Psidium guajava L.: A Systematic Review of the Multifaceted Health Benefits and Economic Importance

References

• Fiolet, T.; Srour, B.; Sellem, L.; Kesse-Guyot, E.; Allès, B.; Méjean, C.; Deschasaux, M.; Fassier, P.; Latino-Martel, P.; Beslay, M., et al. Consumption of Ultra-processed Foods and Cancer Risk: Results from NutriNet-Santé Prospective Cohort. Bmj. 2018, 360, k322. DOI: 10.1136/bmj.k322.
   PubMed Web of Science ®Google Scholar
• Pereira, J. L.; Mattei, J.; Isasi, C. R.; Van Horn, L.; Carnethon, M. R.; Daviglus, M. L.; Perera, M. J.; Sotres-Alvarez, D.; Fisberg, R. M. 2021 Diet Quality, Excess Body Weight and Cardiometabolic Risk Factors in Adolescents Living in São Paulo, Brazil and in the USA: Differences and Similarities. Public. Health. Nutr. 2020, 1–11.
   Google Scholar
• Schnabel, L.; Kesse-Guyot, E.; Allès, B.; Touvier, M.; Srour, B.; Hercberg, S.; Buscail, C.; Julia, C. Association between Ultraprocessed Food Consumption and Risk of Mortality among Middle-aged Adults in France. JAMA Intern. Med. 2019, 179(4), 490–498. DOI: 10.1001/jamainternmed.2018.7289.
   PubMed Web of Science ®Google Scholar
• Li, Y.; Schoufour, J.; Wang, D. D.; Dhana, K.; Pan, A.; Liu, X.; Song, M.; Liu, G.; Shin, H. J.; Sun, Q., et al. Healthy Lifestyle and Life Expectancy Free of Cancer, Cardiovascular Disease, and Type 2 Diabetes: Prospective Cohort Study. Bmj. 2020, 368, l6669. DOI: 10.1136/bmj.l6669.
   PubMed Web of Science ®Google Scholar
• Nardocci, M.; Polsky, J. Y.; Moubarac, J. C. Consumption of Ultra-processed Foods is Associated with Obesity, Diabetes and Hypertension in Canadian Adults. Can. J. Public Health. 2021, 112(3), 421–429. DOI: 10.17269/s41997-020-00429-9.
   PubMed Web of Science ®Google Scholar
• Rychter, A. M.; Ratajczak, A. E.; Zawada, A.; Dobrowolska, A.; Krela-Kaźmierczak, I. Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity. Nutrients. 2020, 12(3), 3. DOI: 10.3390/nu12030814.
   Web of Science ®Google Scholar
• Trautwein, E. A.; McKay, S. The Role of Specific Components of a Plant-Based Diet in Management of Dyslipidemia and the Impact on Cardiovascular Risk. Nutrients. 2020, 12(9), 2671. DOI: 10.3390/nu12092671.
   PubMed Web of Science ®Google Scholar
• Barbalho, S.; Machado, F. Psidium Guajava (Guava): A Plant of Multipurpose Medicinal Applications. Med. Aromat. Plants. 2012.
   Google Scholar
• Daswani, P. G.; Gholkar, M. S.; Birdi, T. J. Psidium Guajava: A Single Plant for Multiple Health Problems of Rural Indian Population. Pharmacogn. Rev. 2017, 11(22), 167–174. DOI: 10.4103/phrev.phrev_17_17.
   PubMedGoogle Scholar
• Gutiérrez, R. M.; Mitchell, S.; Solis, R. V. Psidium Guajava: A Review of its Traditional Uses, Phytochemistry and Pharmacology. J. Ethnopharmacol. 2008, 117(1), 1–27. DOI: 10.1016/j.jep.2008.01.025.
   PubMed Web of Science ®Google Scholar
• Gutiérrez, R. M. P.; Mitchell, S.; Solis, R. V. J. J. O. E. Psidium Guajava: A Review of its Traditional Uses, Phytochemistry and Pharmacology. Med Aromat Plant. 2008, 117(1), 1–27.
   Google Scholar
• Díaz-de-cerio, E.; Verardo, V.; Gómez-Caravaca, A. M.; Fernández-Gutiérrez, A.; Segura-Carretero, A. J. I. J. O. M. S., Health Effects of Psidium Guajava L. Leaves: An Overview of the Last Decade. Int J Mol Sci. 2017, 18(4), 897.
   PubMed Web of Science ®Google Scholar
• Daswani, P. G.; Gholkar, M. S.; Birdi, T. J. J. P. R. Psidium Guajava: A Single Plant for Multiple Health Problems of Rural Indian Population. Pharmacogn Rev. 2017, 11(22), 167.
   PubMedGoogle Scholar
• Barbalho, S. M.; Farinazzi-Machado, F. M.; de Alvares Goulart, R.; Brunnati, A. C. S.; Otoboni, A.; Ottoboni, B. J. M. A. P. Psidium Guajava (Guava): A Plant of Multipurpose Medicinal Applications. Medicinal & Aromatic Plants. 2012, 1(104), 2167–0412.1000104.
   Google Scholar
• Sato, R.; Dang, K. M.; McPherson, B. G.; Brown, A. C. J. J. O. C.; Medicine, I. Anticancer Activity of Guava (Psidium Guajava). Extracts J Complement Integrat Med. 2010, 7, 1.
   Google Scholar
• Jamieson, S.; Wallace, C. E.; Das, N.; Bhattacharyya, P.; Bishayee, A. Guava (Psidium Guajava L.): A Glorious Plant with Cancer Preventive and Therapeutic Potential. Crit. Rev. Food Sci. Nutr. 2021, 1–32.
   Google Scholar
• Kumar, M.; Tomar, M.; Amarowicz, R.; Saurabh, V.; Nair, M. S.; Maheshwari, C.; Sasi, M.; Prajapati, U.; Hasan, M.; Singh, S., et al. Guava (Psidium Guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities. Foods (Basel, Switzerland). 2021, 10(4), 752. DOI: 10.3390/foods10040752.
   PubMed Web of Science ®Google Scholar
• Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G. Preferred Reporting Items for Systematic Reviews and Meta-analyses: The PRISMA Statement. Ann Int Med. 2009, 151(4), 264–9, w64. DOI: 10.7326/0003-4819-151-4-200908180-00135.
   PubMed Web of Science ®Google Scholar
• Nayak, N.; Varghese, J.; Shetty, S.; Bhat, V.; Durgekar, T.; Lobo, R.; Nayak, U. Y.; U, V. Evaluation of a Mouthrinse Containing Guava Leaf Extract as Part of Comprehensive Oral Care Regimen- a Randomized Placebo-controlled Clinical Trial. BMC Complementary Altern. Med. 2019, 19(1), 327. DOI: 10.1186/s12906-019-2745-8.
   PubMed Web of Science ®Google Scholar
• König, A.; Schwarzinger, B.; Stadlbauer, V.; Lanzerstorfer, P.; Iken, M.; Schwarzinger, C.; Kolb, P.; Schwarzinger, S.; Mörwald, K.; Brunner, S., et al. Guava (Psidium Guajava) Fruit Extract Prepared by Supercritical CO(2) Extraction Inhibits Intestinal Glucose Resorption in a Double-Blind, Randomized Clinical Study. Nutrients. 2019, 11(7), 7. DOI: 10.3390/nu11071512.
   Web of Science ®Google Scholar
• Pongsakornpaisan, P.; Lourith, N.; Kanlayavattanakul, M. Anti-sebum Efficacy of Guava Toner: A Split-face, Randomized, Single-blind Placebo-controlled Study. J. Cosmet. Dermatol. 2019, 18(6), 1737–1741. DOI: 10.1111/jocd.12943.
   PubMed Web of Science ®Google Scholar
• Amaliya, A.; Risdiana, A. S.; Van der Velden, U. Effect of Guava and Vitamin C Supplementation on Experimental Gingivitis: A Randomized Clinical Trial. J. Clin. Periodontol. 2018, 45(8), 959–967. DOI: 10.1111/jcpe.12922.
   PubMed Web of Science ®Google Scholar
• Kakuo, S.; Fushimi, T.; Kawasaki, K.; Nakamura, J.; Ota, N. Effects of Psidium Guajava Linn. Leaf Extract in Japanese Subjects with Knee Pain: A Randomized, Double-blind, Placebo-controlled, Parallel Pilot Study. Aging Clin. Exp. Res. 2018, 30(11), 1391–1398. DOI: 10.1007/s40520-018-0953-6.
   PubMed Web of Science ®Google Scholar
• Singla, S.; Malhotra, R.; Nd, S.; Saxena, S. Antibacterial Efficacy of Mouthwash Prepared from Pomegranate, Grape Seed and Guava Extracts against Oral Streptococci: An in Vivo Study. J. Clin. Pediatr. Dent. 2018, 42(2), 109–113. DOI: 10.17796/1053-4628-42.2.5.
   PubMed Web of Science ®Google Scholar
• Thaptimthong, T.; Kasemsuk, T.; Sibmooh, N.; Unchern, S. Platelet Inhibitory Effects of Juices from Pachyrhizus Erosus L. Root and Psidium Guajava L. Fruit: A Randomized Controlled Trial in Healthy Volunteers. BMC Complement. Altern. Med. 2016, 16(1), 269. DOI: 10.1186/s12906-016-1255-1.
   PubMedGoogle Scholar
• Monárrez-Espino, J.; López-Alarcón, M.; Greiner, T. Randomized Placebo-controlled Trial of Guava Juice as a Source of Ascorbic Acid to Reduce Iron Deficiency in Tarahumara Indigenous Schoolchildren of Northern Mexico. J. Am. Coll. Nutr. 2011, 30(3), 191–200. DOI: 10.1080/07315724.2011.10719960.
   PubMed Web of Science ®Google Scholar
• Lozoya, X.; Reyes-Morales, H.; Chávez-Soto, M. A.; Martínez-García Mdel, C.; Soto-González, Y.; Doubova, S. V. Intestinal Anti-spasmodic Effect of a Phytodrug of Psidium Guajava Folia in the Treatment of Acute Diarrheic Disease. J. Ethnopharmacol. 2002, 83(1–2), 19–24. DOI: 10.1016/S0378-8741(02)00185-X.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P.; Thomas, J.; Chandler, J.; Cumpston, M.; Li, T.; Page, M. J.; Welch, V. A. Cochrane Handbook for Systematic Reviews of Interventions; COCHRANE: John Wiley & Sons, 2019.
   Google Scholar
• Feng, C.; Feng, C.; Lin, X.; Liu, S.; Li, Y.; Kang, M. A Chromosome-level Genome Assembly Provides Insights into Ascorbic Acid Accumulation and Fruit Softening in Guava (Psidium Guajava). Plant Biotechnol. J. 2021, 19(4), 717–730. DOI: 10.1111/pbi.13498.
   PubMed Web of Science ®Google Scholar
• Mandal, S.; Sarkar, R.; Patra, P.; Nandan, C. K.; Das, D.; Bhanja, S. K.; Islam, S. S. Structural Studies of a Heteropolysaccharide (PS-I) Isolated from Hot Water Extract of Fruits of Psidium Guajava (Guava). Carbohydr. Res. 2009, 344(11), 1365–1370. DOI: 10.1016/j.carres.2009.05.009.
   PubMed Web of Science ®Google Scholar
• Irshad, Z.; Hanif, M. A.; Ayub, M. A.; Jilani, M. I.; Tavallali, V. Chapter 26 - Guava. In Medicinal Plants of South Asia; Hanif, M.A., Nawaz, H., Khan, M.M., Byrne, H.J., Eds.; Elsevier, 2020; pp 341–354.
   Google Scholar
• Hassan, E. M.; El Gendy, A. E. G.; Abd-elgawad, A. M.; Elshamy, A. I.; Farag, M. A.; Alamery, S. F.; Omer, E. A. Comparative Chemical Profiles of the Essential Oils from Different Varieties of Psidium Guajava L. Molecules. 2020, 26(1), 1. DOI: 10.3390/molecules26010119.
   PubMed Web of Science ®Google Scholar
• Ravi, K.; Divyashree, P. Psidium Guajava: A Review on its Potential as an Adjunct in Treating Periodontal Disease. Pharmacogn. Rev. 2014, 8(16), 96–100. DOI: 10.4103/0973-7847.134233.
   PubMedGoogle Scholar
• Díaz-de-cerio, E.; Verardo, V.; Gómez-Caravaca, A. M.; Fernández-Gutiérrez, A.; Segura-Carretero, A. Health Effects of Psidium Guajava L. Leaves: An Overview of the Last Decade. Int. J. Mol. Sci. 2017, 18(4), 897. DOI: 10.3390/ijms18040897.
   PubMed Web of Science ®Google Scholar
• Khedr, S. I.; Mokhamer, E. H. M.; Hassan, A. A. A.; El-Feki, A. S.; Elkhodary, G. M.; El-Gerbed, M. S. A. Psidium Guajava Linn Leaf Ethanolic Extract: In Vivo Giardicidal Potential with Ultrastructural Damage, Anti-inflammatory and Antioxidant Effects. Saudi J. Biol. Sci. 2021, 28(1), 427–439. DOI: 10.1016/j.sjbs.2020.10.026.
   PubMed Web of Science ®Google Scholar
• Blancas-Benitez, F. J.; Pérez-Jiménez, J.; Montalvo-González, E.; González-Aguilar, G. A.; Sáyago-Ayerdi, S. G. In Vitro Evaluation of the Kinetics of the Release of Phenolic Compounds from Guava (Psidium Guajava L.) Fruit. J. Funct. Foods. 2018, 43, 139–145. DOI: 10.1016/j.jff.2018.02.011.
   Web of Science ®Google Scholar
• Amaral, V.; Alves, T.; Souza, J.; Batain, F.; Crescencio, K.; Soeiro, V.; Barros, C.; Chaud, M. Phenolic Compounds from Psidium Guajava (Linn.) Leaves: Effect of the Extraction-Assisted Method upon Total Phenolics Content and Antioxidant Activity. Biointerface Res. Appl. Chem. 2020, 11, 9346–9357.
   Web of Science ®Google Scholar
• Diaz de Cerio, E.; Caravaca, A. M. G.; Verardo, V.; Fernández-Gutiérrez, A.; Segura Carretero, A. Determination of Guava (Psidium Guajava L.) Leaf Phenolic Compounds Using HPLC-DAD-QTOF-MS. J. Funct. Foods. 2016, 22, 376–388. DOI: 10.1016/j.jff.2016.01.040.
   Web of Science ®Google Scholar
• Vijaya Anand, A.; Velayuthaprabhu, S.; Rengarajan, R. L.; Sampathkumar, P.; Radhakrishnan, R. Bioactive Compounds of Guava (Psidium Guajava L.). In Bioactive Compounds in Underutilized Fruits and Nuts; Murthy, H.N., Bapat, V.A., Eds.; Springer International Publishing: Cham, 2020; pp 503–527.
   Google Scholar
• Shaheena, S.; Chintagunta, A. D.; Dirisala, V. R.; Sampath Kumar, N. S. Extraction of Bioactive Compounds from Psidium Guajava and their Application in Dentistry. AMB Express. 2019, 9(1), 208. DOI: 10.1186/s13568-019-0935-x.
   PubMed Web of Science ®Google Scholar
• Sampath Kumar, N. S.; Sarbon, N. M.; Rana, S. S.; Chintagunta, A. D.; Prathibha, S.; Ingilala, S. K.; Jeevan Kumar, S. P.; Sai Anvesh, B.; Dirisala, V. R. Extraction of Bioactive Compounds from Psidium Guajava Leaves and its Utilization in Preparation of Jellies. AMB Express. 2021, 11(1), 36. DOI: 10.1186/s13568-021-01194-9.
   PubMed Web of Science ®Google Scholar
• Imran, M.; Salehi, B.; Sharifi-Rad, J.; Aslam Gondal, T.; Saeed, F.; Imran, A.; Shahbaz, M.; Tsouh Fokou, P. V.; Umair Arshad, M.; Khan, H., et al. Kaempferol: A Key Emphasis to its Anticancer Potential. Molecules. 2019, 24(12), 12. DOI: 10.3390/molecules24122277.
   Web of Science ®Google Scholar
• Wong, S. K.; Chin, K. Y.; Ima-Nirwana, S. The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies. Drug Des. Devel. Ther. 2019, 13, 3497–3514. DOI: 10.2147/DDDT.S227738.
   PubMed Web of Science ®Google Scholar
• Imran, M.; Rauf, A.; Shah, Z. A.; Saeed, F.; Imran, A.; Arshad, M. U.; Ahmad, B.; Bawazeer, S.; Atif, M.; Peters, D. G., et al. Chemo-preventive and Therapeutic Effect of the Dietary Flavonoid Kaempferol: A Comprehensive Review. Phytother Res. 2019, 33(2), 263–275. DOI: 10.1002/ptr.6227.
   PubMed Web of Science ®Google Scholar
• Zduńska, K.; Dana, A.; Kolodziejczak, A.; Rotsztejn, H. Antioxidant Properties of Ferulic Acid and its Possible Application. Skin Pharmacol. Physiol. 2018, 31(6), 332–336. DOI: 10.1159/000491755.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Wang, Y.; Li, J.; Hua, L.; Han, B.; Zhang, Y.; Yang, X.; Zeng, Z.; Bai, H.; Yin, H., et al. Effects of Caffeic Acid on Learning Deficits in a Model of Alzheimer’s Disease. Int. J. Mol. Med. 2016, 38(3), 869–875. DOI: 10.3892/ijmm.2016.2683.
   PubMed Web of Science ®Google Scholar
• Koga, M.; Nakagawa, S.; Kato, A.; Kusumi, I. Caffeic Acid Reduces Oxidative Stress and Microglial Activation in the Mouse Hippocampus. Tissue Cell. 2019, 60, 14–20. DOI: 10.1016/j.tice.2019.07.006.
   PubMed Web of Science ®Google Scholar
• Marunaka, Y.; Marunaka, R.; Sun, H.; Yamamoto, T.; Kanamura, N.; Inui, T.; Taruno, A. Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules. 2017, 22(2), 209. DOI: 10.3390/molecules22020209.
   PubMed Web of Science ®Google Scholar
• Vauzour, D. Effect of Flavonoids on Learning, Memory and Neurocognitive Performance: Relevance and Potential Implications for Alzheimer’s Disease Pathophysiology. J. Sci. Food Agric. 2014, 94(6), 1042–1056. DOI: 10.1002/jsfa.6473.
   PubMed Web of Science ®Google Scholar
• Wang, D.; Bao, B. Gallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex. Drug Des. Devel. Ther. 2020, 14, 1583–1592. DOI: 10.2147/DDDT.S228123.
   PubMed Web of Science ®Google Scholar
• Verma, S.; Singh, A.; Mishra, A. Gallic Acid: Molecular Rival of Cancer. Environ. Toxicol. Pharmacol. 2013, 35(3), 473–485. DOI: 10.1016/j.etap.2013.02.011.
   PubMed Web of Science ®Google Scholar
• Daglia, M.; Di Lorenzo, A.; Nabavi, S. F.; Talas, Z. S.; Nabavi, S. M. Polyphenols: Well beyond the Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat! Curr. Pharm. Biotechnol. 2014, 15(4), 362–372. DOI: 10.2174/138920101504140825120737.
   PubMed Web of Science ®Google Scholar
• Liu, Y. L.; Hsu, C. C.; Huang, H. J.; Chang, C. J.; Sun, S. H.; Lin, A. M. Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis. Mol. Neurobiol. 2020, 57(1), 96–104. DOI: 10.1007/s12035-019-01759-7.
   PubMed Web of Science ®Google Scholar
• Chandrasekhar, Y.; Phani Kumar, G.; Ramya, E. M.; Anilakumar, K. R. Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line. Neurochem. Res. 2018, 43(6), 1150–1160. DOI: 10.1007/s11064-018-2530-y.
   PubMed Web of Science ®Google Scholar
• Sinegre, T.; Teissandier, D.; Milenkovic, D.; Morand, C.; Lebreton, A. Epicatechin Influences Primary Hemostasis, Coagulation and Fibrinolysis. Food Funct. 2019, 10(11), 7291–7298. DOI: 10.1039/C9FO00816K.
   PubMed Web of Science ®Google Scholar
• Bernatova, I. Biological Activities of (-)-epicatechin and (-)-epicatechin-containing Foods: Focus on Cardiovascular and Neuropsychological Health. Biotechnol. Adv. 2018, 36(3), 666–681. DOI: 10.1016/j.biotechadv.2018.01.009.
   PubMed Web of Science ®Google Scholar
• Simão, A. A.; Marques, T. R.; Marcussi, S.; Corrêa, A. D. Aqueous Extract of Psidium Guajava Leaves: Phenolic Compounds and Inhibitory Potential on Digestive Enzymes. An Acad Bras Cienc. 2017, 89(3 Suppl), 2155–2165.
   Google Scholar
• Chaturvedi, T.; Singh, S.; Nishad, I.; Kumar, A.; Tiwari, N.; Tandon, S.; Saikia, D.; Verma, R. S. Chemical Composition and Antimicrobial Activity of the Essential Oil of Senescent Leaves of Guava (Psidium Guajava L.). Nat. Prod. Res. 2021, 35(8), 1393–1397. DOI: 10.1080/14786419.2019.1648462.
   PubMed Web of Science ®Google Scholar
• de Souza, M. C.; Vieira, A. J.; Beserra, F. P.; Pellizzon, C. H.; Nóbrega, R. H.; Rozza, A. L. Gastroprotective Effect of Limonene in Rats: Influence on Oxidative Stress, Inflammation and Gene Expression. Phytomedicine. 2019, 53, 37–42. DOI: 10.1016/j.phymed.2018.09.027.
   PubMed Web of Science ®Google Scholar
• Salehi, B.; Upadhyay, S.; Erdogan Orhan, I.; Kumar Jugran, A.; S, L. D. J.; D, A. D.; Sharopov, F.; Taheri, Y.; Martins, N.; Baghalpour, N., et al. Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature. Biomolecules. 2019, 9(11), 738. DOI: 10.3390/biom9110738.
   PubMed Web of Science ®Google Scholar
• Njus, D.; Kelley, P. M.; Tu, Y. J.; Schlegel, H. B. Ascorbic Acid: The Chemistry Underlying its Antioxidant Properties. Free Radic. Biol. Med. 2020, 159, 37–43. DOI: 10.1016/j.freeradbiomed.2020.07.013.
   PubMed Web of Science ®Google Scholar
• Ashraf, A.; Sarfraz, R. A.; Rashid, M. A.; Mahmood, A.; Shahid, M.; Noor, N. Chemical Composition, Antioxidant, Antitumor, Anticancer and Cytotoxic Effects of Psidium Guajava Leaf Extracts. Pharm. Biol. 2016, 54(10), 1971–1981. DOI: 10.3109/13880209.2015.1137604.
   PubMed Web of Science ®Google Scholar
• Feng, X. H.; Wang, Z. H.; Meng, D. L.; Li, X. Cytotoxic and Antioxidant Constituents from the Leaves of Psidium Guajava. Bioorg. Med. Chem. Lett. 2015, 25(10), 2193–2198. DOI: 10.1016/j.bmcl.2015.03.058.
   PubMed Web of Science ®Google Scholar
• Wang, L.; Wu, Y.; Bei, Q.; Shi, K.; Wu, Z. Fingerprint Profiles of Flavonoid Compounds from Different Psidium Guajava Leaves and their Antioxidant Activities. J. Sep. Sci. 2017, 40(19), 3817–3829. DOI: 10.1002/jssc.201700477.
   PubMed Web of Science ®Google Scholar
• Zahin, M.; Ahmad, I.; Aqil, F. Antioxidant and Antimutagenic Potential of Psidium Guajava Leaf Extracts. Drug and Chemical Toxicology. Drug Chem Toxic. 2017, 40(2), 146–153. DOI: 10.1080/01480545.2016.1188397.
   PubMed Web of Science ®Google Scholar
• Hosakatte, N.; Bapat, V. Bioactive Compounds in Underutilized Fruits and Nuts. 2020.
   Google Scholar
• Ngbolua, K.-T.-N. A Review on the Phytochemistry and Pharmacology of Psidium Guajava L. (Myrtaceae) and Future Direction. Discovery Phytomed. 2018, 5.
   Google Scholar
• El-Ahmady, S. H.; Ashour, M. L.; Wink, M. Chemical Composition and Anti-inflammatory Activity of the Essential Oils of Psidium Guajava Fruits and Leaves. J. Essent. Oil Res. 2013, 25(6), 475–481. DOI: 10.1080/10412905.2013.796498.
   Web of Science ®Google Scholar
• Fasola, T. R.; Oloyede, G. K.; Aponjolosun, B. S. Chemical Composition, Toxicity and Antioxidant Activities of Essential Oils of Stem Bark of Nigerian Species of Guava (Psidium Guajava Linn.). EXCLI J. 2011, 10, 34–43.
   PubMed Web of Science ®Google Scholar
• Weli, A.; Al-Kaabi, A.; Al-Sabahi, J.; Said, S.; Hossain, M. A.; Al-Riyami, S. Chemical Composition and Biological Activities of the Essential Oils of Psidium Guajava Leaf. J. King Saud Univ. Sci. 2019, 31(4), 993–998. DOI: 10.1016/j.jksus.2018.07.021.
   Web of Science ®Google Scholar
• Siani, A. C.; Souza, M. C.; Henriques, M. G. M. O.; Ramos, M. F. S. Anti-inflammatory Activity of Essential Oils from Syzygium Cumini and Psidium Guajava. Pharm. Biol. 2013, 51(7), 881–887. DOI: 10.3109/13880209.2013.768675.
   PubMed Web of Science ®Google Scholar
• Chen, H.-C.; Sheu, M. J.; Lin, L.-Y.; Wu, C. M. Volatile Constituents of Six Cultivars of Mature Guava (Psidium Guajava L.) Fruits from Taiwan. Acta Hortic. 2008, 765(765), 273–278. DOI: 10.17660/ActaHortic.2008.765.34.
   Google Scholar
• Begum, S.; Siddiqui, B.; Hassan, S. Triterpenoids from Psidium Guajava Leaves. Nat. Prod. Res. 2002, 16, 173–177.
   Google Scholar
• Begum, S.; Hassan, S. I.; Siddiqui, B. S.; Shaheen, F.; Ghayur, M. N.; Gilani, A. H. Triterpenoids from the Leaves of Psidium Guajava. Phytochemistry. 2002, 61(4), 399–403. DOI: 10.1016/S0031-9422(02)00190-5.
   PubMed Web of Science ®Google Scholar
• Bazioli, J. M.; Costa, J. H.; Shiozawa, L.; Ruiz, A.; Foglio, M. A.; Carvalho, J. E. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium Guajava L.). Molecules. 2020, 25(7), 7. DOI: 10.3390/molecules25071525.
   Web of Science ®Google Scholar
• Rizzo, L. Y.; Longato, G. B.; Ruiz, A. L.; Tinti, S. V.; Possenti, A.; Vendramini-Costa, D. B.; Sartoratto, A.; Figueira, G. M.; Silva, F. L.; Eberlin, M. N., et al. In Vitro, in Vivo and in Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts. Curr. Med. Chem. 2014, 21(20), 2322–2330. DOI: 10.2174/0929867321666140120120031.
   PubMed Web of Science ®Google Scholar
• Bontempo, P.; Doto, A.; Miceli, M.; Mita, L.; Benedetti, R.; Nebbioso, A.; Veglione, M.; Rigano, D.; Cioffi, M.; Sica, V., et al. Psidium Guajava L. Anti-neoplastic Effects: Induction of Apoptosis and Cell Differentiation. Cell Prolif. 2012, 45(1), 22–31. DOI: 10.1111/j.1365-2184.2011.00797.x.
   PubMed Web of Science ®Google Scholar
• Correa, M. G.; Couto, J. S.; Teodoro, A. J. Anticancer Properties of Psidium Guajava - a Mini-Review. Asian Pac. J. Cancer Prev. 2016, 17(9), 4199–4204.
   PubMedGoogle Scholar
• Chao, I.-C.; Chen, Y.; Gao, M.-H.; Lin, L.-G.; Zhang, X.-Q.; Ye, W.-C.; Zhang, Q.-W. Simultaneous Determination of α-Glucosidase Inhibitory Triterpenoids in Psidium Guajava Using HPLC–DAD–ELSD and Pressurized Liquid Extraction. Molecules. 2020, 25(6), 1278. DOI: 10.3390/molecules25061278.
   PubMed Web of Science ®Google Scholar
• Khan, H. B.; Shanmugavalli, R.; Rajendran, D.; Bai, M. R.; Sorimuthu, S. Protective Effect of Psidium Guajava Leaf Extract on Altered Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats. J. Diet. Suppl. 2013, 10(4), 335–344. DOI: 10.3109/19390211.2013.830677.
   PubMedGoogle Scholar
• Meles, D. K.; Mustofa, I.; Wurlina, W.; Susilowati, S.; Utama, S.; Suwasanti, N.; Putri, D. K. S. C. The Restorative Effect of Red Guava (Psidium Guajava L.) Fruit Extract on Pulmonary Tissue of Rats (Rattus Norvegicus) Exposed to Cigarette Smoke. Vet. Med. Int. 2021, 2021, 9931001. DOI: 10.1155/2021/9931001.
   PubMed Web of Science ®Google Scholar
• Punthakee, Z.; Goldenberg, R.; Katz, P. Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome. Can. J. Diabetes. 2018, 42 Suppl 1, S10–s15. 10.1016/j.jcjd.2017.10.003
   PubMed Web of Science ®Google Scholar
• Cole, J. B.; Florez, J. C. Genetics of Diabetes Mellitus and Diabetes Complications. Nat. Rev. Nephrol. 2020, 16(7), 377–390. DOI: 10.1038/s41581-020-0278-5.
   PubMed Web of Science ®Google Scholar
• Zheng, Y.; Ley, S. H.; Hu, F. B. Global Aetiology and Epidemiology of Type 2 Diabetes Mellitus and its Complications. Nat. Rev. Endocrinol. 2018, 14(2), 88–98. DOI: 10.1038/nrendo.2017.151.
   PubMed Web of Science ®Google Scholar
• Schmidt, A. M. Highlighting Diabetes Mellitus: The Epidemic Continues. Arterioscler Thromb. Vasc. Biol. 2018, 38(1), e1–e8. DOI: 10.1161/ATVBAHA.117.310221.
   PubMed Web of Science ®Google Scholar
• Galicia-Garcia, U.; Benito-Vicente, A.; Jebari, S.; Larrea-Sebal, A.; Siddiqi, H.; Uribe, K. B.; Ostolaza, H.; Martín, C. Pathophysiology of Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2020, 21(17), 17. DOI: 10.3390/ijms21176275.
   Web of Science ®Google Scholar
• Jayachandran, M.; Vinayagam, R.; Xu, B. Guava Leaves Extract Ameliorates STZ Induced Diabetes Mellitus via Activation of PI3K/AKT Signaling in Skeletal Muscle of Rats. Mol. Biol. Rep. 2020, 47(4), 2793–2799. DOI: 10.1007/s11033-020-05399-2.
   PubMed Web of Science ®Google Scholar
• Jiao, Y.; Zhang, M.; Wang, S.; Yan, C. Consumption of Guava May Have Beneficial Effects in Type 2 Diabetes: A Bioactive Perspective. Int. J. Biol. Macromol. 2017, 101, 543–552. DOI: 10.1016/j.ijbiomac.2017.03.130.
   PubMed Web of Science ®Google Scholar
• Yang, Q.; Wen, Y.-M.; Shen, J.; Chen, -M.-M.; Wen, J.-H.; Li, Z.-M.; Liang, Y.-Z.; Xia, N. Guava Leaf Extract Attenuates Insulin Resistance via the PI3K/Akt Signaling Pathway in a Type 2 Diabetic Mouse Model. Diabetes Metab. Syndr. Obes. 2020, 13, 713–718. DOI: 10.2147/DMSO.S231979.
   PubMed Web of Science ®Google Scholar
• Farinazzi-Machado, F. M. V.; Elen, L.; Guiguer, G.; Barbalho, R. M.; Souza, M. D. S. S. D.; Bueno, P. C. S.; Mendes, C. G.; Araújo, A. C.; Rodrigues, R. R. T.; Lima, L. M., et al. Effects of Psidium Guajava on the Metabolic Profile of Wister Rats. J. Med. Plants Res. 2012, 6, 3450–3454.
   Google Scholar
• Vinayagam, R.; Jayachandran, M.; Chung, S. S. M.; Xu, B. Guava Leaf Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via AMPK/ACC Signaling Pathways in Streptozotocin-induced Diabetic Rats. Biomed. Pharmacother. 2018, 103, 1012–1017. DOI: 10.1016/j.biopha.2018.04.127.
   PubMed Web of Science ®Google Scholar
• Francula-Zaninovic, S.; Nola, I. A. Management of Measurable Variable Cardiovascular Disease’ Risk Factors. Curr. Cardiol. Rev. 2018, 14(3), 153–163. DOI: 10.2174/1573403X14666180222102312.
   PubMed Web of Science ®Google Scholar
• Van Camp, G. Cardiovascular Disease Prevention. Acta Clin Belg. 2014, 69(6), 407–411. DOI: 10.1179/2295333714Y.0000000069.
   Google Scholar
• Fuchs, F. D.; Whelton, P. K. High Blood Pressure and Cardiovascular Disease. Hypertension. 2020, 75(2), 285–292. DOI: 10.1161/HYPERTENSIONAHA.119.14240.
   PubMed Web of Science ®Google Scholar
• Katsimardou, A.; Imprialos, K.; Stavropoulos, K.; Sachinidis, A.; Doumas, M.; Athyros, V. Hypertension in Metabolic Syndrome: Novel Insights. Curr. Hypertens. Rev. 2020, 16(1), 12–18. DOI: 10.2174/1573402115666190415161813.
   PubMed Web of Science ®Google Scholar
• Oparil, S.; Acelajado, M. C.; Bakris, G. L.; Berlowitz, D. R.; Cífková, R.; Dominiczak, A. F.; Grassi, G.; Jordan, J.; Poulter, N. R.; Rodgers, A., et al. Hypertension. Nat. Rev. Dis. Primers. 2018, 4(1), 18014. DOI: 10.1038/nrdp.2018.14.
   PubMedGoogle Scholar
• Perumareddi, P. Prevention of Hypertension Related to Cardiovascular Disease. Prim Care. 2019, 46(1), 27–39. DOI: 10.1016/j.pop.2018.10.005.
   PubMed Web of Science ®Google Scholar
• Piskorz, D. Hypertensive Mediated Organ Damage and Hypertension Management. How to Assess Beneficial Effects of Antihypertensive Treatments? High Blood Press Cardiovasc Prev. 2020, 27(1), 9–17. DOI: 10.1007/s40292-020-00361-6.
   Google Scholar
• Unger, T.; Borghi, C.; Charchar, F.; Khan, N. A.; Poulter, N. R.; Prabhakaran, D.; Ramirez, A.; Schlaich, M.; Stergiou, G. S.; Tomaszewski, M., et al. International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020, 75(6), 1334–1357. DOI: 10.1161/HYPERTENSIONAHA.120.15026.
   PubMed Web of Science ®Google Scholar
• Ojewole, J. A. Hypoglycemic and Hypotensive Effects of Psidium Guajava Linn. (Myrtaceae) Leaf Aqueous Extract. Methods Find. Exp. Clin. Pharmacol. 2005, 27(10), 689–695. DOI: 10.1358/mf.2005.27.10.948917.
   PubMedGoogle Scholar
• Irondi, E. A.; Agboola, S. O.; Oboh, G.; Boligon, A. A.; Athayde, M. L.; Shode, F. O. Guava Leaves Polyphenolics-rich Extract Inhibits Vital Enzymes Implicated in Gout and Hypertension in Vitro. J. Intercult. Ethnopharmacol. 2016, 5(2), 122–130. DOI: 10.5455/jice.20160321115402.
   PubMed Web of Science ®Google Scholar
• Ahmed, M. H.; Aldesouki, H. M.; Badria, F. A. Effect of Phenolic Compounds from the Leaves of Psidium Guajava on the Activity of Three Metabolism-related Enzymes. Biotechnol. Appl. Biochem. 2021, 68(3), 497–512. DOI: 10.1002/bab.1956.
   PubMed Web of Science ®Google Scholar
• Berman, A. N.; Blankstein, R. Optimizing Dyslipidemia Management for the Prevention of Cardiovascular Disease: A Focus on Risk Assessment and Therapeutic Options. Curr. Cardiol. Rep. 2019, 21(9), 110. DOI: 10.1007/s11886-019-1175-z.
   PubMed Web of Science ®Google Scholar
• Brito, A.; Lima, G. M.; Farias, L. M.; Rodrigues, L.; Carvalho, V. B. L.; Pereira, C. F. C.; Frota, K. M. G.; Conde-Júnior, A. M.; Silva, A. M. O.; Rizzo, M. D. S., et al. Lycopene-Rich Extract from Red Guava (Psidium Guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters. Nutrients. 2019, 11(2), 393.
   PubMed Web of Science ®Google Scholar
• Echouffo-Tcheugui, J. B.; Jain, M.; Cheng, S. Breaking through the Surface: More to Learn about Lipids and Cardiovascular Disease. J. Clin. Invest. 2020, 130(3), 1084–1086. DOI: 10.1172/JCI134696.
   PubMed Web of Science ®Google Scholar
• Ference, B. A.; Graham, I.; Tokgozoglu, L.; Catapano, A. L. Impact of Lipids on Cardiovascular Health: JACC Health Promotion Series. J Am Coll Cardiol. 2018, 72(10), 1141–1156.
   PubMed Web of Science ®Google Scholar
• Mamun, M. A. A.; Faruk, M.; Rahman, M. M.; Nahar, K.; Kabir, F.; Alam, M. A.; Subhan, N. High Carbohydrate High Fat Diet Induced Hepatic Steatosis and Dyslipidemia Were Ameliorated by Psidium Guajava Leaf Powder Supplementation in Rats. Evid. Based Complement. Alternat. Med. 2019, 2019, 1897237. DOI: 10.1155/2019/1897237.
   PubMed Web of Science ®Google Scholar
• Mourikis, P.; Zako, S.; Dannenberg, L.; Nia, A. M.; Heinen, Y.; Busch, L.; Richter, H.; Hohlfeld, T.; Zeus, T.; Kelm, M., et al. Lipid Lowering Therapy in Cardiovascular Disease: From Myth to Molecular Reality. Pharmacol. Ther. 2020, 213, 107592. DOI: 10.1016/j.pharmthera.2020.107592.
   PubMed Web of Science ®Google Scholar
• Pownall, H. J.; Gotto, A. M., Jr. Lipids and Cardiovascular Disease: Putting It All Together. Methodist Debakey Cardiovasc. J. 2019, 15(1), 5–8. DOI: 10.14797/mdcj-15-1-5.
   PubMedGoogle Scholar
• Siri-Tarino, P. W.; Krauss, R. M. Diet, Lipids, and Cardiovascular Disease. Curr. Opin. Lipidol. 2016, 27(4), 323–328. DOI: 10.1097/MOL.0000000000000310.
   PubMed Web of Science ®Google Scholar
• Zhu, Y.; Bo, Y.; Liu, Y. Dietary Total Fat, Fatty Acids Intake, and Risk of Cardiovascular Disease: A Dose-response Meta-analysis of Cohort Studies. Lipids Health Dis. 2019, 18(1), 91. DOI: 10.1186/s12944-019-1035-2.
   PubMedGoogle Scholar
• Chiwororo, W. D.; Ojewole, J. A. Biphasic Effect of Psidium Guajava Linn. (Myrtaceae) Leaf Aqueous Extract on Rat Isolated Vascular Smooth Muscles. J. Smooth Muscle Res. 2008, 44(6), 217–229. DOI: 10.1540/jsmr.44.217.
   PubMedGoogle Scholar
• Díaz-de-cerio, E.; Rodríguez-Nogales, A.; Algieri, F.; Romero, M.; Verardo, V.; Segura-Carretero, A.; Duarte, J.; Galvez, J. The Hypoglycemic Effects of Guava Leaf (Psidium Guajava L.) Extract are Associated with Improving Endothelial Dysfunction in Mice with Diet-induced Obesity. Food Res. Int. 2017, 96, 64–71. DOI: 10.1016/j.foodres.2017.03.019.
   PubMed Web of Science ®Google Scholar
• Soman, S.; Rajamanickam, C.; Rauf, A. A.; Indira, M. Beneficial Effects of Psidium Guajava Leaf Extract on Diabetic Myocardium. Exp. Toxicol. Pathol. 2013, 65(1–2), 91–95. DOI: 10.1016/j.etp.2011.06.005.
   PubMedGoogle Scholar
• Soman, S.; Rajamanickam, C.; Rauf, A. A.; Madambath, I. Molecular Mechanisms of the Antiglycative and Cardioprotective Activities of Psidium Guajava Leaves in the Rat Diabetic Myocardium. Pharm. Biol. 2016, 54(12), 3078–3085. DOI: 10.1080/13880209.2016.1207090.
   PubMed Web of Science ®Google Scholar
• Yamashiro, S.; Noguchi, K.; Matsuzaki, T.; Miyagi, K.; Nakasone, J.; Sakanashi, M.; Sakanashi, M.; Kukita, I.; Aniya, Y.; Sakanashi, M. Cardioprotective Effects of Extracts from Psidium Guajava L and Limonium Wrightii, Okinawan Medicinal Plants, against Ischemia-reperfusion Injury in Perfused Rat Hearts. Pharmacology. 2003, 67(3), 128–135. DOI: 10.1159/000067799.
   PubMed Web of Science ®Google Scholar
• Birner, P.; Prager, G.; Streubel, B. Molecular Pathology of Cancer: How to Communicate with Disease. ESMO Open. 2016, 1(5), e000085. DOI: 10.1136/esmoopen-2016-000085.
   PubMedGoogle Scholar
• Correa, M. G.; Couto, J. S.; Trindade, B. B.; Abreu, J. P.; Nakajima, V. M.; Oliveira, F. L.; Farah, A.; Teodoro, A. J. Antiproliferative Effect of Guava Fruit Extracts in MDA-MB-435 and MCF-7 Human Breast Cancer Cell Lines. An Acad Bras Cienc. 2020, 92(2), e20191500. DOI: 10.1590/0001-3765202020191500.
   Google Scholar
• Harris, T. J.; McCormick, F. The Molecular Pathology of Cancer. Nat. Rev. Clin. Oncol. 2010, 7(5), 251–265. DOI: 10.1038/nrclinonc.2010.41.
   PubMed Web of Science ®Google Scholar
• Lewandowska, A. M.; Rudzki, M.; Rudzki, S.; Lewandowski, T.; Laskowska, B. Environmental Risk Factors for Cancer - Review Paper. Ann. Agric. Environ. Med. 2019, 26(1), 1–7. DOI: 10.26444/aaem/94299.
   PubMed Web of Science ®Google Scholar
• Torre, L. A.; Siegel, R. L.; Ward, E. M.; Jemal, A. Global Cancer Incidence and Mortality Rates and Trends–An Update. Cancer Epidemiol. Biomarkers Prev. 2016, 25(1), 16–27. DOI: 10.1158/1055-9965.EPI-15-0578.
   PubMed Web of Science ®Google Scholar
• Polinati, R. M.; Teodoro, A. J.; Correa, M. G.; Casanova, F. A.; Passos, C. L. A.; Silva, J. L.; Fialho, E. Effects of Lycopene from Guava (Psidium Guajava L.) Derived Products on Breast Cancer Cells. Nat. Prod. Res. 2021, 1–4.
   Google Scholar
• Lin, H. C.; Lin, J. Y. GSF3, a Polysaccharide from Guava (Psidium Guajava L.) Seeds, Inhibits MCF-7 Breast Cancer Cell Growth via Increasing Bax/Bcl-2 Ratio or Fas mRNA Expression Levels. Int. J. Biol. Macromol. 2020, 161, 1261–1271. DOI: 10.1016/j.ijbiomac.2020.06.057.
   PubMed Web of Science ®Google Scholar
• Lin, H.-C.; Lin, J.-Y. Pharmacological Effects of Guava (Psidium Guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy in Vitro. Int. J. Mol. Sci. 2021, 22(7), 3631. DOI: 10.3390/ijms22073631.
   PubMed Web of Science ®Google Scholar
• Wu, P.; Meng, X.; Zheng, H.; Zeng, Q.; Chen, T.; Wang, W.; Zhang, X.; Su, J. Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of its Induction of Apoptosis on Bladder Cancer. Molecules. 2018, 23(10), 10. DOI: 10.3390/molecules23102592.
   Web of Science ®Google Scholar
• Zhu, X.; Ouyang, W.; Pan, C.; Gao, Z.; Han, Y.; Song, M.; Feng, K.; Xiao, H.; Cao, Y. Identification of a New Benzophenone from Psidium Guajava L. Leaves and its Antineoplastic Effects on Human Colon Cancer Cells. Food Funct. 2019, 10(7), 4189–4198. DOI: 10.1039/C9FO00569B.
   PubMed Web of Science ®Google Scholar
• Hirudkar, J. R.; Parmar, K. M.; Prasad, R. S.; Sinha, S. K.; Jogi, M. S.; Itankar, P. R.; Prasad, S. K. Quercetin a Major Biomarker of Psidium Guajava L. Inhibits SepA Protease Activity of Shigella Flexneri in Treatment of Infectious Diarrhoea. Microb Pathog. 2020, 138, 103807. Doi:10.1016/j.micpath.2019.103807.
   Google Scholar
• Hirudkar, J. R.; Parmar, K. M.; Prasad, R. S.; Sinha, S. K.; Lomte, A. D.; Itankar, P. R.; Prasad, S. K. The Antidiarrhoeal Evaluation of Psidium Guajava L. Against Enteropathogenic Escherichia Coli Induced Infectious Diarrhoea. J. Ethnopharmacol. 2020, 251, 112561. DOI: 10.1016/j.jep.2020.112561.
   PubMed Web of Science ®Google Scholar
• Morais-Braga, M. F. B.; Sales, D. L.; Carneiro, J. N. P.; Machado, A. J. T.; Dos Santos, A. T. L.; de Freitas, M. A.; Martins, G.; Leite, N. F.; de Matos, Y.; Tintino, S. R., et al. Psidium Guajava L. And Psidium Brownianum Mart Ex DC.: Chemical Composition and Anti - Candida Effect in Association with Fluconazole. Microb Pathog. 2016, 95, 200–207.
   Google Scholar
• Patel, P.; Joshi, C.; Birdi, T.; Kothari, V. Anti-infective Efficacy of Psidium Guajava L. Leaves against Certain Pathogenic Bacteria. F1000Res. 2019, 8, 12. DOI: 10.12688/f1000research.17500.1.
   PubMedGoogle Scholar
• Piña-Vázquez, D. M.; Mayoral-Peña, Z.; Gómez-Sánchez, M.; Salazar-Olivo, L. A.; Arellano-Carbajal, F. Anthelmintic Effect of Psidium Guajava and Tagetes Erecta on Wild-type and Levamisole-resistant Caenorhabditis Elegans Strains. J. Ethnopharmacol. 2017, 202, 92–96. DOI: 10.1016/j.jep.2017.03.004.
   PubMed Web of Science ®Google Scholar
• Singh, G. In RECENT DEVELOPMENT IN PRODUCTION OF GUAVA; International Society for Horticultural Science (ISHS: Leuven, Belgium, 2007; pp 161–176.
   Google Scholar
• Duke Omayio, G.; Abong, G.; Okoth, M.; Gachuiri, C.; Mwang’ombe, A. Trends and Constraints in Guava (Psidium Guajava L.) Production, Utilization, Processing and Preservation in Kenya. Int. J. Fruit Sci. 2020, 20, 1–12.
   Web of Science ®Google Scholar
• Vitti, K.; Lima, L.; Filho, J. Agricultural and Economic Characterization of Guava Production in Brazil. Rev. Bras. Frutic. 2020, 42.
   Google Scholar
• Duke Omayio, G.; Abong, G.; Okoth, M.; Gachuiri, C.; Mwang’ombe, A. Current Status of Guava (Psidium Guajava L) Production, Utilization, Processing and Preservation in Kenya: A Review. Curr. Agric. Res. J. 2019, 7(3), 318–331. DOI: 10.12944/CARJ.7.3.07.
   Google Scholar
• Pommer, C. V.; Murakami, K. R. N. Breeding Guava (Psidium Guajava L.). In Breeding Plantation Tree Crops: Tropical Species; Jain, S.M., Priyadarshan, P.M., Eds.; Springer New York: New York, 2009; pp 83–120.
   Google Scholar
• Maurya, A. Development of Dietary Fibre Rich Yoghurt and Biscuits Using Guava Seed Powder, 2016.
   Google Scholar
• Khalifa, I.; Barakat, H.; Ha, E.-M.; Sa, S. Influencing of Guava Processing Residues Incorporation on Cupcake Characterization. J. Nutr. Food Sci. 2016, 6, 513–521.
   Google Scholar
• El-safy, S.; Salem, R.; Abd El-Ghany, M. Chemical and Nutritional Evaluation of Different Seed Flours as Novel Sources of Protein. World J. Dairy Food Sci. 2012, 7, 59–65.
   Google Scholar
• Lim, S. Y.; Tham, P. Y.; Lim, H. Y. L.; Heng, W. S.; Chang, Y. P. Potential Functional Byproducts from Guava Purée Processing. J. Food Sci. 2018, 83(6), 1522–1532. DOI: 10.1111/1750-3841.14155.
   PubMed Web of Science ®Google Scholar
• Angulo-López, J. E.; Flores-Gallegos, A. C.; Torres-León, C.; Ramírez-Guzmán, K. N.; Martínez, G. A.; Aguilar, C. N. Guava (Psidium Guajava L.) Fruit and Valorization of Industrialization By-Products. Processes. 2021, 9(6), 1075. DOI: 10.3390/pr9061075.
   Web of Science ®Google Scholar
• Kapoor, S. Extraction and Characterization of Guava Seed Oil: A Novel Industrial Byproduct. Lebensmittel-Wissenschaft + [i.e. und] Technologie. 2020, v. 132, 2020.
   Web of Science ®Google Scholar
• Torres-León, C.; Ramírez-Guzman, N.; Londoño-Hernandez, L.; Martinez-Medina, G. A.; Díaz-Herrera, R.; Navarro-Macias, V.; Alvarez-Pérez, O. B.; Picazo, B.; Villarreal-Vázquez, M.; Ascacio-Valdes, J., et al. Food Waste and Byproducts: An Opportunity to Minimize Malnutrition and Hunger in Developing Countries. Front. Sust. Food Syst. 2018, 2, 52. DOI: 10.3389/fsufs.2018.00052.
   Google Scholar
• Angulo-López, J. E.; Flores-Gallegos, A. C.; Torres-León, C.; Ramírez-Guzmán, K. N.; Martínez, G. A.; Aguilar, C. N. Guava (Psidium Guajava L.) Fruit and Valorization of Industrialization By-Products. Processes. 2021, 9(6), 6. DOI: 10.3390/pr9061075.
   Web of Science ®Google Scholar
• Chiari-Andréo, B.; Trovatti, E.; Marto, J.; Almeida-Cincotto, M.; Melero, A.; Corrêa, M.; Chiavacci, L.; Ribeiro, H.; Garrigues, T.; Isaac, V. Guava: Phytochemical Composition of a Potential Source of Antioxidants for Cosmetic And/or Dermatological Applications. Braz. J. Pharm. Sci. 2017, 53.
   Google Scholar
• Mota, M. D.; Costa, R. Y. S.; Guedes, A. A. S.; Silva, L.; Chinalia, F. A. Guava-fruit Extract Can Improve the UV-protection Efficiency of Synthetic Filters in Sun Cream Formulations. J. Photochem. Photobiol. B. 2019, 201, 111639. DOI: 10.1016/j.jphotobiol.2019.111639.
   PubMed Web of Science ®Google Scholar
• Qa’dan, F.; Thewaini, A.-J.; Ali, D. A.; Afifi, R.; Elkhawad, A.; Matalka, K. Z. The Antimicrobial Activities of Psidium Guajava and Juglans Regia Leaf Extracts to Acne-Developing Organisms. Am. J. Chin. Med. 2005, 33(2), 197–204. DOI: 10.1142/S0192415X05002783.
   PubMed Web of Science ®Google Scholar
• Olatunde, O. O.; Tan, S. L. D.; Shiekh, K. A.; Benjakul, S.; Nirmal, N. P. Ethanolic Guava Leaf Extracts with Different Chlorophyll Removal Processes: Anti-melanosis, Antibacterial Properties and the Impact on Qualities of Pacific White Shrimp during Refrigerated Storage. Food Chem. 2021, 341(Pt 2), 128251. DOI: 10.1016/j.foodchem.2020.128251.
   PubMedGoogle Scholar
• Tran, T. T. T.; Ton, N. M. N.; Nguyen, T. T.; Le, V. V. M.; Sajeev, D.; Schilling, M. W.; Dinh, T. T. N. Application of Natural Antioxidant Extract from Guava Leaves (Psidium Guajava L.) In Fresh Pork Sausage. Meat Sci. 2020, 165, 108106. DOI: 10.1016/j.meatsci.2020.108106.
   PubMed Web of Science ®Google Scholar
• Verma, A. K.; Rajkumar, V.; Banerjee, R.; Biswas, S.; Das, A. K. Guava (Psidium Guajava L.) Powder as an Antioxidant Dietary Fibre in Sheep Meat Nuggets. Asian-australas. J. Anim. Sci. 2013, 26(6), 886–895. DOI: 10.5713/ajas.2012.12671.
   PubMed Web of Science ®Google Scholar
• Nikhanj, P.; Kocher, G. Fermentative Production of Guava-Wine (Psidium Guajava L.) Using S. Cerevisiae MTCC 11815. Curr. Nutr. Food Sci. 2015, 11.
   Google Scholar
• Del’Arco, A.; Sylos, C. Effect of Industrial Processing for Obtaining Guava Paste on the Antioxidant Compounds of Guava (Psidium Guajava L.) ‘Paluma’ Cv. Rev. Bras. Frutic. 2018, 40.
   Google Scholar
• Casarotti, S. N.; Borgonovi, T. F.; Batista, C. L. F. M.; Penna, A. L. B. Guava, Orange and Passion Fruit By-products: Characterization and its Impacts on Kinetics of Acidification and Properties of Probiotic Fermented Products. LWT. 2018, 98, 69–76. DOI: 10.1016/j.lwt.2018.08.010.
   Web of Science ®Google Scholar
• Araújo, C. M.; Sampaio, K. B.; Menezes, F.; Almeida, E.; Lima, M. D. S.; Viera, V. B.; Garcia, E. F.; Gómez-Zavaglia, A.; de Souza, E. L.; de Oliveira, M. E. G. Protective Effects of Tropical Fruit Processing Coproducts on Probiotic Lactobacillus Strains during Freeze-Drying and Storage. Microorganisms. 2020, 8(1), 1. DOI: 10.3390/microorganisms8010096.
   Web of Science ®Google Scholar
• Martínez, Y.; Bertot, R.; Olmo-González, C.; Valdivie, M. Phytobiotic Effect of Psidium Guajava Leaf Powder on Productivity and Quality of the Egg of Laying Hens. Cuban J Agricult Sci. 2020, 54, 1–12.
   Google Scholar
• Lira, R.; Rabello, C.; Ferreira, P.; Lana, G.; Ludke, J. V.; Moreira, D. Inclusion of Guava Wastes in Feed for Broiler Chickens. Revista Brasileira de Zootecnia-brazilian Journal of Animal Science - REV BRAS ZOOTECN. 2009, 38.
   Google Scholar
• Santos, W.; Cruz, G.; Costa, R.; Ribeiro, N.; Filho, E.; Sousa, S.; Justino, E.; Santos, D. Production and Quality of Cheese and Milk of Goats Fed with Guava Agroindustrial Waste (Psidium Guajava L.). Food Sci. Technol. 2021.
   Web of Science ®Google Scholar
• Caicedo, Q.; O., W.; Ferreira, F.; Quintana, M.; Crespo, Y.; Silva Neta, C.; Motta Ferreira, W. Guava (Psidium Guajava L.) Leaf Meal and Cooked Extract in Post-weaning Piglets’ Diets Improve Production Rates and Control the Incidence of Diarrhea. Livestock Res. Rural Dev. 2021, 33.
   Google Scholar
• K. Iha, O.; Martins, G.; Ehlert, E.; A. Montenegro, M.; R. Sucupira, R.; Suarez, Z. Extraction and Characterization of Passion Fruit and Guava Oils from Industrial Residual Seeds and their Application as Biofuels. J. Braz. Chem. Soc. 2018, 29.
   Google Scholar
• Darmasiwi, S.; Herawati, O.; Retnaningrum, E. Edible Biofilm Formation from Guava Seed Waste Fermentation Phys Sci Eng. 2018, 1 39–43 .
   Google Scholar
• Wongsanao, T.; Leemingsawat, W.; Panapisal, V.; Kritpet, T. Thermoregulatory Effects of Guava Leaf Extract-menthol Toner Application for Post-exercise Use. Pharm. Biol. 2021, 59(1), 854–859. DOI: 10.1080/13880209.2021.1942925.
   PubMed Web of Science ®Google Scholar
• Ramos-Vargas, S.; Alfaro-Cuevas-Villanueva, R.; Huirache-Acuña, R.; Cortés-Martínez, R. Removal of Fluoride and Arsenate from Aqueous Solutions by Aluminum-modified Guava Seeds. Appl. Sci. 2018, 8(10), 1807. DOI: 10.3390/app8101807.
   Google Scholar
• Wang, L.; Luo, Y.; Wu, Y.; Wu, Z. Impact of Fermentation Degree on Phenolic Compositions and Bioactivities during the Fermentation of Guava Leaves with Monascus Anka and Bacillus Sp. J. Funct. Foods. 2018, 41, 183–190. DOI: 10.1016/j.jff.2017.12.044.
   Web of Science ®Google Scholar
• Ravindranath, D.; O V, N. Antimicrobial Plant Extract Incorporated Gelatin Beads for Potential Application in Pharmaceutical Industry. Biotechnol. Res. 2016, 2, 11–14.
   Google Scholar
• Manekeng, H. T.; Mbaveng, A. T.; Ntyam Mendo, S. A.; Agokeng, A. D.; Kuete, V. Evaluation of Acute and Subacute Toxicities of Psidium Guajava Methanolic Bark Extract: A Botanical with in Vitro Antiproliferative Potential. Evid. Based Complement. Alternat. Med. 2019, 2019, 8306986. DOI: 10.1155/2019/8306986.
   PubMed Web of Science ®Google Scholar
• Morais-Braga, M. F. B.; Carneiro, J. N. P.; Machado, A. J. T.; Dos Santos, A. T. L.; Sales, D. L.; Lima, L. F.; Figueredo, F. G.; Coutinho, H. D. M. J. J. O. E., Psidium Guajava L., From Ethnobiology to Scientific Evaluation: Elucidating Bioactivity against Pathogenic Microorganisms. J Ethnopharmacol. 2016, 194, 1140–1152.
   PubMed Web of Science ®Google Scholar
• Teixeira, R. D. O.; Camparoto, M. L.; Mantovani, M. S.; Vicentini, V. E. P. J. G.; Biology, M. Assessment of Two Medicinal Plants, Psidium Guajava L. And Achillea Millefolium L., In In Vitro and in Vivo Assays. Genet. Mol. Biol. 2003, 26, 551–555.
   Web of Science ®Google Scholar
• Grover, I.; Bala, S. J. M. R. G. T. Studies on Antimutagenic Effects of Guava (Psidium Guajava) in Salmonella Typhimurium. Mutat Res. 1993, 300(1), 1–3. DOI: 10.1016/0165-1218(93)90133-x.
   PubMedGoogle Scholar
• Ojewole, J. A.; Awe, E. O.; Chiwororo, W. D. J. J. O. S. M. R. Antidiarrhoeal Activity of Psidium Guajava Linn.(Myrtaceae) Leaf Aqueous Extract in Rodents. J Smooth Muscle Res. 2008, 44(6), 195–207.
   PubMedGoogle Scholar
• Etuk, E.; Francis, U. J. P. J. O. B. S. 2003 Acute Toxicity and Efficacy of Psidium Guajava Leaves Water Extract on Salmonella Typhi Infected Wistar Rats. Pakistan Journal of Biological Sciences 6(3) . 195–197.
   Google Scholar
• Dutta, S.; Das, S. J. P. R. A Study of the Anti-inflammatory Effect of the Leaves of Psidium Guajava Linn. On Experimental Animal Models. Pharmacognosy Res. 2010, 2(5), 313. DOI: 10.4103/0974-8490.72331.
   PubMedGoogle Scholar