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Review

Postharvest strategies for decontamination of aflatoxins in cereals

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References

  • Magan, N.; Aldred, D. Post-harvest Control Strategies: Minimizing Mycotoxins in the Food Chain. Int. J. Food Microbiol. 2007, 119(1), 131–139. DOI: 10.1016/j.ijfoodmicro.2007.07.034.
  • Buszewska-Forajta, M.;. Mycotoxins, Invisible Danger of Feedstuff with Toxic Effect on Animals. Toxicon. 2020, 182, 34–53. DOI: 10.1016/j.toxicon.2020.04.101.
  • IARC Chemical Agents and Related Occupations: Review of Human Carcinogens - Aflatoxins. IARC. http://monographs.iarc.fr/ENG/Monographs/vol100F/. (accessed June 2020).
  • Iqbal, S. Z.; Asi, M. R.; Ariño, A. Aflatoxins. In Brenner's Encyclopedia of Genetics Maloy, S., and Hughes, K.; Academic Press 43–47 doi:10.1016/B978-0-12-809633-8.06021-0 , 2013.
  • Mousavi Khaneghah, A.; Es, I.; Raeisi, S.; Fakhri, Y. Aflatoxins in Cereals: State of the Art. J. Food Saf. 2018, 38(6), e12532. DOI: 10.1111/jfs.12532.
  • van Duijn, G.;. Chapter 13 - Oils and Fats. In Food Safety Management; Motarjemi, Y., and Lelieveld, H., Eds.; USA: Academic Press: San Diego, 2014; 325–345 doi:10.1016/B978-0-12-381504-0.00013-5.
  • Mahato, D. K.; Lee, K. E.; Kamle, M.; Devi, S.; Dewangan, K. N.; Kumar, P.; Kang, S. G. Aflatoxins in Food and Feed: An Overview on Prevalence, Detection and Control Strategies. Front. Microbiol. 2019, 10(2266). DOI: 10.3389/fmicb.2019.02266.
  • Omara, T.; Nassazi, W.; Omute, T.; Awath, A.; Laker, F.; Kalukusu, R.; Musau, B.; Nakabuye, B. V.; Kagoya, S.; Otim, G., et al. Aflatoxins in Uganda: An Encyclopedic Review of the Etiology, Epidemiology, Detection, Quantification, Exposure Assessment, Reduction, and Control. Int J Microbiol. 2020, 2020, 4723612. DOI: 10.1155/2020/4723612.
  • Pretari, A.; Hoffmann, V.; Tian, L. Postharvest Practices for Aflatoxin Control: Evidence from Kenya. J. Stored Prod. Res. 2019, 82, 31–39. DOI: 10.1016/j.jspr.2019.03.001.
  • Varga, J.; Frisvad, J. C.; Samson, R. A. Two New Aflatoxin Producing Species, and an Overview of Aspergillus Section Flavi. Stud. Mycol. 2011, 69, 57–80. DOI: 10.3114/sim.2011.69.05.
  • Varga, J.; Frisvad, J.; Samson, R. A Reappraisal of Fungi Producing Aflatoxins. World Mycotoxin J. 2009, 2(3), 263–277. DOI: 10.3920/WMJ2008.1094.
  • Baranyi, N.; Kocsubé, S.; Varga, J. Aflatoxins: Climate Change and Biodegradation. Curr. Opin. Food Sci. 2015, 5, 60–66. DOI: 10.1016/j.cofs.2015.09.002.
  • Frisvad, J. C.; Hubka, V.; Ezekiel, C. N.; Hong, S.-B.; Nováková, A.; Chen, A. J.; Arzanlou, M.; Larsen, T. O.; Sklenář, F.; Mahakarnchanakul, W.; et al. Taxonomy of Aspergillus Section Flavi and Their Production of Aflatoxins, Ochratoxins and Other Mycotoxins. Stud. Mycol. 2019, 93, 1–63. DOI: 10.1016/j.simyco.2018.06.001.
  • Samapundo, S.; Devlieghere, F.; De Meulenaer, B.; Lamboni, Y.; Osei-Nimoh, D.; Debevere, J. M. Interaction of Water Activity and Bicarbonate Salts in the Inhibition of Growth and Mycotoxin Production by Fusarium and Aspergillus Species of Importance to Corn. Int. J. Food Microbiol. 2007, 116(2), 266–274. DOI: 10.1016/j.ijfoodmicro.2007.01.005.
  • Kabak, B.; The Fate of Mycotoxins during Thermal Food Processing. J. Sci. Food Agric. 2009, 89(4), 549–554. DOI: 10.1002/jsfa.3491.
  • Calado, T.; Venâncio, A.; Abrunhosa, L. Irradiation for Mold and Mycotoxin Control: A Review. Compr. Rev. Food Sci. Food Saf. 2014, 13(5), 1049–1061. DOI: 10.1111/1541-4337.12095.
  • Luo, X.; Wang, R.; Wang, L.; Li, Y.; Bian, Y.; Chen, Z. Effect of Ozone Treatment on Aflatoxin B1 and Safety Evaluation of Ozonized Corn. Food Control. 2014, 37, 171–176. DOI: 10.1016/j.foodcont.2013.09.043.
  • Vijayanandraj, S.; Brinda, R.; Kannan, K.; Adhithya, R.; Vinothini, S.; Senthil, K.; Chinta, R. R.; Paranidharan, V.; Velazhahan, R. Detoxification of Aflatoxin B1 by an Aqueous Extract from Leaves of Adhatoda Vasica Nees. Microbiol. Res. 2014, 169(4), 294–300. DOI: 10.1016/j.micres.2013.07.008.
  • Jardon-Xicotencatl, S.; Díaz-Torres, R.; Marroquín-Cardona, A.; Villarreal-Barajas, T.; Méndez-Albores, A. Detoxification of Aflatoxin-Contaminated Maize by Neutral Electrolyzed Oxidizing Water. Toxins. 2015, 7(10), 4294. DOI: 10.3390/toxins7104294.
  • Zavala-Franco, A.; Martínez-Flores, H. E.; Vázquez-Durán, A.; Méndez-Albores, A. Fate of Aflatoxins from a Novel Procedure for Tortilla Making Based on Infrared Heating. Philipp Agric Sci. 2016, 99(1), 42–49.
  • Śliżewska, K.; Smulikowska, S. Detoxification of Aflatoxin B1 and Change in Microflora Pattern by Probiotic in Vitro Fermentation of Broiler Feed. J. Animal Feed Sci. 2011, 20(2), 300–309. DOI: 10.22358/jafs/66187/2011.
  • Liu, N.; Wang, J.; Deng, Q.; Gu, K.; Wang, J. Detoxification of Aflatoxin B1 by Lactic Acid Bacteria and Hydrated Sodium Calcium Aluminosilicate in Broiler Chickens. Livestock Sci. 2018, 208, 28–32. DOI: 10.1016/j.livsci.2017.12.005.
  • Kamala, A.; Ortiz, J.; Kimanya, M.; Haesaert, G.; Donoso, S.; Tiisekwa, B.; De Meulenaer, B. Multiple Mycotoxin Co-occurrence in Maize Grown in Three Agro-ecological Zones of Tanzania. Food Control. 2015, 54, 208–215. DOI: 10.1016/j.foodcont.2015.02.002.
  • Martínez-Miranda, M.; Taborda-Ocampo, G.; Rosero-Moreano, M. Validation of a High Performance Liquid Chromatography Method for Aflatoxins Determination in Corn Arepas. J. Braz. Chem. Soc. 2015, 26, 797–803. DOI: 10.5935/0103-5053.20150042.
  • Sirma, A. J.; Ouko, E. O.; Murithi, G.; Mburugu, C.; Mapenay, I.; Ombui, J. N.; Kang’ethe, E. K.; Korhonen, H. Prevalence of Aflatoxin Contamination in Cereals from Nandi County, Kenya. Int J Agric Sci Vet Med. 2015, 3(3), 55–63.
  • Kara, G. N.; Ozbey, F.; Kabak, B. Co-occurrence of Aflatoxins and Ochratoxin A in Cereal Flours Commercialised in Turkey. Food Control. 2015, 54, 275–281. DOI: 10.1016/j.foodcont.2015.02.014.
  • Pleadin, J.; Vulić, A.; Perši, N.; Škrivanko, M.; Capek, B.; Cvetnić, Ž. Annual and Regional Variations of Aflatoxin B1 Levels Seen in Grains and Feed Coming from Croatian Dairy Farms over a 5-year Period. Food Control. 2015, 47, 221–225. DOI: 10.1016/j.foodcont.2014.07.017.
  • Shtëmbari, A.; Topi, D. Study of Aflatoxins’ Contamination in Wheat and Maize from Albania. J Hygienic Eng Des. 2015, 12, 44–48.
  • Hove, M.; De Boevre, M.; Lachat, C.; Jacxsens, L.; Nyanga, L. K.; De Saeger, S. Occurrence and Risk Assessment of Mycotoxins in Subsistence Farmed Maize from Zimbabwe. Food Control. 2016, 69, 36–44. DOI: 10.1016/j.foodcont.2016.04.038.
  • Kamika, I.; Ngbolua, K.-T.-N.; Tekere, M. Occurrence of Aflatoxin Contamination in Maize Throughout the Supply Chain in the Democratic Republic of Congo. Food Control. 2016, 69, 292–296. DOI: 10.1016/j.foodcont.2016.05.014.
  • Geary, P. A.; Chen, G.; Kimanya, M. E.; Shirima, C. P.; Oplatowska-Stachowiak, M.; Elliott, C. T.; Routledge, M. N.; Gong, Y. Y. Determination of Multi-mycotoxin Occurrence in Maize Based Porridges from Selected Regions of Tanzania by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), a Longitudinal Study. Food Control. 2016, 68, 337–343. DOI: 10.1016/j.foodcont.2016.04.018.
  • Huong, B. T. M.; Tuyen, L. D.; Do, T. T.; Madsen, H.; Brimer, L.; Dalsgaard, A. Aflatoxins and Fumonisins in Rice and Maize Staple Cereals in Northern Vietnam and Dietary Exposure in Different Ethnic Groups. Food Control. 2016, 70, 191–200. DOI: 10.1016/j.foodcont.2016.05.052.
  • Murashiki, T. C.; Chidewe, C.; Benhura, M. A.; Maringe, D. T.; Dembedza, M. P.; Manema, L. R.; Mvumi, B. M.; Nyanga, L. K. Levels and Daily Intake Estimates of Aflatoxin B1 and Fumonisin B1 in Maize Consumed by Rural Households in Shamva and Makoni Districts of Zimbabwe. Food Control. 2017, 72, 105–109. DOI: 10.1016/j.foodcont.2016.07.040.
  • Oliveira, M. S.; Rocha, A.; Sulyok, M.; Krska, R.; Mallmann, C. A. Natural Mycotoxin Contamination of Maize (Zea Mays L.) In the South Region of Brazil. Food Control. 2017, 73, 127–132. DOI: 10.1016/j.foodcont.2016.07.033.
  • Nishimwe, K.; Wanjuki, I.; Karangwa, C.; Darnell, R.; Harvey, J. An Initial Characterization of Aflatoxin B1 Contamination of Maize Sold in the Principal Retail Markets of Kigali, Rwanda. Food Control. 2017, 73, 574–580. DOI: 10.1016/j.foodcont.2016.09.006.
  • Sun, X. D.; Su, P.; Shan, H. Mycotoxin Contamination of Maize in China. Compr. Rev. Food Sci. Food Saf. 2017, 16(5), 835–849. DOI: 10.1111/1541-4337.12286.
  • Lee, H. S.; Nguyen-Viet, H.; Lindahl, J.; Thanh, H. M.; Khanh, T. N.; Hien, L. T. T.; Grace, D. A Survey of Aflatoxin B 1 in Maize and Awareness of Aflatoxins in Vietnam. World Mycotoxin J. 2017, 10(2), 195–202. DOI: 10.3920/WMJ2016.2144.
  • Nduti, N.;. Aflatoxin Variations in Maize Flour and Grains Collected from Various Regions of Kenya. Afr. J. Food Agric. Nutr. Dev. 2017, 17(1), 11743–11756. DOI: 10.18697/ajfand.77.16875.
  • Kachapulula, P. W.; Akello, J.; Bandyopadhyay, R.; Cotty, P. J. Aflatoxin Contamination of Groundnut and Maize in Zambia: Observed and Potential Concentrations. J. Appl. Microbiol. 2017, 122(6), 1471–1482. DOI: 10.1111/jam.13448.
  • Pleadin, J.; Staver, M. M.; Markov, K.; Frece, J.; Zadravec, M.; Jaki, V.; Krupić, I.; Vahčić, N. Mycotoxins in Organic and Conventional Cereals and Cereal Products Grown and Marketed in Croatia. Mycotoxin Res. 2017, 33(3), 219–227. DOI: 10.1007/s12550-017-0280-3.
  • Granados-Chinchilla, F.; Molina, A.; Chavarría, G.; Alfaro-Cascante, M.; Bogantes-Ledezma, D.; Murillo-Williams, A. Aflatoxins Occurrence through the Food Chain in Costa Rica: Applying the One Health Approach to Mycotoxin Surveillance. Food Control. 2017, 82, 217–226. DOI: 10.1016/j.foodcont.2017.06.023.
  • Seetha, A.; Munthali, W.; Msere, H. W.; Swai, E.; Muzanila, Y.; Sichone, E.; Tsusaka, T. W.; Rathore, A.; Okori, P. Occurrence of Aflatoxins and Its Management in Diverse Cropping Systems of Central Tanzania. Mycotoxin Res. 2017, 33(4), 323–331. DOI: 10.1007/s12550-017-0286-x.
  • Agbetiameh, D.; Ortega-Beltran, A.; Awuah, R. T.; Atehnkeng, J.; Cotty, P. J.; Bandyopadhyay, R. Prevalence of Aflatoxin Contamination in Maize and Groundnut in Ghana: Population Structure, Distribution, and Toxigenicity of the Causal Agents. Plant Dis. 2018, 102(4), 764–772. DOI: 10.1094/PDIS-05-17-0749-RE.
  • Kanwal, R.; Mehmood, A.; Saleem, S.; Randhawa, M. A.; Ihsan, A.; Amir, R. M.; Nadeem, M.; Sajid, M. W. Seasonal Impact and Daily Intake Assessment of Mycotoxins in Flour, Bread, and Nixtamalized Maize. J. Food Saf. 2018, 38(6), e12505. DOI: 10.1111/jfs.12505.
  • Hanvi, D. M.; Lawson-Evi, P.; De Boevre, M.; Goto, C. E.; De Saeger, S.; Eklu-Gadegbeku, K. Natural Occurrence of Mycotoxins in Maize and Sorghum in Togo. Mycotoxin Res. 2019, 35(4), 321–327. DOI: 10.1007/s12550-019-00351-1.
  • Gilbert Sandoval, I.; Wesseling, S.; Rietjens, I. M. C. M. Aflatoxin B1 in Nixtamalized Maize in Mexico; Occurrence and Accompanying Risk Assessment. Toxicol. Rep. 2019, 6, 1135–1142. DOI: 10.1016/j.toxrep.2019.10.008.
  • Manu, N.; Osekre, E. A.; Opit, G. P.; Arthur, F. H.; Mbata, G.; Armstrong, P.; Danso, J. K.; McNeill, S. G.; Campbell, J. Moisture Content, Insect Pests and Mycotoxin Levels of Maize on Farms in Tamale Environs in the Northern Region of Ghana. J. Stored Prod. Res. 2019, 83, 153–160. DOI: 10.1016/j.jspr.2019.05.015.
  • Blanco-Lizarazo, C. M.; Gamboa-Marín, A.; Vega, S.; Jiménez-Rodríguez, L. P.; Sánchez, B. I. C. Assessment of Dietary Exposure to Aflatoxin B1 from Corn Arepas in Colombia. Food Addit. Contam. 2019, 36(7), 1109–1117. DOI: 10.1080/19440049.2019.1615643.
  • Liverpool-Tasie, L. S. O.; Turna, N. S.; Ademola, O.; Obadina, A.; Wu, F. The Occurrence and Co-occurrence of Aflatoxin and Fumonisin along the Maize Value Chain in Southwest Nigeria. Food Chem. Toxicol. 2019, 129, 458–465. DOI: 10.1016/j.fct.2019.05.008.
  • Jiang, D.; Li, F.; Zheng, F.; Zhou, J.; Li, L.; Shen, F.; Chen, J.; Li, W. Occurrence and Dietary Exposure Assessment of Multiple Mycotoxins in Corn-based Food Products from Shandong, China. Food Addit. Contam. B. 2019, 12(1), 10–17. DOI: 10.1080/19393210.2018.1503341.
  • Yilma, S.; Sadessa, K.; Kebede, D.; Infections, F. Aflatoxin Contamination in Maize Grains Collected from West Showa and East Wallega Zones, Ethiopia. Int J Curr Res Rev. 2019, 11(21), 16–22. DOI: 10.31782/ijcrr.2019.11213.
  • Martinez-Miranda, M. M.; Rosero-Moreano, M.; Taborda-Ocampo, G. Occurrence, Dietary Exposure and Risk Assessment of Aflatoxins in Arepa, Bread and Rice. Food Control. 2019, 98, 359–366. DOI: 10.1016/j.foodcont.2018.11.046.
  • Aristil, J.; Venturini, G.; Maddalena, G.; Toffolatti, S. L.; Spada, A. Fungal Contamination and Aflatoxin Content of Maize, Moringa and Peanut Foods from Rural Subsistence Farms in South Haiti. J. Stored Prod. Res. 2020, 85, 101550. DOI: 10.1016/j.jspr.2019.101550.
  • Asghar, M. A.; Ahmed, A.; Asghar, M. A. Influence of Temperature and Environmental Conditions on Aflatoxin Contamination in Maize Collected from Different Regions of Pakistan during 2016–2019. J. Stored Prod. Res. 2020, 88, 101637. DOI: 10.1016/j.jspr.2020.101637.
  • Wajih Ul Hassan, S.; Sadef, Y.; Hussain, S.; Rafique Asi, M.; Ashraf, M. Y.; Anwar, S.; Malik, A. Unusual Pattern of Aflatoxins and Ochratoxin in Commercially Grown Maize Varieties of Pakistan. Toxicon. 2020, 182, 66–71. DOI: 10.1016/j.toxicon.2020.05.008.
  • Tarazona, A.; Gómez, J. V.; Mateo, F.; Jiménez, M.; Romera, D.; Mateo, E. M. Study on Mycotoxin Contamination of Maize Kernels in Spain. Food Control. 2020, 118, 107370. DOI: 10.1016/j.foodcont.2020.107370.
  • Kos, J.; Janić Hajnal, E.; Malachová, A.; Steiner, D.; Stranska, M.; Krska, R.; Poschmaier, B.; Sulyok, M. Mycotoxins in Maize Harvested in Republic of Serbia in the Period 2012–2015. Part 1: Regulated Mycotoxins and Its Derivatives. Food Chem. 2020, 312, 126034. DOI: 10.1016/j.foodchem.2019.126034.
  • Do, T. H.; Tran, S. C.; Le, C. D.; Nguyen, H.-B. T.; Le, P.-T.-T.; Le, -H.-H. T.; Le, T. D.; Thai-Nguyen, H.-T. Dietary Exposure and Health Risk Characterization of Aflatoxin B1, Ochratoxin A, Fumonisin B1, and Zearalenone in Food from Different Provinces in Northern Vietnam. Food Control. 2020, 112, 107108. DOI: 10.1016/j.foodcont.2020.107108.
  • Sserumaga, J. P.; Ortega-Beltran, A.; Wagacha, J. M.; Mutegi, C. K.; Bandyopadhyay, R. Aflatoxin-producing Fungi Associated with Pre-harvest Maize Contamination in Uganda. Int. J. Food Microbiol. 2020, 313, 108376. DOI: 10.1016/j.ijfoodmicro.2019.108376.
  • Nabwire, W. R.; Ombaka, J.; Dick, C. P.; Strickland, C.; Tang, L.; Xue, K. S.; Wang, J.-S. Aflatoxin in Household Maize for Human Consumption in Kenya, East Africa. Food Addit. Contam. B. 2020, 13(1), 45–51. DOI: 10.1080/19393210.2019.1690053.
  • Mallmann, C. A.; Tyska, D.; Almeida, C. A. A.; Oliveira, M. S.; Gressler, L. T. Mycotoxicological Monitoring of Breakfast and Infant Cereals Marketed in Brazil. Int. J. Food Microbiol. 2020, 331, 108628. DOI: 10.1016/j.ijfoodmicro.2020.108628.
  • Leggieri, M. C.; Lanubile, A.; Dall’Asta, C.; Pietri, A.; Battilani, P. The Impact of Seasonal Weather Variation on Mycotoxins: Maize Crop in 2014 in Northern Italy as a Case Study. World Mycotoxin J. 2020, 13(1), 25–36. DOI: 10.3920/WMJ2019.2475.
  • Sacco, C.; Donato, R.; Zanella, B.; Pini, G.; Pettini, L.; Marino, M. F.; Rookmin, A. D.; Marvasi, M. Mycotoxins and Flours: Effect of Type of Crop, Organic Production, Packaging Type on the Recovery of Fungal Genus and Mycotoxins. Int. J. Food Microbiol. 2020, 334, 108808. DOI: 10.1016/j.ijfoodmicro.2020.108808.
  • Skendi, A.; Papageorgiou, M.; Irakli, M.; Katsantonis, D. Presence of Mycotoxins, Heavy Metals and Nitrate Residues in Organic Commercial Cereal-based Foods Sold in the Greek Market. J Consumer Protect Food Safety. 2020, 15(2), 109–119. DOI: 10.1007/s00003-019-01231-7.
  • Omari, R.; Anyebuno, G. Risk Assessment of Aflatoxins in Maize-Groundnuts Complementary Foods Consumed by Ghanaian Infants. J Food Qual Hazards Control. 2020, 7(3), 128–135. DOI: 10.18502/jfqhc.7.3.4144.
  • Rahayu, W. P.; Herawati, D.; Broto, W.; Indrostristanto, N.; Ambarwati, S.; Adhi, W. Risk Estimation of Hepatocellular Carcinoma Due to Exposure to Aflatoxins in Maize from Yogyakarta, Indonesia. J Food Qual Hazards Control. 2020, 7(1), 45–50. DOI: 10.18502/jfqhc.7.1.2451.
  • Onyedum, S. C.; Adefolalu, F. S.; Muhammad, H. L.; Apeh, D. O.; Agada, M. S.; Imienwanrin, M. R.; Makun, H. A. Occurrence of Major Mycotoxins and Their Dietary Exposure in North-Central Nigeria Staples. Sci Afr. 2020, 7, e00188. DOI: 10.1016/j.sciaf.2019.e00188.
  • Hanvi, M. D.; Lawson-Evi, P.; Bouka, E. C.; Eklu-Gadegbeku, K. Aflatoxins in Maize Dough and Dietary Exposure in Rural Populations of Togo. Food Control. 2021, 121, 107673. DOI: 10.1016/j.foodcont.2020.107673.
  • Lai, X.; Liu, R.; Ruan, C.; Zhang, H.; Liu, C. Occurrence of Aflatoxins and Ochratoxin A in Rice Samples from Six Provinces in China. Food Control. 2015, 50, 401–404. DOI: 10.1016/j.foodcont.2014.09.029.
  • Prietto, L.; Moraes, P. S.; Kraus, R. B.; Meneghetti, V.; Fagundes, C. A. A.; Furlong, E. B. Post-harvest Operations and Aflatoxin Levels in Rice (Oryza Sativa). Crop Prot. 2015, 78, 172–177. DOI: 10.1016/j.cropro.2015.09.011.
  • Eslami, M.; Mashak, Z.; Heshmati, A.; Shokrzadeh, M.; Mozaffari Nejad, A. S. Determination of Aflatoxin B1 Levels in Iranian Rice by ELISA Method. Toxin Rev. 2015, 34(3), 125–128. DOI: 10.3109/15569543.2015.1074925.
  • Iqbal, S. Z.; Asi, M. R.; Hanif, U.; Zuber, M.; Jinap, S. The Presence of Aflatoxins and Ochratoxin A in Rice and Rice Products; and Evaluation of Dietary Intake. Food Chem. 2016, 210, 135–140. DOI: 10.1016/j.foodchem.2016.04.104.
  • Sun, X. D.; Su, P.; Shan, H. Mycotoxin Contamination of Rice in China. J. Food Sci. 2017, 82(3), 573–584. DOI: 10.1111/1750-3841.13631.
  • Majeed, S.; De Boevre, M.; De Saeger, S.; Rauf, W.; Tawab, A.; Fazal-e-habib; Rahman, M.; Iqbal, M.; Iqbal, M. Multiple Mycotoxins in Rice: Occurrence and Health Risk Assessment in Children and Adults of Punjab, Pakistan. Toxins. 2018, 10(2), 77. DOI: 10.3390/toxins10020077.
  • Al-Zoreky, N. S.; Saleh, F. A. Limited Survey on Aflatoxin Contamination in Rice. Saudi J. Biol. Sci. 2019, 26(2), 225–231. DOI: 10.1016/j.sjbs.2017.05.010.
  • Zhao, Y.; Wang, Q.; Huang, J.; Chen, Z.; Liu, S.; Wang, X.; Wang, F. Mycotoxin Contamination and Presence of Mycobiota in Rice Sold for Human Consumption in China. Food Control. 2019, 98, 19–23. DOI: 10.1016/j.foodcont.2018.11.014.
  • Al-Shuhaib, M. B. S.; Albakri, A. H.; Hashim, H. O.; Alwan, S. L.; Almandil, N. B.; Selvaraj, P.; Jermy, R.; Abdul Azeez, S.; Francis Borgio, J. High Prevalence of Aflatoxin B1 in Aspergillus Flavus Infecting Stored Rice Grains. mdrsjrns. 2020, 22(3), 737–745.
  • Lee, H. J.; Ryu, D. Worldwide Occurrence of Mycotoxins in Cereals and Cereal-Derived Food Products: Public Health Perspectives of Their Co-occurrence. J. Agric. Food Chem. 2017, 65(33), 7034–7051. DOI: 10.1021/acs.jafc.6b04847.
  • IGC Five-year Baseline Projections of Supply and Demand for Wheat, Maize (Corn), Rice and Soyabeans to 2025/26; International Grains Council: 2021; p 8.
  • Ranum, P.; Peña-Rosas, J. P.; Garcia-Casal, M. N. Global Maize Production, Utilization, and Consumption. Ann. N Y Acad. Sci. 2014, 1312(1), 105–112. DOI: 10.1111/nyas.12396.
  • USDA Brazil: Agricultural Biotechnology Annual; 2020; p 28.
  • ArgenBIO Evolución superficie de cultivos GM; Consejo Argentino para la Información y el Desarrollo de la Biotecnología: 2021.
  • García-Lara, S.; Serna-Saldivar, S. O. Chapter 1 - Corn History and Culture. In Corn, Third Edition ed.; Serna-Saldivar, S.O., Ed.; USA: AACC International Press: Oxford, 2019; pp 1–18 doi:10.1016/B978-0-12-811971-6.00001-2.
  • Karami-Osboo, R.; Mirabolfathy, M.; Kamran, R.; Shetab-Boushehri, M.; Sarkari, S. Aflatoxin B1 in Maize Harvested over 3 Years in Iran. Food Control. 2012, 23(1), 271–274. DOI: 10.1016/j.foodcont.2011.06.007.
  • FAO Perspectivas alimentarias; Organización de las Naciones Unidas para la Alimentación y la Agricultura: 2019; p 12.
  • Taylor, R. D.; Koo, W. W. Outlook of the U.S. And World Wheat Industries, 2015-2024; Center for Agricultural Policy and Trade Studies: North Dakota: USA, 2015; pp 23.
  • MINCYT, 2020 El MINCYT, el CONICET y La Universidad Nacional Del Litoral Anunciaron La Aprobación Del Trigo HB4® En Argentina ;. https://www.conicet.gov.ar/el-mincyt-conicet-y-universidad-nacional-del-litoral-anunciaron-la-aprobacion-del-trigo-hb4-en-argentina/; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): Argentina, 2020. May 2021
  • ISAAA, GM Approval Database. https://www.isaaa.org/gmapprovaldatabase/cropslist/default.asp 2021 ( accessed April 2021).
  • Asghar, M. A.; Ahmed, A.; Iqbal, J.; Zahir, E.; Nauman, H. Fungal Flora and Aflatoxin Contamination in Pakistani Wheat Kernels (Triticum Aestivum L.) And Their Attribution in Seed Germination. J. Food Drug Anal. 2016, 24(3), 635–643. DOI: 10.1016/j.jfda.2016.02.001.
  • Armorini, S.; Altafini, A.; Zaghini, A.; Roncada, P. Occurrence of Aflatoxin B1 in Conventional and Organic Flour in Italy and the Role of Sampling. Food Control. 2015, 50, 858–863. DOI: 10.1016/j.foodcont.2014.10.031.
  • Quiles, J. M.; Saladino, F.; Mañes, J.; Fernández-Franzón, M.; Meca, G. Occurrence of Mycotoxins in Refrigerated Pizza Dough and Risk Assessment of Exposure for the Spanish Population. Food Chem. Toxicol. 2016, 94, 19–24. DOI: 10.1016/j.fct.2016.05.011.
  • Zhao, Y.; Wang, Q.; Huang, J.; Ma, L.; Chen, Z.; Wang, F. Aflatoxin B1 and Sterigmatocystin in Wheat and Wheat Products from Supermarkets in China. Food Addit. Contam. B. 2018, 11(1), 9–14. DOI: 10.1080/19393210.2017.1388295.
  • Krulj, J.; Đisalov, J.; Bočarov-Stančić, A.; Pezo, L.; Kojić, J.; Vidaković, A.; Solarov, M. B. Occurrence of Aflatoxin B1 in Triticum Species Inoculated with Aspergillus Flavus. World Mycotoxin J. 2018, 11(2), 247–257. DOI: 10.3920/WMJ2017.2229.
  • Udomkun, P.; Tirawattanawanich, C.; Ilukor, J.; Sridonpai, P.; Njukwe, E.; Nimbona, P.; Vanlauwe, B. Promoting the Use of Locally Produced Crops in Making Cereal-legume-based Composite Flours: An Assessment of Nutrient, Antinutrient, Mineral Molar Ratios, and Aflatoxin Content. Food Chem. 2019, 286, 651–658. DOI: 10.1016/j.foodchem.2019.02.055.
  • Schabo, D. C.; Martins, L. M.; Iamanaka, B. T.; Maciel, J. F.; Taniwaki, M. H.; Schaffner, D. W.; Magnani, M. Modeling Aflatoxin B1 Production by Aspergillus Flavus during Wheat Malting for Craft Beer as a Function of Grains Steeping Degree, Temperature and Time of Germination. Int. J. Food Microbiol. 2020, 333, 108777. DOI: 10.1016/j.ijfoodmicro.2020.108777.
  • Schabo, D. C.; Martins, L. M.; Maciel, J. F.; Iamanaka, B. T.; Taniwaki, M. H.; Schaffner, D. W.; Magnani, M. Production of Aflatoxin B1 and B2 by Aspergillus Flavus in Inoculated Wheat Using Typical Craft Beer Malting Conditions. Food Microbiol. 2020, 89, 103456. DOI: 10.1016/j.fm.2020.103456.
  • Hathout, A. S.; Abel-Fattah, S. M.; Abou-Sree, Y. H.; Fouzy, A. S. M. Incidence and Exposure Assessment of Aflatoxins and Ochratoxin A in Egyptian Wheat. Toxicol. Rep. 2020, 7, 867–873. DOI: 10.1016/j.toxrep.2020.07.003.
  • Prasad, R.; Shivay, Y. S.; Kumar, D. Current Status, Challenges, and Opportunities in Rice Production. In Rice Production Worldwide; Chauhan, B.J.K., and Mahajan, G., Eds.; Switzerland: Springer 1–32 doi:10.1007/978-3-319-47516-5_1 , 2017.
  • Ferre, F. S.;. Worldwide Occurrence of Mycotoxins in Rice. Food Control. 2016, 62, 291–298. DOI: 10.1016/j.foodcont.2015.10.051.
  • Degen, G.;. Tools for Investigating Workplace-related Risks from Mycotoxin Exposure. World Mycotoxin J. 2011, 4(3), 315–327. DOI: 10.3920/WMJ2011.1295.
  • Groopman, J. D.; Hall, A. J.; Whittle, H.; Hudson, G. J.; Wogan, G. N.; Montesano, R.; Wild, C. P. Molecular Dosimetry of aflatoxin-N7-guanine in Human Urine Obtained in the Gambia, West Africa. Cancer Epidemiol Biomarkers Prevent. 1992, 1(3), 221–227.
  • Sun, L.-H.; Zhang, N.-Y.; Zhu, M.-K.; Zhao, L.; Zhou, J.-C.; Qi, D.-S. Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver. J. Nutr. 2016, 146(4), 655–661. DOI: 10.3945/jn.115.224626.
  • Bastaki, S. A.; Osman, N.; Kochiyil, J.; Shafiullah, M.; Padmanabhan, R.; Abdulrazzaq, Y. M. Toxicokinetics of Aflatoxin in Pregnant Mice. Int. J. Toxicol. 2010, 29(4), 425–431. DOI: 10.1177/1091581810369565.
  • Tuanny Franco, L.; Mousavi Khaneghah, A.; Lee, S. H.; Fernandes Oliveira, C. A. Biomonitoring of Mycotoxin Exposure Using Urinary Biomarker Approaches: A Review. Toxin Rev. 2019, 1–21. DOI: 10.1080/15569543.2019.1619086.
  • Riley, R. T.; Kemppainen, B. W.; Norred, W. P. Penetration of Aflatoxins through Isolated Human Epidermis. J. Toxicol. Environ. Health. 1985, 15(6), 769–777. DOI: 10.1080/15287398509530703.
  • Kemppainen, B. W.; Riley, R. T.; Pace, J. G. Skin Absorption as a Route of Exposure for Aflatoxin and Trichothecenes. J. Toxicol. 1988, 7(2), 95–120. DOI: 10.3109/15569548809059728.
  • Boonen, J.; Malysheva, S. V.; Taevernier, L.; Diana Di Mavungu, J.; De Saeger, S.; De Spiegeleer, B. Human Skin Penetration of Selected Model Mycotoxins. Toxicology. 2012, 301(1), 21–32. DOI: 10.1016/j.tox.2012.06.012.
  • Rastogi, S.; Dogra, R. K. S.; Khanna, S. K.; Das, M. Skin Tumorigenic Potential of Aflatoxin B1 in Mice. Food Chem. Toxicol. 2006, 44(5), 670–677. DOI: 10.1016/j.fct.2005.09.008.
  • Autrup, J. L.; Schmidt, J.; Seremet, T.; Autrup, H. Determination of Exposure to Aflatoxins among Danish Workers in Animal-feed Production through the Analysis of Aflatoxin B1 Adducts to Serum Albumin. Scand J Work Environ Health. 1991, 17(6), 436–440. DOI: 10.5271/sjweh.1683.
  • Alavanja, M. C. R.; Malker, H.; Hayes, R. B. Occupational Cancer Risk Associated with the Storage and Bulk Handling of Agricultural Foodstuff. J. Toxicol. Environ. Health. 1987, 22(3), 247–254. DOI: 10.1080/15287398709531068.
  • Wangia, R. N.; Tang, L.; Wang, J.-S. Occupational Exposure to Aflatoxins and Health Outcomes: A Review. J. Environ. Sci. Health C. 2019, 37(4), 215–234. DOI: 10.1080/10590501.2019.1664836.
  • Dvorácková, I. Aflatoxin Inhalation and Alveolar Cell Carcinoma. Br. Med. J. 1976, 1(6011), 691. DOI: 10.1136/bmj.1.6011.691.
  • Williams, J. H.; Phillips, T. D.; Jolly, P. E.; Stiles, J. K.; Jolly, C. M.; Aggarwal, D. Human Aflatoxicosis in Developing Countries: A Review of Toxicology, Exposure, Potential Health Consequences, and Interventions. Am. J. Clin. Nutr. 2004, 80(5), 1106–1122. DOI: 10.1093/ajcn/80.5.1106.
  • Marchese, S.; Polo, A.; Ariano, A.; Velotto, S.; Costantini, S.; Severino, L. Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development. Toxins. 2018, 10(6), 214. DOI: 10.3390/toxins10060214.
  • Huang, B.; Chen, Q.; Wang, L.; Gao, X.; Zhu, W.; Mu, P.; Deng, Y. Aflatoxin B1 Induces Neurotoxicity through Reactive Oxygen Species Generation, DNA Damage, Apoptosis, and S-Phase Cell Cycle Arrest. Int. J. Mol. Sci. 2020, 21(18), 6517. DOI: 10.3390/ijms21186517.
  • Fouad, A. M.; Ruan, D.; El-Senousey, H. K.; Chen, W.; Jiang, S.; Zheng, C. Harmful Effects and Control Strategies of Aflatoxin B1 Produced by Aspergillus Flavus and Aspergillus Parasiticus Strains on Poultry: Review. Toxins (Basel). 2019, 11(3), 176. DOI: 10.3390/toxins11030176.
  • Benkerroum, N.;. Aflatoxins: Producing-Molds, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries. Int. J. Environ. Res. Public Health. 2020, 17(4), 1215. DOI: 10.3390/ijerph17041215.
  • Ross, R. K.; Yu, M. C.; Henderson, B. E.; Yuan, J. M.; Qian, G. S.; Tu, J. T.; Gao, Y. T.; Wogan, G. N.; Groopman, J. D. Urinary Aflatoxin Biomarkers and Risk of Hepatocellular Carcinoma. Lancet. 1992, 339(8799), 943–946. DOI: 10.1016/0140-6736(92)91528-G.
  • Wang, J. S.; Qian, G. S.; Zarba, A.; He, X.; Zhu, Y. R.; Zhang, B. C.; Jacobson, L.; Gange, S. J.; Muñoz, A.; Kensler, T. W. Temporal Patterns of Aflatoxin-albumin Adducts in Hepatitis B Surface Antigen-positive and Antigen-negative Residents of Daxin, Qidong County, People’s Republic of China. Cancer Epidemiol Biomarkers Prevent. 1996, 5(4), 253–261.
  • Kew, M. C.;. Synergistic Interaction between Aflatoxin and Hepatitis B Virus in Hepatocarcinogenesis. In Aflatoxins - Recent Advances and Future Prospects Razzaghi-Abyaneh, M. (United Kingdom: IntechOpen), 2013; pp 223–238 doi:10.5772/51396.
  • Gnonlonfin, G. J. B.; Hell, K.; Adjovi, Y.; Fandohan, P.; Koudande, D. O.; Mensah, G. A.; Sanni, A.; Brimer, L. A Review on Aflatoxin Contamination and Its Implications in the Developing World: A Sub-Saharan African Perspective. Crit. Rev. Food Sci. Nutr. 2013, 53(4), 349–365. DOI: 10.1080/10408398.2010.535718.
  • IARC. Economics of Mycotoxins: Evaluating Costs to Society and Cost-effectiveness of Interventions. IARC Sci. Publ n/a . 2012, 158, 119–129.
  • Udomkun, P.; Wiredu, A. N.; Nagle, M.; Bandyopadhyay, R.; Müller, J.; Vanlauwe, B. Mycotoxins in Sub-Saharan Africa: Present Situation, Socio-economic Impact, Awareness, and Outlook. Food Control. 2017, 72, 110–122. DOI: 10.1016/j.foodcont.2016.07.039.
  • Zain, M. E.;. Impact of Mycotoxins on Humans and Animals. J. Saudi Chem. Soc. 2011, 15, 129–144. DOI: 10.1016/j.jscs.2010.06.006.
  • Otsuki, T.; Wilson, J. S.; Sewadeh, M. Saving Two in a Billion: Quantifying the Trade Effect of European Food Safety Standards on African Exports. Food Policy. 2001, 26(5), 495–514. DOI: 10.1016/S0306-9192(01)00018-5.
  • Mamo, F. T.; Abate, B. A.; Tesfaye, K.; Nie, C.; Wang, G.; Liu, Y. Mycotoxins in Ethiopia: A Review on Prevalence, Economic and Health Impacts. Toxins. 2020, 12(10), 648. DOI: 10.3390/toxins12100648.
  • Daou, R.; Joubrane, K.; Maroun, R. G.; Khabbaz, L. R.; Ismail, A.; Khoury, A. E 2021 . Mycotoxins: Factors Influencing Production and Control Strategies AIMS Agriculture and Food 6 1 416–447 . DOI: 10.3934/agrfood.2021025.
  • European Commission, RASFF - Food and Feed Safety Alerts. https://webgate.ec.europa.eu/rasff-window/screen/list ( accessed May 2021).
  • Coulibaly, O.; Hell, K.; Bandyopadhyay, R.; Hounkponou, S.; Leslie, J. Economic Impact of Aflatoxin Contamination in Sub-Saharan Africa. Mycotoxins. 2008, 67–76. DOI: 10.1079/9781845930820.0067.
  • Wu, F. Mycotoxin Reduction in Bt Corn: Potential Economic, Health, and Regulatory Impacts. Transgenic Res. 2006, 15(3), 277–289. DOI: 10.1007/s11248-005-5237-1.
  • Robens, J.; Cardwell, K. The Costs of Mycotoxin Management to the USA: Management of Aflatoxins in the United States. J. Toxicol. 2003, 22(2–3), 139–152. DOI: 10.1081/TXR-120024089.
  • Mitchell, N. J.; Bowers, E.; Hurburgh, C.; Wu, F. Potential Economic Losses to the US Corn Industry from Aflatoxin Contamination. Food Addit. Contam. 2016, 33(3), 540–550. DOI: 10.1080/19440049.2016.1138545.
  • Yu, J.; Hennessy, D. A.; Wu, F. The Impact of Bt Corn on Aflatoxin-Related Insurance Claims in the United States. Sci. Rep. 2020, 10(1), 10046. DOI: 10.1038/s41598-020-66955-1.
  • Wan, J.; Chen, B.; Rao, J. Occurrence and Preventive Strategies to Control Mycotoxins in Cereal-based Food. Compr. Rev. Food Sci. Food Saf. 2020, 19(3), 928–953. DOI: 10.1111/1541-4337.12546.
  • Méndez-Albores, A.; De Jesús-Flores, F.; Castañeda-Roldan, E.; Arámbula-Villa, G.; Moreno-Martı́nez, E. The Effect of Toasting and Boiling on the Fate of B-aflatoxins during Pinole Preparation. J. Food Eng. 2004, 65(4), 585–589. DOI: 10.1016/j.jfoodeng.2004.02.024.
  • Hwang, J.-H.; Lee, K.-G. Reduction of Aflatoxin B1 Contamination in Wheat by Various Cooking Treatments. Food Chem. 2006, 98(1), 71–75. DOI: 10.1016/j.foodchem.2005.04.038.
  • Bol, E. K.; Araujo, L.; Veras, F. F.; Welke, J. E. Estimated Exposure to Zearalenone, Ochratoxin A and Aflatoxin B1 through the Consume of Bakery Products and Pasta considering Effects of Food Processing. Food Chem. Toxicol. 2016, 89, 85–91. DOI: 10.1016/j.fct.2016.01.013.
  • Bryła, M.; Ksieniewicz-Woźniak, E.; Stępniewska, S.; Modrzewska, M.; Waśkiewicz, A.; Szymczyk, K.; Szafrańska, A. Transformation of Ochratoxin A during Bread-making Processes. Food Control. 2021, 125, 107950. DOI: 10.1016/j.foodcont.2021.107950.
  • Raters, M.; Matissek, R. Thermal Stability of Aflatoxin B1 and Ochratoxin A. Mycotoxin Res. 2008, 24(3), 130–134. DOI: 10.1007/BF03032339.
  • Bretz, M.; Beyer, M.; Cramer, B.; Knecht, A.; Humpf, H.-U. Thermal Degradation of the Fusarium Mycotoxin Deoxynivalenol. J. Agric. Food Chem. 2006, 54(17), 6445–6451. DOI: 10.1021/jf061008g.
  • Massarolo, K. C.; Ferreira, C. F. J.; Collazzo, C. C.; Bianchini, A.; Kupski, L.; Badiale-Furlong, E. Resistant Starch and Hydrothermal Treatment of Cornmeal: Factors in Aflatoxins and Fumonisin B1 Reduction and Bioaccessibility. Food Control. 2020, 114, 107274. DOI: 10.1016/j.foodcont.2020.107274.
  • Marina Nogueira, S.; Massarolo, K. C.; Kupski, L.; Furlong, E. B.; Application of new technologies in decontamination of mycotoxins in cereal grains: Challenges, a. p; Hydrothermal Treatment of Rice: Reduction of Aflatoxins and Bioaccessibility. J. Cereal Sci. 2019, 85, 199–205. 10.1016/j.jcs.2018.12.009.
  • Gbashi, S.; Madala, N. E.; De Saeger, S.; De Boevre, M.; Njobeh, P. B. Numerical Optimization of Temperature-time Degradation of Multiple Mycotoxins. Food Chem. Toxicol. 2019, 125, 289–304. DOI: 10.1016/j.fct.2019.01.009.
  • Park, J. W.; Kim, Y.-B. Effect of Pressure Cooking on Aflatoxin B1 in Rice. J. Agric. Food Chem. 2006, 54(6), 2431–2435. DOI: 10.1021/jf053007e.
  • Deng, L.-Z.; Tao, Y.; Mujumdar, A. S.; Pan, Z.; Chen, C.; Yang, X.-H.; Liu, Z.-L.; Wang, H.; Xiao, H.-W. Recent Advances in Non-thermal Decontamination Technologies for Microorganisms and Mycotoxins in Low-moisture Foods. Trends Food Sci. Technol. 2020, 106, 104–112. DOI: 10.1016/j.tifs.2020.10.012.
  • Ghanghro, A. B.; Channa, M. J.; Sheikh, S. A.; Nizamani, S. M.; I.h., G. Assessment of Aflatoxin Level in Stored Wheat of Godowns of Hyderabad Division and Decontamination by UV Radiation. Int J Biosci. 2016, 8(1), 8–16.
  • Mir, S. A.; Dar, B. N.; Shah, M. A.; Sofi, S. A.; Hamdani, A. M.; Oliveira, C. A. F.; Hashemi Moosavi, M.; Mousavi Khaneghah, A.; Sant’Ana, A. S. Application of New Technologies in Decontamination of Mycotoxins in Cereal Grains: Challenges, and Perspectives. Food Chem. Toxicol. 2021, 148, 111976. DOI: 10.1016/j.fct.2021.111976.
  • Moreau, M.; Lescure, G.; Agoulon, A.; Svinareff, P.; Orange, N.; Feuilloley, M. Application of the Pulsed Light Technology to Mycotoxin Degradation and Inactivation. J. Appl. Toxicol. 2013, 33(5), 357–363. DOI: 10.1002/jat.1749.
  • Wang, B.; Mahoney, N. E.; Pan, Z.; Khir, R.; Wu, B.; Ma, H.; Zhao, L. Effectiveness of Pulsed Light Treatment for Degradation and Detoxification of Aflatoxin B1 and B2 in Rough Rice and Rice Bran. Food Control. 2016, 59, 461–467. DOI: 10.1016/j.foodcont.2015.06.030.
  • Mohamed, N.; El-Dine, R.; Kotb, M.; Saber, A. Assessing the Possible Effect of Gamma Irradiation on the Reduction of Aflatoxin B1, and on the Moisture Content in Some Cereal Grains. Am J Biomed Sci. 2015, 33–39. DOI: 10.5099/aj150100033.
  • Tezerji, N. S.; Foroughi, M. M.; Bezenjani, R. R.; Jandaghi, N.; Rezaeipour, E.; Rezvani, F. A Facile One-pot Green Synthesis of β-cyclodextrin Decorated Porous Graphene Nanohybrid as A Highly Efficient Adsorbent for Extracting Aflatoxins from Maize and Animal Feeds. Food Chem. 2020, 311, 125747. DOI: 10.1016/j.foodchem.2019.125747.
  • Khan, F. A.; Zahoor, M. In Vivo Detoxification of aflatoxinB1 by Magnetic Carbon Nanostructures Prepared from Bagasse. BMC Vet. Res. 2014, 10(1), 255. DOI: 10.1186/s12917-014-0255-y.
  • Park, B. J.; Takatori, K.; Sugita-Konishi, Y.; Kim, I.-H.; Lee, M.-H.; Han, D.-W.; Chung, K.-H.; Hyun, S. O.; Park, J.-C. Degradation of Mycotoxins Using Microwave-induced Argon Plasma at Atmospheric Pressure. Surf. Coat. Technol. 2007, 201(9), 5733–5737. DOI: 10.1016/j.surfcoat.2006.07.092.
  • Zhang, Y.; Li, M.; Liu, Y.; Guan, E.; Bian, K. Reduction of Aflatoxin B1 in Corn by Water-Assisted Microwaves Treatment and Its Effects on Corn Quality. Toxins. 2020, 12(9), 605. DOI: 10.3390/toxins12090605.
  • Torres, P.; Guzmán-Ortiz, M.; Ramírez-Wong, B. Revising the Role of pH and Thermal Treatments in Aflatoxin Content Reduction during the Tortilla and Deep Frying Processes. J. Agric. Food Chem. 2001, 49(6), 2825–2829. DOI: 10.1021/jf0007030.
  • Castro-Ríos, K.; Montoya-Estrada, C. N.; Martínez-Miranda, M. M.; Hurtado Cortés, S.; Taborda-Ocampo, G. Physicochemical Treatments for the Reduction of Aflatoxins and Aspergillus niger in Corn Grains (Zea Mays). J. Sci. Food Agric. 2020, 101(n/a 3707–3713). DOI: 10.1002/jsfa.11001.
  • Méndez-Albores, A.; Veles-Medina, J.; Urbina-Álvarez, E.; Martínez-Bustos, F.; Moreno-Martínez, E. Effect of Citric Acid on Aflatoxin Degradation and on Functional and Textural Properties of Extruded Sorghum. Anim. Feed Sci. Technol. 2009, 150(3–4), 316–329. DOI: 10.1016/j.anifeedsci.2008.10.007.
  • Velazhahan, R.; Vijayanandraj, S.; Vijayasamundeeswari, A.; Paranidharan, V.; Samiyappan, R.; Iwamoto, T.; Friebe, B.; Muthukrishnan, S. Detoxification of Aflatoxins by Seed Extracts of the Medicinal Plant, Trachyspermum Ammi (L.) Sprague Ex Turrill – Structural Analysis and Biological Toxicity of Degradation Product of Aflatoxin G1. Food Control. 2010, 21(5), 719–725. DOI: 10.1016/j.foodcont.2009.10.014.
  • Kalli, V.; Kollia, E.; Roidaki, A.; Proestos, C.; Markaki, P. Cistus Incanus L. Extract Inhibits Aflatoxin B1 Production by Aspergillus Parasiticus in Macadamia Nuts. Ind. Crops Prod. 2018, 111, 63–68. DOI: 10.1016/j.indcrop.2017.10.003.
  • Aly, S. E.; Sabry, B. A.; Shaheen, M. S.; Hathout, A. S. Assessment of Antimycotoxigenic and Antioxidant Activity of Star Anise (Illicium Verum) in Vitro. J. Saudi Soc. Agric. Sci. 2016, 15(1), 20–27. DOI: 10.1016/j.jssas.2014.05.003.
  • FDA, . Title 21. , 2019 CFR - Code of Federal Regulations Title 21 ; 1 https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1563.
  • Savi, G. D.; Piacentini, K. C.; Scussel, V. M. Ozone Treatment Efficiency in Aspergillus and Penicillium Growth Inhibition and Mycotoxin Degradation of Stored Wheat Grains (Triticum aestivum L.). J. Food Process. Preserv. 2015, 39(6), 940–948. DOI: 10.1111/jfpp.12307.
  • Tiwari, B. K.; Brennan, C. S.; Curran, T.; Gallagher, E.; Cullen, P. J.; O’ Donnell, C. P. Application of Ozone in Grain Processing. J. Cereal Sci. 2010, 51(3), 248–255. DOI: 10.1016/j.jcs.2010.01.007.
  • Porto, Y. D.; Trombete, F. M.; Freitas-Silva, O.; de Castro, I. M.; Direito, G. M.; Ascheri, J. L. R. Gaseous Ozonation to Reduce Aflatoxins Levels and Microbial Contamination in Corn Grits. Microorganisms. 2019, 7(8), 220. DOI: 10.3390/microorganisms7080220.
  • Freitas-Silva, O.; Venâncio, A. Ozone Applications to Prevent and Degrade Mycotoxins: A Review. Drug Metab Rev. 2010, 42(4), 612–620. DOI: 10.3109/03602532.2010.484461.
  • Grenier, B.; Loureiro-Bracarense, A.-P.; Leslie, J. F.; Oswald, I. P. Physical and Chemical Methods for Mycotoxin Decontamination in Maize. In Mycotoxin Reduction in Grain Chains Leslie, J.F., and Logrieco, A.F. (United Kingdom: John Wiley & Sons, Inc), 2014; pp 116–129 doi:10.1002/9781118832790.ch9.
  • Moerck, K. E.; McElfresh, P.; Wohlman, A.; Hilton, B. W. Aflatoxin Destruction in Corn Using Sodium Bisulfite, Sodium Hydroxide and Aqueous Ammonia. J. Food Prot. 1980, 43(7), 571–574. DOI: 10.4315/0362-028X-43.7.571.
  • Lee, J.; Her, J.-Y.; Lee, K.-G. Reduction of Aflatoxins (B1, B2, G1, and G2) in Soybean-based Model Systems. Food Chem. 2015, 189, 45–51. DOI: 10.1016/j.foodchem.2015.02.013.
  • Komala, V. V.; Ratnavathi, C. V.; Vijay Kumar, B. S.; Das, I. K. Inhibition of Aflatoxin B1 Production by an Antifungal Component, Eugenol in Stored Sorghum Grains. Food Control. 2012, 26(1), 139–146. DOI: 10.1016/j.foodcont.2012.01.013.
  • Aiko, V.; Mehta, A. Control of Aspergillus Flavus and Aflatoxin Production with Spices in Culture Medium and Rice. World Mycotoxin J. 2013, 6(1), 43–50. DOI: 10.3920/WMJ2012.1437.
  • Guan, Y.; Chen, J.; Nepovimova, E.; Long, M.; Wu, W.; Kuca, K. Aflatoxin Detoxification Using Microorganisms and Enzymes. Toxins. 2021, 13, 1. DOI: 10.3390/toxins13010046.
  • Nešić, K.; Habschied, K.; Mastanjević, K. Possibilities for the Biological Control of Mycotoxins in Food and Feed. Toxins. 2021, 13(3). DOI: 10.3390/toxins13030198.
  • Rawal, S.; Kim, J. E.; Coulombe, R. Aflatoxin B1 in Poultry: Toxicology, Metabolism and Prevention. Res. Vet. Sci. 2010, 89(3), 325–331. DOI: 10.1016/j.rvsc.2010.04.011.
  • Zuo, R.-Y.; Chang, J.; Yin, Q.-Q.; Wang, P.; Yang, Y.-R.; Wang, X.; Wang, G.-Q.; Zheng, Q.-H. Effect of the Combined Probiotics with Aflatoxin B1-degrading Enzyme on Aflatoxin Detoxification, Broiler Production Performance and Hepatic Enzyme Gene Expression. Food Chem. Toxicol. 2013, 59, 470–475. DOI: 10.1016/j.fct.2013.06.044.
  • Udomkun, P.; Wiredu, A. N.; Nagle, M.; Müller, J.; Vanlauwe, B.; Bandyopadhyay, R. Innovative Technologies to Manage Aflatoxins in Foods and Feeds and the Profitability of Application – A Review. Food Control. 2017, 76, 127–138. DOI: 10.1016/j.foodcont.2017.01.008.
  • Ahlberg, S. H.; Joutsjoki, V.; Korhonen, H. J. Potential of Lactic Acid Bacteria in Aflatoxin Risk Mitigation. Int. J. Food Microbiol. 2015, 207, 87–102. DOI: 10.1016/j.ijfoodmicro.2015.04.042.
  • Gourama, H.; Bullerman, L. B. Inhibition of Growth and Aflatoxin Production of Aspergillus Flavus by Lactobacillus Species†. J. Food Prot. 1995, 58(11), 1249–1256. DOI: 10.4315/0362-028X-58.11.1249.
  • Chlebicz, A.; Śliżewska, K. In Vitro Detoxification of Aflatoxin B1, Deoxynivalenol, Fumonisins, T-2 Toxin and Zearalenone by Probiotic Bacteria from Genus Lactobacillus and Saccharomyces Cerevisiae Yeast. Probiotics Antimicrob. Proteins. 2020, 12(1), 289–301. DOI: 10.1007/s12602-018-9512-x.
  • Ghazvini, R. D.; Kouhsari, E.; Zibafar, E.; Hashemi, S. J.; Amini, A.; Niknejad, F.; Activity, A. Aflatoxin Degradation of Bifidobacterium Bifidum and Lactobacillus Fermentum against Toxigenic Aspergillus Parasiticus. Open Microbiol. J. 2016, 10, 197–201. DOI: 10.2174/1874285801610010197.
  • Gratz, S.; Mykkänen, H.; El-Nezami, H. Aflatoxin B1 Binding by a Mixture of Lactobacillus and Propionibacterium: In Vitro versus Ex Vivo. J. Food Prot. 2005, 68(11), 2470–2474. DOI: 10.4315/0362-028X-68.11.2470.
  • Prettl, Z.; Dési, E.; Lepossa, A.; Kriszt, B.; Kukolya, J.; Nagy, E. Biological Degradation of Aflatoxin B 1 by a Rhodococcus Pyridinivorans Strain in By-product of Bioethanol. Anim. Feed Sci. Technol. 2017, 224, 104–114. DOI: 10.1016/j.anifeedsci.2016.12.011.
  • Branà, M. T.; Cimmarusti, M. T.; Haidukowski, M.; Logrieco, A. F.; Altomare, C.; Kunze, G. Bioremediation of Aflatoxin B1-contaminated Maize by King Oyster Mushroom (Pleurotus Eryngii). PLoS One. 2017, 12(8), e0182574. DOI: 10.1371/journal.pone.0182574.
  • Moral, J.; Garcia-Lopez, M. T.; Camiletti, B. X.; Jaime, R.; Michailides, T. J.; Bandyopadhyay, R.; Ortega-Beltran, A. Present Status and Perspective on the Future Use of Aflatoxin Biocontrol Products. Agronomy. 2020, 10(4), 491. DOI: 10.3390/agronomy10040491.
  • Zhang, W.; Xue, B.; Li, M.; Mu, Y.; Chen, Z.; Li, J.; Shan, A. Screening a Strain of Aspergillus Niger and Optimization of Fermentation Conditions for Degradation of Aflatoxin B1. Toxins. 2014, 6(11), 3157–3172. DOI: 10.3390/toxins6113157.
  • Hackbart, H. C. S.; Machado, A. R.; Christ-Ribeiro, A.; Prietto, L.; Badiale-Furlong, E. Reduction of Aflatoxins by Rhizopus Oryzae and Trichoderma Reesei. Mycotoxin Res. 2014, 30(3), 141–149. DOI: 10.1007/s12550-014-0202-6.
  • Pfliegler, W. P.; Pusztahelyi, T.; Pócsi, I. Mycotoxins - Prevention and Decontamination by Yeasts. J. Basic Microbiol. 2015, 55(7), 805–818. DOI: 10.1002/jobm.201400833.
  • Li, J.; Huang, J.; Jin, Y.; Wu, C.; Shen, D.; Zhang, S.; Zhou, R. Mechanism and Kinetics of Degrading Aflatoxin B1 by Salt Tolerant Candida Versatilis CGMCC 3790. J. Hazard. Mater. 2018, 359, 382–387. DOI: 10.1016/j.jhazmat.2018.05.053.
  • Parker, W. A.; Melnick, D. Absence of Aflatoxin from Refined Vegetable Oils. J. Am. Oil Chem. Soc. 1966, 43(11), 635–638. DOI: 10.1007/bf02640803.
  • Samarajeewa, U.; Sen, A. C.; Cohen, M. D.; Wei, C. I. Detoxification of Aflatoxins in Foods and Feeds by Physical and Chemical Methods. J. Food Prot. 1990, 53(6), 489–501. DOI: 10.4315/0362-028X-53.6.489.
  • Tabata, S.; Kamimura, H.; Ibe, A.; Hashimoto, H.; Tamura, Y. Degradation of Aflatoxins by Food Additives. J. Food Prot. 1994, 57(1), 42–47. DOI: 10.4315/0362-028X-57.1.42.
  • Kim, J. H.; Mahoney, N.; Chan, K. L.; Molyneux, R. J.; Campbell, B. C. Controlling Food-contaminating Fungi by Targeting Their Antioxidative Stress-response System with Natural Phenolic Compounds. Appl. Microbiol. Biotechnol. 2006, 70(6), 735–739. DOI: 10.1007/s00253-005-0123-6.
  • Mao, J.; He, B.; Zhang, L.; Li, P.; Zhang, Q.; Ding, X.; Zhang, W. A Structure Identification and Toxicity Assessment of the Degradation Products of Aflatoxin B₁ in Peanut Oil under UV Irradiation. Toxins. 2016, 8(11), 332. DOI: 10.3390/toxins8110332.
  • Rustom, I. Y. S.;. Aflatoxin in Food and Feed: Occurrence, Legislation and Inactivation by Physical Methods. Food Chem. 1997, 59(1), 57–67. DOI: 10.1016/S0308-8146(96)00096-9.
  • Suzuki, T.; Noro, T.; Kawamura, Y.; Fukunaga, K.; Watanabe, M.; Ohta, M.; Sugiue, H.; Sato, Y.; Kohno, M.; Hotta, K. Decontamination of Aflatoxin-forming Fungus and Elimination of Aflatoxin Mutagenicity with Electrolyzed NaCl Anode Solution. J. Agric. Food Chem. 2002, 50(3), 633–641. DOI: 10.1021/jf0108361.
  • Zhang, Q.; Xiong, K.; Tatsumi, E.; Li, L.-T.; Liu, H.-J. Elimination of Aflatoxin B1 in Peanuts by Acidic Electrolyzed Oxidizing Water. Food Control. 2012, 27(1), 16–20. DOI: 10.1016/j.foodcont.2012.02.029.
  • Pankaj, S. K.; Shi, H.; Keener, K. M. A Review of Novel Physical and Chemical Decontamination Technologies for Aflatoxin in Food. Trends Food Sci. Technol. 2018, 71, 73–83. DOI: 10.1016/j.tifs.2017.11.007.
  • Liu, Y.; Li, M.; Liu, Y.; Bian, K. Structures of Reaction Products and Degradation Pathways of Aflatoxin B(1) by Ultrasound Treatment. Toxins. 2019, 11(9), 526. DOI: 10.3390/toxins11090526.
  • Abbasi Pirouz, A.; Abedi Karjiban, R.; Abu Bakar, F.; Selamat, J.; Novel Adsorbent, A. Magnetic Graphene Oxide Modified with Chitosan for the Simultaneous Reduction of Mycotoxins. Toxins. 2018, 10(9), 361. DOI: 10.3390/toxins10090361.
  • Misra, N. N.; Yadav, B.; Roopesh, M. S.; Jo, C. Cold Plasma for Effective Fungal and Mycotoxin Control in Foods: Mechanisms, Inactivation Effects, and Applications. Compr. Rev. Food Sci. Food Saf. 2019, 18(1), 106–120. DOI: 10.1111/1541-4337.12398.
  • Chizoba Ekezie, F.-G.; Sun, D.-W.; Cheng, J.-H. A Review on Recent Advances in Cold Plasma Technology for the Food Industry: Current Applications and Future Trends. Trends Food Sci. Technol. 2017, 69, 46–58. DOI: 10.1016/j.tifs.2017.08.007.
  • Shi, H.; Cooper, B.; Stroshine, R. L.; Ileleji, K. E.; Keener, K. M. Structures of Degradation Products and Degradation Pathways of Aflatoxin B1 by High-Voltage Atmospheric Cold Plasma (HVACP) Treatment. J. Agric. Food Chem. 2017, 65(30), 6222–6230. DOI: 10.1021/acs.jafc.7b01604.
  • Wang, S.-Q.; Huang, G.-Q.; Li, Y.-P.; Xiao, J.-X.; Zhang, Y.; Jiang, W.-L. Degradation of Aflatoxin B1 by Low-temperature Radio Frequency Plasma and Degradation Product Elucidation. Eur. Food Res. Technol. 2015, 241(1), 103–113. DOI: 10.1007/s00217-015-2439-5.
  • Muaz, K.; Riaz, M.; de Oliveira, C. A. F.; Akhtar, S.; Ali, S. W.; Nadeem, H.; Park, S.; Balasubramanian, B. Aflatoxin M1 in Milk and Dairy Products: Global Occurrence and Potential Decontamination Strategies. Toxin Rev. 2021, 1–18. DOI: 10.1080/15569543.2021.1873387.
  • Ismail, A.; Gonçalves, B. L.; de Neeff, D. V.; Ponzilacqua, B.; Coppa, C. F. S. C.; Hintzsche, H.; Sajid, M.; Cruz, A. G.; Corassin, C. H.; Oliveira, C. A. F. Aflatoxin in Foodstuffs: Occurrence and Recent Advances in Decontamination. Food Res. Int. 2018, 113, 74–85. DOI: 10.1016/j.foodres.2018.06.067.
  • Adebo, O. A.; Njobeh, P. B.; Gbashi, S.; Nwinyi, O. C.; Mavumengwana, V. Review on Microbial Degradation of Aflatoxins. Crit. Rev. Food Sci. Nutr. 2017, 57(15), 3208–3217. DOI: 10.1080/10408398.2015.1106440.
  • Karaman, M.; Basmacioglu, H.; Ortatatli, M.; Oguz, H. Evaluation of the Detoxifying Effect of Yeast Glucomannan on Aflatoxicosis in Broilers as Assessed by Gross Examination and Histopathology. Br. Poult. Sci. 2005, 46(3), 394–400. DOI: 10.1080/00071660500124487.
  • Lahtinen, S. J.; Haskard, C. A.; Ouwehand, A. C.; Salminen, S. J.; Ahokas, J. T. Binding of Aflatoxin B1 to Cell Wall Components of Lactobacillus Rhamnosus Strain GG. Food Addit. Contam. 2004, 21(2), 158–164. DOI: 10.1080/02652030310001639521.
  • Bovo, F.; Corassin, C. H.; Rosim, R. E.; de Oliveira, C. A. F. Efficiency of Lactic Acid Bacteria Strains for Decontamination of Aflatoxin M1 in Phosphate Buffer Saline Solution and in Skimmed Milk. Food Bioproc. Tech. 2013, 6(8), 2230–2234. DOI: 10.1007/s11947-011-0770-9.
  • Corassin, C. H.; Bovo, F.; Rosim, R. E.; Oliveira, C. A. F. Efficiency of Saccharomyces Cerevisiae and Lactic Acid Bacteria Strains to Bind Aflatoxin M1 in UHT Skim Milk. Food Control. 2013, 31(1), 80–83. DOI: 10.1016/j.foodcont.2012.09.033.
  • Rao, J. P.; Sashidhar, R. B.; Subramanyam, C. Inhibition of Aflatoxin Production by Trifluoperazine in Aspergillus Parasiticus NRRL 2999. World J. Microbiol. Biotechnol. 1997, 14, 71–75. DOI: 10.1023/A:1008876517450.
  • Kim, S.; Lee, H.; Lee, S.; Lee, J.; Ha, J.; Choi, Y.; Yoon, Y.; Choi, K. H. Microbe-mediated Aflatoxin Decontamination of Dairy Products and Feeds. J.Dairy Sci. 2017, 100, 871–880. DOI: 10.3168/jds.2016-11264.
  • Smiley, R. D.; Draughon, F. A. Preliminary Evidence that Degradation of Aflatoxin B1 by Flavobacterium Aurantiacum Is Enzymatic. J. Food Prot. 2000, 63, 415–418. DOI: 10.4315/0362-028X-63.3.415.
  • Guan, S.; Ji, C.; Zhou, J.; Li, J.; Ma, Q.; Niu, T. Aflatoxin B(1) Degradation by Stenotrophomonas Maltophilia and Other Microbesselected Using Coumarin Medium. Int. J. Mol. Sci. 2008, 9, 1489–1503. DOI: 10.3390/ijms9081489.
  • Zhao, L. H.; Guan, S.; Gao, X.; Ma, Q. G.; Lei, Y. P.; Bai, X. M.; Ji, C. Preparation, Purification and Characteristics of an Aflatoxin Degradation Enzyme from Myxococcus Fulvus ANSM068. J. Appl. Microbiol. 2011, 110, 147–155. DOI: 10.1111/j.1365-2672.2010.04867.x.
  • D’Souza, D. H.; Brackett, R. E. Aflatoxin B1 Degradation by Flavobacterium Aurantiacum in the Presence of Reducing Conditions and Seryl and Sulfhydryl Group Inhibitors. J. Food Prot. 2001, 64, 268–271. DOI: 10.4315/0362-028X-64.2.268.
  • Motomura, M.; Toyomasu, T.; Mizuno, K.; Shinozawa, T. Purification and Characterization of an Aflatoxin Degradation Enzyme from Pleurotus Ostreatus. Microbiol. Res. 2003, 158(3), 237–242. DOI: 10.1078/0944-5013-00199.
  • Bol, J.; Smith, J. E. Biotransformation of Aflatoxin. Food Biotechnol. 1989, 3, 127–144. DOI: 10.1080/08905438909549704.
  • Jackson, I. I. I.; Pryor, L. W.; B., M. Degradation of Aflatoxin B1 from Naturally Contamined Maize Using the Edible Fungus Pleurotus Ostreatus. AMB Express. 2017, 7(110), 1–7. DOI: 10.1186/s13568-017-0415-0.
  • Hackbart, H. C.; Machado, A. R.; Christ-Ribeiro, A.; Prietto, L.; Badiale-Furlong, E. Reduction of Aflatoxins by Rhizopus Oryzae and Trichoderma Reesei. Mycotoxin Res. 2014, 30, 141–149. DOI: 10.1007/s12550-014-0202-6.
  • Liu, D. L.; Yao, D. S.; Liang, R.; Ma, L.; Cheng, W. Q.; Gu, L. Q. Detoxification of Aflatoxin B1 by Enzymes Isolated from Armillariella Tabescens. Food Chem. Toxicol. 1998, 36(7), 563–574. DOI: 10.1016/S0278-6915(98)00017-9.
  • Kusumaningtyas, E.; Widiastuti, R.; Maryam, R. Reduction of Aflatoxin B1 in Chicken Feed by Using Saccharomyces Cerevisiae, Rhizopues Oligosporus, and Their Combination. Mycopathologia. 2006, 162(4), 307–311. DOI: 10.1007/s11046-006-0047-4.
  • Inoue, T.; Nagatomi, Y.; Uyama, A.; Naoki, M. Degradation of Aflatoxin B1 during the Fermentation of Alcoholic Beverages. Toxins. 2013, 5, 1219–1229. DOI: 10.3390/toxins5071219.

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