The Pros and Cons of Soybean Bioactive Compounds: An Overview

References

• Friedman, M.; Brandon, D. L. Nutritional and Health Benefits of Soy Proteins. J. Agric. Food Chem. 2001, 49(3), 1069–1086. DOI: 10.1021/jf0009246.
   PubMed Web of Science ®Google Scholar
• Lee, K. J.; Baek, D.-Y.; Lee, G.-A.; Cho, G.-T.; So, Y.-S.; Lee, J.-R.; Ma, K.-H.; Chung, J.-W.; Hyun, D. Y. Phytochemicals and Antioxidant Activity of Korean Black Soybean (Glycine Max L.) Landraces. Antioxidants. 2020, 9(3), 213. DOI: 10.3390/antiox9030213.
   Web of Science ®Google Scholar
• Lu, Y.-B., and C, P.A.N. Research Progress of Soybean Functional Factors [J]. Modern Food Sci. Technol. 2007, 2, 105–108. DOI: 10.13982/j.mfst.1673-9078.2007.02.036.
   Google Scholar
• Li, Y.; Guan, R.; Liu, Z.; Ma, Y.; Wang, L.; Li, L.; Lin, F.; Luan, W.; Chen, P.; Yan, Z. Genetic Structure and Diversity of Cultivated Soybean (Glycine Max (L.) Merr.) Landraces in China. Theor. Appl. Genet. 2008, 117(6), 857–871. DOI: 10.1007/s00122-008-0825-0.
   PubMed Web of Science ®Google Scholar
• Qiu, L., and Chang, R.The Origin and History of SoybeanThe Soybean: Botany, Production and Uses. In Singh, G. (Ed.), CAB International, Cambridge, MA. 2010; pp 1–23.
   Google Scholar
• Vernaza, M. G.; Schmiele, M.; Paucar-Menacho, L. M.; Steel, C. J., and Chang, Y. K. Brazilian Soybean Products: Functional Properties and Bioactive Compounds. In Hispanic Foods: Chemistry and Bioactive Compounds 16. In Tunick, M. H, de Mejía, G. (Eds.), Washington, DC, ACSSymposium Series; American Chemical Society; 2012, pp 259–277. DOI: 10.1021/bk-2012-1109.ch016.
   Google Scholar
• Feng, J.-Y.; Wang, R.; Thakur, K.; Ni, Z.-J.; Zhu, Y.-Y.; Hu, F.; Zhang, J.-G.; Wei, Z.-J. Evolution of Okara from Waste to Value Added Food Ingredient: An Account of Its Bio-Valorization for Improved Nutritional and Functional Effects. Trends Food Sci. Technol. 2021, 116, 669–680. DOI: 10.1016/j.tifs.2021.08.011.
   Web of Science ®Google Scholar
• Swallah, M. S.; Yu, H.; Piao, C.; Fu, H.; Yakubu, Z., and Sossah, F. L. Synergistic Two-Way Interactions of Dietary Polyphenols and Dietary Components on the Gut Microbial Composition: Is There a Positive, Negative, or Neutralizing Effect in the Prevention and Management of Metabolic Diseases? Curr. Protein Pept. Sci 2021, 22(4), 313–327. DOI: 10.2174/1389203722666210122143840.
   PubMed Web of Science ®Google Scholar
• Messina, M. A Brief Historical Overview of the Past Two Decades of Soy and Isoflavone Research. J. Nutr. 2010, 140(7), 1350S–1354S. DOI: 10.3945/jn.109.118315.
   PubMed Web of Science ®Google Scholar
• Zhu, Y.-Y.; Thakur, K.; Feng, J.-Y.; Cai, J.-S.; Zhang, J.-G.; Hu, F.; Russo, P.; Spano, G.; Wei, Z.-J. Riboflavin-Overproducing Lactobacilli for the Enrichment of Fermented Soymilk: Insights into Improved Nutritional and Functional Attributes. Appl. Microbiol. Biotechnol. 2020, 104(13), 5759–5772. DOI: 10.1007/s00253-020-10649-1.
   PubMed Web of Science ®Google Scholar
• Wu, H.; Zhang, Z.; Huang, H.; Li, Z. Health Benefits of Soy and Soy Phytochemicals. AME Med. J. 2017, 2, 162. DOI: 10.21037/amj.2017.10.04.
   Google Scholar
• Min, S.; Yu, Y.; Martin, S. S. Effect of Soybean Varieties and Growing Locations on the Physical and Chemical Properties of Soymilk and Tofu. J. Food Sci. 2005, 70(1), C8–C21. DOI: 10.1111/j.1365-2621.2005.tb09026.x.
   Web of Science ®Google Scholar
• Kerwin, S. M. Soy Saponins and the Anticancer Effects of Soybeans and Soy-Based Foods. Curr. Med. Chem-Anti-Cancer Agents. 2004, 4(3), 263–272. DOI: 10.2174/1568011043352993.
   PubMedGoogle Scholar
• Hwang, Y. W.; Kim, S. Y.; Jee, S. H.; Kim, Y. N.; Nam, C. M. Soy Food Consumption and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies. Nutr. Cancer. 2009, 61(5), 598–606. DOI: 10.1080/01635580902825639.
   PubMed Web of Science ®Google Scholar
• Prabhakaran, M. P.; Perera, C. O.; Valiyaveettil, S. Quantification of Isoflavones in Soymilk and Tofu from South East Asia. Int. J. Food Prop. 2005, 8(1), 113–123. DOI: 10.1081/JFP-200048055.
   Web of Science ®Google Scholar
• Food Administration, D. Food Labeling Health Claims; Soy Protein and Coronary Heart Disease. Fed. Regist. 1999, 64, 57699–57733.
   Google Scholar
• Nurmi, T.; Mazur, W.; Heinonen, S.; Kokkonen, J.; Adlercreutz, H. Isoflavone Content of the Soy Based Supplements. J. Pharm. Biomed. Anal. 2002, 28(1), 1–11. DOI: 10.1016/S0731-7085(01)00612-4.
   PubMed Web of Science ®Google Scholar
• Anderson, R. L.; Wolf, W. J. Compositional Changes in Trypsin Inhibitors, Phytic Acid, Saponins and Isoflavones Related to Soybean Processing. J. Nutr. 1995, 125(suppl_3), 581S–588S. DOI: 10.1093/jn/125.3_Suppl.581S.
   PubMed Web of Science ®Google Scholar
• Messina, M.; Watanabe, S.; Setchell, K. D. Report on the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment. J. Nutr. 2009, 139(4), 796S–802S. DOI: 10.3945/jn.108.104182.
   PubMed Web of Science ®Google Scholar
• Xiao, C. 22-Functional Foods, Elsevier. In Saarela, M. (Ed.), Sawston, UK, Woodhead Publishing. 2011, pp 534–556. DOI: 10.1533/9780857092557.3.534.
   Google Scholar
• Nakamori, T. Soy Peptides as Functional Food Materials. In Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals. In Mine, Y., Li-Chan, ECY., Jiang, B. (Eds.), Wiley-Blackwell Publishing; 2010, pp 265–271.
   Google Scholar
• Gonzalez-Soto, M.; Abdelmagid, S. A.; Ma, D. W.; El-Sohemy, A.; Mutch, D. M. Soy Consumption, but Not Dairy Consumption, is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults. Nutrients. 2021, 13(8), 2817. DOI: 10.3390/nu13082817.
   PubMed Web of Science ®Google Scholar
• Swallah, M. S.; Fu, H.; Sun, H.; Affoh, R.; Yu, H. The Impact of Polyphenol on General Nutrient Metabolism in the Monogastric Gastrointestinal Tract. J. Food Qual. 2020, 2020, 1–12. DOI: 10.1155/2020/5952834.
   Web of Science ®Google Scholar
• Mariane, L. Soy Isoflavones as Bioactive Ingredients of Functional Foods. Soybean Health. 2011, 1, 329–360. Accessed 20th January 2021.
   Google Scholar
• Garg, S.; Lule, V. K.; Malik, R. K.; Tomar, S. K. Soy Bioactive Components in Functional Perspective: A Review. Int. J. Food Prop. 2016, 19(11), 2550–2574. DOI: 10.1080/10942912.2015.1136936.
   Web of Science ®Google Scholar
• Thakur, A.; Sharma, V.; Thakur, A. An Overview of Anti-Nutritional Factors in Food. Int. J. Chem. Stud. 2019, 7(1), 2472–2479.
   Google Scholar
• Anta, L.; Marina, M. L.; García, M. C. Simultaneous and Rapid Determination of the Anticarcinogenic Proteins Bowman-Birk Inhibitor and Lectin in Soybean Crops by Perfusion RP-HPLC. J. Chromatogr. A. 2010, 1217(45), 7138–7143. DOI: 10.1016/j.chroma.2010.09.026.
   PubMed Web of Science ®Google Scholar
• Hall, C.; Hillen, C.; Garden Robinson, J. Composition, Nutritional Value, and Health Benefits of Pulses. Cereal Chem. 2017, 94(1), 11–31. DOI: 10.1094/CCHEM-03-16-0069-FI.
   Web of Science ®Google Scholar
• Central, F. D. USDA and U.S. Department of Health and Human Services Dietary Guidelines for Americans, 7th ed; Washington, DC: U.S. Government Printing Office, 2010.
   Google Scholar
• Southgate, D. Nature and Variability of Human Food Consumption. Philosophical Trans Royal Soc London. Ser B. 1991, 334(1270), 281–288.
   PubMed Web of Science ®Google Scholar
• Slavin, J. L.; Lloyd, B. Health Benefits of Fruits and Vegetables. Adv. Nutr. 2012, 3(4), 506–516. DOI: 10.3945/an.112.002154.
   PubMed Web of Science ®Google Scholar
• Siriwardhana, N.; Kalupahana, N. S.; Cekanova, M.; LeMieux, M.; Greer, B.; Moustaid-Moussa, N. Modulation of Adipose Tissue Inflammation by Bioactive Food Compounds. J. Nutr. Biochem. 2013, 24(4), 613–623. DOI: 10.1016/j.jnutbio.2012.12.013.
   PubMed Web of Science ®Google Scholar
• Ng, T. B.; Cheung, R. C. F., and Wong, J. H. . In: Board, J. E. , editor. A Comprehensive Survey of International Soybean Research - Genetics, Physiology, Agronomy and Nitrogen Relationships. Biologically Active Constituents of Soybean. London: IntechOpen. 2013, pp 239–260. DOI: 10.5772/52526.
   Google Scholar
• Singh, B.; Yadav, D., and Vij, S. Soybean Bioactive Molecules: Current Trend and Future Prospective. eds., Mérillon, JM., Ramawat, K., Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. 2017, pp 1–29. DOI: 10.1007/978-3-319-78030-6_4.
   Google Scholar
• Chatterjee, C.; Gleddie, S.; Xiao, C.-W. Soybean Bioactive Peptides and Their Functional Properties. Nutrients. 2018, 10(9), 1211. DOI: 10.3390/nu10091211.
   PubMed Web of Science ®Google Scholar
• Zaheer, K.; Humayoun Akhtar, M. An Updated Review of Dietary Isoflavones: Nutrition, Processing, Bioavailability and Impacts on Human Health. Crit. Rev. Food Sci. Nutr. 2017, 57(6), 1280–1293. DOI: 10.1080/10408398.2014.989958.
   PubMed Web of Science ®Google Scholar
• Sakamoto, T.; Horiguchi, H.; Oguma, E.; Kayama, F. Effects of Diverse Dietary Phytoestrogens on Cell Growth, Cell Cycle and Apoptosis in Estrogen-Receptor-Positive Breast Cancer Cells. J. Nutr. Biochem. 2010, 21(9), 856–864. DOI: 10.1016/j.jnutbio.2009.06.010.
   PubMed Web of Science ®Google Scholar
• Andres, S.; Abraham, K.; Appel, K. E.; Lampen, A. Risks and Benefits of Dietary Isoflavones for Cancer. Critical Rev. Toxicol. 2011, 41(6), 463–506. DOI: 10.3109/10408444.2010.541900.
   PubMed Web of Science ®Google Scholar
• Bustamante‐rangel, M.; Delgado‐zamarreño, M. M.; Pérez‐martín, L.; Rodríguez‐gonzalo, E.; Domínguez‐álvarez, J. Analysis of Isoflavones in Foods. Compr. Rev. Food Sci. Food Saf. 2018, 17(2), 391–411. DOI: 10.1111/1541-4337.12325.
   PubMed Web of Science ®Google Scholar
• Swallah, M. S.; Sun, H.; Affoh, R.; Fu, H.; Yu, H. Antioxidant Potential Overviews of Secondary Metabolites (Polyphenols) in Fruits. Int. J. Food Sci. 2020, 2020, 1–8. DOI: 10.1155/2020/9081686.
   Google Scholar
• Swallah, M. S.; Fan, H.; Wang, S.; Yu, H.; Piao, C. Prebiotic Impacts of Soybean Residue (Okara) on Eubiosis/dysbiosis Condition of the Gut and the Possible Effects on Liver and Kidney Functions. Molecules. 2021, 26(2), 326. DOI: 10.3390/molecules26020326.
   PubMed Web of Science ®Google Scholar
• (NCI), N. C. I. Antioxidants and Cancer Prevention; 2017.
   Google Scholar
• Isanga, J.; Zhang, G.-N. Soybean Bioactive Components and Their Implications to Health—a Review. Food Rev. Int. 2008, 24(2), 252–276. DOI: 10.1080/87559120801926351.
   Web of Science ®Google Scholar
• Marazza, J. A.; Garro, M. S.; de Giori, G. S. Aglycone Production by Lactobacillus Rhamnosus CRL981 During Soymilk Fermentation. Food Microbiol. 2009, 26(3), 333–339. DOI: 10.1016/j.fm.2008.11.004.
   PubMed Web of Science ®Google Scholar
• Yun, D.-Y.; Kang, Y.-G.; Kim, M.; Kim, D.; Kim, E.-H.; Hong, Y.-S. Metabotyping of Different Soybean Genotypes and Distinct Metabolism in Their Seeds and Leaves. Food Chem. 2020, 330, 127198. DOI: 10.1016/j.foodchem.2020.127198.
   PubMed Web of Science ®Google Scholar
• Yuksekdag, Z.; Cinar Acar, B.; Aslim, B.; Tukenmez, U. β-Glucosidase Activity and Bioconversion of Isoflavone Glycosides to Aglycones by Potential Probiotic Bacteria. Int. J. Food Prop. 2017, 20(sup3), S2878–S2886. DOI: 10.1080/10942912.2017.1382506.
   Web of Science ®Google Scholar
• Son, S.-H.; Jeon, H.-L.; Yang, S.-J.; Sim, M.-H.; Kim, Y.-J.; Lee, N.-K.; Paik, H.-D. Probiotic Lactic Acid Bacteria Isolated from Traditional Korean Fermented Foods Based on β-Glucosidase Activity. Food Sci. Biotechnol. 2018, 27(1), 123–129. DOI: 10.1007/s10068-017-0212-1.
   PubMed Web of Science ®Google Scholar
• Rekha, C.; Vijayalakshmi, G. Isoflavone Phytoestrogens in Soymilk Fermented with β-Glucosidase Producing Probiotic Lactic Acid Bacteria. Int. J. Food Sci. Nutr. 2011, 62(2), 111–120. DOI: 10.3109/09637486.2010.513680.
   PubMed Web of Science ®Google Scholar
• Kim, I.-S. Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans. Antioxidants. 2021, 10(7), 1064. DOI: 10.3390/antiox10071064.
   Web of Science ®Google Scholar
• Rietjens, I. M.; Sotoca, A. M.; Vervoort, J.; Louisse, J. Mechanisms Underlying the Dualistic Mode of Action of Major Soy Isoflavones in Relation to Cell Proliferation and Cancer Risks. Mol. Nutr. Food Res. 2013, 57(1), 100–113. DOI: 10.1002/mnfr.201200439.
   PubMed Web of Science ®Google Scholar
• Seibold, P.; Vrieling, A.; Johnson, T. S.; Buck, K.; Behrens, S.; Kaaks, R.; Linseisen, J.; Obi, N.; Heinz, J.; Flesch‐janys, D. Enterolactone Concentrations and Prognosis After Postmenopausal Breast Cancer: Assessment of Effect Modification and Meta‐analysis. Int. J. Cancer. 2014, 135(4), 923–933. DOI: 10.1002/ijc.28729.
   PubMed Web of Science ®Google Scholar
• Jungbauer, A.; Medjakovic, S. Phytoestrogens and the Metabolic Syndrome. J. Steroid Biochem. Mol. Biol. 2014, 139, 277–289. DOI: 10.1016/j.jsbmb.2012.12.009.
   PubMed Web of Science ®Google Scholar
• Cederroth, C. R.; Nef, S. Soy, Phytoestrogens and Metabolism: A Review. Mol. Cell. Endocrinol. 2009, 304(1–2), 30–42. DOI: 10.1016/j.mce.2009.02.027.
   PubMed Web of Science ®Google Scholar
• Duncan, A. M.; Phipps, W. R.; Kurzer, M. S. Phyto-Oestrogens. Best Pract. Res. Clin. Endocrinol. Metab. 2003, 17(2), 253–271. DOI: 10.1016/S1521-690X(02)00103-3.
   PubMed Web of Science ®Google Scholar
• Jargin, S. V. Soy and Phytoestrogens: Possible Side Effects. GMS German Med. Sci. 2014, 12. DOI: 10.3205/000203. PMID: 25587246.
   Google Scholar
• Luo, Q.; Cheng, D.; Huang, C.; Li, Y.; Lao, C.; Xia, Y.; Liu, W.; Gong, X.; Hu, D.; Li, B. Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats. Molecules. 2019, 24(6), 1139. DOI: 10.3390/molecules24061139.
   PubMed Web of Science ®Google Scholar
• Masilamani, M.; Wei, J.; Sampson, H. A. Regulation of the Immune Response by Soybean Isoflavones. Immunol. Res. 2012, 54(1–3), 95–110. DOI: 10.1007/s12026-012-8331-5.
   PubMed Web of Science ®Google Scholar
• Millas, I.; Duarte Barros, M. Estrogen Receptors and Their Roles in the Immune and Respiratory Systems. Anat. Rec. 2021, 304(6), 1185–1193. DOI: 10.1002/ar.24612.
   Google Scholar
• Prada, G. Immunosenescence and Inflamm-Ageing. Acta Endocrinologica (18410987). 2014, 10(4).
   Google Scholar
• Bauer, M. E. The Role of Stress and Adrenal Hormones in Immunosenescence. In Bosch, JA., Phillips, AC., Lord, JM. (Eds.), Immunosenescence: Psychosocial and Behavioral Determinants; Springer, New York, NY: Springer, 2013; pp 221–239.
   Google Scholar
• Porter, V.; Greendale, G.; Schocken, M.; Zhu, X.; Effros, R. Immune Effects of Hormone Replacement Therapy in Post-Menopausal Women. Exp. Gerontology. 2001, 36(2), 311–326. DOI: 10.1016/S0531-5565(00)00195-9.
   PubMed Web of Science ®Google Scholar
• Carbonel, A. A. F.; Baracat, M. C. P.; Simoes, R. S.; Simoes, M. J.; Baracat, E. C.; Soares, J. M., Jr. The Soybean Concentrated Extract Proliferates the Vagina of Adult Rats. Menopause. 2011, 18(1), 93–101. DOI: 10.1097/gme.0b013e3181e5ee25.
   PubMed Web of Science ®Google Scholar
• Chiu, T.-M.; Huang, C.-C.; Lin, T.-J.; Fang, J.-Y.; Wu, N.-L.; Hung, C.-F. In vitro and in vivo Anti-Photoaging Effects of an Isoflavone Extract from Soybean Cake. J. Ethnopharmacol. 2009, 126(1), 108–113. DOI: 10.1016/j.jep.2009.07.039.
   PubMed Web of Science ®Google Scholar
• Sethi, S.; Tyagi, S. K.; Anurag, R. K. Plant-Based Milk Alternatives an Emerging Segment of Functional Beverages: A Review. J. Food Sci. Technol. 2016, 53(9), 3408–3423. DOI: 10.1007/s13197-016-2328-3.
   PubMed Web of Science ®Google Scholar
• Wang, B.; Wu, C. Dietary Soy Isoflavones Alleviate Dextran Sulfate Sodium‑induced Inflammation and Oxidative Stress in Mice. Exp. Ther. Med. 2017, 14(1), 276–282. DOI: 10.3892/etm.2017.4469.
   PubMed Web of Science ®Google Scholar
• Noda, S.; Tanabe, S.; Suzuki, T. Differential Effects of Flavonoids on Barrier Integrity in Human Intestinal Caco-2 Cells. J. Agric. Food Chem. 2012, 60(18), 4628–4633. DOI: 10.1021/jf300382h.
   PubMed Web of Science ®Google Scholar
• Blay, M.; Espinel, A.; Delgado, M.; Baiges, I.; Blade, C.; Arola, L.; Salvado, J. Isoflavone Effect on Gene Expression Profile and Biomarkers of Inflammation. J. Pharm. Biomed. Anal. 2010, 51(2), 382–390. DOI: 10.1016/j.jpba.2009.03.028.
   PubMed Web of Science ®Google Scholar
• Seibel, J.; Molzberger, A. F.; Hertrampf, T.; Laudenbach-Leschowski, U.; Diel, P. Oral Treatment with Genistein Reduces the Expression of Molecular and Biochemical Markers of Inflammation in a Rat Model of Chronic TNBS-Induced Colitis. Eur. J. Nutr. 2009, 48(4), 213–220. DOI: 10.1007/s00394-009-0004-3.
   PubMed Web of Science ®Google Scholar
• Dijsselbloem, N.; Goriely, S.; Albarani, V.; Gerlo, S.; Francoz, S.; Marine, J.-C.; Goldman, M.; Haegeman, G.; Berghe, W. V. A Critical Role for P53 in the Control of NF-κB-Dependent Gene Expression in TLR4-Stimulated Dendritic Cells Exposed to Genistein. J. Immunol. 2007, 178(8), 5048–5057. DOI: 10.4049/jimmunol.178.8.5048.
   PubMed Web of Science ®Google Scholar
• Satsu, H.; Hyun, J. S.; Shin, H. S.; Shimizu, M. Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells. J. Nutr. Sci. Vitaminol. 2009, 55(5), 442–446. DOI: 10.3177/jnsv.55.442.
   PubMed Web of Science ®Google Scholar
• Zhang, R.; Xu, J.; Zhao, J.; Chen, Y. Genistein Improves Inflammatory Response and Colonic Function Through NF-κB Signal in DSS-Induced Colonic Injury. Oncotarget. 2017, 8(37), 61385. DOI: 10.18632/oncotarget.18219.
   PubMedGoogle Scholar
• Calvello, R.; Aresta, A.; Trapani, A.; Zambonin, C.; Cianciulli, A.; Salvatore, R.; Clodoveo, M. L.; Corbo, F.; Franchini, C.; Panaro, M. A. Bovine and Soybean Milk Bioactive Compounds: Effects on Inflammatory Response of Human Intestinal Caco-2 Cells. Food Chem. 2016, 210, 276–285. DOI: 10.1016/j.foodchem.2016.04.067.
   PubMed Web of Science ®Google Scholar
• Vagadia, B. H.; Vanga, S. K.; Raghavan, V. Inactivation Methods of Soybean Trypsin Inhibitor–a Review. Trends Food Sci. Technol. 2017, 64, 115–125. DOI: 10.1016/j.tifs.2017.02.003.
   Web of Science ®Google Scholar
• Singh, B. P.; Vij, S.; Hati, S. Functional Significance of Bioactive Peptides Derived from Soybean. Peptides. 2014, 54, 171–179. DOI: 10.1016/j.peptides.2014.01.022.
   PubMed Web of Science ®Google Scholar
• Sarmadi, B. H.; Ismail, A. Antioxidative Peptides from Food Proteins: A Review. Peptides. 2010, 31(10), 1949–1956. DOI: 10.1016/j.peptides.2010.06.020.
   PubMed Web of Science ®Google Scholar
• Chaudhary, A.; Bhalla, S.; Patiyal, S.; Raghava, G. P.; Sahni, G. FermFoodb: A Database of Bioactive Peptides Derived from Fermented Foods. Heliyon. 2021, 7(4), e06668. DOI: 10.1016/j.heliyon.2021.e06668.
   PubMed Web of Science ®Google Scholar
• Jia, L.; Wang, L.; Liu, C.; Liang, Y., and Lin, Q. Bioactive Peptides from Foods: Production, Function, and Application. Food & Function. 2021, 12, 7108–7125.
   PubMed Web of Science ®Google Scholar
• Quintal-Bojórquez, N.; Segura-Campos, M. R. Bioactive Peptides as Therapeutic Adjuvants for Cancer. Nutr. Cancer. 2021, 73(8), 1309–1321. DOI: 10.1080/01635581.2020.1813316.
   PubMed Web of Science ®Google Scholar
• Sanjukta, S.; Rai, A. K. Production of Bioactive Peptides During Soybean Fermentation and Their Potential Health Benefits. Trends Food Sci. Technol. 2016, 50, 1–10. DOI: 10.1016/j.tifs.2016.01.010.
   Web of Science ®Google Scholar
• Agyei, D.; Danquah, M. K. Industrial-Scale Manufacturing of Pharmaceutical-Grade Bioactive Peptides. Biochem. Adv. 2011, 29(3), 272–277. DOI: 10.1016/j.biotechadv.2011.01.001.
   Google Scholar
• Nongonierma, A. B.; FitzGerald, R. J. The Scientific Evidence for the Role of Milk Protein-Derived Bioactive Peptides in Humans: A Review. J. Funct. Foods. 2015, 17, 640–656. DOI: 10.1016/j.jff.2015.06.021.
   Web of Science ®Google Scholar
• Fekete, A. A.; Givens, D. I.; Lovegrove, J. A. The Impact of Milk Proteins and Peptides on Blood Pressure and Vascular Function: A Review of Evidence from Human Intervention Studies. Nutr. Res. Rev. 2013, 26(2), 177–190. DOI: 10.1017/S0954422413000139.
   PubMed Web of Science ®Google Scholar
• Li-Chan, E. C. Bioactive Peptides and Protein Hydrolysates: Research Trends and Challenges for Application as Nutraceuticals and Functional Food Ingredients. Curr. Opin. Food Sci. 2015, 1, 28–37. DOI: 10.1016/j.cofs.2014.09.005.
   Web of Science ®Google Scholar
• Sirtori, C. R.; Galli, C.; Anderson, J. W.; Sirtori, E.; Arnoldi, A. Functional Foods for Dyslipidaemia and Cardiovascular Risk Prevention. Nutr. Res. Rev. 2009, 22(2), 244–261. DOI: 10.1017/S0954422409990187.
   PubMed Web of Science ®Google Scholar
• Lammi, C.; Zanoni, C.; Arnoldi, A.; Vistoli, G. Two Peptides from Soy β-Conglycinin Induce a Hypocholesterolemic Effect in HepG2 Cells by a Statin-Like Mechanism: Comparative in vitro and in silico Modeling Studies. J. Agric. Food Chem. 2015, 63(36), 7945–7951. DOI: 10.1021/acs.jafc.5b03497.
   PubMed Web of Science ®Google Scholar
• Nishi, H.; Higashihara, T.; Inagi, R. Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction. Nutrients. 2019, 11(7), 1664. DOI: 10.3390/nu11071664.
   PubMed Web of Science ®Google Scholar
• Power, O.; Jakeman, P.; FitzGerald, R. Antioxidative Peptides: Enzymatic Production, in vitro and in vivo Antioxidant Activity and Potential Applications of Milk-Derived Antioxidative Peptides. Amino Acids. 2013, 44(3), 797–820. DOI: 10.1007/s00726-012-1393-9.
   PubMed Web of Science ®Google Scholar
• Roopashree, K.; Naik, D. Saponins: Properties, Applications and as Insecticides: A Review. Biosci. Trends. 2019, 8, 1–14.
   Google Scholar
• Guang, C.; Chen, J.; Sang, S.; Cheng, S. Biological Functionality of Soyasaponins and Soyasapogenols. J. Agric. Food Chem. 2014, 62(33), 8247–8255. DOI: 10.1021/jf503047a.
   PubMed Web of Science ®Google Scholar
• He, Y.; Hu, Z.; Li, A.; Zhu, Z.; Yang, N.; Ying, Z.; He, J.; Wang, C.; Yin, S.; Cheng, S. Recent Advances in Biotransformation of Saponins. Molecules. 2019, 24(13), 2365. DOI: 10.3390/molecules24132365.
   PubMed Web of Science ®Google Scholar
• Tsai, C.-Y.; Chen, Y.-H.; Chien, Y.-W.; Huang, W.-H.; Lin, S.-H. Effect of Soy Saponin on the Growth of Human Colon Cancer Cells. World J. Gastroenterol. 2010, 16(27), 3371. DOI: 10.3748/wjg.v16.i27.3371.
   PubMed Web of Science ®Google Scholar
• Juritsch, A. F.; Moreau, R. Role of Soybean-Derived Bioactive Compounds in Inflammatory Bowel Disease. Nutr. Rev. 2018, 76(8), 618–638. DOI: 10.1093/nutrit/nuy021.
   PubMed Web of Science ®Google Scholar
• Lee, I.-A.; Park, Y.-J.; Yeo, H.-K.; Han, M. J.; Kim, D.-H. Soyasaponin I Attenuates TNBS-Induced Colitis in Mice by Inhibiting NF-κB Pathway. J. Agric. Food Chem. 2010, 58(20), 10929–10934. DOI: 10.1021/jf102296y.
   PubMed Web of Science ®Google Scholar
• Kang, J.-H.; Sung, M.-K.; Kawada, T.; Yoo, H.; Kim, Y.-K.; Kim, J.-S.; Yu, R. Soybean Saponins Suppress the Release of Proinflammatory Mediators by LPS-Stimulated Peritoneal Macrophages. Cancer Lett. 2005, 230(2), 219–227. DOI: 10.1016/j.canlet.2004.12.041.
   PubMed Web of Science ®Google Scholar
• Liu, M.-J.; Wang, Z.; Ju, Y.; Wong, R.-N.-S.; Wu, Q.-Y. Diosgenin Induces Cell Cycle Arrest and Apoptosis in Human Leukemia K562 Cells with the Disruption of Ca 2+ Homeostasis. Cancer Chemother. Pharmacol. 2005, 55(1), 79–90. DOI: 10.1007/s00280-004-0849-3.
   PubMed Web of Science ®Google Scholar
• Carbonell‐capella, J. M.; Buniowska, M.; Barba, F. J.; Esteve, M. J.; Frígola, A. Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review. Compr. Rev. Food Sci. Food Saf. 2014, 13(2), 155–171. DOI: 10.1111/1541-4337.12049.
   PubMed Web of Science ®Google Scholar
• Van Buggenhout, S.; Alminger, M.; Lemmens, L.; Colle, I.; Knockaert, G.; Moelants, K.; Van Loey, A.; Hendrickx, M. In vitro Approaches to Estimate the Effect of Food Processing on Carotenoid Bioavailability Need Thorough Understanding of Process Induced Microstructural Changes. Trends Food Sci. Technol. 2010, 21(12), 607–618. DOI: 10.1016/j.tifs.2010.09.010.
   Web of Science ®Google Scholar
• Shahidi, F.; Peng, H. Bioaccessibility and Bioavailability of Phenolic Compounds. J. Food Bioactives. 2018, 4, 11–68. DOI: 10.31665/JFB.2018.4162.
   Google Scholar
• Septembre-Malaterre, A.; Remize, F.; Poucheret, P. Fruits and Vegetables, as a Source of Nutritional Compounds and Phytochemicals: Changes in Bioactive Compounds During Lactic Fermentation. Food Res. Int. 2018, 104, 86–99. DOI: 10.1016/j.foodres.2017.09.031.
   PubMed Web of Science ®Google Scholar
• Bao, C.; Jiang, P.; Chai, J.; Jiang, Y.; Li, D.; Bao, W.; Liu, B.; Liu, B.; Norde, W.; Li, Y. The Delivery of Sensitive Food Bioactive Ingredients: Absorption Mechanisms, Influencing Factors, Encapsulation Techniques and Evaluation Models. Food Res. Int. 2019, 120, 130–140. DOI: 10.1016/j.foodres.2019.02.024.
   PubMed Web of Science ®Google Scholar
• Bohn, T.; McDougall, G. J.; Alegría, A.; Alminger, M.; Arrigoni, E.; Aura, A. M.; Brito, C.; Cilla, A.; El, S. N.; Karakaya, S. Mind the Gap—deficits in Our Knowledge of Aspects Impacting the Bioavailability of Phytochemicals and Their Metabolites—a Position Paper Focusing on Carotenoids and Polyphenols. Mol. Nutr. Food Res. 2015, 59(7), 1307–1323. DOI: 10.1002/mnfr.201400745.
   PubMed Web of Science ®Google Scholar
• Palafox‐carlos, H.; Ayala‐zavala, J. F.; González‐aguilar, G. A. The Role of Dietary Fiber in the Bioaccessibility and Bioavailability of Fruit and Vegetable Antioxidants. J. Food Sci. 2011, 76(1), R6–R15. DOI: 10.1111/j.1750-3841.2010.01957.x.
   PubMed Web of Science ®Google Scholar
• Swallah, M. S.; Yu, H.; Piao, C.; Fu, H.; Yakubu, Z.; Sossah, F. L. Synergistic Two-Way Interactions of Dietary Polyphenols and Dietary Components on the Gut Microbial Composition: Is There a Positive, Negative, or Neutralizing Effect in the Prevention and Management of Metabolic Diseases? Curr. Protein Pept. Sci. 2021, 22(4), 313–327. DOI: 10.2174/1389203722666210122143840.
   PubMed Web of Science ®Google Scholar
• Neilson, A. P.; Ferruzzi, M. G. Influence of Formulation and Processing on Absorption and Metabolism of Flavan-3-Ols from Tea and Cocoa. Annual Review of Food Science and Technology. 2011, 2, 125–151.
   PubMed Web of Science ®Google Scholar
• Mondal, S.; Soumya, N. P. P.; Mini, S.; Sivan, S. K. Bioactive Compounds in Functional Food and Their Role as Therapeutics. Bioact. Compd. Health Dis. 2021, 4(3), 24–39. DOI: 10.31989/bchd.v4i3.786.
   Google Scholar
• Kamble, D. B.; Rani, S. Bioactive Components, in vitro Digestibility, Microstructure and Application of Soybean Residue (Okara): A Review. Legume Sci. 2020, 2(1), e32. DOI: 10.1002/leg3.32.
   Google Scholar
• Bhattacharya, S. Reactive Oxygen Species and Cellular Defense System. In Rani, V, Yadav, U (Eds.), Free Radicals in Human Health and Disease; Springer, 2015; pp 17–29.
   Google Scholar
• Birch‐machin, M.; Bowman, A. Oxidative Stress and Ageing. British J. Dermatol. 2016, 175, 26–29. DOI: 10.1111/bjd.14906.
   PubMed Web of Science ®Google Scholar
• De Rosa, V.; Galgani, M.; Santopaolo, M.; Colamatteo, A.; Laccetti, R.; Matarese, G. In Nutritional Control of Immunity: Balancing the Metabolic Requirements with an Appropriate Immune Function. Seminars Immunol. Elsevier. 2015, 27(5), 300–309. DOI: 10.1016/j.smim.2015.10.001.
   PubMed Web of Science ®Google Scholar
• Chandra, P.; Sharma, R. K.; Arora, D. S. Antioxidant Compounds from Microbial Sources: A Review. Food Res. Int. 2020, 129, 108849. DOI: 10.1016/j.foodres.2019.108849.
   PubMed Web of Science ®Google Scholar
• Bitzer, Z. T.; Wopperer, A. L.; Chrisfield, B. J.; Tao, L.; Cooper, T. K.; Vanamala, J.; Elias, R. J.; Hayes, J. E.; Lambert, J. D. Soy Protein Concentrate Mitigates Markers of Colonic Inflammation and Loss of Gut Barrier Function in vitro and in vivo. J. Nutr. Biochem. 2017, 40, 201–208. DOI: 10.1016/j.jnutbio.2016.11.012.
   PubMed Web of Science ®Google Scholar
• Rohr, M. W.; Narasimhulu, C. A.; Rudeski-Rohr, T. A.; Parthasarathy, S. Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review. Adv. Nutr. 2020, 11(1), 77–91. DOI: 10.1093/advances/nmz061.
   PubMed Web of Science ®Google Scholar
• Landy, J.; Ronde, E.; English, N.; Clark, S. K.; Hart, A. L.; Knight, S. C.; Ciclitira, P. J.; Al-Hassi, H. O. Tight Junctions in Inflammatory Bowel Diseases and Inflammatory Bowel Disease Associated Colorectal Cancer. World J. Gastroenterol. 2016, 22(11), 3117. DOI: 10.3748/wjg.v22.i11.3117.
   PubMed Web of Science ®Google Scholar
• Wang, W.; De Mejia, E. G. A New Frontier in Soy Bioactive Peptides That May Prevent Age‐related Chronic Diseases. Comprehensive Reviews in Food Science and Food Safety. 2005, 4(4), 63–78. DOI: 10.1111/j.1541-4337.2005.tb00075.x.
   Google Scholar
• Mercier, A.; Gauthier, S. F.; Fliss, I. L. Immunomodulating Effects of Whey Proteins and Their Enzymatic Digests. Int. Dairy J. 2004, 14(3), 175–183. DOI: 10.1016/j.idairyj.2003.08.003.
   Web of Science ®Google Scholar
• Zhang, Q.; Tong, X.; Li, Y.; Wang, H.; Wang, Z.; Qi, B.; Sui, X.; Jiang, L. Purification and Characterization of Antioxidant Peptides from Alcalase-Hydrolyzed Soybean (Glycine Max L.) Hydrolysate and Their Cytoprotective Effects in Human Intestinal Caco-2 Cells. J. Agric. Food Chem. 2019, 67(20), 5772–5781. DOI: 10.1021/acs.jafc.9b01235.
   PubMed Web of Science ®Google Scholar
• Jiang, S.; Cai, W.; Xu, B. Food Quality Improvement of Soy Milk Made from Short-Time Germinated Soybeans. Foods. 2013, 2(2), 198–212. DOI: 10.3390/foods2020198.
   PubMedGoogle Scholar
• Indiano-Romacho, P.; Fernández-Tomé, S.; Amigo, L.; Hernández-Ledesma, B. Multifunctionality of Lunasin and Peptides Released During Its Simulated Gastrointestinal Digestion. Food Res. Int. 2019, 125, 108513. DOI: 10.1016/j.foodres.2019.108513.
   PubMed Web of Science ®Google Scholar
• Tung, C.-Y.; Flores, S.; Han, L.; Yao, S.; Zhou, B.; Sun, J., and Chang, H.-C. Activation of Dendritic Cells by Soypeptide Lunasin as a Novel Vaccine Adjuvant (VAC6P. 942). Am. Assoc. Immnol. 2014; pp 140–3.
   Google Scholar
• Udenigwe, C. C.; Rouvinen-Watt, K. The Role of Food Peptides in Lipid Metabolism During Dyslipidemia and Associated Health Conditions. Int. J. Mol. Sci. 2015, 16(5), 9303–9313. DOI: 10.3390/ijms16059303.
   PubMed Web of Science ®Google Scholar
• Xiao, C. W. Health Effects of Soy Protein and Isoflavones in Humans. J. Nutr. 2008, 138(6), 1244S–1249S. DOI: 10.1093/jn/138.6.1244S.
   PubMed Web of Science ®Google Scholar
• Rao, R. K.; Basuroy, S.; Rao, V. U.; Karnaky, K. J., Jr; Gupta, A. Tyrosine Phosphorylation and Dissociation of Occludin–zo-1 and E-cadherin–β-Catenin Complexes from the Cytoskeleton by Oxidative Stress. Biochem. J. 2002, 368(2), 471–481. DOI: 10.1042/bj20011804.
   PubMedGoogle Scholar
• Donovan, S. M.; Andres, A.; Mathai, R. A.; Kuhlenschmidt, T. B.; Kuhlenschmidt, M. S. Soy Formula and Isoflavones and the Developing Intestine. Nutr. Rev. 2009, 67(suppl_2), S192–S200. DOI: 10.1111/j.1753-4887.2009.00240.x.
   PubMedGoogle Scholar
• Martino, H. S. D.; Cardoso, L. D. M.; Ribeiro, S. M. R.; Dantas, M. D. S.; Piovesan, N. D., and De Mejía, E. Soybean Health IntechOpen. London, UK. 2011; pp 465–488. DOI:10.5772/17575.
   Google Scholar
• Zhong, C.; Schleifenbaum, J. Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research. Front. Med. 2019, 6, 128. DOI: 10.3389/fmed.2019.00128.
   Web of Science ®Google Scholar
• De Mejia, E.; Ben, O. Soybean Bioactive Peptides: A New Horizon in Preventing Chronic Diseases. Sex. Reprod. Menopause. 2006, 4(2), 91–95. DOI: 10.1016/j.sram.2006.08.012.
   Google Scholar
• Natesh, R.; Schwager, S. L.; Sturrock, E. D.; Acharya, K. R. Crystal Structure of the Human Angiotensin-Converting Enzyme–lisinopril Complex. Nature. 2003, 421(6922), 551–554. DOI: 10.1038/nature01370.
   PubMed Web of Science ®Google Scholar
• Margatan, W.; Ruud, K.; Wang, Q.; Markowski, T.; Ismail, B. Angiotensin Converting Enzyme Inhibitory Activity of Soy Protein Subjected to Selective Hydrolysis and Thermal Processing. J. Agric. Food Chem. 2013, 61(14), 3460–3467. DOI: 10.1021/jf4001555.
   PubMed Web of Science ®Google Scholar
• Welty, F. K.; Lee, K. S.; Lew, N. S.; Zhou, J.-R. Effect of Soy Nuts on Blood Pressure and Lipid Levels in Hypertensive, Prehypertensive, and Normotensive Postmenopausal Women. Arch. Internal. Med. 2007, 167(10), 1060–1067. DOI: 10.1001/archinte.167.10.1060.
   PubMedGoogle Scholar
• Zhao, W.; Xue, S.; Yu, Z.; Ding, L.; Li, J.; Liu, J. Novel ACE Inhibitors Derived from Soybean Proteins Using in silico and in vitro Studies. J. Food Biochem. 2019, 43(9), e12975. DOI: 10.1111/jfbc.12975.
   PubMed Web of Science ®Google Scholar
• Kim, K.; Lim, K.-M.; Kim, C.-W.; Shin, H.-J.; Seo, D.-B.; Lee, S.-J.; Noh, J.-Y.; Bae, O.-N.; Shin, S.; Chung, J.-H. Black Soybean Extract Can Attenuate Thrombosis Through Inhibition of Collagen-Induced Platelet Activation. J. Nutr. Biochem. 2011, 22(10), 964–970. DOI: 10.1016/j.jnutbio.2010.08.008.
   PubMed Web of Science ®Google Scholar
• Lassissi, T. A.; Hettiarachchy, N. S.; Rayaprolu, S. J.; Kannan, A.; Davis, M. Functional Properties and Angiotensin-I Converting Enzyme Inhibitory Activity of Soy–whey Proteins and Fractions. Food Res. Int. 2014, 64, 598–602. DOI: 10.1016/j.foodres.2014.07.015.
   PubMed Web of Science ®Google Scholar
• Singh, B. P.; Vij, S. Growth and Bioactive Peptides Production Potential of Lactobacillus Plantarum Strain C2 in Soy Milk: A LC-MS/MS Based Revelation for Peptides Biofunctionality. Lwt. 2017, 86, 293–301. DOI: 10.1016/j.lwt.2017.08.013.
   Web of Science ®Google Scholar
• Acharjee, S.; Zhou, J.-R.; Elajami, T. K.; Welty, F. K. Effect of Soy Nuts and Equol Status on Blood Pressure, Lipids and Inflammation in Postmenopausal Women Stratified by Metabolic Syndrome Status. Metabolism. 2015, 64(2), 236–243. DOI: 10.1016/j.metabol.2014.09.005.
   PubMed Web of Science ®Google Scholar
• Hu, X.; Gao, J.; Zhang, Q.; Fu, Y.; Li, K.; Zhu, S.; Li, D. Soy Fiber Improves Weight Loss and Lipid Profile in Overweight and Obese Adults: A Randomized Controlled Trial. Mol. Nutr. Food Res. 2013, 57(12), 2147–2154. DOI: 10.1002/mnfr.201300159.
   PubMed Web of Science ®Google Scholar
• Bonacasa, B.; Siow, R. C.; Mann, G. E. Impact of Dietary Soy Isoflavones in Pregnancy on Fetal Programming of Endothelial Function in Offspring. Microcirculation. 2011, 18(4), 270–285. DOI: 10.1111/j.1549-8719.2011.00088.x.
   PubMed Web of Science ®Google Scholar
• Messina, M. Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients. 2016, 8(12), 754. DOI: 10.3390/nu8120754.
   PubMed Web of Science ®Google Scholar
• Duewell, P.; Kono, H.; Rayner, K. J.; Sirois, C. M.; Vladimer, G.; Bauernfeind, F. G.; Abela, G. S.; Franchi, L.; Nunez, G.; Schnurr, M. NLRP3 Inflammasomes are Required for Atherogenesis and Activated by Cholesterol Crystals. Nature. 2010, 464(7293), 1357–1361. DOI: 10.1038/nature08938.
   PubMed Web of Science ®Google Scholar
• Progatzky, F.; Sangha, N. J.; Yoshida, N.; McBrien, M.; Cheung, J.; Shia, A.; Scott, J.; Marchesi, J. R.; Lamb, J. R.; Bugeon, L. Dietary Cholesterol Directly Induces Acute Inflammasome-Dependent Intestinal Inflammation. Nat. Commun. 2014, 5(1), 1–14. DOI: 10.1038/ncomms6864.
   Google Scholar
• Du, Q.; Wang, Q.; Fan, H.; Wang, J.; Liu, X.; Wang, H.; Wang, Y.; Hu, R. Dietary Cholesterol Promotes AOM-Induced Colorectal Cancer Through Activating the NLRP3 Inflammasome. Biochem. Pharmacol. 2016, 105, 42–54. DOI: 10.1016/j.bcp.2016.02.017.
   PubMed Web of Science ®Google Scholar
• Zhang, X.; Veliky, C. V.; Birru, R. L.; Barinas-Mitchell, E.; Magnani, J. W.; Sekikawa, A. Potential Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—from Molecular Mechanisms to Studies in Humans. Nutrients. 2021, 13(11), 3739. DOI: 10.3390/nu13113739.
   PubMed Web of Science ®Google Scholar
• Torres, N.; Guevara-Cruz, M.; Velázquez-Villegas, L. A.; Tovar, A. R. Nutrition and Atherosclerosis. Arch. Med. Res. 2015, 46(5), 408–426. DOI: 10.1016/j.arcmed.2015.05.010.
   PubMed Web of Science ®Google Scholar
• Millar, C. L.; Duclos, Q.; Blesso, C. N. Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function. Adv. Nutr. 2017, 8(2), 226–239. DOI: 10.3945/an.116.014050.
   PubMed Web of Science ®Google Scholar
• Tall, A. R.; Yvan-Charvet, L. Cholesterol, Inflammation and Innate Immunity. Nat. Rev. Immunol. 2015, 15(2), 104–116. DOI: 10.1038/nri3793.
   PubMed Web of Science ®Google Scholar
• Bensinger, S. J.; Bradley, M. N.; Joseph, S. B.; Zelcer, N.; Janssen, E. M.; Hausner, M. A.; Shih, R.; Parks, J. S.; Edwards, P. A.; Jamieson, B. D. LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response. Cell. 2008, 134(1), 97–111. DOI: 10.1016/j.cell.2008.04.052.
   PubMed Web of Science ®Google Scholar
• Kloudova, A.; Guengerich, F. P.; Soucek, P. The Role of Oxysterols in Human Cancer. Trends Endocrinol. Metab. 2017, 28(7), 485–496. DOI: 10.1016/j.tem.2017.03.002.
   PubMed Web of Science ®Google Scholar
• Bhoite, R.; Chandrasekaran, A.; Pratti, V. L.; Satyavrat, V.; Aacharya, S.; Mane, A.; Mehta, S.; Kale, R. M.; Nagamuthu, G.; Selvaraj, S. Effect of a High-Protein High-Fibre Nutritional Supplement on Lipid Profile in Overweight/obese Adults with Type 2 Diabetes Mellitus: A 24-Week Randomized Controlled Trial. J. Nutr. Metab. 2021, 2021, 1–9. DOI: 10.1155/2021/6634225.
   Web of Science ®Google Scholar
• Wang, Q.; Ge, X.; Tian, X.; Zhang, Y.; Zhang, J.; Zhang, P. Soy Isoflavone: The Multipurpose Phytochemical. Biomed. Rep. 2013, 1(5), 697–701. DOI: 10.3892/br.2013.129.
   PubMedGoogle Scholar
• Koutelidakis, A., and Dimou, C. The Effects of Functional Food and Bioactive Compounds on Biomarkers of Cardiovascular Diseases. In Functional Foods Text Book, 1st ed.; Martirosyan, D. (Eds.), Dallas, TX, USA, 2016; pp 89–117.
   Google Scholar
• Torre-Villalvazo, I.; Gonzalez, F.; Aguilar-Salinas, C. A.; Tovar, A. R.; Torres, N. Dietary Soy Protein Reduces Cardiac Lipid Accumulation and the Ceramide Concentration in High-Fat Diet-Fed Rats and Ob/ob Mice. J. Nutr. 2009, 139(12), 2237–2243. DOI: 10.3945/jn.109.109769.
   PubMed Web of Science ®Google Scholar
• Lule, V. K.; Garg, S.; Pophaly, S. D.; Tomar, S. K. Potential Health Benefits of Lunasin: A Multifaceted Soy‐derived Bioactive Peptide. J. Food Sci. 2015, 80(3), R485–R494. DOI: 10.1111/1750-3841.12786.
   PubMed Web of Science ®Google Scholar
• Adams, M. R.; Golden, D. L.; Franke, A. A.; Potter, S. M.; Smith, H. S.; Anthony, M. S. Dietary Soy β-Conglycinin (7S Globulin) Inhibits Atherosclerosis in Mice. J. Nutr. 2004, 134(3), 511–516. DOI: 10.1093/jn/134.3.511.
   PubMed Web of Science ®Google Scholar
• Kwon, D. Y.; Oh, S. W.; Lee, J. S.; Yang, H. J.; Lee, S. H.; Lee, J. H.; Lee, Y. B.; Sohn, H. S. Amino Acid Substitution of Hypocholesterolemic Peptide Originated from Glycinin Hydrolyzate. Food Sci. Biotechnol. 2002, 11(1), 55–61.
   Google Scholar
• Mangano, K. M.; Hutchins-Wiese, H. L.; Kenny, A. M.; Walsh, S. J.; Abourizk, R. H.; Bruno, R. S.; Lipcius, R.; Fall, P.; Kleppinger, A.; Kenyon-Pesce, L. Soy Proteins and Isoflavones Reduce Interleukin-6 but Not Serum Lipids in Older Women: A Randomized Controlled Trial. Nutr. Res. 2013, 33(12), 1026–1033. DOI: 10.1016/j.nutres.2013.08.009.
   PubMed Web of Science ®Google Scholar
• Pak, V. V.; Koo, M.; Kwon, D. Y.; Yun, L. Design of a Highly Potent Inhibitory Peptide Acting as a Competitive Inhibitor of HMG-CoA Reductase. Amino Acids. 2012, 43(5), 2015–2025. DOI: 10.1007/s00726-012-1276-0.
   PubMed Web of Science ®Google Scholar
• Galvez, A. F. Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease. Am. Heart Assoc. 2012, 126, A10693–A10693.
   Google Scholar
• Udenigwe, C. C., and Aluko, R. E. Hypolipidemic and Hypocholesterolemic Food Proteins and Peptides. In Bioactive Food Proteins and Peptides. Applications in Human Health. In Hettiarachchy, N. (Eds.), Applications in human health, New York: Applications in human health, 2011.
   Google Scholar
• Bhandari, P. Dietary Botanicals for Chemoprevention of Prostate Cancer. J. Traditional Complementary Med. 2014, 4(2), 75. DOI: 10.4103/2225-4110.130371.
   PubMedGoogle Scholar
• Nagata, C.; Wada, K.; Tamura, T.; Konishi, K.; Goto, Y.; Koda, S.; Kawachi, T.; Tsuji, M.; Nakamura, K. Dietary Soy and Natto Intake and Cardiovascular Disease Mortality in Japanese Adults: The Takayama Study. Am. J. Clin. Nutr. 2017, 105(2), 426–431. DOI: 10.3945/ajcn.116.137281.
   PubMed Web of Science ®Google Scholar
• Kim, S.-H.; Kim, C.-W.; Jeon, S.-Y.; Go, R.-E.; Hwang, K.-A.; Choi, K.-C. Chemopreventive and Chemotherapeutic Effects of Genistein, a Soy Isoflavone, Upon Cancer Development and Progression in Preclinical Animal Models. Lab. Anim. Res. 2014, 30(4), 143–150. DOI: 10.5625/lar.2014.30.4.143.
   PubMedGoogle Scholar
• Banerjee, S.; Li, Y.; Wang, Z.; Sarkar, F. H. Multi-Targeted Therapy of Cancer by Genistein. Cancer Lett. 2008, 269(2), 226–242. DOI: 10.1016/j.canlet.2008.03.052.
   PubMed Web of Science ®Google Scholar
• Varinska, L.; Gal, P.; Mojzisova, G.; Mirossay, L.; Mojzis, J. Soy and Breast Cancer: Focus on Angiogenesis. Int. J. Mol. Sci. 2015, 16(5), 11728–11749. DOI: 10.3390/ijms160511728.
   PubMed Web of Science ®Google Scholar
• Chen, F.; Chien, M. Phytoestrogens Induce Differential Effects on Both Normal and Malignant Human Breast Cells in vitro. Climacteric. 2014, 17(6), 682–691. DOI: 10.3109/13697137.2014.937688.
   PubMed Web of Science ®Google Scholar
• Gertz, J.; Reddy, T. E.; Varley, K. E.; Garabedian, M. J.; Myers, R. M. Genistein and Bisphenol a Exposure Cause Estrogen Receptor 1 to Bind Thousands of Sites in a Cell Type-Specific Manner. Genome Res. 2012, 22(11), 2153–2162. DOI: 10.1101/gr.135681.111.
   PubMed Web of Science ®Google Scholar
• Fürst, R. W.; Kliem, H.; Meyer, H. H.; Ulbrich, S. E. A Differentially Methylated Single CpG-Site is Correlated with Estrogen Receptor Alpha Transcription. J. Steroid Biochem. Mol. Biol. 2012, 130(1–2), 96–104. DOI: 10.1016/j.jsbmb.2012.01.009.
   PubMed Web of Science ®Google Scholar
• Shu, X. O.; Jin, F.; Dai, Q.; Wen, W.; Potter, J. D.; Kushi, L. H.; Ruan, Z.; Gao, Y.-T.; Zheng, W. Soyfood Intake During Adolescence and Subsequent Risk of Breast Cancer Among Chinese Women. Cancer Epidemiol. Prev. Biomarkers. 2001, 10(5), 483–488.
   PubMed Web of Science ®Google Scholar
• Masaoka, Y.; Watanabe, H.; Katoh, O.; Ito, A., and Dohi, K. Effects of Miso and NaCl on the Development of Colonic Aberrant Crypt Foci Induced by Azoxymethane in F344 Rats. 1998; pp. 25-28. DOI: 10.1080/01635589809514712.
   Google Scholar
• Masaoka, Y.; Katoh, O.; Watanabe, H. Inhibitory Effects of Crude Salts on the Induction and Development of Colonic Aberrant Crypt Foci in F-344 Rats Given Azoxymethane. Nutr. Cancer. 2000, 37(1), 78–81. DOI: 10.1207/S15327914NC3701_10.
   PubMed Web of Science ®Google Scholar
• Nishio, K.; Niwa, Y.; Toyoshima, H.; Tamakoshi, K.; Kondo, T.; Yatsuya, H.; Yamamoto, A.; Suzuki, S.; Tokudome, S.; Lin, Y. Consumption of Soy Foods and the Risk of Breast Cancer: Findings from the Japan Collaborative Cohort (JACC) Study. Cancer Causes Control. 2007, 18(8), 801–808. DOI: 10.1007/s10552-007-9023-7.
   PubMed Web of Science ®Google Scholar
• Wu, S. H.; Shu, X. O.; Chow, W.-H.; Xiang, Y.-B.; Zhang, X.; Li, H.-L.; Cai, Q.; Ji, B.-T.; Cai, H.; Rothman, N. Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women. J. Acad. Nutr. Diet. 2012, 112(7), 996–1004. e4. DOI: 10.1016/j.jand.2012.04.001.
   PubMed Web of Science ®Google Scholar
• Yan, L.; Spitznagel, E. L.; Bosland, M. C. Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis. Cancer Epidemiol. Prev. Biomarkers. 2010, 19(1), 148–158. DOI: 10.1158/1055-9965.EPI-09-0856.
   PubMed Web of Science ®Google Scholar
• Ryan-Borchers, T. A.; Park, J. S.; Chew, B. P.; McGuire, M. K.; Fournier, L. R.; Beerman, K. A. Soy Isoflavones Modulate Immune Function in Healthy Postmenopausal Women. Am. J. Clin. Nutr. 2006, 83(5), 1118–1125. DOI: 10.1093/ajcn/83.5.1118.
   PubMed Web of Science ®Google Scholar
• MacGregor, C.; Canney, P.; Patterson, G.; McDonald, R.; Paul, J. A Randomised Double-Blind Controlled Trial of Oral Soy Supplements versus Placebo for Treatment of Menopausal Symptoms in Patients with Early Breast Cancer. Euro. J. Cancer. 2005, 41(5), 708–714. DOI: 10.1016/j.ejca.2005.01.005.
   PubMed Web of Science ®Google Scholar
• Pabona, J. M. P.; Dave, B.; Su, Y.; Montales, M. T. E.; Ben, O.; De Mejia, E. G.; Rahal, O. M.; Simmen, R. C. The Soybean Peptide Lunasin Promotes Apoptosis of Mammary Epithelial Cells via Induction of Tumor Suppressor PTEN: Similarities and Distinct Actions from Soy Isoflavone Genistein. Genes Nutr. 2013, 8(1), 79–90. DOI: 10.1007/s12263-012-0307-5.
   PubMed Web of Science ®Google Scholar
• Chen, Y.; Xu, Z.; Zhang, C.; Kong, X.; Hua, Y. Heat-Induced Inactivation Mechanisms of Kunitz Trypsin Inhibitor and Bowman-Birk Inhibitor in Soymilk Processing. Food Chem. 2014, 154, 108–116. DOI: 10.1016/j.foodchem.2013.12.092.
   PubMed Web of Science ®Google Scholar
• Fereidunian, A.; Sadeghalvad, M.; Oscoie, M. O.; Mostafaie, A. Soybean Bowman-Birk Protease Inhibitor (BBI): Identification of the Mechanisms of BBI Suppressive Effect on Growth of Two Adenocarcinoma Cell Lines: AGS and HT29. Arch. Med. Res. 2014, 45(6), 455–461. DOI: 10.1016/j.arcmed.2014.07.001.
   PubMed Web of Science ®Google Scholar
• Clemente, A.; Marín-Manzano, M. C.; Jiménez, E.; Arques, M. C.; Domoney, C. The Anti-Proliferative Effect of TI1B, a Major Bowman–birk Isoinhibitor from Pea (Pisum Sativum L.), on HT29 Colon Cancer Cells is Mediated Through Protease Inhibition. Br. J. Nutr. 2012, 108(S1), S135–S144. DOI: 10.1017/S000711451200075X.
   PubMedGoogle Scholar
• Clemente, A.; Del Carmen Arques, M. Bowman-Birk Inhibitors from Legumes as Colorectal Chemopreventive Agents. World J. Gastroenterol. 2014, 20(30), 10305. DOI: 10.3748/wjg.v20.i30.10305.
   PubMed Web of Science ®Google Scholar
• da Costa Souza, L.; Camargo, R.; Demasi, M.; Santana, J. M.; de Sa, C. M., and de Freitas, S. M. Effects of an Anticarcinogenic Bowman-Birk Protease Inhibitor on Purified 20S Proteasome and MCF-7 Breast Cancer Cells. PLoS One. 2014, 9(1), p.e86600.
   Web of Science ®Google Scholar
• Cruz-Huerta, E.; Fernández-Tomé, S.; Arques, M. C.; Amigo, L.; Recio, I.; Clemente, A.; Hernández-Ledesma, B. The Protective Role of the Bowman-Birk Protease Inhibitor in Soybean Lunasin Digestion: The Effect of Released Peptides on Colon Cancer Growth. Food Function. 2015, 6(8), 2626–2635. DOI: 10.1039/C5FO00454C.
   PubMed Web of Science ®Google Scholar
• Cavazos, A.; Morales, E.; Dia, V. P.; De Mejia, E. G. Analysis of Lunasin in Commercial and Pilot Plant Produced Soybean Products and an Improved Method of Lunasin Purification. J. Food Sci. 2012, 77(5), C539–C545. DOI: 10.1111/j.1750-3841.2012.02676.x.
   PubMed Web of Science ®Google Scholar
• Dia, V. P.; de Mejia, E. G. Differential Gene Expression of RAW 264.7 Macrophages in Response to the RGD Peptide Lunasin with and Without Lipopolysaccharide Stimulation. Peptides. 2011, 32(10), 1979–1988. DOI: 10.1016/j.peptides.2011.09.009.
   PubMed Web of Science ®Google Scholar
• Chang, H.-C.; Lewis, D.; Tung, C.-Y.; Han, L.; Henriquez, S. M.; Voiles, L.; Lupov, I. P.; Pelloso, D.; Sinn, A. L.; Pollok, K. E. Soypeptide Lunasin in Cytokine Immunotherapy for Lymphoma. Cancer Immunol. Immunother. 2014, 63(3), 283–295. DOI: 10.1007/s00262-013-1513-8.
   PubMed Web of Science ®Google Scholar
• Fernández-Tomé, S.; Ramos, S.; Cordero-Herrera, I.; Recio, I.; Goya, L.; Hernández-Ledesma, B. In vitro Chemo-Protective Effect of Bioactive Peptide Lunasin Against Oxidative Stress in Human HepG2 Cells. Food Res. Int. 2014, 62, 793–800. DOI: 10.1016/j.foodres.2014.04.054.
   Web of Science ®Google Scholar
• Hamid, H.; Yusoff, M.; Liu, M.; Karim, M. α-Glucosidase and α-Amylase Inhibitory Constituents of Tinospora Crispa: Isolation and Chemical Profile Confirmation by Ultra-High Performance Liquid Chromatography-Quadrupole Time-Of-Flight/mass Spectrometry. J. Funct. Foods. 2015, 16, 74–80. DOI: 10.1016/j.jff.2015.04.011.
   Web of Science ®Google Scholar
• Mohamed, S. Functional Foods Against Metabolic Syndrome (Obesity, Diabetes, Hypertension and Dyslipidemia) and Cardiovasular Disease. Trends Food Sci. Technol. 2014, 35(2), 114–128. DOI: 10.1016/j.tifs.2013.11.001.
   Web of Science ®Google Scholar
• Hunter, P. M.; Hegele, R. A. Functional Foods and Dietary Supplements for the Management of Dyslipidaemia. Nat. Rev. Endocrinol. 2017, 13(5), 278–288. DOI: 10.1038/nrendo.2016.210.
   PubMed Web of Science ®Google Scholar
• Yang, H.-Y.; Tzeng, Y.-H.; Chai, C.-Y.; Hsieh, A.-T.; Chen, J.-R.; Chang, L.-S.; Yang, S.-S. Soy Protein Retards the Progression of Non-Alcoholic Steatohepatitis via Improvement of Insulin Resistance and Steatosis. Nutrition. 2011, 27(9), 943–948. DOI: 10.1016/j.nut.2010.09.004.
   PubMed Web of Science ®Google Scholar
• Niamnuy, C.; Nachaisin, M.; Laohavanich, J.; Devahastin, S. Evaluation of Bioactive Compounds and Bioactivities of Soybean Dried by Different Methods and Conditions. Food Chem. 2011, 129(3), 899–906. DOI: 10.1016/j.foodchem.2011.05.042.
   PubMed Web of Science ®Google Scholar
• Tsou, M.-J.; Lin, S.-B.; Chao, C.-H.; Chiang, W.-D. Enhancing the Lipolysis-Stimulating Activity of Soy Protein Using Limited Hydrolysis with Flavourzyme and Ultrafiltration. Food Chem. 2012, 134(3), 1564–1570. DOI: 10.1016/j.foodchem.2012.03.093.
   PubMed Web of Science ®Google Scholar
• Lammi, C.; Zanoni, C.; Arnoldi, A. IAVPGEVA, IAVPTGVA, and LPYP, Three Peptides from Soy Glycinin, Modulate Cholesterol Metabolism in HepG2 Cells Through the Activation of the LDLR-SREBP2 Pathway. J. Funct. Foods. 2015, 14, 469–478. DOI: 10.1016/j.jff.2015.02.021.
   Web of Science ®Google Scholar
• Lammi, C.; Zanoni, C.; Arnoldi, A.; Vistoli, G. Peptides Derived from Soy and Lupin Protein as Dipeptidyl-Peptidase IV Inhibitors: In vitro Biochemical Screening and in silico Molecular Modeling Study. J. Agric. Food Chem. 2016, 64(51), 9601–9606. DOI: 10.1021/acs.jafc.6b04041.
   PubMed Web of Science ®Google Scholar
• Moghaddam, A. S.; Entezari, M. H.; Iraj, B.; Askari, G. R.; Maracy, M. R. The Effects of Consumption of Bread Fortified with Soy Bean Flour on Metabolic Profile in Type 2 Diabetic Women: A Cross-Over Randomized Controlled Clinical Trial. Int. J. Preventive Med. 2014, 5(12), 1529.
   PubMedGoogle Scholar
• Pabich, M.; Materska, M. Biological Effect of Soy Isoflavones in the Prevention of Civilization Diseases. Nutrients. 2019, 11(7), 1660. DOI: 10.3390/nu11071660.
   PubMed Web of Science ®Google Scholar
• Testa, I.; Salvatori, C.; Di Cara, G.; Latini, A.; Frati, F.; Troiani, S.; Principi, N., and Esposito, S. Soy-Based Infant Formula: Are Phyto-Oestrogens Still in Doubt? Front. Nutr. 2018, 5, 110. DOI: 10.3389/fnut.2018.00110.
   PubMed Web of Science ®Google Scholar
• Squadrito, F., and Bitto, A. Isoflavones and Thyroid Function: An Overview. In Preedy, V.R. (Ed.), Isoflavones: Chemistry, analysis, function, and effects. 2012; pp 423–437.
   Google Scholar
• Guo, R. Isoflavones in Soy-Based Infant Formulas and Effects on Thyroid Function; University of Pittsburgh, 2014.
   Google Scholar
• Zhang, J.; Zhang, X.; Li, Y.; Zhou, Z.; Wu, C.; Liu, Z.; Hao, L.; Fan, S.; Jiang, F.; Xie, Y. Low Dose of Bisphenol a Enhance the Susceptibility of Thyroid Carcinoma Stimulated by DHPN and Iodine Excess in F344 Rats. Oncotarget. 2017, 8(41), 69874. DOI: 10.18632/oncotarget.19434.
   PubMedGoogle Scholar
• Šošić-Jurjević, B.; Lütjohann, D.; Jarić, I.; Miler, M.; Milutinović, D. V.; Filipović, B.; Ajdžanović, V.; Renko, K.; Wirth, E. K.; Janković, S. Effects of Age and Soybean Isoflavones on Hepatic Cholesterol Metabolism and Thyroid Hormone Availability in Acyclic Female Rats. Exp. Gerontol. 2017, 92, 74–81. DOI: 10.1016/j.exger.2017.03.016.
   PubMed Web of Science ®Google Scholar
• Chang, H. C.; Doerge, D. R. Dietary Genistein Inactivates Rat Thyroid Peroxidase in vivo Without an Apparent Hypothyroid Effect. Toxicol. Appl. Pharmacol. 2000, 168(3), 244–252. DOI: 10.1006/taap.2000.9019.
   PubMed Web of Science ®Google Scholar
• Patterson, C. A.; Curran, J.; Der, T. Effect of Processing on Antinutrient Compounds in Pulses. Cereal Chem. 2017, 94(1), 2–10. DOI: 10.1094/CCHEM-05-16-0144-FI.
   Web of Science ®Google Scholar
• Ao, T.; Cantor, A.; Pescatore, A.; Pierce, J.; Dawson, K. Effects of Citric Acid, Alpha-Galactosidase and Protease Inclusion on in vitro Nutrient Release from Soybean Meal and Trypsin Inhibitor Content in Raw Whole Soybeans. Anim. Feed Sci. Technol. 2010, 162(1–2), 58–65. DOI: 10.1016/j.anifeedsci.2010.08.014.
   Web of Science ®Google Scholar
• Colletti, A.; Attrovio, A.; Boffa, L.; Mantegna, S.; Cravotto, G. Valorisation of By-Products from Soybean (Glycine Max (L.) Merr.). Proc. Mol. 2020, 25(9), 2129. DOI: 10.3390/molecules25092129.
   Google Scholar
• Sleiman, H. K.; de Oliveira, J. M.; de Freitas, G. B. L. Isoflavones Alter Male and Female Fertility in Different Development Windows. Biomed. Pharmacother. 2021, 140, 111448. DOI: 10.1016/j.biopha.2021.111448.
   PubMed Web of Science ®Google Scholar
• Patisaul, H. B.; Jefferson, W. The Pros and Cons of Phytoestrogens. Front. Neuroendocrinol. 2010, 31(4), 400–419. DOI: 10.1016/j.yfrne.2010.03.003.
   PubMed Web of Science ®Google Scholar
• Chavarro, J. E.; Mínguez-Alarcón, L.; Chiu, Y.-H.; Gaskins, A. J.; Souter, I.; Williams, P. L.; Calafat, A. M.; Hauser, R.; Team, E. S. Soy Intake Modifies the Relation Between Urinary Bisphenol a Concentrations and Pregnancy Outcomes Among Women Undergoing Assisted Reproduction. J. Clin. Endocrinol. Metab. 2016, 101(3), 1082–1090. DOI: 10.1210/jc.2015-3473.
   PubMed Web of Science ®Google Scholar