Which is worst in patients undergoing primary angioplasty for acute myocardial infarction? Hyperglycaemia? Diabetes mellitus? Or both?

References

• Mukamal KJ, Nesto RW, Cohen MC, Muller JE, MaclureM, Sherwood JB, Mittleman MA. Impact of diabetes onlong-term survival after acute myocardial infarction: com-parability of risk with prior myocardial infarction. Diabetes Care 2001; 24: 1422–7.
   Google Scholar
• Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339: 229–34.
   Google Scholar
• Kasiborod M, Rathore SS, Inzucchi SE, Masoudi FA, Wang Y, Havranek EP, Krumholz HM. Admission glucose and mortality in elderly patients hospitalized with acute myocar-dial infarction: implications for patients with and without recognized diabetes. Circulation 2005; 111: 3078–86.
   Google Scholar
• Foo K, Cooper J, Deaner A, Knight C, Su’Liman A, Randa-jadayalan K, Timmis AD. A single serum glucose measure-ment predicts adverse outcomes across the whole range of acute coronary syndromes. Heart 2003; 89: 512–6.
   Google Scholar
• Hadjadj S, Coisne D, Mauco G, Ragot S, Duengler F, Sos-ner P, Torremocha F, Herpin D, Marechaud R. Prognostic value of admission plasma glucose and HbA in acute myocardial infarction. Diabet Med 2004; 21: 305–10.
   Google Scholar
• Wahab NN, Cowden EA, Pearce NJ, Gardner MJ, Merry H, Cox JL. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era? J Am Coll Cardiol 2002; 40: 1748–54.
   Google Scholar
• Bhadriraju S, Ray KK, DeFranco AC, Barber K, Bhadriraju P, Murphy SA, Morrow DA, McCabe CH, Gibson CM, Cannon CP, Braunwald E. Association between blood glu-cose and long-term mortality in patients with acute coro-nary syndromes in the OPUS-TIMI 16 trial. Am J Cardiol 2006; 97: 1573–7.
   Google Scholar
• Mizock BA. Alterations in fuel metabolism in critical illness: hyperglycemia. Best Pract Res Clin Endocrinol Metab 2001; 15: 533–51.
   Google Scholar
• Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischemia and arrhytmias. Lancet 1994; 343: 155–8.
   Google Scholar
• Vetter NJ, Adams W, Strange RC, Oliver MF. Initial meta-bolic and hormonal response to acute myocardial infarc-tion. Lancet 1974; 303: 284–9.
   Google Scholar
• Gresele P, Guglielmini G, De Angelis M, Ciferri S. Ciofetta M, Falcinelli E, Lalli C, Ciabattoni G, Davi G, Bolli GB. Acute, short-term hyperglycemia enhances shear stres-induced platelet activation in patients with type II diabetes mellitus. J Am Coll Cardiol 2003; 41: 1013–20.
   Google Scholar
• Marfella R, Siniscalchi M, Esposito K, Sellitto A, DeFanis U, Romano C, Portoghese M, Siciliano S, Nappo F, Sasso FC, Minini N, Cacciapuoti F, Lucivero G, Giunta R. Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac out-come. Diabetes Care 2003; 26: 3129–35.
   Google Scholar
• Ainla T, Baburin A, Teesalu R, Rahu M. The association between hyperglycemia on admission and 180-day mortality in acute myocardial infarction patients with and without diabetes. Diabet Med 2005; 22: 1321–5.
   Google Scholar
• Lavi S, Kapeliovich M, Gruberg L, Roguin A, Boulos M, Grenadier E, Amikam S, Markiewicz W, Beyar R, Ham-merman H. Hyperglycemia during acute myocardial infarc-tion in patients who are treated by primary percutaneous coronary intervention: Impact on long-term prognosis. Int J Cardiol 2008; 123: 117–22.
   Google Scholar
• Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Mod-ification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461–70.
   Google Scholar
• Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function-measured and estimated glomerular filtration rate. N Engl J Med 2006; 354: 2473–83.
   Google Scholar
• Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Sub-committee on Quantitation of Two-Dimensional Echocar-diograms. J Am Soc Echocardiogr 1989; 2: 358–67.
   Google Scholar
• Chesebro JH, Knatterud G, Roberts R, Borer J, Cohen LS, Dalen J, Dodge HT, Francis CK, Hillis D, Ludbrook P. Thrombolysis in Myocardial Infarction (TIMI) Trial, PhaseI: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation 1987; 76: 142–54.
   Google Scholar
• Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyper-glycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000; 355: 773–8.
   Google Scholar
• Naber CK, Mehta RH, Ringer C, Zeymer MSU, Wienbergen H, Sabin GV, Erbel R, Senges J, Gitt S. Impact of admis-sion blood glucose on outcomes of nondiabetic patients with acute ST-elevation myocardial infarction (from the German acute coronary syndromes (ACOS) registry. Am J Cardiol 2009; 103: 583–7.
   Google Scholar
• Dziewierz A, Giszterowicz D, Siudak Z, Rakowski T, Mielecki W, Suska M, Dubiel JS, Dudek D. Impact of admission glucose level and presence of diabetes mellitus on mortality in patients with non-ST segment elevation acute coronary syndrome treated conservatively. Am J Cardiol 2009; 103: 954–8.
   Google Scholar
• Gasior M, Stasik-Pres G, Pres D, Lech P, Gierlotka M, Lekston A, Hawranek M, Tajstra M, Kalarus Z, Poloriski L. Relationship between blood glucose on admission and prog-nosis in patients with acute myocardial infarction treated with percutaneous coronary intervention. Kardiol Pol 2007; 65: 1031–8.
   Google Scholar
• Ishihara M, Kagawa E, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Nakama Y, Maruhashi T, Ookawa K, Dai K, Aokage Y Impact of admission hyperglycemia and diabetes mellitus on short- and long-term mortality after acute myocardial infarction in the coronary intervention era. Am J Cardiol 2007; 99: 1674–9.
   Google Scholar
• Kadri Z, Danchin N, Vaur L, Cottin Y, Guéret P, Zeller M, Lablanche JM, Blanchard D, Hanania G, Genes N, Cambou JP; USIC 2000 Investigators. Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study. Heart 2006; 92: 910–5.
   Google Scholar
• Stranders I, Diamant M, van Gelder RE, Spruijt HJ, Twisk JW, Heine RJ, Visser FC. Admission blood glucose level as risk indicator of death after myocardial infarction in patientswith and without diabetes mellitus. Arch Intern Med 2004; 164: 982–8.
   Google Scholar
• Mjos OD. Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs. J Clin Invest 1971; 50: 1386–9.
   Google Scholar
• Verma S, Wang CH, Weisel RD, Badiwala MV, Li SH, Fedak PW, Li RK, Miclde DA. Hyperglycemia potentiates the proatherogenic effects of C-reactive protein: reversal with rosiglitazone. J Mol Cell Cardiol 2003; 35: 417–9.
   Google Scholar
• Timmer JR, Ottervanger JP, de Boer MJ, Dambrink JHE, Hoorntje JCA, Gosselink ATM, Suryapranata H, Zijlstra F, van’t Hof AWJ, on behalf of the Zwolle Myocardial Infarction Study Group. Hyperglycemia is an important predictor of coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction. J Am Coll Cardiol 2005; 45: 999–1002.
   Google Scholar
• L’Huillier I, Zeller M, Mock L, Beer JC, Laurent Y, Sicard P, Vincent-Martin M, Lorgis L, Makki H, Wolf JE, Freysz M, Cottin Y Relation of hyperglycemia to ST-segment res-olution after reperfusion for acute myocardial infarction (from Observatoire des Infarctus de Cote-d’Or Survey [RICO]). Am J Cardiol 2006; 98: 167–71.
   Google Scholar
• Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC, Creager MA. Acute hyperglycemia attenuates endothelium-dependent vasodilatation in humans in vivo. Circulation 1998; 97: 1695–1701.
   Google Scholar
• Takahashi T, Hiasa Y, Ohara Y, Miyazaki S, Mahara K, Ogura R, Miyajima H, Yuba K, Suzuki N, Hosokawa S, Kishi K, Ohtani R. Acute hyperglycaemia prevents the protective effect of pre-infarction angina on microvascular function after primary angioplasty for acute myocardial infarction. Heart 2008; 94: 1402–6.
   Google Scholar
• Holubarsch C, Ruf T, Goldstein DJ, Ashton RC, Nickl W, Pieske B, Pioch K, Liidemann J, Wiesner S, Hasenfuss G, Posival H, Just H, Burkhoff D. Existence of the Frank-Star-ling mechanism in the failing human heart: investigations on the organ, tissue, and sarcomere levels. Circulation 1996; 94: 683–9.
   Google Scholar
• Iwakura K, Ito H, Ikushima M, Kawano S, Okamura A, Asano K, Kuroda T, Tanaka K, Masuyama T, Hon M, Fujii K. Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol 2003; 41: 1–7.
   Google Scholar
• Hadjadj S, Coisne D, Mauco G, Ragot S, Duengler F, Sosner P, Torremocha F, Herpin D, Marechaud R. Diabetes mellitus and outcome after primary coronary angioplasty for acute myocardial infarction: lessons from the GUSTO-IIb angioplasty substudy. J Am Coll Cardiol 2000; 35: 1502–12.
   Google Scholar
• Jain SK, Nagi DK, Slavin BM, Lumb PJ, Yudkin JS. Insulin therapyin type 2 diabetic patients suppresses plasminogen activator inhibitor (PAI-1) activity and proinsulin-like mol-ecules independently of glycaemic control. Diabetes Med 1993; 10: 27–32.
   Google Scholar