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(RG) Obstetrics and Gynaecology

Biological effects of progestins in breast cancer

&
Pages 11-19 | Published online: 28 Aug 2009

References

  • Segaloff A. Hormones and mammary carcino-genesis. In McGuire WL, ed. Breast Cancer 2: Advances in Research and Treatment. New York: Plenum Press, 1978:1–22
  • Kirschner MA. The role of hormones in the development of human breast cancer. In McGuire WL, ed. Breast Cancer 3: Advances in Research and Treatment, Current Topics. New York: Plenum Press, 1979:199–226
  • Henderson B, Ross R, Bernstein L. Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res 1988;48:246–53
  • Raam S, Robert N, Pappas CA, et al. Defective estrogen receptors in human mammary cancers: their significance in defining hormone dependence. J Natl Cancer Inst 1988;80:756–61
  • Fuqua SAW, Fitzgerald SD, Chamness GC, et al. Variant humanbreasttumorestrogen receptor with constitutive transcriptional activity. Cancer Res 1991;51:105–9
  • McGuire WL, Chamness GC, Fuqua SAW. Abnormal estrogen receptor in clinical breast cancer. J Steroid Biochem MolBiol 1992;43: 243–7
  • Castles CG, Fuqua SAW, Klotz DM, et al. Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line. Cancer Res 1993;53: 5934–9
  • Murphy LC, Dotzlaw H, Leygue E, et al. Minireview: Estrogen receptor variants and mutations. J Steroid Biochem Mol Biol 1997;62: 363–72
  • EdwardsDP, ChamnessGC, McGuire WL. Estrogen and progesterone receptors in breast cancer. Biochim Biophys Acta 1979;560:457–86
  • Litherland S, Jackson IM. Antiestrogens in the management of hormone-dependent cancer. Cancer Treat Rev 1988;15:183–94
  • Hall JM, Lee MK, Newman B, et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 1990;250:1684–9
  • Cropp CS, Nevanlinna HA, Pyrhönen S, et al. Evidence for involvement of BRCA1 in sporadic breast carcinomas. Cancer Res 1994;54: 2548–51
  • Wooster R, Neuhauson SL, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12–13. Science 1994; 265:2088–90
  • Loriaux DL, Ruder HJ, Lipsett MB. The measurement of estrone sulfate in plasma. Steroids 1971;18: 463–72
  • Roberts KD, Rochefort JG, Bleau G, et al. Plasma estrone sulfate levels in postmenopausal women. Steroids 1980;35:179–87
  • Pasqualini JR, Chetrite G, Blacker C, et al. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and post-menopausalbreast cancer patients. J Clin Endocrinol Metab 1996;81:1460–4
  • Dao TL, Hayes C, Libby PR. Steroid sulfatase activities in human breast tumors. Proc Soc Exp Biol Med 1974;146:381–4
  • Vignon F, Terqui M, Westley B, et al. Effects of plasma estrogen sulfates in mammary cancer cells. Endocrinology 1980;106:1079–86
  • Tseng L, Mazella J, Lee LY, et al. Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma. J Steroid Biochem 1983;19: 1413–17
  • Pasqualini JR, Gelly C, Lecerf F. Biological effects and morphological responses to estriol, estriol-3-sulfate, estriol-17-sulfate and tamoxifen in a tamoxifen-resistant cell line (R-27) derived from MCF-7 humanbreastcancer cells. Eur J Cancer Clin Oncol 1986;22: 1495–501
  • Pasqualini JR, Gelly C, Nguyen B-L, et al. Importance of estrogen sulfates in breast cancer. J Steroid Biochem 1989;34:155–63
  • Pasqualini JR, Schatz B, Varin C, et al. Recent data on estrogen sulfatase and sulfotransferase activities in human breast cancer. J Steroid Biochem Mol Biol 1992;41:323–9
  • Perel E, Wilkins D, Killinger DW. The conversion of androstenedione to estrone, estradiol, and testosterone in human breast tissue. J Steroid Biochem 1980;13:89–94
  • Silva MC, Rowlands MG, Dowsett M, et al. Intratumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res 1989;49: 2588–91
  • Pollow K, BoquoiE, Baumann J, et al. Comparison of the in vitro conversion of estradiol-17b to estrone of normal and neoplastic human breast tissue. Mol Cell Endocrinol 1977;6:333–48
  • Abul-Hajj YJ, Iverson R, Kiang DT. Estradiol 17b-dehydrogenase and estradiol binding in humanmammarytumors.Steroids 1979;33: 477–84
  • Vermeulen A, Deslypere JP, Paridaens R, et al. Aromatase, 17b-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur J Cancer Clin Oncol 1986;22:515–25
  • Nguyen B-L, Chetrite G, Pasqualini JR. Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020). Breast Cancer Res Treat 1995;34: 139–46
  • Raju U, Blaustein A, Levitz M. Conjugation of androgensand estrogens by humanbreast tumors in vitro. Steroids 1980;35:685–95
  • PasqualiniJR, Chetrite G, Nguyen B-L, et al. Control of estrone sulfatase activity and its expression in human breast cancer. In Motta M, Serio M, eds. Sex Hormones, and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects. Amsterdam: Elsevier Science, 1994:257–65
  • Pasqualini JR. Steroid sulphotransferase activity in human hormone-independent MDA-MB-468 mammary cancer cells. Eur J Cancer 1992;28A: 758–62
  • Labrie F, Dupont A, Luu The V, et al. Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer. Eur Urol 1993;24(Suppl 2):94–105
  • MacIndoe JH, with the technical assistance of WoodsG, Jeffried L, HinkhouseM. The hydrolysis of estrone sulfate and dehydroepiandrosterone sul-fate by MCF-7 human breast cancer cells. Endocrinology 1988;123:1281–7
  • Pasqualini JR, Gelly C, Lecerf F. Biological effects and morphological responses to estriol, estriol-3-sulfate, estriol-17-sulfate and tamoxifen in a tamoxifen-resistant cell line (R-27) derived from MCF-7 humanbreast cancer cells. Eur J Cancer Clin Oncol 1986;22: 1495–501
  • Pasqualini JR, Gelly C, Nguyen B-L, et al. Importance of estrogen sulfates in breast cancer. J Steroid Biochem 1989;34:155–63
  • Pasqualini JR, Schatz B, Varin C, et al. Recent data on estrogen sulfatases and sulfotransferases activities in human breast cancer. J Steroid Biochem Mol Biol 1992;41:323–9
  • Pasqualini JR, Varin C, Nguyen B-L. Effect of the progestagen R5020 (promegestone) and of progesterone on the uptake and on the transformation of estrone sulfate in the MCF-7 and T-47D human mammary cancer cells: correlation with progesterone receptor levels. Cancer Lett 1992;66: 55–60
  • PasqualiniJR, Chetrite G, Nguyen B-L, et al. Control of estrone sulfatase activity and its expression in human breast cancer. In Motta M, Serio M, eds. Sex Hormones, and Antihormones in Endocrine-Dependent Pathology: Basic and Clinical Aspects, Amsterdam: Excerpta Medica International Congress Series, Elsevier, 1994:257–65
  • Pasqualini JR, Chetrite G, Le Nestour E. Control and expression of oestrone sulphatase activities in human breast cancer. J Endocrinol 1996;150: S99–S105
  • Pasqualini JR, Nguyen B-L. Estrone sulfatase activity and effect of antiestrogens on transformation of estrone sulfate in hormone-dependent vs -independent human breast cancer cell lines. Breast Cancer Res Treat 1991;18:93–8
  • Prost-Avallet O, Oursin J, Adessi GL. In vitro effect of synthetic progestogens on estrone sulfatase activity in humanbreastcarcinoma. J Steroid Biochem Mol Biol 1991;39:967–73
  • Santner SJ, Santen RJ. Inhibition of estrone sulfatase and 17b-hydroxysteroid dehydrogenase by anti-estrogens. J Steroid Biochem Mol Biol 1993; 45:383–90
  • Pasqualini JR, Ebert C, Chetrite G. Control of estradiol in human breast cancer. Effect of medrogestone on sulfatase, 17b-hydroxysteroid dehydrogenase and sulfotransferases activities in human breast cancer cells. In Birkhauser MH, Rozenbaum H, eds. Proceedings of the IV European Congress on Menopause, Paris: Editions ESKA, 1998:625–33
  • Pasqualini JR, Varin C, Nguyen B-L. Effect of the progestagen R-5020 (promegestone) and of progesterone on the uptake and on the transformation of estrone sulfate in the MCF-7 and T-47D human mammary cancer cells: correlation with progesteronereceptor levels. Cancer Lett 1992; 66:55–60
  • Chetrite G, Paris J, Botella J, et al. Effect of nomegestrol acetate on estrone-sulfatase and 17b-hydroxysteroid dehydrogenase activities in human breast cancer cells. J Steroid Biochem Mol Biol 1996;58:525–31
  • Nguyen B-L, Fermé I, Chetrite G, et al. Action of danazol on the conversion of estrone sulfate to estradioland on the sulfataseactivity in the MCF-7, T-47D and MDA-MB-231 human mammary cancer cells. J Steroid Biochem Mol Biol 1993;46: 17–23
  • Carlström K, Doberl A, PousetteA, et al. Inhibition of steroid sulfatase activity by danazol. Acta Obstet Gynecol Scand 1984;123:107–11
  • Evans TRJ, Rowlands MG, Jarman M, et al. Inhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma. J Steroid Biochem Mol Biol 1991;39:493–9
  • Chetrite G, Kloosterboer HJ, Pasqualini JR. Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells. Anticancer Res 1997;17: 135–40
  • Chetrite G, Varin C, Delalonde L, et al. Effect of promegestone, tamoxifen, 4-hydroxytamoxifen and ICI 164,384 on the oestrone sulphataseactivity of human breast cancer cells. Anticancer Res 1993; 13:931–4
  • Pasqualini JR, Maloche C, Maroni M, et al. Effect of the progestagen promegestone (R-5020) on mRNA of the oestrone sulphatase in the MCF-7 human mammary cancer cells. Anticancer Res 1994; 14:1589–4
  • Andersson S, Moghrabi N. Physiology and molecular genetics of 17b-hydroxysteroid dehydro-genases. Steroids 1997;62:143–7
  • Isomaa VV, Ghersevich SA, Môaentausta OK, et al. Steroid biosynthetic enzymes: 17b-hydroxysteroid dehydrogenase. Annals Med 1993; 2591–7
  • Penning TM. Molecular endocrinology of hydroxysteroid dehydrogenases. Endocr Rev 1997; 18:281–305
  • Pollow K, BoquoiE, Baumann J, et al. Comparison of the in vitro conversion of estradiol-17b to estrone of normal and neoplastic human breast tissue. Mol Cell Endocrinol 1977;6:333–48
  • Gompel A, Malet C, Spritzer P, et al. Progestin effect on cell proliferation and 17b-hydroxysteroid dehydrogenase activity in normal human breast cells in culture. J Clin Endocrinol Metab 1986;63: 1174–80
  • Prudhomme JF, Malet C, Gompel A, et al. 17b-Hydroxysteroid dehydrogenase activity in human breast epithelial cells and fibroblast cultures. Endocrinology 1984;114:1483–9
  • Poutanen M, Moncharmont B, Vihko R. 17b-Hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin. Cancer Res 1992;52: 290–4
  • Malet C, Vacca A, Kuttenn F, et al. 17b-Hydroxysteroid dehydrogenase(E2DH) activity in T47D cells. J Steroid Biochem Mol Biol 1991;39: 769–75
  • Pasqualini JR, Chetrite G, Nguyen B-L, et al. Estrone sulfate-sulfatase and 17b-hydroxysteroid dehydrogenase activities: a hypothesis for their role in the evolution of human breast cancer from hormone-dependence to hormone-independence. J Steroid Biochem Mol Biol 1995;53: 407–12
  • Adams EF, Coldham NG, James VHT. Steroidal regulation of oestradiol-17b-dehydrogenase activity of the human breast cancer cell line MCF-7. J Endocrinol 1988;118: 149–54
  • Coldham NG, James VHT. A possible mechanism for increased breast cell proliferation by progestins through increased reductive 17b-hydroxysteroid dehydrogenaseactivity. Int J Cancer 1990;45:174–8
  • Couture P, Thériault C, Simard J, et al. Androgen receptor-mediated stimulation of 17b-hydroxy-steroid dehydrogenase activity by dihydrotes-tosterone and medroxyprogesterone acetate in ZR-75–1 human breast cancer cells. Endocrinology 1993;132:179–85
  • Poutanen M, Isomaa V, Kainulainen K, et al. Progestin induction of 17b-hydroxysteroid dehydrogenase enzyme protein in the T-47D human breast cancer cell line. Int J Cancer 1990; 46:897–901
  • Harris AL, Mitchell MD, Smith IE, et al. Aminoglutethimide in the treatment of advanced postmenopausalbreast cancer. Cancer Res 1982;42: 3405–8
  • Coombes RC, Goss PE, Dowsett M, et al. 4-Hydroxyandrostenedione treatment for post-menopausal patients with advanced breast cancer. Steroids 1987;50:245–52
  • de Jong PC, van de Ven J, Nortier HWR, et al. Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor Vorozole. Cancer Res 1997;57:2109–11
  • Miller WR. Aromatase inhibitors. Endocr-Rel Cancer 1996;3:65–79
  • Perel E, Daniilescu D, Kharlip L, et al. Steroid modulation of aromatase activity in human cultured breast carcinoma cells. J Steroid Biochem 1988;29:393–9
  • Godefroi VC, Locke ER, Singh DV, et al. The steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors. Cancer Res
  • Adams JB, Philips NS, Hall R. Metabolic fate of estradiol in human mammary cancer cells in culture: estrogen sulfate formation and cooperativity exhibited by estrogen sulfotransferase. Mol Cell Endocrinol 1988;58:231–42
  • Chetrite G, Le Nestour E, Pasqualini JR. Estrogen sulfotransferase activities and its mRNA in various breast cancer cell lines. Effect of the progestin, promegestone (R-5020). J Steroid Biochem Mol Biol 1998;66: 295–302

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