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Review

Coix Seed: A Review of Its Physicochemical Composition, Bioactivity, Processing, Application, Functionality, and Safety Aspects

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References

  • Corke, H.; Huang, Y.; Li, J. S. Coix: Overview. Encycl. Food Grains 2016, 1–4, 184–189. Second Ed. DOI: 10.1016/B978-0-12-394437-5.00008-5.
  • Yin, H. M.; Wang, S. N.; Nie, S. P.; Xie, M. Y. Coix Polysaccharides: Gut Microbiota Regulation and Immunomodulatory. Bioact. Carbohydrates Diet. Fibre. 2018, 16, 53–61. DOI: 10.1016/j.bcdf.2018.04.002.
  • Yu, F.; Zhang, J.; Li, Y.; Zhao, Z.; Liu, C.-X.; Research and Application of Adlay in Medicinal Field. Chin. Herb. Med. 2017, 9 (2), 126–133. DOI:10.1016/s1674-6384(17)60086-8.
  • Chen, C.; Zhang, Y.; Gao, Y.; Xu, Q.; Ju, X.; Wang, L. Identification and Anti-tumour Activities of Phenolic Compounds Isolated from Defatted Adlay (Coix Lachryma-jobi L. Var. Ma-yuen Stapf) Seed Meal. J. Funct. Foods. 2016, 26, 394–405. https://doi.org/10.1016/j.jff.2016.08.016.
  • Yamada, H.; Yanahira, S.; Kiyohara, H.; Cyong, J.-C.; Otsuka, Y.; Water-soluble Glucans from the Seed of Coix Lacryma-jobi Var. Ma-yuen. Phytochemistry. 1985, 25(1), 129–132. DOI: 10.1016/S0031-9422(00)94516-3
  • Lee, H. J.; Ryu, J.; Park, S. H.; Seo, E. K.; Han, A. R.; Lee, S. K.; Kim, Y. S.; Hong, J. H.; Seok, J. H.; Lee, C. J. Suppressive Effects of Coixol, Glyceryl Trilinoleate and Natural Products Derived from Coix Lachryma-Jobi Var. Ma-yuen on Gene Expression, Production and Secretion of Airway MUC5AC Mucin. Arch. Pharm. Res. 2015, 38, 620–627. https://doi.org/10.1007/s12272-014-0377-6.
  • Lakkham, K.; Wangsomnuk, P.; Aromdee, C. Identification and Quality of Four Varieties of Adlay. Songklanakarin J. Sci. Technol. 2009, 31, 425–431.
  • Kim, M. J.; Choi, S. J.; Shin, S. I.; Sohn, M. R.; Lee, C. J.; Kim, Y.; Cho, W., Il; Moon, T. W. Resistant Glutarate Starch from Adlay: Preparation and Properties. Carbohydr. Polym. 2008, 74(4), 787–796. DOI: 10.1016/j.carbpol.2008.04.043.
  • Lee, M. Y.; Lin, H. Y.; Cheng, F.; Chiang, W.; Kuo, Y. H. Isolation and Characterization of New Lactam Compounds that Inhibit Lung and Colon Cancer Cells from Adlay (Coix Lachryma-jobi L. Var. Ma-yuen Stapf) Bran. Food Chem. Toxicol. 2008, 46, 1933–1939. https://doi.org/10.1016/j.fct.2008.01.033.
  • Li, D.;. Research Advance on Ethnopharmacology, Pharmacokinetics and Clinical Therapeutics of Coix Seed and Its preparation,Kanglaite Injection. Asian J Pharmacodyn Pharmacokinet. 2006, 6, 83–102.
  • Tagliaferri, M. A.; Schwartzberg, L. S.; Chen, M. M.; Camacho, L. H.; Kaplan, E. H.; Arena, P.; Bienvenu, B. J.; North, S. E.; Patel, H.; Li, D. A Phase IIb Trial of Coix Seed Injection for Advanced Pancreatic Cancer. J. Clin. Oncol. 2013, 31(15_suppl), e15023–e15023. DOI: 10.1200/jco.2013.31.15_suppl.e15023.
  • Thakur, A.; Pathak, S. R. Introduction to Medicinally Important Constituent from Chinese Medicinal Plants. Elsevier Ltd, 2018. DOI: 10.1016/b978-0-08-102071-5.00014-3.
  • Bernhoft, A.;. Bioactive Compounds in Plants – Benefits and Risks for Man and Animals. Laeknabladid. 2010, 88, 821–825.
  • Liu, X.; Zhang, B.; Xu, J. H.; Mao, D. Z.; Yang, Y. J.; Wang, Z. W. Rapid Determination of the Crude Starch Content of Coix Seed and Comparing the Pasting and Textural Properties of the Starches. Starch/Staerke. 2017, 69, 1–8. DOI: 10.1002/star.201600115.
  • Wang, H.; Ding, J.; Xiao, N.; Liu, X.; Zhang, Y.; Zhang, H. Insights into the Hierarchical Structure and Digestibility of Starch in Heat-moisture Treated Adlay Seeds. Food Chem. 2020, 318, 126489. DOI: 10.1016/j.foodchem.2020.126489.
  • Yao, Y.; Zhu, Y.; Gao, Y.; Ren, G. Effect of Ultrasonic Treatment on Immunological Activities of Polysaccharides from Adlay. Int. J. Biol. Macromol. 2015, 80, 246–252. DOI: 10.1016/j.ijbiomac.2015.06.033.
  • Apirattananusorn, S.; Tongta, S.; Cui, S. W.; Wang, Q. Chemical, Molecular, and Structural Characterization of Alkali Extractable Nonstarch Polysaccharides from Job’s Tears. J. Agric. Food Chem. 2008, 56(18), 8549–8557. DOI: 10.1021/jf801231y.
  • Bejosano, F. P.; Corke, H. Amaranthus and Buckwheat Protein Concentrate Effects on an Emulsion-type Meat Product. Meat Sci. 1998, 50, 343–353. DOI: 10.1016/S0309-1740(98)00044-8.
  • Youssef, M. K.; Barbut, S. Effects of Two Types of Soy Protein Isolates, Native and Preheated Whey Protein Isolates on Emulsified Meat Batters Prepared at Different Protein Levels. Meat Sci. 2011, 87(1), 54–60. DOI: 10.1016/j.meatsci.2010.09.002.
  • Yeater, M.; Casco, G.; Miller, R. K.; Alvarado, C. Z. Comparative Evaluation of Texture Wheat Ingredients and Soy Proteins in the Quality and Acceptability of Emulsified Chicken Nuggets. Poult. Sci. 2017, 96, 4430–4438. DOI: 10.3382/ps/pex250.
  • Martins, J. T.; Bourbon, A. I.; Pinheiro, A. C.; Fasolin, L. H.; Vicente, A. A. Protein-Based Structures for Food Applications: From Macro to Nanoscale. Front. Sustainable Food Syst. 2018, 2, 1–18. DOI: 10.3389/fsufs.2018.00077.
  • Leite, A.; Neto, G. C.; Vettore, A. L.; Yunes, J. A.; Arruda, P. The Prolamins of Sorghum, Coix and Millets. Seed Proteins. 1999, 141–157. DOI: 10.1007/978-94-011-4431-5_7.
  • Lin, L. J.; Hsiao, E. S. L.; Tseng, H. S.; Chung, M. C.; Chua, A. C. N.; Kuo, M. E.; Tzen, J. T. C. Molecular Cloning, Mass Spectrometric Identification, and Nutritional Evaluation of 10 Coixins in Adlay (Coix Lachryma-jobi L.). J. Agric. Food Chem. 2009, 57, 10916–10921. https://doi.org/10.1021/jf903025n.
  • Liu, X.; Yang, Y.-J.; Wang, Z.-W. Structure Characteristics of Coix Seeds Prolamins and Physicochemical and Mechanical Properties of Their Films. J Cereal Sci. 2018, 79, 233–239. DOI: 10.1016/j.jcs.2017.11.002.
  • Xu, L.; Yang, N.; Wu, F.; Jin, Z.; Xu, X. Impact of Germination on the Chemical Components and Bioactive Properties of Adlay (Coix Lachryma-jobi L.) Water Extract. Int. J. Food Sci. Technol. 2017, 53, 449–456. https://doi.org/10.1111/ijfs.13603.
  • Huang, Y.; Zhu, J.; Lin, X.; Hong, Y.; Feng, Y.; Shen, L. Potential of Fatty Oils from Traditional Chinese Medicine in Cancer Therapy: A Review for Phytochemical, Pharmacological and Clinical Studies. Am. J. Chin. Med. 2019, 47(4), 727–750. DOI: 10.1142/S0192415X19500381.
  • Xi, X. J.; Zhu, Y. G.; Tong, Y. P.; Yang, X. L.; Tang, N. N.; Ma, S. M.; Li, S.; Cheng, Z. Assessment of the Genetic Diversity of Different Job’s Tears (Coix Lacryma-jobi L.) Accessions and the Active Composition and Anticancer Effect of Its Seed Oil. PLoS One. 2016, 11, 1–22. DOI: 10.1371/journal.pone.0153269.
  • Numata, M.; Yamamoto, A.; Moribayashi, A.; Yamada, H. Antitumor Components Isolated from the Chinese Herbal Medicine Coix Lachryma-jobi. Planta Med. 1994, 60(4), 356–359. DOI: 10.1055/s-2006-959500.
  • Lu, H. C.; Jiang, P. L.; Hsu, L. R. C.; Chyan, C. L.; Tzen, J. T. C. Characterization of Oil Bodies in Adlay (Coix Lachryma-jobi L). Biosci. Biotechnol. Biochem. 2010, 74, 1841–1847. DOI: 10.1271/bbb.100247.
  • Li, D.; US10314878B2.pdf Coix Seed Oil Containing 11 Triglycerides and Pharmaceutical Preparation and Use Thereof; 2019:1–19.
  • Lin, L.; Yang, Q.; Zhao, K.; Zhao, M. Identification of the Free Phenolic Profile of Adlay Bran by UPLC-QTOF-MS/MS and Inhibitory Mechanisms of Phenolic Acids against Xanthine Oxidase. Food Chem. 2018, 253, 108–118. DOI: 10.1016/j.foodchem.2018.01.139.
  • Zhao, M.; Zhu, D.; Sun-Waterhouse, D.; Su, G.; Lin, L.; Wang, X.; Dong, Y. In Vitro and in Vivo Studies on Adlay-derived Seed Extracts: Phenolic Profiles, Antioxidant Activities, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Effects. J. Agric. Food Chem. 2014, 62, 7771–7778. DOI: 10.1021/jf501952e.
  • Wang, L.; Chen, J.; Xie, H.; Ju, X.; Liu, R. H. Phytochemical Profiles and Antioxidant Activity of Adlay Varieties. J. Agric. Food Chem. 2013, 61(21), 5103–5113. DOI: 10.1021/jf400556s.
  • Yao, Y.; Wang, H.; Xu, F.; Zhang, Y.; Li, Z.; Ju, X.; Wang, L. Insoluble-bound Polyphenols of Adlay Seed Ameliorate H2O2-induced Oxidative Stress in HepG2 Cells via Nrf2 Signalling. Food Chem. 2020, 325, 126865. DOI: 10.1016/j.foodchem.2020.126865.
  • Wang, L.; Chen, C.; Su, A.; Zhang, Y.; Yuan, J.; Ju, X. Structural Characterization Of Phenolic Compounds And Antioxidant Activity Of The Phenolic-rich Fraction From Defatted Adlay (Coix lachryma-jobi L . var. ma-yuen Stapf) seed meal. Food Chem. 2016, 196, 509–517. DOI: 10.1016/j.foodchem.2015.09.083
  • Hu, A.; Zhang, Z.; Zheng, J.; Wang, Y.; Chen, Q.; Liu, R.; Liu, X.; Zhang, S. Optimizations and Comparison of Two Supercritical Extractions of Adlay Oil. Innov. Food Sci. Emerg. Technol. 2012, 13, 128–133. DOI: 10.1016/j.ifset.2011.10.002.
  • Li, J.; Corke, H. Physicochemical Properties of Normal and Waxy Job’s Tears (Coix Lachryma-jobi L.) Starch. Cereal Chem. 1999, 76, 413–416. DOI: 10.1094/CCHEM.1999.76.3.413.
  • Xiang-yu, C.; Jian-li, L.; Lu, X.-L.; Li, Q.-J.; Cao, H. X. Comparative Study on Methods for Extracting Protein from Job's tears seed. Food Sci. 2011, 8, 88-92.
  • Zhu, F.;. Coix: Chemical Composition and Health Effects. Trends Food Sci Technol. 2017, 61, 160–175. DOI: 10.1016/j.tifs.2016.12.003.
  • Yu, F.; Li, Y.; Zhang, J.; Liu, C. Dietary Chinese Herbs. Diet Chinese Herbs. 2015. DOI: 10.1007/978-3-211-99448-1.
  • Dharmananda, S. Coix: Food and Medicine: 2007 http://www.itmonline.org/articles/coix/coix.htm (accessed Sep 25, 2020).
  • Liu, X.; Wu, J. H.; Xu, J. H.; Mao, D. Z.; Yang, Y. J.; Wang, Z. W. The Impact of Heat-moisture Treatment on the Molecular Structure and Physicochemical Properties of Coix Seed Starches. Starch/Staerke. 2016, 68, 662–674. DOI: 10.1002/star.201500290.
  • Xu, L.; Yang, N.; Wu, F.; Jin, Z.; Xu, X. Effect of Acid Pretreatment on the Physicochemical and Antioxidant Properties of Germinated Adlay (Coix Lachryma-jobi L.). J. Food Process. Preserv. 2017, 42, 1–9. https://doi.org/10.1111/jfpp.13511.
  • Xu, L.; Chen, L.; Ali, B.; Yang, N.; Chen, Y.; Wu, F.; Jin, Z.; Xu, X. Impact of Germination on Nutritional and Physicochemical Properties of Adlay Seed (Coixlachryma-jobi L.). Food Chem. 2017, 229, 312–318. DOI: 10.1016/j.foodchem.2017.02.096
  • Chang, -C.-C.; Huang, L.-H.; Chiang, W.; Hsia, S.-M. Hexane Fraction of Adlay (Coix Lachryma-jobi L.) Testa Ethanolic Extract Inhibits Human Uterine Sarcoma Cancer Cells Growth and Chemosensitizes Human Uterine Sarcoma Cells to Doxorubicin. Phytomedicine. 2018, 47, 69–80. DOI: 10.1016/j.phymed.2018.03.056.
  • Lu, X.; Liu, W.; Wu, J.; Li, M.; Wang, J.; Wu, J.; Luo, C. A Polysaccharide Fraction of Adlay Seed (Coix Lachryma-jobi L.) Induces Apoptosis in Human Non-small Cell Lung Cancer A549 Cells. Biochem. Biophys. Res. Commun. 2012, 430, 846–851. https://doi.org/10.1016/j.bbrc.2012.11.058.
  • Son, E. S.; Kim, Y. O.; Park, C. G.; Park, K. H.; Jeong, S. H.; Park, J.-W.; Kim, S.-H.; Coix Lacryma-jobi Var. Ma-yuen Stapf Sprout Extract Has Anti-metastatic Activity in Colon Cancer Cells in Vitro. BMC Complementary Altern. Med. 2017, 17(1), 1–9. DOI: 10.1186/s12906-017-1990-y
  • Woo, J. H.; Li, D.; Wilsbach, K.; Orita, H.; Coulter, J.; Tully, E.; Taeg, K. K.; Xu, S.; Gabrielson, E. Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibits NFκB and Protein Kinase C Signaling. Cancer Biol. Ther. 2007, 6, 2005–2011. DOI: 10.4161/cbt.6.12.5168.
  • Chen, H.-J.; Chung, C.-P.; Chiang, W.; Lin, Y.-L. Anti-inflammatory Effects and Chemical Study of a Flavonoid-enriched Fraction from Adlay Bran. Food Chem. 2011, 126(4), 1741–1748. DOI: 10.1016/j.foodchem.2010.12.074.
  • Huang, D. W.; Wu, C. H.; Shih, C. K.; Liu, C. Y.; Shih, P. H.; Shieh, T. M.; Lin, C. I.; Chiang, W.; Hsia, S. M. Application of the Solvent Extraction Technique to Investigation of the Anti-inflammatory Activity of Adlay Bran. Food Chem. 2014, 145, 445–453. DOI: 10.1016/j.foodchem.2013.08.071.
  • Seo, W.-G.; Pae, H.-O.; Chai, K.-Y.; Yun, Y.-G.; Kwon, T.-H.; Chung, H.-T. Inhibitory Effects Of Methanol Extract Of Seeds Of Job’s Tears (Coix Lachryma-Jobi L Var. Ma-Yuen) On Nitric Oxide and Superoxide Production in Raw 264.7 Macrophages. Immunopharmacol. Immunotoxicol. 2000, 22(3), 545–554. DOI: 10.3109/08923970009026011.
  • He, C.; Li, Z.; Liu, H.; Zhang, H.; Wang, L.; Chen, H.; Chemical Compositions And Antioxidant Activity Of Adlay Seed (Coixlachryma-jobi L.) oil extracted from four main producing areas in China. J. Food Sci. 2020, 85(1), 123–131. DOI: 10.1111/1750-3841.14982
  • Manosroi, J.; Khositsuntiwong, N.; Manosroi, A. Biological Activities of Fructooligosaccharide (Fos)-containing Coix Lachryma-jobi Linn. Extract. J Food Sci Technol. 2014, 51, 341–346. DOI: 10.1007/s13197-011-0498-6.
  • Chiang, W.; Cheng, C.; Chiang, M.; Chung, K. Effects of Dehulled Adlay on the Culture Count of Some Microbiota.J Agric Food Chem. 2000, 48, 69–72.
  • Wang, Q.; Du, Z.; Zhang, H.; Zhao, L.; Sun, J.; Zheng, X.; Ren, F. Modulation of Gut Microbiota by Polyphenols from Adlay (Coix Lacryma-jobi L. Var. Ma-yuen Stapf.) In Rats Fed a High-cholesterol Diet. Int. J. Food Sci. Nutr. 2015, 66, 783–789. https://doi.org/10.3109/09637486.2015.1088941.
  • Liu, S.; Li, F.; Zhang, X. Structural Modulation of Gut Microbiota Reveals Coix Seed Contributes to Weight Loss in Mice. Appl. Microbiol. Biotechnol. 2019, 103(13), 5311–5321. DOI: 10.1007/s00253-019-09786-z.
  • Chen, L. C.; Jiang, B. K.; Zheng, W. H.; Zhang, S. Y.; Li, J. J.; Fan, Z. Y. Preparation, Characterization and Anti-diabetic Activity of Polysaccharides from Adlay Seed. Int. J. Biol. Macromol. 2019, 139, 605–613. DOI: 10.1016/j.ijbiomac.2019.08.018.
  • Chen, L.-C.; Fan, Z.-Y.; Wang, H.-Y.; Wen, D.-C.; Zhang, S.-Y. Effect of Polysaccharides from Adlay Seed on Anti-diabetic and Gut Microbiota. Food Funct. 2019, 10(7), 4372–4380. DOI: 10.1039/c9fo00406h.
  • Yin, Y.; Yang, W.; Jiao, Y.; Yang, H.; Li, X. Hypoglycaemic Effect of Coixan from Coix Seeds on Mice. E3S Web Conf. 2019, 78. 1–4. https://doi.org/10.1051/e3sconf/20197801009
  • Kim, S. O.; Yun, S. J.; Jung, B.; Lee, E. H.; Hahm, D. H.; Shim, I.; Lee, H. J. Hypolipidemic Effects of Crude Extract of Adlay Seed (Coix Lachrymajobi Var. Mayuen) in Obesity Rat Fed High Fat Diet: Relationsof TNF-α and Leptin mRNA Expressions and Serum Lipid Levels. Life Sci. 2004, 75, 1391–1404. DOI: 10.1016/j.lfs.2004.03.006.
  • Wang, L.; Sun, J.; Yi, Q.; Wang, X.; Ju, X. Protective Effect of Polyphenols Extract of Adlay (Coix Lachryma-jobi L. Var. Ma-yuen Stapf) on Hypercholesterolemia-induced Oxidative Stress in Rats. Molecules. 2012, 17, 8886–8897. https://doi.org/10.3390/molecules17088886.
  • Sen, Y. R.; Lu, Y. H.; Chiang, W.; Liu, S. H. Osteoporosis Prevention by Adlay (Yì Yǐ: Theseeds of Coix Lachryma-Jobi L. Var. Ma-yuen Stapf) in a Mouse Model. J. Tradit. Complement. Med. 2013, 3, 134–138. DOI: 10.4103/2225-4110.110408.
  • Hsia, S.-M.; Kuo, Y.-H.; Chiang, W.; Wang, P. S.; Effects of Adlay Hull Extracts on Uterine Contraction and Ca 2+Mobilization in the Rat. Am. J. Physiol-Endocrinol. Metab. 2008, 2953, E719–E726. DOI:10.1152/ajpendo.90367.2008.
  • Zhang, G.; Ding, Y.; Ni, C.; Ban, Q.; Xu, L.; Guo, L.; Cheng, J. Physicochemical and Morphological Properties of Extruded Adlay (Coix Lachryma-jobi L) Flour. J. Chem. 2019, 2019. DOI: 10.1155/2019/6239870.
  • Luithui, Y.; Meera, M. S. Effect of Heat Processing on the Physicochemical Properties of Job’s Tears Grain. J. Food Meas. Charact. 2019, 13, 874–882. DOI: 10.1007/s11694-018-0001-4.
  • Miao, L.; Zhao, S.; Zhang, B.; Tan, M.; Niu, M.; Jia, C.; Huang, Q. Understanding the Supramolecular Structures and Pasting Features of Adlay Seed Starches. Food Hydrocoll. 2018, 83, 411–418. DOI: 10.1016/j.foodhyd.2018.05.034.
  • Huang, X.; Qin, J.; Lu, S. Kanglaite Stimulates Anticancer Immune Responses and Inhibits HepG2 Cell Transplantation-induced Tumor Growth. Mol. Med. Rep. 2014, 10, 2153–2159. DOI: 10.3892/mmr.2014.2479.
  • Chung, C.-P.; Hsu, C.-Y.; Lin, J.-H.; Kuo, Y.-H.; Chiang, W.; Lin, Y.-L. Antiproliferative Lactams and Spiroenone from Adlay Bran in Human Breast Cancer Cell Lines. J. Agric. Food Chem. 2011, 59(4), 1185–1194. DOI: 10.1021/jf104088x.
  • A Jun, H.; Zhao, S.; Liang, H.; Qiu, T. Q.; Chen, G. Ultrasound Assisted Supercritical Fluid Extraction of Oil and Coixenolide from Adlay Seed. Ultrason. Sonochem. 2007, 14, 219–224. https://doi.org/10.1016/j.ultsonch.2006.03.005.
  • Choi, G.; Han, A. R.; Lee, J. H.; Park, J. Y.; Kang, U.; Hong, J.; Kim, Y. S.; Seo, E. K. A Comparative Study on Hulled Adlay and Unhulled Adlay through Evaluation of Their LPS-induced Anti-inflammatory Effects, and Isolation of Pure Compounds. Chem. Biodivers. 2015, 12, 380–387. DOI: 10.1002/cbdv.201400242.
  • Slade, D.; Radman, M.; Oxidative Stress Resistance in Deinococcus Radiodurans. Microbiol. mol. biol. reviews : MMBR. 2011, 751, 133–191. DOI:10.1128/mmbr.00015-10.
  • Huang, H.-C.; Hsieh, W.-Y.; Niu, Y.-L.; Chang, T.-M. Inhibitory Effects of Adlay Extract on Melanin Production and Cellular Oxygen Stress in B16F10 Melanoma Cells. Int. J. Mol. Sci. 2014, 15(9), 16665–16679. DOI: 10.3390/ijms150916665.
  • Chang, H. C.; Huang, Y. C.; Hung, W. C. Antiproliferative and Chemopreventive Effects of Adlay Seed on Lung Cancer in Vitro and in Vivo. J. Agric. Food Chem. 2003, 51, 3656–3660. DOI: 10.1021/jf021142a./
  • Manosroi, A.; Sainakham, M.; Chankhampan, C.; Manosroi, W.; Manosroi, J. In Vitro Anti-cancer Activities of Job’s Tears (Coix Lachryma-jobi Linn.) Extracts on Human Colon Adenocarcinoma. Saudi J. Biol. Sci. 2016, 23(2), 248–256. DOI: 10.1016/j.sjbs.2015.03.008.
  • Qu, D.; Wang, L.; Liu, M.; Shen, S.; Li, T.; Liu, Y.; Huang, M.; Liu, C.; Chen, Y.; Mo, R. Oral Nanomedicine Based on Multicomponent Microemulsions for Drug-Resistant Breast Cancer Treatment. Biomacromolecules. 2017, 18, 1268–1280. DOI: 10.1021/acs.biomac.7b00011.
  • Chen, F.; Zhang, M.; Yang, C.-H. Application of Ultrasound Technology in Processing of Ready-to-eat Fresh Food: A Review. Ultrason. Sonochem. 2020, 63, 104953. DOI: 10.1016/j.ultsonch.2019.104953.
  • Krishnan, S.; Alden, N.; Lee, K.Pathways and Functions of Gut Microbiota Metabolism Impacting Host Physiology. Curr. Opin. Biotechnol. 2015, 36, 137–145. DOI: 10.1016/j.copbio.2015.08.015.
  • Yu, F.; Gao, J.; Zeng, Y.; Liu, C. X. Effects of Adlay Seed Oil on Blood Lipids and Antioxidant Capacity in Hyperlipidemic Rats. J. Sci. Food Agric. 2011, 91, 1843–1848. DOI: 10.1002/jsfa.4393.
  • Yeh, Y.; Chiang, C.; Chiang, C. Effects of Dehulled Adlay on Plasma Glucose and Lipid Concentrations in Streptozotocin-induced Diabetic Rats Fed a Diet Enriched in Cholesterol. Int. J. Vitam. Nutr. Res. 2006, 76(5), 299–305. DOI: 10.1024/0300-9831.76.5.299.
  • Nishimura, M.; Ohkawara, T.; Kagami-Katsuyama, H.; Sekiguchi, S.; Taira, T.; Tsukada, M.; Shibata, H.; Nishihira, J. Alteration of Intestinal Flora by the Intake of Enzymatic Degradation Products of Adlay (Coix Lachryma-jobi L. Var. Ma-yuen Stapf) with Improvement of Skin Condition. J. Funct. Foods. 2014, 7, 487–494. DOI: 10.1016/j.jff.2014.01.007
  • Ruan, -J.-J.; Weng, W.-F.; Yan, J.; Zhou, Y.-X.; Chen, H.; Ren, M.-J.; Cheng, J.-P. Coix Lacryma-jobi Chymotrypsin Inhibitor Displays Antifungal Activity. Pestic. Biochem. Physiol. 2019, 160, 49–57. DOI: 10.1016/j.pestbp.2019.06.016
  • Hsu, H. Y.; Lin, B. F.; Lin, J. Y.; Kuo, C. C.; Chiang, W. Suppression of Allergic Reactions by Dehulled Adlay in Association with the Balance of Th1/Th2 Cell Responses. J. Agric. Food Chem. 2003, 51, 3763–3769. DOI: 10.1021/jf021154w.
  • Schwartzberg, L. S.; Arena, F. P.; Bienvenu, B. J.; Kaplan, E. H.; Camacho, L. H.; Campos, L. T.; Waymack, J. P.; Tagliaferri, M. A.; Chen, M. M.; Li, D. A Randomized, Open-label, Safety and Exploratory Efficacy Study of Kanglaite Injection (Klti) Plus Gemcitabine versus Gemcitabine in Patients with Advanced Pancreatic Cancer. J. Cancer. 2017, 8(10), 1872–1883. DOI: 10.7150/jca.15407.
  • Hayashi, H.; Arai, T.; Strong, J. M.; Tokuda, H.; Shimano, Y.; Ohta, Y.; Enomoto, T.; UebabaEBABA, K.; Ohta, T.; Suzuki, N. 28-day Repeated Dose Oral Toxicity Test of Coix Lacryma-jobi L. Var. Ma-yuen Stapf in Rats. Japanese J Complement Altern Med. 2009, 6. 131–135. https://doi.org/10.1625/jcam.6.131

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