03.003.
  • Majumdar, A. M.; Dhuley, J. N.; Deshmukh, V. K.; Raman, P. H.; Naik, S. R. Anti-inflammatory Activity of Piperine. Japan J. Med. Sci. Biol. 1990, 43, 95–100. DOI: 10.7883/yoken1952.43.95.
  • Bang, J. S.; Oh, D. H.; Choi, H. M.; Surh, B. J.; Lim, S. J.; Kim, J. Y.; Yang, H.-I.; Yoo, M. C.; Hahm, D.-H.; Kim, K. S.; et al. Anti-inflammatory and Antiarthritic Effects of Piperine in Human Interleukin 1β-stimulated Fibroblast-like Synoviocytes and in Rat Arthritis Models. Arthritis Res. Ther. 2009, 11, R49. DOI: 10.1186/ar2662.
  • Kumar, V.; Shrivastava, P.; Javed, H.; Khan, A.; Ahmed, M. E.; Tabassum, R.; Khan, M. M.; Khuwaja, G.; Islam, F.; Saeed Siddiqui, M.; et al. Piperine Suppresses Cerebral Ischemia-reperfusion-induced Inflammation through the Repression of COX-2, NOS-2, and NF-κB in Middle Cerebral Artery Occlusion Rat Model. Mol. Cell. Biochem. 2012, 367, 73–84. DOI: 10.1007/s11010-012-1321-z.
  • Bae, G. S.; Kim, M. S.; Jung, W. S.; Seo, S. W.; Yun, S. W.; Kim, S. G.; Park, R.-K.; Kim, E.-C.; Song, H.-J.; Park, S.-J.; et al. Inhibition of Lipopolysaccharide-induced Inflammatory Responses by Piperine. Eur. J. Pharmacol. 2010, 642, 154–162. DOI: 10.1016/j.ejphar.2010.05.026.
  • Chen, W. S.; Jie, A.; Li, J. J.; Hong, L.; Xing, Z. B.; Li, C. Q. Piperine Attenuates Lipopolysaccharide (Lps)-induced Inflammatory Responses in BV2 Microglia. Int. Immunopharmacol. 2017, 42, 44–48. DOI: 10.1016/j.intimp.2016.11.001.
  • Chuchawankul, S.; Khorana, N.; Poovorawan, Y. Piperine Inhibits Cytokine Production by Human Peripheral Blood Mononuclear Cells. Genet. Mol. Res. 2012, 11, 617–627. DOI: 10.4238/2012.March.14.5.
  • Ying, X.; Yu, K.; Chen, X.; Chen, H.; Hong, J.; Cheng, S.; Peng, L. Piperine Inhibits LPS Induced Expression of Inflammatory Mediators in RAW 264.7 Cells. Cell. Immunol. 2013, 285, 49–54. DOI: 10.1016/j.cellimm.2013.09.001.
  • Dong, Y.; Huihui, Z.; Li, C. Piperine Inhibit Inflammation, Alveolar Bone Loss and Collagen Fibers Breakdown in a Rat Periodontitis Model. J. Periodontal. Res. 2015, 50, 758–765. DOI: 10.1111/jre.12262.
  • Son, D. J.; Akiba, S.; Hong, J. T.; Yun, Y. P.; Hwang, S. Y.; Park, Y. H.; Lee, S. E. Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response. Nutrients. 2014, 6, 3336–3352.
  • Wei, J.; Zhang, X.; Bi, Y.; Miao, R.; Zhang, Z.; Anti-Inflammatory, S. H. Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Cells. Evid. Based Complem. Altern. Med. 2015, 2015, 474509. DOI: 10.1155/2015/474509.
  • Payahoo, L.; Ostadrahimi, A.; Mobasseri, M.; Khajebishak, Y.; Jafarabadi, M. A.; Mahdavi, A. B.; Mahluji, S. Anethum Graveolens L. Supplementation Has Anti-inflammatory Effect in Type 2 Diabetic Patients. Indian J. Trad. Knowledge. 2014, 13, 461–465.
  • Mandegary, A.; Pournamdari, M.; Sharififar, F.; Pournourmohammadi, S.; Fardiar, R.; Shooli, S. Alkaloid and Flavonoid Rich Fractions of Fenugreek Seeds (Trigonella Foenum-graecum L.) With Antinociceptive and Anti-inflammatory Effects. Food Chem. Toxicol. 2012, 50, 2503–2507.
  • Kawabata, T.; Cui, M.; Hasegawa, T.; Takano, F.; Ohta, T. Anti-Inflammatory and Anti-Melanogenic Steroidal Saponin Glycosides from Fenugreek (Trigonella Foenum-graecum L.) Seeds. Planta Med. 2010, 77, 705–710. DOI: 10.1055/s-0030-1250477.
  • Ansary, J.; Forbes-Hernández, T. Y.; Gil, E.; Cianciosi, D.; Zhang, J.; Elexpuru-Zabaleta, M.; Simal-Gandara, J.; Giampieri, F.; Battino, M. Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview. Antioxidants (Basel). 2020, 9, 619. DOI: 10.3390/antiox9070619.
  • Girisa, S.; Shabnam, B.; Monisha, J.; Fan, L.; Halim, C. E.; Arfuso, F.; Ahn, K.; Sethi, G.; Kunnumakkara, A. Potential of Zerumbone as an Anti-cancer Agent. Molecules. 2019, 24, 734. DOI: 10.3390/molecules24040734.
  • Kammath, A. J.; Nair, B.; Sreelekshmi, P.; Nath, L. R. Curry versus Cancer: Potential of Some Selected Culinary Spices against Cancer with in Vitro, in Vivo, and Human Trials Evidences. J. Food Biochem. DOI: 10.1111/jfbc.13285. Published online: June 11, 2020, e13285.
  • Aggarwal, B. B.; Van Kuiken, M. E.; Iyer, L. H.; Harikumar, K. B.; Sung, B. Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis. Exp. Biol. Med. 2009, 234, 825–849. DOI: 10.3181/0902-MR-78.
  • Lv, J.; Qi, L.; Yu, C.; Yang, L.; Guo, Y.; Chen, Y.; Bian, Z.; Sun, D.; Du, J.; Ge, P.; et al. Consumption of Spicy Foods and Total and Cause Specific Mortality: Population Based Cohort Study. BioMed. J. 2015, 351, h3942.

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