Seaweed proteins as a novel protein alternative: Types, extractions, and functional food applications

References

• Fleurence, J.; Morançais, M.; Dumay, J. Seaweed Proteins. In Proteins in Food Processing, Second Edition ed. USA,2018; 245–262. DOI: 10.1016/B978-0-08-100722-8.00010-3
   Google Scholar
• Wijesekara, I.; Lang, M.; Marty, C.; Gemin, M. P.; Boulho, R.; Douzenel, P.; Wickramasinghe, I.; Bedoux, G.; Bourgougnon, N. Different Extraction Procedures and Analysis of Protein from Ulva Sp. In Brittany, France. J. Appl. Phycol. 2017, 29(5), 2503–2511. DOI: 10.1007/s10811-017-1239-7.
   Web of Science ®Google Scholar
• Zemke-White, W. L.; Ohno, M. World Seaweed Utilisation: An End-of-Century Summary. J. Appl. Phycol. 1999, 11(4), 369–376. DOI: 10.1023/A:1008197610793.
   Web of Science ®Google Scholar
• Liuzzi, M. G.; Gappa, J. L.; Piriz, M. L. Latitudinal Gradients in Macroalgal Biodiversity in the Southwest Atlantic between 36 and 55°S. Hydrobiologia. 2011, 673(1), 205–214. DOI: 10.1007/s10750-011-0780-7.
   Web of Science ®Google Scholar
• Wernberg, T.; Russell, B. D.; Moore, P. J.; Ling, S. D.; Smale, D. A.; Campbell, A.; Coleman, M. A.; Steinberg, P. D.; Kendrick, G. A.; Connell, S. D. Impacts of Climate Change in a Global Hotspot for Temperate Marine Biodiversity and Ocean Warming. J. Exp. Mar. Bio. Ecol. 2011, 400(1–2), 7–16. DOI: 10.1016/j.jembe.2011.02.021.
   Web of Science ®Google Scholar
• Schmid, M.; Guihéneuf, F.; Stengel, D. B. Ecological and Commercial Implications of Temporal and Spatial Variability in the Composition of Pigments and Fatty Acids in Five Irish Macroalgae. Mar. Biol. 2017, 164(8), 1–18. DOI: 10.1007/s00227-017-3188-8.
   PubMed Web of Science ®Google Scholar
• Dumay, J.; Morançais, M.; Munier, M.; Le Guillard, C.; Fleurence, J. Phycoerythrins: Valuable Proteinic Pigments in Red Seaweeds. In Advances in Botanical Research.Elsevier,2014; pp 321–343. doi:10.1016/B978-0-12-408062-1.00011-1
   Google Scholar
• Aryee, A. N.; Agyei, D.; Akanbi, T. O. Recovery and Utilization of Seaweed Pigments in Food Processing. Curr. Opin. Food Sci. 2018, 19, 113–119. DOI: 10.1016/j.cofs.2018.03.013.
   Web of Science ®Google Scholar
• Brotosudarmo, T. H. P.; Heriyanto,; Shioi, Y.; Indriatmoko,; Adhiwibawa, M. A. S.; Indrawati, R.; Limantara, L. Composition of the Main Dominant Pigments from Potential Two Edible Seaweeds. Philipp. J. Sci. 2018, 147(1), 47–55.
   Google Scholar
• Norziah, M. H.; Ching, C. Y. Nutritional Composition of Edible Seaweed Gracilaria Changgi. Food Chem. 2000, 68(1), 69–76. DOI: 10.1016/S0308-8146(99)00161-2.
   Web of Science ®Google Scholar
• Cian, R. E.; Drago, S. R.; De Medina, F. S.; Martínez-Augustin, O. Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota. Mar. Drugs. 2015, 13(8), 5358–5383. DOI: 10.3390/md13085358.
   PubMed Web of Science ®Google Scholar
• Gorissen, S. H. M.; Crombag, J. J. R.; Senden, J. M. G.; Waterval, W. A. H.; Bierau, J.; Verdijk, L. B.; van Loon, L. J. C. Protein Content and Amino Acid Composition of Commercially Available Plant-Based Protein Isolates. Amino Acids. 2018, 50(12), 1685–1695. DOI: 10.1007/s00726-018-2640-5.
   PubMed Web of Science ®Google Scholar
• Morgan, K. C.; Wright, J. L. C.; Simpson, F. J. Review of Chemical Constituents of the Red Alga Palmaria Palmata (Dulse). Econ. Bot. 1980, 34(1), 27–50. DOI: 10.1007/BF02859553.
   Web of Science ®Google Scholar
• Vázquez-Delfín, E.; Freile-Pelegrín, Y.; Pliego-Cortés, H.; Robledo, D. Seaweed Resources of Mexico: Current Knowledge and Future Perspectives. Bot. Mar. 2019, 95, 289–326. DOI: 10.1515/bot-2018-0070.
   Google Scholar
• Fleurence, J. Seaweed Proteins: Biochemical, Nutritional Aspects and Potential Uses. Trends Food Sci. Technol. 1999, 11(3), 231–239. DOI: 10.1016/S0924-2244(99)00015-1.
   Google Scholar
• Fleurence, J.; Morançais, M.; Dumay, J.; Decottignies, P.; Turpin, V.; Munier, M.; Garcia-Bueno, N.; Jaouen, P. What are the Prospects for Using Seaweed in Human Nutrition and for Marine Animals Raised through Aquaculture? Trends Food Sci. Technol. 2012, 27(1), 57–61. DOI: 10.1016/j.tifs.2012.03.004.
   Web of Science ®Google Scholar
• Lourenço, S. O.; Barbarino, E.; De-Paula, J. C.; Pereira, L. O. D. S.; Lanfer Marquez, U. M. Amino Acid Composition, Protein Content and Calculation of Nitrogen-to-Protein Conversion Factors for 19 Tropical Seaweeds. Phycol. Res. 2002, 50(3), 233–241. DOI: 10.1046/j.1440-1835.2002.00278.x.
   Google Scholar
• Heidelbaugh, N. D.; Huber, C. S.; Bednarczyk, J. F.; Smith, M. C.; Rambaut, P. C.; Wheeler, H. O. Comparison of Three Methods for Calculating Protein Content of Foods. J. Agric. Food Chem. 1975, 23(4), 611–613. DOI: 10.1021/jf60200a006.
   PubMed Web of Science ®Google Scholar
• Anh, N. T. N.; Hai, T. N.; Hien, T. T. T. Effects of Partial Replacement of Fishmeal Protein with Green Seaweed (Cladophora Spp.) Protein in Practical Diets for the Black Tiger Shrimp (Penaeus Monodon) Postlarvae. J. Appl. Phycol. 2018, 30(4), 2649–2658. DOI: 10.1007/s10811-018-1457-7.
   Web of Science ®Google Scholar
• Sharma, S.; Hansen, L. D.; Hansen, J. O.; Mydland, L. T.; Horn, S. J.; Øverland, M.; Eijsink, V. G. H.; Vuoristo, K. S. Microbial Protein Produced from Brown Seaweed and Spruce Wood as a Feed Ingredient. J. Agric. Food Chem. 2018, 66(31), 8328–8335. DOI: 10.1021/acs.jafc.8b01835.
   PubMed Web of Science ®Google Scholar
• Cornish, M. L.; Garbary, D. J. Antioxidants from Macroalgae: Potential Applications in Human Health and Nutrition. ALGAE. 2010, 25(4), 155–171. DOI: 10.4490/algae.2010.25.4.155.
   Google Scholar
• Mariotti, F.; Tomé, D.; Mirand, P. P. Converting Nitrogen into Protein - beyond 6.25 And Jones’ Factors. Crit. Rev. Food Sci. Nutr. 2008, 48(2), 177–184. DOI: 10.1080/10408390701279749.
   PubMed Web of Science ®Google Scholar
• Angell, A. R.; Mata, L.; de Nys, R.; Paul, N. A. The Protein Content of Seaweeds: A Universal Nitrogen-to-Protein Conversion Factor of Five. J. Appl. Phycol. 2016, 28(1), 511–524. DOI: 10.1007/s10811-015-0650-1.
   Web of Science ®Google Scholar
• Conklin-Brittain, N. L.; Dierenfeld, E. S.; Wrangham, R. W.; Norconk, M.; Silver, S. C. Chemical Protein Analysis: A Comparison of Kjeldahl Crude Protein and Total Ninhydrin Protein from Wild, Tropical Vegetation. J. Chem. Ecol. 1999, 25(12), 2601–2622. DOI: 10.1023/A:1020835120701.
   Web of Science ®Google Scholar
• Kazir, M.; Abuhassira, Y.; Robin, A.; Nahor, O.; Luo, J.; Israel, A.; Golberg, A.; Livney, Y. D. Extraction of Proteins from Two Marine Macroalgae, Ulva Sp. And Gracilaria Sp., For Food Application, and Evaluating Digestibility, Amino Acid Composition and Antioxidant Properties of the Protein Concentrates. Food Hydrocoll. 2019, 87(July 2018), 194–203. DOI: 10.1016/j.foodhyd.2018.07.047.
   Google Scholar
• Wong, K.; Chikeung Cheung, P. Influence of Drying Treatment on Three Sargassum Species 2. Protein Extractability, in Vitro Protein Digestibility and Amino Acid Profile of Protein Concentrates. J. Appl. Phycol. 2001, 13(1), 51–58. DOI: 10.1023/A:1008188830177.
   Web of Science ®Google Scholar
• Abdollahi, M.; Axelsson, J.; Carlsson, N. G.; Nylund, G. M.; Albers, E.; Undeland, I. Effect of Stabilization Method and Freeze/Thaw-Aided Precipitation on Structural and Functional Properties of Proteins Recovered from Brown Seaweed (Saccharina Latissima). Food Hydrocoll. 2019, 96(January), 140–150. DOI: 10.1016/j.foodhyd.2019.05.007.
   Google Scholar
• Chan, J. C. C.; Cheung, P. C. K.; Ang, P. O. Comparative Studies on the Effect of Three Drying Methods on the Nutritional Composition of Seaweed Sargassum Hemiphyllum (Turn.) C. Ag. J. Agric. Food Chem. 1997, 45(8), 3056–3059. DOI: 10.1021/jf9701749.
   Web of Science ®Google Scholar
• Julkunen-Tiitto, R. Phenolic Constituents in the Leaves of Northern Willows: Methods for the Analysis of Certain Phenolics. J. Agric. Food Chem. 1985, 33(2), 213–217. DOI: 10.1021/jf00062a013.
   Web of Science ®Google Scholar
• Gupta, S.; Cox, S.; Abu-Ghannam, N. Effect of Different Drying Temperatures on the Moisture and Phytochemical Constituents of Edible Irish Brown Seaweed. LWT - Food Sci. Technol. 2011, 44(5), 1266–1272. DOI: 10.1016/j.lwt.2010.12.022.
   Web of Science ®Google Scholar
• Garcia-Vaquero, M.; Lopez-Alonso, M.; Hayes, M. Assessment of the Functional Properties of Protein Extracted from the Brown Seaweed Himanthalia Elongata (Linnaeus) S. F. Gray. Food Res. Int. 2017, 99, 971–978. DOI: 10.1016/j.foodres.2016.06.023.
   PubMed Web of Science ®Google Scholar
• Garcia-Vaquero, M.; Hayes, M. Red and Green Macroalgae for Fish and Animal Feed and Human Functional Food Development. Food Rev. Int. 2016, 32(1), 15–45. DOI: 10.1080/87559129.2015.1041184.
   Web of Science ®Google Scholar
• Ogunwolu, S. O.; Henshaw, F. O.; Mock, H. P.; Santros, A.; Awonorin, S. O. Functional Properties of Protein Concentrates and Isolates Produced from Cashew (Anacardium Occidentale L.) Nut. Food Chem. 2009, 15(3), 852–858. DOI: 10.1016/j.foodchem.2009.01.011.
   Google Scholar
• Mwasaru, M. A.; Muhammad, K.; Bakar, J.; Man, Y. B. C. Effects of Isolation Technique and Conditions on the Extractability, Physicochemical and Functional Properties of Pigeonpea (Cajanus Cajan) and Cowpea (Vigna Unguiculata) Protein Isolates. I. Physicochemical Properties. Food Chem. 1999, 67(4), 435–443. DOI: 10.1016/S0308-8146(99)00150-8.
   Google Scholar
• Wong, K.; Cheung, P. C. Influence of Drying Treatment on Three Sargassum Species: 1. Proximate Composition, Amino Acid Profile and Some Physico-Chemical Properties. J. Appl. Phycol. 2001, 13(1), 43–50. DOI: 10.1023/A:1008149215156.
   Web of Science ®Google Scholar
• MacArtain, P.; Gill, C. I. R.; Brooks, M.; Campbell, R.; Rowland, I. R. Nutritional Value of Edible Seaweeds. Nutr. Rev. 2007, 65(12), 535–543. DOI: 10.1301/nr.2007.dec.535-543.
   PubMed Web of Science ®Google Scholar
• Urbano, M. G.; Goi, I. Bioavailability of Nutrients in Rats Fed on Edible Seaweeds, Nori (Porphyra Tenera) and Wakame (Undaria Pinnatifida), as a Source of Dietary Fibre. Food Chem. 2002, 76(3), 281–286. DOI: 10.1016/S0308-8146(01)00273-4.
   Web of Science ®Google Scholar
• Önning, G.; Asp, N.-G. Effect of Oat Saponins and Different Types of Dietary Fibre on the Digestion of Carbohydrates. Br. J. Nutr. 1995, 74(2), 229–237. DOI: 10.1079/bjn19950126.
   PubMed Web of Science ®Google Scholar
• Galland-Irmouli, A. V.; Fleurence, J.; Lamghari, R.; Luçon, M.; Rouxel, C.; Barbaroux, O.; Bronowicki, J. P.; Villaume, C.; Guéant, J. L. Nutritional Value of Proteins from Edible Seaweed Palmaria Palmata (Dulse). J. Nutr. Biochem. 1999, 10(6), 353–359. DOI: 10.1016/S0955-2863(99)00014-5.
   PubMed Web of Science ®Google Scholar
• Fleddermann, M.; Fechner, A.; Rößler, A.; Bähr, M.; Pastor, A.; Liebert, F.; Jahreis, G. Nutritional Evaluation of Rapeseed Protein Compared to Soy Protein for Quality, Plasma Amino Acids, and Nitrogen Balance - A Randomized Cross-over Intervention Study in Humans. Clin. Nutr. 2013, 32(4), 519–526. DOI: 10.1016/j.clnu.2012.11.005.
   PubMed Web of Science ®Google Scholar
• Zhao, Y.; Li, B.; Dong, S.; Liu, Z.; Zhao, X.; Wang, J.; Zeng, M. A Novel ACE Inhibitory Peptide Isolated from Acaudina Molpadioidea Hydrolysate. Peptides. 2009, 30(6), 1028–1033. DOI: 10.1016/j.peptides.2009.03.002.
   PubMed Web of Science ®Google Scholar
• Pangestuti, R.; Kim, S. K. Seaweed Proteins, Peptides, and Amino Acids. In Seaweed Sustainability: Food and Non-Food Applications; Academic press:USA,2015; pp 125–140. doi:10.1016/B978-0-12-418697-2.00006-4
   Google Scholar
• Sheih, I. C.; Fang, T. J.; Wu, T. K. Isolation and Characterisation of a Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptide from the Algae Protein Waste. Food Chem. 2009, 115(1), 279–284. DOI: 10.1016/j.foodchem.2008.12.019.
   Web of Science ®Google Scholar
• Kim, S.; Woo, S.; Yun, H.; Yum, S.; Choi, E.; Do, J.; Jo, J.; Kim, D.; Lee, T. Total Phenolic Contents and Biological Activities of Korean Seaweed Extracts. Food Sci. Biotechnol. 2005, 14, 798–802.
   Web of Science ®Google Scholar
• Kim, E. Y.; Kim, D. G.; Kim, Y. R.; Hwang, H. J.; Nam, T. J.; Kong, I. S. An Improved Method of Protein Isolation and Proteome Analysis with Saccharina Japonica (Laminariales) Incubated under Different PH Conditions. J. Appl. Phycol. 2011, 23(1), 123–130. DOI: 10.1007/s10811-010-9550-6.
   Web of Science ®Google Scholar
• Peinado, I.; Girón, J.; Koutsidis, G.; Ames, J. M. Chemical Composition, Antioxidant Activity and Sensory Evaluation of Five Different Species of Brown Edible Seaweeds. Food Res. Int. 2014, 66, 36–44. DOI: 10.1016/j.foodres.2014.08.035.
   Web of Science ®Google Scholar
• Sánchez-Machado, D. I.; López-Cervantes, J.; López-Hernández, J.; Paseiro-Losada, P. Fatty Acids, Total Lipid, Protein and Ash Contents of Processed Edible Seaweeds. Food Chem. 2004, 85(3), 439–444. DOI: 10.1016/j.foodchem.2003.08.001.
   Web of Science ®Google Scholar
• Spiro, R. G. Glycoproteins. Adv. Protein Chem. 1973, 27, 349–467. DOI: 10.1016/S0065-3233(08)60451-9.
   PubMedGoogle Scholar
• Senthilkumar, D.; Jayanthi, S. Partial Characterization and Anticancer Activities of Purified Glycoprotein Extracted from Green Seaweed Codium Decorticatum. J. Funct. Foods. 2016, 25, 323–332. DOI: 10.1016/j.jff.2016.06.010.
   Web of Science ®Google Scholar
• Domozych, D. S.; Ciancia, M.; Fangel, J. U.; Mikkelsen, M. D.; Ulvskov, P.; Willats, W. G. T. The Cell Walls of Green Algae: A Journey through Evolution and Diversity. Front. Plant Sci. 2012, 3, 82. DOI: 10.3389/fpls.2012.00082.
   PubMed Web of Science ®Google Scholar
• Popper, Z. A.; Michel, G.; Hervé, C.; Domozych, D. S.; Willats, W. G. T.; Tuohy, M. G.; Kloareg, B.; Stengel, D. B. Evolution and Diversity of Plant Cell Walls: From Algae to Flowering Plants. Annu. Rev. Plant Biol. 2011, 62(1), 567–590. DOI: 10.1146/annurev-arplant-042110-103809.
   PubMedGoogle Scholar
• Fernández, P. V.; Ciancia, M.; Miravalles, A. B.; Estevez, J. M. Cell-Wall Polymer Mapping in the Coenocytic Macroalga Codium Vermilara (Bryopsidales, Chlorophyta). J. Phycol. 2010, 46, 456–465. DOI: 10.1111/j.1529-8817.2010.00821.x.
   Web of Science ®Google Scholar
• Estevez, J. M.; Fernández, P. V.; Kasulin, L.; Dupree, P.; Estevez, J. M. Chemical and in Situ Characterization of Macromolecular Components of the Cell Walls from the Green Seaweed Codium Fragile. Glycobiology. 2009, 19(3), 212–228. DOI: 10.1093/glycob/cwn101.
   PubMed Web of Science ®Google Scholar
• Fincher, G. B.; Stone, B. A.; Clarke, A. E. Arabinogalactan-Proteins: Structure, Biosynthesis, and Function. Annu. Rev. Plant Physiol. 1983, 34(1), 47–70. DOI: 10.1146/annurev.pp.34.060183.000403.
   Google Scholar
• Thangam, R.; Senthilkumar, D.; Suresh, V.; Sathuvan, M.; Sivasubramanian, S.; Pazhanichamy, K.; Gorlagunta, P. K.; Kannan, S.; Gunasekaran, P.; Rengasamy, R., et al. Induction of ROS-Dependent Mitochondria-Mediated Intrinsic Apoptosis in MDA-MB-231 Cells by Glycoprotein from Codium Decorticatum. J. Agric. Food Chem. 2014, 62(15), 3410–3421. DOI: 10.1021/jf405329e.
   PubMed Web of Science ®Google Scholar
• Pliego-Cortés, H.; Wijesekara, I.; Lang, M.; Bourgougnon, N.; Bedoux, G. Current Knowledge and Challenges in Extraction, Characterization and Bioactivity of Seaweed Protein and Seaweed-Derived Proteins. Adv. Bot. Res. 2020, 95, 289–326. DOI: 10.1016/bs.abr.2019.11.008.
   Web of Science ®Google Scholar
• Rafiquzzaman, S. M.; Kim, E. Y.; Lee, J. M.; Mohibbullah, M.; Alam, M. B.; Soo Moon, I.; Kim, J. M.; Kong, I. S. Anti-Alzheimers and Anti-Inflammatory Activities of a Glycoprotein Purified from the Edible Brown Alga Undaria Pinnatifida. Food Res. Int. 2015, 77, 118–124. DOI: 10.1016/j.foodres.2015.08.021.
   Web of Science ®Google Scholar
• Rafiquzzaman, S. M.; Kim, E. Y.; Kim, Y. R.; Nam, T. J.; Kong, I. S. Antioxidant Activity of Glycoprotein Purified from Undaria Pinnatifida Measured by an in Vitro Digestion Model. Int. J. Biol. Macromol. 2013, 62, 265–272. DOI: 10.1016/j.ijbiomac.2013.09.009.
   PubMed Web of Science ®Google Scholar
• Rafiquzzaman, S. M.; Min Lee, J.; Ahmed, R.; Lee, J. H.; Kim, J. M.; Kong, I. S. Characterisation of the Hypoglycaemic Activity of Glycoprotein Purified from the Edible Brown Seaweed, Undaria Pinnatifida. Int. J. Food Sci. Technol. 2015, 50(1), 143–150. DOI: 10.1111/ijfs.12663.
   Web of Science ®Google Scholar
• Kim, E. Y.; Kim, Y. R.; Nam, T. J.; Kong, I. S. Antioxidant and DNA Protection Activities of a Glycoprotein Isolated from a Seaweed, Saccharina Japonica. Int. J. Food Sci. Technol. 2012, 47(5), 1020–1027. DOI: 10.1111/j.1365-2621.2012.02936.x.
   Web of Science ®Google Scholar
• Cardozo, K. H. M.; Guaratini, T.; Barros, M. P.; Falcão, V. R.; Tonon, A. P.; Lopes, N. P.; Campos, S.; Torres, M. A.; Souza, A. O.; Colepicolo, P., et al. Metabolites from Algae with Economical Impact. Comp. Biochem. Physiol. - C Toxicol. Pharmacol. 2007,146(1–2), 60–78. doi: 10.1016/j.cbpc.2006.05.007
   PubMed Web of Science ®Google Scholar
• Barre, A.; Simplicien, M.; Benoist, H.; Van Damme, E. J. M.; Rougé, P. Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties. Mar. Drugs. 2019, 17(8), 440. DOI: 10.3390/md17080440.
   PubMed Web of Science ®Google Scholar
• Chaves, R. P.; Silva, S. R. D.; Nascimento Neto, L. G.; Carneiro, R. F.; Silva, A. L. C. D.; Sampaio, A. H.; Sousa, B. L. D.; Cabral, M. G.; Videira, P. A.; Teixeira, E. H., et al. Structural Characterization of Two Isolectins from the Marine Red Alga Solieria Filiformis (Kützing) P.W. Gabrielson and Their Anticancer Effect on MCF-7 Breast Cancer Cells. Int. J. Biol. Macromol. 2018, 107, 1320–1329. DOI: 10.1016/j.ijbiomac.2017.09.116.
   PubMed Web of Science ®Google Scholar
• Abreu, T. M.; Monteiro, V. S.; Martins, A. B. S.; Teles, F. B.; Da Conceição Rivanor, R. L.; Mota, É. F.; Macedo, D. S.; de Vasconcelos, S. M. M.; Júnior, J. E. R. H.; Benevides, N. M. B. Involvement of the Dopaminergic System in the Antidepressant-like Effect of the Lectin Isolated from the Red Marine Alga Solieria Filiformis in Mice. Int. J. Biol. Macromol. 2018, 111, 534–541. DOI: 10.1016/j.ijbiomac.2017.12.132.
   PubMed Web of Science ®Google Scholar
• Da Conceição Rivanor, R. L.; Chaves, H. V.; Do Val, D. R.; De Freitas, A. R.; Lemos, J. C.; Rodrigues, J. A. G.; Pereira, K. M. A.; De Araújo, I. W. F.; Bezerra, M. M.; Benevides, N. M. B. A Lectin from the Green Seaweed Caulerpa Cupressoides Reduces Mechanical Hyper-Nociception and Inflammation in the Rat Temporomandibular Joint during Zymosan-Induced Arthritis. Int. Immunopharmacol. 2014, 21(1), 34–43. DOI: 10.1016/j.intimp.2014.04.009.
   PubMed Web of Science ®Google Scholar
• Mu, J.; Hirayama, M.; Sato, Y.; Morimoto, K.; Hori, K. A Novel High-Mannose Specific Lectin from the Green Alga Halimeda Renschii Exhibits A Potent Anti-Influenza Virus Activity through High-Affinity Binding to the Viral Hemagglutinin. Mar. Drugs. 2017, 15(8), 255. DOI: 10.3390/md15080255.
   PubMed Web of Science ®Google Scholar
• Matsubara, K.; Sumi, H.; Hori, K. Platelet Aggregation Is Inhibited by Phycolectins. Experientia. 1996, 52(6), 540–543. DOI: 10.1007/BF01969724.
   PubMedGoogle Scholar
• Oren, A.; Gunde-Cimerman, N. Mycosporines and Mycosporine-like Amino Acids: UV Protectants or Multipurpose Secondary Metabolites? FEMS Microbiol. Lett. 2007, 269(1), 1–10. DOI: 10.1111/j.1574-6968.2007.00650.x.
   PubMed Web of Science ®Google Scholar
• Bhatia, S.; Sharma, K.; Namdeo, A. G.; Chaugule, B. B.; Kavale, M.; Nanda, S. Broad-Spectrum Sun-Protective Action of Porphyra-334 Derived from Porphyra Vietnamensis. Pharmacogn. Res. 2010, 2(1), 45. DOI: 10.4103/0974-8490.60578.
   PubMedGoogle Scholar
• Cermeño, M.; Kleekayai, T.; Amigo-Benavent, M.; Harnedy-Rothwell, P.; FitzGerald, R. J. Current Knowledge on the Extraction, Purification, Identification, and Validation of Bioactive Peptides from Seaweed. Electrophoresis. 2020, 41(20), 1694–1717. DOI: 10.1002/elps.202000153.
   PubMed Web of Science ®Google Scholar
• Doust, A. B.; Wilk, K. E.; Curmi, P. M. G.; Scholes, G. D. The Photophysics of Cryptophyte Light-Harvesting. J. Photochem. Photobiol. A Chem. 2006, 184(1–2), 1–17. DOI: 10.1016/j.jphotochem.2006.06.006.
   Web of Science ®Google Scholar
• Denis, C.; Ledorze, C.; Jaouen, P.; Fleurence, J. Comparison of Different Procedures for the Extraction and Partial Purification of R-Phycoerythrin from the Red Macroalga Grateloupia Turuturu. Bot. Mar. 2009, 52(3), 278–328. DOI: 10.1515/BOT.2009.034.
   Web of Science ®Google Scholar
• Fleurence, J.; Chenard, E.; Luçon, M. Determination of the Nutritional Value of Proteins Obtained from Ulva Armoricana. J. Appl. Phycol. 1999, 11(3), 231–239. DOI: 10.1023/A:1008067308100.
   Web of Science ®Google Scholar
• Fujiwara-Arasaki, T.; Mino, N.; Kuroda, M. The Protein Value in Human Nutrition of Edible Marine Algae in Japan. Hydrobiologia. 1984, 116(117), 513–516. DOI: 10.1007/BF00027735.
   Google Scholar
• Abdel-fattah, A. F.; Sary, H. H. Glycoproteins from Ulva Lactuca. Phytochemistry. 1987, 26, 1447–1448. DOI: 10.1016/S0031-9422(00)81831-2.
   Web of Science ®Google Scholar
• Oh, J. H.; Nam, T. J. Hydrophilic Glycoproteins of an Edible Green Alga Capsosiphon Fulvescens Prevent Aging-Induced Spatial Memory Impairment by Suppressing Gsk-3β-Mediated Er Stress in Dorsal Hippocampus. Mar. Drugs. 2019, 17(3), 168. DOI: 10.3390/md17030168.
   PubMed Web of Science ®Google Scholar
• Harnedy, P. A.; FitzGerald, R. J. Extraction of Protein from the Macroalga Palmaria Palmata. LWT - Food Sci. Technol. 2013, 51(1), 375–382. DOI: 10.1016/j.lwt.2012.09.023.
   Web of Science ®Google Scholar
• Dumay, J.; Clément, N.; Morançais, M.; Fleurence, J. Optimization of Hydrolysis Conditions of Palmaria Palmata to Enhance R-Phycoerythrin Extraction. Bioresour. Technol. 2013, 131, 21–27. DOI: 10.1016/j.biortech.2012.12.146.
   PubMed Web of Science ®Google Scholar
• Elango, R.; Ball, R. O.; Pencharz, P. B. Amino Acid Requirements in Humans: With a Special Emphasis on the Metabolic Availability of Amino Acids. Amino Acids. 2009, 37(1), 19–27. DOI: 10.1007/s00726-009-0234-y.
   PubMed Web of Science ®Google Scholar
• Dawczynski, C.; Schubert, R.; Jahreis, G. Amino Acids, Fatty Acids, and Dietary Fibre in Edible Seaweed Products. Food Chem. 2007, 103(3), 891–899. DOI: 10.1016/j.foodchem.2006.09.041.
   Web of Science ®Google Scholar
• Laohakunjit, N.; Selamassakul, O.; Kerdchoechuen, O. Seafood-like Flavour Obtained from the Enzymatic Hydrolysis of the Protein by-Products of Seaweed (Gracilaria Sp.). Food Chem. 2014, 158, 162–170. DOI: 10.1016/j.foodchem.2014.02.101.
   PubMed Web of Science ®Google Scholar
• Ratana-arporn, P.; Chirapart, A. Nutritional Evaluation of Tropical Green Seaweeds Caulerpa Lentillifera and Ulva Reticulata. Kasetsart J. - Nat. Sci. 2006, 40, 75–83.
   Google Scholar
• Lumbessy, S. Y.; Andayani, S.; Nursyam, H.; Firdaus, M. Biochemical Study of Amino Acid Profile of Kappaphycus Alvarezii and Gracilaria Salicornia Seaweeds from Gerupuk Waters, West Nusa Tenggara (NTB). EurAsian J. Biosci. 2019, 13, 303–307.
   Google Scholar
• Zubia, M.; Payri, C. E.; Deslandes, E.; Guezennec, J. Chemical Composition of Attached and Drift Specimens of Sargassum Mangarevense and Turbinaria Ornata (Phaeophyta: Fucales) from Tahiti, French Polynesia. Bot. Mar. 2003, 46(6), 562–571. DOI: 10.1515/BOT.2003.059.
   Web of Science ®Google Scholar
• Uribe, E.; Vega-Gálvez, A.; Vargas, N.; Pasten, A.; Rodríguez, K.; Ah-Hen, K. S. Phytochemical Components and Amino Acid Profile of Brown Seaweed Durvillaea Antarctica as Affected by Air Drying Temperature. J. Food Sci. Technol. 2018, 55(12), 4792–4801. DOI: 10.1007/s13197-018-3412-7.
   PubMed Web of Science ®Google Scholar
• Biancarosa, I.; Espe, M.; Bruckner, C. G.; Heesch, S.; Liland, N.; Waagbø, R.; Torstensen, B.; Lock, E. J. Amino Acid Composition, Protein Content, and Nitrogen-to-Protein Conversion Factors of 21 Seaweed Species from Norwegian Waters. J. Appl. Phycol. 2017, 29(2), 1001–1009. DOI: 10.1007/s10811-016-0984-3.
   Web of Science ®Google Scholar
• Conde, E.; Balboa, E. M.; Parada, M.; Falqué, E. Algal Proteins, Peptides and Amino Acids. In Functional Ingredients from Algae for Foods and Nutraceuticals. USA, 2013; pp 135–180. doi:10.1533/9780857098689.1.135
   Google Scholar
• Holdt, S. L.; Kraan, S. Bioactive Compounds in Seaweed: Functional Food Applications and Legislation. J. Appl. Phycol. 2011, 23, 543–597. DOI: 10.1007/s10811-010-9632-5.
   Web of Science ®Google Scholar
• Vieira, E. F.; Soares, C.; Machado, S.; Correia, M.; Ramalhosa, M. J.; Oliva-teles, M. T.; Paula Carvalho, A.; Domingues, V. F.; Antunes, F.; Oliveira, T. A. C., et al. Seaweeds from the Portuguese Coast as a Source of Proteinaceous Material: Total and Free Amino Acid Composition Profile. Food Chem. 2018, 269, 264–275. DOI: 10.1016/j.foodchem.2018.06.145.
   PubMed Web of Science ®Google Scholar
• Wong, P. F.; Tan, L. J.; Nawi, H.; AbuBakar, S. Proteomics of the Red Alga, Gracilaria Changii (Gracilariales, Rhodophyta). J. Phycol. 2006, 42(1), 113–120. DOI: 10.1111/j.1529-8817.2006.00182.x.
   Web of Science ®Google Scholar
• Nagai, K.; Yotsukura, N.; Ikegami, H.; Kimura, H.; Morimoto, K. Protein Extraction for 2-DE from the Lamina of Ecklonia Kurome (Laminariales): Recalcitrant Tissue Containing High Levels of Viscous Polysaccharides. Electrophoresis. 2008, 29(3), 672–681. DOI: 10.1002/elps.200700461.
   PubMed Web of Science ®Google Scholar
• Yotsukura, N.; Nagai, K.; Kimura, H.; Morimoto, K. Seasonal Changes in Proteomic Profiles of Japanese Kelp: Saccharina Japonica (Laminariales, Phaeophyceae). J. Appl. Phycol. 2010, 22(4), 443–451. DOI: 10.1007/s10811-009-9477-y.
   Web of Science ®Google Scholar
• Fleurence, J.; Gutbier, G.; Mabeau, S.; Leray, C. Fatty Acids from 11 Marine Macroalgae of the French Brittany Coast. J. Appl. Phycol. 1994, 6(5–6), 527–532. DOI: 10.1007/BF02182406.
   Web of Science ®Google Scholar
• Buschmann, A. H.; Hurd, C. L.; Harrison, P. J.; Bischof, K.; Lobban, C. S. Seaweed Ecology and Physiology; Cambridge University Press: Cambridge, UK, 2016, pp 551. DOI: 10.1111/jpy.12398.
   Google Scholar
• Jordan, P.; Vilter, H. Extraction of Proteins from Material Rich in Anionic Mucilages: Partition and Fractionation of Vanadate-Dependent Bromoperoxidases from the Brown Algae Laminaria Digitata and L. Saccharina in Aqueous Polymer Two-Phase Systems. BBA - Gen. Subj. 1991, 1073(1), 98–106. DOI: 10.1016/0304-4165(91)90188-M.
   PubMedGoogle Scholar
• Ozdal, T.; Capanoglu, E.; Altay, F. A Review on Protein-Phenolic Interactions and Associated Changes. Food Res. Int. 2013, 51(2), 954–970. DOI: 10.1016/j.foodres.2013.02.009.
   Web of Science ®Google Scholar
• Stern, J. L.; Hagerman, A. E.; Steinberg, P. D.; Mason, P. K. Phlorotannin-Protein Interactions. J. Chem. Ecol. 1996, 22(10), 1877–1899. DOI: 10.1007/BF02028510.
   PubMed Web of Science ®Google Scholar
• Harrysson, H.; Hayes, M.; Eimer, F.; Carlsson, N. G.; Toth, G. B.; Undeland, I. Production of Protein Extracts from Swedish Red, Green, and Brown Seaweeds, Porphyra Umbilicalis Kützing, Ulva Lactuca Linnaeus, and Saccharina Latissima (Linnaeus) J. V. Lamouroux Using Three Different Methods. J. Appl. Phycol. 2018, 30(6), 3565–3580. DOI: 10.1007/s10811-018-1481-7.
   Web of Science ®Google Scholar
• Barbarino, E.; Lourenço, S. O. An Evaluation of Methods for Extraction and Quantification of Protein from Marine Macro- and Microalgae. Journal of Applied Phycology. 2005, 17(5), 447–460. DOI: 10.1007/s10811-005-1641-4.
   Web of Science ®Google Scholar
• Bleakley, S.; Hayes, M. Algal Proteins: Extraction, Application, and Challenges Concerning Production. Foods. 2017, 6(5), 33. DOI: 10.3390/foods6050033.
   PubMed Web of Science ®Google Scholar
• Kadam, S. U.; Tiwari, B. K.; O’Donnell, C. P. Application of Novel Extraction Technologies for Bioactives from Marine Algae. J. Agric. Food Chem. 2013, 61(20), 4667–4675. DOI: 10.1021/jf400819p.
   PubMed Web of Science ®Google Scholar
• Vásquez, V.; Martínez, R.; Bernal, C. Enzyme-Assisted Extraction of Proteins from the Seaweeds Macrocystis Pyrifera and Chondracanthus Chamissoi: Characterization of the Extracts and Their Bioactive Potential. Journal of Applied Phycology. 2019, 31(3), 1999–2010. DOI: 10.1007/s10811-018-1712-y.
   Web of Science ®Google Scholar
• Wijesinghe, W. A. J. P.; Jeon, Y. J. Enzyme-Assistant Extraction (EAE) of Bioactive Components: A Useful Approach for Recovery of Industrially Important Metabolites from Seaweeds: A Review. Fitoterapia. 2012, 83, 6–12. DOI: 10.1016/j.fitote.2011.10.016.
   PubMed Web of Science ®Google Scholar
• Veide Vilg, J.; Undeland, I. PH-Driven Solubilization and Isoelectric Precipitation of Proteins from the Brown Seaweed Saccharina Latissima—Effects of Osmotic Shock, Water Volume and Temperature. J. Appl. Phycol. 2017, 29(1), 585–593. DOI: 10.1007/s10811-016-0957-6.
   PubMed Web of Science ®Google Scholar
• Siriwardhana, N.; Kim, K. N.; Lee, K. W.; Kim, S. H.; Ha, J. H.; Song, C. B.; Lee, J. B.; Jeon, Y. J. Optimisation of Hydrophilic Antioxidant Extraction from Hizikiafusiformis by Integrating Treatments of Enzymes, Heat and PH Control. Int. J. Food Sci. Technol. 2008, 43, 587–596. DOI: 10.1111/j.1365-2621.2006.01485.x.
   Web of Science ®Google Scholar
• Sanz-Pintos, N.; Pérez-Jiménez, J.; Buschmann, A. H.; Vergara-Salinas, J. R.; Pérez-Correa, J. R.; Saura-Calixto, F. Macromolecular Antioxidants and Dietary Fiber in Edible Seaweeds. J. Food Sci. 2017, 82(2), 289–295. DOI: 10.1111/1750-3841.13592.
   PubMed Web of Science ®Google Scholar
• Le Guillard, C.; Bergé, J. P.; Donnay-Moreno, C.; Bruzac, S.; Ragon, J. Y.; Baron, R.; Fleurence, J.; Dumay, J. Soft Liquefaction of the Red Seaweed Grateloupia Turuturu Yamada by Ultrasound-Assisted Enzymatic Hydrolysis Process. J. Appl. Phycol. 2016, 28(4), 2575–2585. DOI: 10.1007/s10811-015-0788-x.
   Web of Science ®Google Scholar
• Contreras, L.; Ritter, A.; Dennett, G.; Boehmwald, F.; Guitton, N.; Pineau, C.; Moenne, A.; Potin, P.; Correa, J. A. Two-dimensional Gel Electrophoresis Analysis of Brown Algal Protein Extracts. J. Phycol. 2008, 44(5), 1315–1321. DOI: 10.1111/j.1529-8817.2008.00575.x.
   PubMed Web of Science ®Google Scholar
• Wang, W.; Vignani, R.; Scali, M.; Cresti, M. A Universal and Rapid Protocol for Protein Extraction from Recalcitrant Plant Tissues for Proteomic Analysis. Electrophoresis. 2006, 27(13), 2782–2786. DOI: 10.1002/elps.200500722.
   PubMed Web of Science ®Google Scholar
• Esquivel-Hernández, D. A.; Ibarra-Garza, I. P.; Rodríguez-Rodríguez, J.; Cuéllar-Bermúdez, S. P.; Rostro-Alanis, M. D. J.; Alemán-Nava, G. S.; García-Pérez, J. S.; Parra-Saldívar, R. Green Extraction Technologies for High-Value Metabolites from Algae: A Review. Biofuels, Bioprod. Biorefining. 2017, 11(1), 215–231. DOI: 10.1002/bbb.1735.
   Web of Science ®Google Scholar
• Grote, B. Recent Developments in Aquaculture of Palmaria Palmata (Linnaeus) (Weber & Mohr 1805): Cultivation and Uses. Rev. Aquac. 2019, 11(1), 25–41. DOI: 10.1111/raq.12224.
   Web of Science ®Google Scholar
• Alemañ, A. E.; Robledo, D.; Hayashi, L. Development of Seaweed Cultivation in Latin America: Current Trends and Future Prospects. Phycologia. 2019, 58(5), 462–471. DOI: 10.1080/00318884.2019.1640996.
   Web of Science ®Google Scholar
• Magnusson, M.; Glasson, C. R. K.; Vucko, M. J.; Angell, A.; Neoh, T. L.; de Nys, R. Enrichment Processes for the Production of High-Protein Feed from the Green Seaweed Ulva Ohnoi. Algal Res. 2019, 41, 101555. DOI: 10.1016/j.algal.2019.101555.
   Google Scholar
• Mittal, R.; Sharma, R.; Raghavarao, K. S. M. S. Aqueous Two-Phase Extraction of R-Phycoerythrin from Marine Macro-Algae, Gelidium Pusillum. Bioresour. Technol. 2019, 280, 277–286. DOI: 10.1016/j.biortech.2019.02.044.
   PubMed Web of Science ®Google Scholar
• Mittal, R.; Tavanandi, H. A.; Mantri, V. A.; Raghavarao, K. S. M. S. Ultrasound Assisted Methods for Enhanced Extraction of Phycobiliproteins from Marine Macro-Algae, Gelidium Pusillum (Rhodophyta). Ultrason. Sonochem. 2017, 38, 92–103. DOI: 10.1016/j.ultsonch.2017.02.030.
   PubMed Web of Science ®Google Scholar
• Grosso, C.; Valentão, P.; Ferreres, F.; Andrade, P. B. Alternative and Efficient Extraction Methods for Marine-Derived Compounds. Mar. Drugs. 2015, 13(5), 3182–3230. DOI: 10.3390/md13053182.
   PubMed Web of Science ®Google Scholar
• Jung, K. A.; Lim, S. R.; Kim, Y.; Park, J. M. Potentials of Macroalgae as Feedstocks for Biorefinery. Bioresour. Technol. 2013, 135, 182–190. DOI: 10.1016/j.biortech.2012.10.025.
   PubMed Web of Science ®Google Scholar
• Hardouin, K.; Bedoux, G.; Burlot, A. S.; Donnay-Moreno, C.; Bergé, J. P.; Nyvall-Collén, P.; Bourgougnon, N. Enzyme-Assisted Extraction (EAE) for the Production of Antiviral and Antioxidant Extracts from the Green Seaweed Ulva Armoricana (Ulvales, Ulvophyceae). Algal Res. 2016, 16, 233–239. DOI: 10.1016/j.algal.2016.03.013.
   Google Scholar
• Escobedo-Avellaneda, Z.; Pateiro-Moure, M.; Chotyakul, N.; Torres, J. A.; Welti-Chanes, J.; Pérez-Lamela, C. Benefits and Limitations of Food Processing by High-Pressure Technologies: Effects on Functional Compounds and Abiotic Contaminants. CYTA - J. Food. 2011, 9(4), 351–364. DOI: 10.1080/19476337.2011.616959.
   Web of Science ®Google Scholar
• Gomez, L.; Tiwari, B.; Garcia-Vaquero, M. Emerging Extraction Techniques: Microwave-Assisted Extraction. In Sustainable Seaweed Technologies. Elsevier, 2020; pp 207–224. doi:10.1016/b978-0-12-817943-7.00008-1
   Google Scholar
• Zabetakis, I.; Leclerc, D.; Kajda, P. The Effect of High Hydrostatic Pressure on the Strawberry Anthocyanins. J. Agric. Food Chem. 2000, 48(7), 2749–2754. DOI: 10.1021/jf9911085.
   PubMed Web of Science ®Google Scholar
• Suwal, S.; Perreault, V.; Marciniak, A.; Tamigneaux, É.; Deslandes, É.; Bazinet, L.; Jacques, H.; Beaulieu, L.; Doyen, A. Effects of High Hydrostatic Pressure and Polysaccharidases on the Extraction of Antioxidant Compounds from Red Macroalgae, Palmaria Palmata and Solieria Chordalis. J. Food Eng. 2019, 252, 53–59. DOI: 10.1016/j.jfoodeng.2019.02.014.
   Web of Science ®Google Scholar
• Machmudah, S.; Wahyudiono,; Kanda, H.; Goto, M. Emerging Seaweed Extraction Techniques: Supercritical Fluid Extraction. In Sustainable Seaweed Technologies. Elsevier, 2020; pp 257–286. doi:10.1016/b978-0-12-817943-7.00010-x
   Google Scholar
• Zhang, X.; Cao, D.; Sun, X.; Sun, S.; Xu, N. Preparation and Identification of Antioxidant Peptides from Protein Hydrolysate of Marine Alga Gracilariopsis Lemaneiformis. J. Appl. Phycol. 2019, 31(4), 2585–2596. DOI: 10.1007/s10811-019-1746-9.
   Web of Science ®Google Scholar
• Plaza, M.; Cifuentes, A.; Ibáñez, E. In the Search of New Functional Food Ingredients from Algae. Trends Food Sci. Technol. 2008, 19(1), 31–39. DOI: 10.1016/j.tifs.2007.07.012.
   Web of Science ®Google Scholar
• Smit, A. J. Medicinal and Pharmaceutical Uses of Seaweed Natural Products: A Review. J. Appl. Phycol. 2004, 16(4), 245–262. DOI: 10.1023/B:JAPH.0000047783.36600.ef.
   Web of Science ®Google Scholar
• Wijesekara, I.; Pangestuti, R.; Kim, S. K. Biological Activities and Potential Health Benefits of Sulfated Polysaccharides Derived from Marine Algae. Carbohydr. Polym. 2011, 84(1), 14–21. DOI: 10.1016/j.carbpol.2010.10.062.
   Web of Science ®Google Scholar
• Pangestuti, R.; Kim, S. K. Biological Activities and Health Benefit Effects of Natural Pigments Derived from Marine Algae. J. Funct. Foods. 2011, 3(4), 255–266. DOI: 10.1016/j.jff.2011.07.001.
   Web of Science ®Google Scholar
• Wijesekara, I.; Yoon, N. Y.; Kim, S. K. Phlorotannins from Ecklonia Cava (Phaeophyceae): Biological Activities and Potential Health Benefits. BioFactors. 2010, 36(6), 408–414. DOI: 10.1002/biof.114.
   PubMed Web of Science ®Google Scholar
• Kim, S. K.; Wijesekara, I. Development and Biological Activities of Marine-Derived Bioactive Peptides: A Review. J. Funct. Foods. 2010, 2(1), 1–9. DOI: 10.1016/j.jff.2010.01.003.
   Web of Science ®Google Scholar
• Zehlila, A.; Schaumann, A.; Mlouka, A. B.; Bourguiba, I.; Hardouin, J.; Masmoudi, O.; Cosette, P.; Amri, M.; Jouenne, T. Glioprotective Effect of Ulva Rigida Extract against UVB Cellular Damages. Algal Res. 2017, 23, 203–215. DOI: 10.1016/j.algal.2017.02.001.
   Google Scholar
• Scalbert, A.; Johnson, I. T.; Saltmarsh, M. Polyphenols. Antioxidants and Beyond. Am. J. Clin. Nutr. 2005, 1(1), 16–22.
   Google Scholar
• Devi, K. P.; Suganthy, N.; Kesika, P.; Pandian, S. K. Bioprotective Properties of Seaweeds: In Vitro Evaluation of Antioxidant Activity and Antimicrobial Activity against Food Borne Bacteria in Relation to Polyphenolic Content. BMC Complement. Altern. Med. 2008, 8(1), 38. DOI: 10.1186/1472-6882-8-38.
   PubMedGoogle Scholar
• Chattopadhyay, N.; Ghosh, T.; Sinha, S.; Chattopadhyay, K.; Karmakar, P.; Ray, B. Polysaccharides from Turbinaria Conoides: Structural Features and Antioxidant Capacity. Food Chem. 2010, 118(3), 823–829. DOI: 10.1016/j.foodchem.2009.05.069.
   Web of Science ®Google Scholar
• Romay, C.; Gonzalez, R.; Ledon, N.; Remirez, D.; Rimbau, V. C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects. Curr. Protein Pept. Sci. 2005, 4(3), 207–216. DOI: 10.2174/1389203033487216.
   Web of Science ®Google Scholar
• Jung, J. H.; Choi, J. W.; Lee, M. K.; Choi, Y. H.; Nam, T. J. Effect of Cyclophilin from Pyropia Yezoensis on the Proliferation of Intestinal Epithelial Cells by Epidermal Growth Factor Receptor/Ras Signaling Pathway. Mar. Drugs. 2019, 17(5), 297. DOI: 10.3390/md17050297.
   PubMed Web of Science ®Google Scholar
• Wang, W.; Wang, S. X.; Guan, H. S. The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview. Mar. Drugs. 2012, 10(12), 2795–2816. DOI: 10.3390/md10122795.
   PubMed Web of Science ®Google Scholar
• Sridharan, M. C.; Dhamotharan, R. Antibacterial Activity of Marine Brown Alga Turbinaria Conoides. J. Chem. Pharm. Res. 2012, 4, 2292–2294.
   Google Scholar
• Heo, S. J.; Park, E. J.; Lee, K. W.; Jeon, Y. J. Antioxidant Activities of Enzymatic Extracts from Brown Seaweeds. Bioresour. Technol. 2005, 96(14), 1613–1623. DOI: 10.1016/j.biortech.2004.07.013.
   PubMed Web of Science ®Google Scholar
• Elias, R. J.; Kellerby, S. S.; Decker, E. A. Antioxidant Activity of Proteins and Peptides. Crit. Rev. Food Sci. Nutr. 2008, 48(5), 430–441. DOI: 10.1080/10408390701425615.
   PubMed Web of Science ®Google Scholar
• Admassu, H.; Gasmalla, M. A. A.; Yang, R.; Zhao, W. Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties. J. Food Sci. 2018, 83(1), 6–16. DOI: 10.1111/1750-3841.14011.
   PubMed Web of Science ®Google Scholar
• Papadopoulou, A.; Frazier, R. A. Characterization of Protein-Polyphenol Interactions. Trends Food Sci. Technol. 2004, 15(3–4), 186–190. DOI: 10.1016/j.tifs.2003.09.017.
   Web of Science ®Google Scholar
• Lu, Y. A.; Lee, H. G.; Li, X.; Hyun, J. M.; Kim, H. S.; Kim, T. H.; Kim, H. M.; Lee, J. J.; Kang, M. C.; Jeon, Y. J. Anti-Obesity Effects of Red Seaweed, Plocamium Telfairiae, in C57BL/6 Mice Fed a High-Fat Diet. Food Funct. 2020, 11(3), 2299–2308. DOI: 10.1039/c9fo02924a.
   PubMed Web of Science ®Google Scholar
• Joel, C. H.; Sutopo, C. C. Y.; Prajitno, A.; Su, J. H.; Hsu, J. L. Screening of Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from Caulerpa Lentillifera. Molecules. 2018, 23(11), 3005. DOI: 10.3390/molecules23113005.
   PubMed Web of Science ®Google Scholar
• Samarathunga, J.; Jayasinghe, M.; Edirisinghe, M.; Wijesekara, I.; Abeysundara, P.; Shafi, A.; Farooq, U.; Senadheera, S. A Comparative Study to Develop Calcium, Zinc, and Antioxidant Rich Drinking Yoghurt Products Using Plant and Pharmaceutical Ingredients. Asian J. Agric. Biol. 2020, 8(2), 174–185. DOI: 10.35495/ajab.2019.08.360.
   Web of Science ®Google Scholar
• Hirayama, M.; Shibata, H.; Imamura, K.; Sakaguchi, T.; Hori, K. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus Alvarezii Represent a Potent Anti-HIV Activity through High-Affinity Binding to the Viral Envelope Glycoprotein Gp120. Mar. Biotechnol. 2016, 18(1), 144–160. DOI: 10.1007/s10126-015-9684-2.
   PubMed Web of Science ®Google Scholar
• Charoensiddhi, S.; Conlon, M. A.; Franco, C. M. M.; Zhang, W. The Development of Seaweed-Derived Bioactive Compounds for Use as Prebiotics and Nutraceuticals Using Enzyme Technologies. Trends Food Sci. Technol. 2017, 70, 20–33. DOI: 10.1016/j.tifs.2017.10.002.
   Web of Science ®Google Scholar
• Tapotubun, A. M.; Matrutty, T. E. A. A.; Riry, J.; Tapotubun, E. J.; Fransina, E. G.; Mailoa, M. N.; Riry, W. A.; Setha, B.; Rieuwpassa, F. Seaweed Caulerpa Sp Position as Functional Food. IOP Conf. Ser. Earth Environ. Sci. 2020, 517(1), 012021. DOI: 10.1088/1755-1315/517/1/012021.
   Google Scholar
• Suresh Kumar, K.; Ganesan, K.; Selvaraj, K.; Subba Rao, P. V. Studies on the Functional Properties of Protein Concentrate of Kappaphycus Alvarezii (Doty) Doty - an Edible Seaweed. Food Chem. 2014, 153, 353–360. DOI: 10.1016/j.foodchem.2013.12.058.
   PubMed Web of Science ®Google Scholar
• Fernández-Segovia, I.; Lerma-García, M. J.; Fuentes, A.; Barat, J. M. Characterization of Spanish Powdered Seaweeds: Composition, Antioxidant Capacity and Technological Properties. Food Res. Int. 2018, 111, 212–219. DOI: 10.1016/j.foodres.2018.05.037.
   PubMed Web of Science ®Google Scholar
• Chandi, G. K.; Sogi, D. S. Functional Properties of Rice Bran Protein Concentrates. J. Food Eng. 2007, 79(2), 592–597. DOI: 10.1016/j.jfoodeng.2006.02.018.
   Web of Science ®Google Scholar
• Banach, J. L.; Hoek-van Den Hil, E. F.; van der Fels-klerx, H. J. Food Safety Hazards in the European Seaweed Chain. Compr. Rev. Food Sci. Food Saf. 2020, 19(2), 332–364. DOI: 10.1111/1541-4337.12523.
   PubMed Web of Science ®Google Scholar
• Bogolitsyn, K. G.; Kaplitsin, P. A.; Pochtovalova, A. S. Amino-Acid Composition of Arctic Brown Algae. Chem. Nat. Compd. 2014, 49(6), 1110–1113. DOI: 10.1007/s10600-014-0831-1.
   Web of Science ®Google Scholar
• Hardouin, K.; Burlot, A. S.; Umami, A.; Tanniou, A.; Stiger-Pouvreau, V.; Widowati, I.; Bedoux, G.; Bourgougnon, N. Biochemical and Antiviral Activities of Enzymatic Hydrolysates from Different Invasive French Seaweeds. J. Appl. Phycol. 2014, 26(2), 1029–1042. DOI: 10.1007/s10811-013-0201-6.
   Web of Science ®Google Scholar
• Fareeha, A.; Atika, A.; Aliya, R. Protein Extraction from Ulva Lactuca and Padina Pavonica Found at Buleji Coast, Karachi, Pakistan. Int. J. Phycol. Phycochem. 2013, 9(1), 49–52.
   Google Scholar
• Lee, S. E.; Chung, H.; Kim, Y. S. Effects of Enzymatic Modification of Wheat Protein on the Formation of Pyrazines and Other Volatile Components in the Maillard Reaction. Food Chem. 2012, 131(4), 1248–1254. DOI: 10.1016/j.foodchem.2011.09.113.
   Web of Science ®Google Scholar
• Wu, Y. F. G.; Cadwallader, K. R. Characterization of the Aroma of a Meatlike Process Flavoring from Soybean-Based Enzyme-Hydrolyzed Vegetable Protein. J. Agric. Food Chem. 2002, 50(10), 2900–2907. DOI: 10.1021/jf0114076.
   PubMed Web of Science ®Google Scholar
• Guo, X.; Tian, S.; Small, D. M. Generation of Meat-like Flavourings from Enzymatic Hydrolysates of Proteins from Brassica Sp. Food Chemistry. 2010, 119(1), 167–172. DOI: 10.1016/j.foodchem.2009.05.089.
   Web of Science ®Google Scholar
• Imm, J. Y.; Lee, C. M. Production of Seafood Flavor from Red Hake (Urophycis Chuss) by Enzymatic Hydrolysis. J. Agric. Food Chem. 1999, 47, 2360–2366. DOI: 10.1021/jf9811020.
   PubMed Web of Science ®Google Scholar
• Chronakis, I. S.; Madsen, M. Algal Proteins. Handbook of Food Proteins. 2011, 353–394. DOI: 10.1016/B978-1-84569-758-7.50014-9.
   Google Scholar
• Román, R. B.; Alvárez-Pez, J. M.; Fernández, F. G. A.; Grima, E. M. Recovery of Pure B-Phycoerythrin from the Microalga Porphyridium Cruentum. J. Biotechnol. 2002, 93(1), 73–85. DOI: 10.1016/S0168-1656(01)00385-6.
   PubMed Web of Science ®Google Scholar
• Kadam, S. U.; Prabhasankar, P. Marine Foods as Functional Ingredients in Bakery and Pasta Products. Food Res. Int. 2010, 43(8), 1975–1980. DOI: 10.1016/j.foodres.2010.06.007.
   Web of Science ®Google Scholar
• Roohinejad, S.; Koubaa, M.; Barba, F. J.; Saljoughian, S.; Amid, M.; Greiner, R. Application of Seaweeds to Develop New Food Products with Enhanced Shelf-Life, Quality and Health-Related Beneficial Properties. Food Res. Int. 2017, 99, 1066–1083. DOI: 10.1016/j.foodres.2016.08.016.
   PubMed Web of Science ®Google Scholar
• Gilani, G. S.; Xiao, C. W.; Cockell, K. A. Impact of Antinutritional Factors in Food Proteins on the Digestibility of Protein and the Bioavailability of Amino Acids and on Protein Quality. Br. J. Nutr. 2012, 108(S2), S315–S332. DOI: 10.1017/S0007114512002371.
   PubMedGoogle Scholar
• Gilani, G. S.; Cockell, K. A.; Sepehr, E. Effects of Antinutritional Factors on Protein Digestibility and Amino Acid Availability in Foods. J. AOAC Int. 2005, 88(3), 967–987. DOI: 10.1093/jaoac/88.3.967.
   PubMed Web of Science ®Google Scholar
• Lahaye, M.; Vigouroux, J. Liquefaction of Dulse (Palmaria Palmata (L.) Kuntze) by a Commercial Enzyme Preparation and a Purified Endo,β-1,4-D-Xylanase. J. Appl. Phycol. 1992, 4(4), 329–337. DOI: 10.1007/BF02185790.
   Web of Science ®Google Scholar
• Horie, Y.; Sugase, K.; Horie, K. Physiological Differences of Soluble and Insoluble Dietary Fibre Fractions of Brown Algae and Mushrooms in Pepsin Activity in Vitro and Protein Digestibility. Asia Pac. J. Clin. Nutr. 1995, 4(2), 251–255.
   PubMedGoogle Scholar
• Benevides, N.; Silva, S.; Magalhães, S.; Melo, F.; Freitas, A.; Vasconcelos, M. Proximate Analysis, Toxic and Antinutritional Factors of Ten Brazilian Marine Algae. Rev. Bras. Fisiol. Veg. 1998, 10, 31–36.
   Google Scholar
• Dumay, J.; Morançais, M. Proteins and Pigments. In Seaweed in Health and Disease Prevention. Elsevier, 2016; pp 275–318. doi:10.1016/B978-0-12-802772-1.00009-9
   Google Scholar
• Bobin-Dubigeon, C.; Hoebler, C.; Lognoné, V.; Dagorn-Scaviner, C.; Mabeau, S.; Barry, J. L.; Lahaye, M. Chemical Composition, Physico-Chemical Properties, Enzymatic Inhibition and Fermentative Characteristics of Dietary Fibres from Edible Seaweeds. Sci. Aliments. 1997, 17, 619–639.
   Google Scholar
• O’ Connor, J.; Meaney, S.; Williams, G. A.; Hayes, M. Extraction of Protein from Four Different Seaweeds Using Three Different Physical Pre-Treatment Strategies. Molecules. 2020, 25(8), 2005. DOI: 10.3390/molecules25082005.
   PubMed Web of Science ®Google Scholar
• Sánchez-Machado, D. I.; López-Cervantes, J.; López-Hernández, J.; Paseiro-Losada, P.; Simal-Lozano, J. High-Performance Liquid Chromatographic Analysis of Amino Acids in Edible Seaweeds after Derivatization with Phenyl Isothiocyanate. Chromatographia. 2003, 58(3–4), 159–163. DOI: 10.1365/s10337-003-0031-9.
   Web of Science ®Google Scholar
• Prisacaru, V.; Sevciuc, T. Supporting the Soybean Production and Processing Sector in the Context of Concern for Sustainable Development. Scientific papers: management, economic engineering in agriculture & rural development; http://dspace.uasm.md:8080/xmlui/handle/123456789/4497 (accessed April 2, 2020).
   Google Scholar
• Fernand, F.; Israel, A.; Skjermo, J.; Wichard, T.; Timmermans, K. R.; Golberg, A. Offshore Macroalgae Biomass for Bioenergy Production: Environmental Aspects, Technological Achievements and Challenges. Renew. Sustain. Energy Rev. 2017, 75, 35–45. DOI: 10.1016/j.rser.2016.10.046.
   Web of Science ®Google Scholar
• Cheney, D. Toxic and Harmful Seaweeds. In Seaweed in Health and Disease Prevention. Elsevier, 2016; pp 407–421. doi:10.1016/B978-0-12-802772-1.00013-0
   Google Scholar
• Sarwar, G.; Peace, R. W. Comparisons between True Digestibility of Total Nitrogen and Limiting Amino Acids in Vegetable Proteins Fed to Rats. J. Nutr. 1986, 116(7), 1172–1184. DOI: 10.1093/jn/116.7.1172.
   PubMed Web of Science ®Google Scholar
• Gilani, G. S.; Sepehr, E. Protein Digestibility and Quality in Products Containing Antinutritional Factors are Adversely Affected by Old Age in Rats. J. Nutr. 2003, 133(1), 220–225. DOI: 10.1093/jn/133.1.220.
   PubMed Web of Science ®Google Scholar
• Evenepoel, P.; Geypens, B.; Luypaerts, A.; Hiele, M.; Ghoos, Y.; Rutgeerts, P. Digestibility of Cooked and Raw Egg Protein in Humans as Assessed by Stable Isotope Techniques. J. Nutr. 1998, 128(10), 1716–1722. DOI: 10.1093/jn/128.10.1716.
   PubMed Web of Science ®Google Scholar
• Yin, Y.; Zhou, L.; Pereira, J.; Zhang, J.; Zhang, W. Insights into Digestibility and Peptide Profiling of Beef Muscle Proteins with Different Cooking Methods. J. Agric. Food Chem. 2020, 68(48), 14243–14251. DOI: 10.1021/acs.jafc.0c04054.
   Web of Science ®Google Scholar
• Niccolai, A.; Chini Zittelli, G.; Rodolfi, L.; Biondi, N.; Tredici, M. R. Microalgae of Interest as Food Source: Biochemical Composition and Digestibility. Algal Res. 2019, 42, 101617. DOI: 10.1016/j.algal.2019.101617.
   Google Scholar
• Marrion, O.; Schwertz, A.; Fleurence, J.; Guéant, J. L.; Villaume, C. Improvement of the Digestibility of the Proteins of the Red Alga Palmaria Palmata by Physical Processes and Fermentation. Nahrung – Food. 2003, 47(5), 339–344. DOI: 10.1002/food.200390078.
   PubMedGoogle Scholar
• Marrion, O.; Fleurence, J.; Schwertz, A.; Guéant, J. L.; Mamelouk, L.; Ksouri, J.; Villaume, C. Evaluation of Protein in Vitro Digestibility of Palmaria Palmata and Gracilaria Verrucosa. J. Appl. Phycol. 2005, 17(2), 99–102. DOI: 10.1007/s10811-005-5154-y.
   Web of Science ®Google Scholar
• Wong, K. H.; Cheung, P. C. K. Nutritional Evaluation of Some Subtropical Red and Green Seaweeds Part II. In Vitro Protein Digestibility and Amino Acid Profiles of Protein Concentrates. Food Chem. 2001, 72(1), 11–17. DOI: 10.1016/S0308-8146(00)00176-X.
   Web of Science ®Google Scholar
• Mišurcová, L.; Kráčmar, S.; Klejdus, B.; Vacek, J. Nitrogen Content Dietary Fiber, and Digestibility in Algal Food Products. Czech J. Food Sci. 2010, 28(1), 27–35. DOI: 10.17221/111/2009-cjfs.
   Web of Science ®Google Scholar