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Research Article

Molecular biology and gene transfer in atherosclerosis in the stenting era

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Pages 141-152 | Published online: 10 Jul 2009

  • Ross R. Cell biology of atherosclerosis. Ann Rev Physiol 1995; 57: 791-804.
  • Schwartz SM, de Blois D, O'Brien ER. The intima. Soil for atherosclerosis and restenosis. Circ Res 1995; 77: 445-465.
  • Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med 1994; 330: 1431-1438.
  • Alexander RW.Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension 1995; 25: 155-161.
  • Steinberg D. Role of oxidized LDL and antioxidants in atherosclerosis. Adv Exp Med Biol 1995; 369: 39-48.
  • Ohara Y, Peterson TE, Sayegh HS, Subramanian RR, Wilcox JN, Harrison DG. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation 1995; 92: 898-903.
  • Schmidt AM, Hori O, Chen JX, et al. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1(VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 1995; 96: 1395-1403.
  • Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994; 74: 1141-1148.
  • Liao F, Andalibi A, Qiao JH, Allayee H, Fogelman AM, Lusis AJ. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction and aortic fatty streak formation in mice. J Clin Invest 1994; 94: 877-884.
  • Marui N, Offermann MK, Swerlick R, et al. Vascular cell adhesion molecule--1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993; 92: 1866-1874.
  • Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial adhesion molecules: NF-kappa B and cytokine inducible enhancers. FASEB J 1995; 9: 899-909.
  • Peng HB, Libby P, Liao JK. Induction and stabilization of I kappa alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem 1995; 270: 14214-14219.
  • De Caterina R, Libby P, Peng HB, et al. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995; 96: 60-68.
  • Cayatte AJ, Palacino JJ, Horten K, Cohen RA. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscl Thromb Vasc Biol 1994; 14; 753-759.
  • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature 1993; 362: 801-809.
  • Di Corleto PE, Bowen-Pope DF. Cultured endothelial cells produce a platelet derived growth factor-like protein. Proc Natl Acad Sci USA 1983; 80: 1919-1923.
  • Amento EP, Ehsani N, Palmer H, Libby P. Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscl Thromb 1991; 11: 1223-1230.
  • Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA 1974; 71: 1207-1210.
  • McCaffrey TA, Falcone DJ, Brayton CF, Agarwal LA, Welt FG, Weksler BB. Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex. J Cell Biol 1989; 109: 441-448.
  • McCaffrey TA, Consigli S, Du B, et al. Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta 1. J Clin Invest 1995; 95: 446-455.
  • Gibbons GH, Dzau VJ. Molecular therapies for vascular diseases. Science 1996; 272: 689-693.
  • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
  • Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994; 73: 2013-2026.
  • Desmouliere A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during transition between granulation tissue and scar. Am J Pathol 1995; 146: 56-66.
  • Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 1983; 49: 327-333.
  • Han DK, Haudenschild CC, Hong MK, Tinkle BT, Leon MB, Liau G. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol 1995; 147: 267-277.
  • Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995; 91: 2703-2711.
  • Kockx MM, Cambier BA, Bortier HE, et al. Foam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts. Histopathology 1994; 25: 365-371.
  • Geng YJ, Libby P. Evidence for apoptosi in advanced human atheroma. Colocalization with interleukin-1 beta converting enzyme. Am J Pathol 1995; 147: 251-266.
  • Weissberg PL, Clesham GJ, Bennett MR. Is vascular smooth muscle cell proliferation beneficial. Lancet 1996; 347: 305-307.
  • Cho A, Courtman DW, Langille BL. Apoptosis (programmed cell death) in arteries of the neonatal lamb. Circ Res 1995; 76: 168-175.
  • Geng YJ, Wu Q, Muszynski M, Hansson GK, Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscl Thromb Vasc Biol 1996; 16: 19-27.
  • Bennett MR, Evan GI, Schwartz SM. Apoptosis of rat vascular smooth muscle cells is regulated by p53-dependent and -independent pathways. Circ Res 1995; 77: 266-273.
  • Ruoslahti E, Reed JC. Anchorage dependence, integrins and apoptosis. Cell 1994; 77: 477-478.
  • Bennett MR, Evan GI, Schwartz SM. Apoptosis of human vascular smooth muscle cells derived from vessels and atherosclerotic plaques. J Clin Invest 1995; 95: 2266- 2274.
  • Han DK, Haudenscild CC, Hong MK, et al. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol 1995; 147: 267-277.
  • Kondo S, Yin D, Aoki T, Takahashi JA, Morimura T, Takeuchi J. bcl 2 gene prevents apoptosis of basic fibroblast factor-derived murine aortic endothelial cells. Exp Cell Res 1994; 213: 428-432.
  • Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 1326-1331.
  • Brooks PC, Montgomery AM, Rosenfeld M, et al. Integrin alpha V beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994; 79: 1157-1164.
  • Liaw L, Skinner MP, Raines EW, et al. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha V beta 3 in smooth muscle cell migration to osteopontin in vitro. J Clin Invest 1995; 95: 713-724.
  • Matsuno H, Stassen JM, Vermylen J, Deckmyn H. Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation. Circulation 1994; 90(5): 2203-2206.
  • Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H202 for platelet-derived growth factor signal transduction. Science 1995; 270(5234): 296-299.
  • Tsai JC, Jain M, Hsieh CM, et al. Induction of apoptosis by pyrrolidinedithiocarbarnate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem 1996; 271(7): 3667-3670.
  • Schwartz RS, Holmes DR Jr, Topol EJ. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol 1992; 20: 1284-1293.
  • Boyd CD, Song JY, Pierce RA, et al. Increased elastin mRNA levels associated with surgically induced intimal injury. Conn Tiss Res 1988; 18: 65-78.
  • Clark RS, Kochanek PM, Schwarz MA, et al. Inducible nitric oxide synthase expression in cerebrovascular smooth muscle and neutrophils after traumatic brain injury in immature rats. Ped Res 1996; 39: 784-790.
  • Juliano RL, Haskill S. Signal transduction from the extracellular matrix. J Cell Biol 1993; 120: 577-585.
  • Zimmerman GA, McIntyre TM, Prescott SM. Adhesion and signaling in vascular cell-cell interactions. J Clin Invest 1996; 98: 1699-1702.
  • Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991; 67: 1033-1036.
  • Murphy G, Docherty AJ. The matrix metalloproteinases and their inhibitors. Am J Resp Cell Mol Biol 1992; 7: 120-125.
  • Goldstein JL, Brown MS. The low density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem 1977; 46: 897-930.
  • Steinberg D. Lipoprotein and atherosclerosis: A look back and a look forward. Arterioscl 1983; 3: 283-301.
  • Breslow JJ. Apolipoprotein genes and atherosclerosis. Clin Invest 1992; 70: 377-384.
  • Henriksen T, Mahoney EM, Steinberg D. Enhancing macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells. Recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci USA 1981; 78: 6499-6503.
  • Heinecke JW, Rosen H, Chait A. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. J Clin Invest 1984; 74: 1890-1894.
  • Hiramatsu K, Rosen H, Heinecke JW, Wolfbauer G, Chait A. Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arterioscl 1987; 7: 55-60.
  • Palinski W, Rosenfeld ME, Yla-Herttuala S, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 1989; 86: 1372-1376.
  • Fuster V, Stein B, Ambrose JA, et al. Atherosclerotic plaque rupture and thrombosis: evolving concepts. Circulation 1990; 82(Suppl II): 47-59.
  • Falk E, Shah P, Fuster V. Coronary plaque disruption. Circulation 1995; 92: 657-671.
  • Libby P, Sukhova G, Lee RT, Liao JK. Molecular biology of atherosclerosis. Int J Cardiol 1997; 62(Suppl 2): S23-S29.
  • Wilcox JN, Smith KM, Schwartz SM, Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 1989; 86: 2839-2843.
  • Davies MJ, Thomas AC. Plaque fissuring--the cause of acute myocardial infarction, sudden ischemic death and crescendo angina. Br Heart J 1985; 53: 363-373.
  • Libby P. Molecular bases of the acute coronary syndromes. Circulation 1995; 91: 2844-2850.
  • Newby AC. Molecular and cell biology of native coronary and vein-graft atherosclerosis: regulation of plaque stability and vessel-wall remodelling by growth factors and cell-extracellular matrix interactions. Cor Art Dis 1997; 8: 213-224.
  • Amento EP, Ehsani N, Palmer H, Libby P. Cytokines positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscl 1991; 11: 1223-1230.
  • van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994; 89: 36-44.
  • Galis Z, Muszynski M, Sukhova G, et al. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res 1994; 75: 181-189.
  • Sukhova G, Simon D, Chapman H, Libby P. Cytokines regulate the expression by vascular smooth muscle cells of cathepsin S, an elastase found in human atheroma. J Invest Med 1995; 43: 311A.
  • Liu MW, Roubin GS, King SB. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 1989; 79: 1374-1387.
  • Fingerle J, Johnson R, Clowes AW, Majesky MW, Reidy MA. Role of platelets in smooth muscle proliferation and migration after vascular injury in the rat carotid artery. Proc Natl Acad Sci USA 1989; 86: 8412-8416.
  • Almony GT, Lefkovits J, Topol EJ. Antiplatelet and anticoagulant use after myocardial infarction. Clin Cardiol 1996; 19: 357-365.
  • Marmur J, Thiruvikraman S, Fyfe B, et al. Identification of active tissue factor in human coronary atheroma. Circulation 1996; 94: 1226-1232.
  • Toschi V, Gallo R, Lettino M, et al. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation 1997; 95: 594-599.
  • Tipping P, Malliaros J, Holdsworth S. Procoagulant activity expression by macrophages from atheromatous vascular plaques. Atherosclerosis 1989; 79: 237-243.
  • Caplice NM, Mueske CS, Kleppe LS, Simari RD. Tissue factor pathway inhibitor in human atherosclerotic plaques. Circulation 1998; 98: 1051-1057.
  • Haber E, Quertermous T, Matsuda GR, Runge MS. Innovative approaches to plasminogen activator therapy. Science 1989; 243: 51-56.
  • Larsen GR, Barnathan ES. Thrombolytic therapy with tissue-type plasminogen activator: new modes and novel variant plasminogen activators. Curr Opin Biotech 1991; 2: 220-226.
  • Collen D, Lijnen HR, Bulens F, Vandamme AM, Tulinsky A, Nelles L. Biochemical and functional characterization of human tissue-type plasminogen activator variants with mutagenized kringle domains. J Biol Chem 1990; 265(21): 12184-12191.
  • Runge MS, Quertermous T, Zavodny PJ, et al. A recombinant chimeric plasminogen activator with high affinity for fibrin has increased thrombolytic potency in vitro and in vivo. Proc Nat Acad Sci USA 1991; 88(22): 10337-10341.
  • Gardell SJ, Duong LT, Diehl RE, et al. Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. J Biol Chem 1989; 264(30): 17947-17952.
  • Falk E. Unstable angina with fatal outcome. Dynamic coronary thrombosis leading to infarction and/or sudden death. Circulation 1985; 71: 699-708.
  • Davies MJ. A macro and micro view of coronary vascular insult in ischemic heart disease. Circulation 1990; 82(Suppl)II: 38-46.
  • Bini A, Fenoglio JJ, Mesa-Tejada R, Kudyk KB, Kaplan KL. Identification and distribution of fibrinogen, fibrin and fibrinogen degradation products in atherosclerosis: use of monoclonal antibodies. Arteriosclerosis 1989; 9: 109-121.
  • Cunningham D, Farrell DH. Thrombin interactions with cultured fibroblasts. Relationship to mitogenic situations. Ann NY Acad Sci 1986; 485: 240-248.
  • Shuman MA. Thrombin-cellular interactions. Ann NY Acad Sci 1989; 485: 228-239.
  • Wilcox JN. Thrombotic mechanisms in atherosclerosi. Cor Art Dis 1994; 5: 223-229.
  • Barger A, Beeuwkes IR, Lainey L, Silverman K. Hypothesis: vasa vasorum and neovascularization of human coronary arteries. N Engl J Med 1984; 310: 175-177.
  • Brogi E, Winkles JA, Underwood R, et al. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages. J Clin Inv 1993; 92(5): 2408-2418.
  • Braunwald E. Shattuck lecture-cardiovascular medicines at the turn of the millenium: triumphs, concerns, and opportunities. New Engl J Med 1997; 337(19): 1360-1369.
  • Franz WM, Mueller OJ, Hartong R, Frey N, Katus HA. Transgenic animal models: new avenues in cardiovascular physiology. J Mol Med 1997; 75(2): 130-138.
  • Paigen B, Morrow A, Brandon C, Mitchell D, Holmes P. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 1985; 57(1): 65-73.
  • Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993; 92(2): 883-893.
  • Hoffmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE. Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science 1988; 239(4845): 1277-1281.
  • Grossman M, Rader DJ, Muller DW, et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Nat Med 1995; 1: 1148-1154.
  • Fazio S, Sanan DA, Lee YL, Ji ZS, Mahley RW, Rall SC. Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg112,Cys 142). Arterioscl Thromb 1994; 14: 1873-1879.
  • Mahley RW, Nathan BP, Bellosta S, Pitas RE. Apolipoprotein E: impact of cytoskeletal stability in neusrons and the relationship to Alzheimer's disease. Curr Op Lipid 1995; 6: 86-91.
  • Shimano H, Yamada N, Katsuki M, et al. Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. Proc Natl Acad Sci USA 1992; 89: 1750-1754.
  • Shimano H, Ohsuga J, Shimada M, et al. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. J Clin Invest 1995; 95: 469-476.
  • Grainger DJ, Kirschenlohr HL, Metcalfe JC, Weissberg PL, Wade DP, Lawn RM. Proliferation of human smooth muscle cells promoted by lipoprotein(a). Science 1993; 260: 1655-1658.
  • Grainger DJ, Kemp PR, Liu AC, Lawn RM, Metcalfe JC. Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice. Nature 1994; 370: 460-462.
  • Grainger DJ, Jemp PR, Metcalfe JC, et al. The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis. Nat Med 1995; 1: 74-79.
  • McCormick SP, Nielsen LB. Expression of large genomic clones in transgenic mice: new insights in apolipoprotein B structure, function and regulation. Curr Opin Lipid 1998; 9: 103-111.
  • Carmeliet P, Kieckens L, Schoonjans L, et al. Plasminogen activator inhibitor-1 gene deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. J Clin Invest 1993; 92: 2756-2760.
  • Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 228: 815-822.
  • The EPIC Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994; 330: 956-961.
  • Marui N, Offermann MK, Swerlick R, et al. Vascular cell adhesion moleculae-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993; 92: 1866-1874.
  • Khachigian LM, Lindner V, Williams AJ, Collins T. Erg-1-induced endothelial gene expression: a common theme in vascular injury. Science 1996; 271: 1427-1431.
  • Lieberman EH, Gerhard MD, Uehata A, et al. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Int Med 1994; 121: 936-941.
  • Yang NN, Venugopalan M, Hardikar S, Glasebrook A. Identification of an estrogen response element activated by metabolites of 17 beta-estradiol and raloxifene. Science 1996; 273: 1222-1225.
  • Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-236.
  • Loscalzo J, Weinfeld M, Fleiss GM, Scanu AM. Lipoprotein(a), fibrin binding, and plasminogen activation. Arteriosclerosis 1990; 10: 240-245.
  • Ridker PM. C-reactive protein and risks of future myocardial infarction and thrombotic stroke. Eur Heart J 1998; 19: 1-3.
  • Gurfinkel E, Bozovich G, Daroca A, Beck E, Mautner B. Randomised trial of roxithromycin in non Q wave coronary syndromes. ROXIS Pilot Study. Lancet 1997; 350: 404-407.
  • Nabel EG, Plautz G, Boyce FM, Stanley JC, Nabel GJ. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989; 244: 1342-1344.
  • Isner JM, Pieczek A, Schainfeld R, et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF 165 in patient with ischaemic limb. Lancet 1996; 348: 370-374.
  • Simari RD, San H, Rekhter M, et al. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries. J Clin Invest 1996; 98: 225-235.
  • Newman KD, Dunn PF, Owens JW, et al. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation and neointimal hyperplasia. J Clin Invest 1995; 96: 2955-2965.
  • Schulick AH, Vassalli G, Dunn PF, et al. Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity. J Clin Invest 1997; 99: 209-219.
  • Kim S, Lin H, Barr E, Chu L, Leiden JM, Parmacek MS. Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo. J Clin Invest 1997; 100: 1006-1014.
  • Ohno T, Gordon D, San H, et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 1994; 265: 781-784.
  • Harrell R, Rajanayagam M, Doanes A, et al. Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase. Circulation 1997; 96: 621-627.
  • Yang ZY, Simari R, Perkins N, et al. Role of the p21 cyclin dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA 1996; 93: 7905-7910.
  • Chang M, Barr E, Seltzer J, et al. Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of retinoblastoma gene product. Science 1995; 267: 518-522.
  • Sata M, Perlman H, Muruve D, et al. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. Proc Natl Acad Sci USA 1998; 95: 1213-1217.
  • Van der Leyen H, Gibbons H, Morishita R, et al. Gene therapy inhibiting neointimal vascular lesion formation: In vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 1995; 92: 1137-1141.
  • Rade JJ, Schulick AH, Virmani R, Dichek DA. Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat Med 1996; 2: 293-298.
  • Van der Leyen H, Gibbons H, Morishita R, et al. Gene therapy inhibiting neointimal vascular lesion formation: In vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 1995; 92: 1137-1141.
  • Kullo I, Mozez G, Schwartz R, et al. Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity. Circulation 1997; 96: 2254-2261.
  • Ueno H, Haruno A, Morisaki N, et al. Local expression of C-type natriuretic peptide markedly suppresses neointimal formation in rat injured arteries through an autocrine/ paracrine loop. Circulation 1997; 96: 2272-2279.

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