References
- Cameron JL, No sbis ch C. Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta). Endocrinology 1991;128:1532–40
- Cameron JL, Weltzin TE, McConaha C, et al. Slowing of pulsatile luteinizing hormone secre-tion in men after 48 hours of fasting. J Clin Endocrinol Metab 1991;73:35–41
- Foster DL, Nagatani S. Physiological perspective of leptin as a regulator of reproduction: role in timing puberty. J Biol Reprod 1999;60:205–15
- Foster DL, Olster DH. Effects of restricted nutrition on puberty in the lamb: pattern of tonic luteinizing hormone (LH) secretion and competency of the LH surge system. Endocrinology 1985;116:375–81
- Kennedy GC, Mitra J. Body weight and food intake as initiating factors for puberty in the rat. J Physiol 1963;166:408–18
- Schillo KK. Effects of dietary energy on control of luteinizing hormone secretion in cattle and sheep. J Anim Sci 1882;70:1271–82
- Wade GN, Schneider JE, Li H-Y. Control of fertility by metabolic cues. Am J Physiol 1996; 270:E1–E19
- Gill CJ, Rissmann EF. Female sexual behaviour is inhibited by short- and long-term food restriction. Physiol Behav 1997;61:387–94
- Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–32
- Madej T, Boguski MS, Buyaub SM. Threadly analysis suggests that the obese gene product may be a helical cytokine. FEBS Letters 1995;373: 13–18
- Masuzaki H, Ogawa Y, Isse N, et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855–8
- Sinha M, Opentanova I, Ohannesian JP, et al. Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. J Clin Invest 1996; 98:1277–82
- Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619–32
- Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive leptin concentrations in normal-weight and obese women. N Engl J Med 1996;334:292–5
- Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurements of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995;1:1155–61
- Ma Z, Gingerich RL, Santiago JV, et al. Radio-immunoassay of leptin in human plasma. Clin Chem 1996;42:942–6
- Di Carlo C, Tommaselli GA, Pisano G, et al. Serum leptin levels in postmenopausal women: effects of transdermal hormone replacement therapy. Menopause 2000;7:36–41
- Ingalls AM, Dickie MD, Snell GD. Obese, new mutation in the mouse.JHered 1950;41:317–18
- Han-is RB, Zhou J, Redman SM, et al. A leptin dose response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 1998;139:8–19
- Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene on body weight regulation in ob/ob mice. Science 1995;269:540–3
- Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse Ob protein: evidence for a peripheral signal linking adiposity and central neuronal networks. Science 1995;269:546–9
- Halaas JL, Gajwala KS, Maffei M, et al. Weight-reducing effect of the plasma protein encoded by the obese gene. Science 1995; 269:543–6
- Barash IA, Cheung CC, Weigle DS, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;137:144–7
- Chehab FF, Lim ME, Lu R. Correction of sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet 1996;12:318–20
- Mouzih K, Lu R, Chehab FF. Leptin treatment recues the sterility of genetically obese ob/ob males. Endocrinology 1997;138:1190–3
- The writing group for the PEPI trial. Effects of estrogen or estrogen/pro gestin regimens on heart disease risk factors in postmenopausal women. J Am Med Assoc 1995;273:199–208
- Gambacciani M, Ciaponi M, Cappagli B, et al. Body weight, body fat distribution, and hormonal replacement therapy in early post-menopausalwo men. J Clin Endocrinol Metab 1997; 82:414–17
- Gambacciani M, Ciaponi M, Cappagli B, et al. Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy. Maturitas 2001;39:125–32
- Burger HG, Dudley EC, Hopper JL, et al. The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample. J Clin Endocrinol Metab 1995;80:3537–45
- Forbes GB, Reina JC. Adult lean body mass declines with age: longitudinal observations. Metabolism 1970;19:653–63
- Swerdloff RS, Batt RA, Bray GA. Reproductive hormonal function in the genetically obese (ob/ob) mouse. Endocrinology 1994;98:1359–64
- Yu WH, Walczewska A, Karanth S, et al. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997;94:1023–8
- Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;334:292–5
- Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999; 341:879–84
- Strobel A, Issad T, Camoin L, et al. A leptin mis-sense mutation associated with hypo-gonadism and morbid obesity. Nature Genet 1998;18:213–15
- Clement K, Vaisse C, Lahlou N. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398–401
- Edwardson JA, Hough LC. The pituitary-adrenal system of the genetically obese (ob/ob) mouse. J Endocrinol 1975;65:99–107
- Cioffi JA, Shafer AW, Zupancic TJ, et al. Novel B219/0B receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med 1996;12:585–9
- Karlsson C, Lindell K, Svensson E, et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997;82: 4144–8
- Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, et al. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and somatotropic axis in the intact adult female rats. Endocrinology 1993;132: 335–34
- Pierroz DD, Catzeflis C, Aebi AC, et al. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 1996;137:3–12
- Raposinho PD, Pedrazzini T, Tommaselli GA, et al. The neuropeptide Y Y1 antagonist/Y4 ago nist 1229U91 stimulates LH secretion through NPY Y4 receptors: assessment using NPY Y1-deficient mice. The Endocrine Society's 82nd Annual Meeting, June 21–24 2000, Toronto, Canada
- Murakami T, Iida M, Shinam K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem Biophys Res Commun 1995;214:5301–4
- Sliker LJ, Sloop KW, Surface PL, et al. Regulation of ob m-RNA and protein by glucocorticoids and cAMP.J Biol Chem 1996;27:5301–4
- Kristiensen K, Pedersen SB, Richelsen B. Regulation of leptin by steroid hormones in rat adipose tissue. Biochem Biophys Res Commun 1999;259:624–30
- Shimizu H, Shimomura Y, Nakanishi Y, et al. Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 1997; 154:285–92
- Machinal F, Dieudonne MN, Leneveu MC, et al. In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones. Endocrinology 1999;140:1567–74
- Casabiell X, Pineiro V, Peino R, et al. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulates leptin release in women, but not in men. J Clin Endocrinol Metab 1998;83:2149–55
- Pineiro V, Casabiell X, Lage M, et al. Dihydrotestosterone, stanozolol, androstene- dione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: lack of effect of testosterone. J Endocrinol 1999;160: 425–32
- Montague C, Prins J, Sanders L, et al. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 1997;46:342–7
- Lonnquist F, Amer P, Nordfors L, et al. Over-expression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med 1995; 1:950–3
- Hamilton BS, Paglia D, Kwan AY, et al. Increased obese mRNA expression in omental fat cells from massively obese human. Nature Med 1995;1: 953–6
- Kumar V, Chambon P. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 1988;55:145–56
- Savouret JF, Rauch M, Redeuilh G, et al. Interplay between estrogen, pro gestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene. J Biol Chem 1994; 269:28955–62
- Wade GN, Gray JM. Cytoplasmic 1713-[3H1 estradiol binding in rat adipose tissue. Endocrinology 1978;103:1695–701
- Wabitsch M, Blum W, Vogel E, et al. Contrib-ution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997;100:808–813
- Yoneda N, Saito S, Kimura M, et al. The influence of ovariectomy on ob gene expression in rats. Horm Metab Res 1998;30:263–5
- Watanobe H, Suda T. A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats. Biochem Biophys Res Commun 1999;259:56–9
- Wu-Peng S, Rosenbaum M, Nicolson M, et al. Effects of exogenous gonadal steroids on leptin homeostasis in rats. Obes Res 1999;7:586–92
- Pelleymounter MA, Baker MB, McCaleb M. Does estradiol mediate leptin's effects on adiposity and body weight? Am J Physiol 1999;276:E955—E963
- Pinilla L, Seoane M, Gonzalez L, et al. Regulation of serum leptin levels by gonadal function in rats. Eur J Endocrinol 1999;140:468–73
- Chu SC, Chou YC, Liu JY, et al. Fluctuation of serum leptin level in rats after ovariectomy and the influence of estrogen supplement. Life Sci 1999;64:2299–306
- Brann DW, De Sevilla L, Zamorano PL, et al. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 1999; 64:659–63
- Richards RJ, Porter JR, Svec F. Serum leptin, lipids, free fatty acids, and fat pads in long-term dehydroepiandrosterone-treated Zucker rats. Proc Soc Exp Biol Med 2000;223:258–62
- Wade GN, Gray JM, Bartness TJ. Gonadal influences on adiposity. Int J Obes 1985;9:83–92
- Ambrosius W, Compton J, Bowsher R, et al. Relationship ofrace, age, and sex hormone differ-ences to serum leptin concentrations in children and adolescents. Horm Res 1998;49:240–6
- Paolisso G, Rizoo MR, Marone CM, et al. Plasma sex hormones are significantly associated with plasma leptin concentrations. Clin Endocrinol 1998;48:291–7
- Licinio J, Negrao A, Mantzoros C, et al. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 1998;83:4140–7
- Hellstrom L, Wahrenberg H, Hruska K, et al. Mechanism behind gender differences in circulat-ing leptin levels. J Intern Med 2000;247:457–62
- Matsuda V, Yokoda I, Iida M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab 1997;82:1642–4
- Ellis K, Nicolson M. Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development. Pediatr Res 1997;42: 484–8
- Arslanian S, Suprasongsin C, Kalhan S, et al. Plasma leptin in children: relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure. Metabolism 1998;47:309–12
- Argente J, Barrios V, Chowen J, et al. Leptin levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr 1997;131:833–8
- Kotani K, Tokunaga K, Fujioka S, et al. Sexual dimorphism of age-related whole body fat changes in the obese. Int J Obes 1994;18:207–12
- Leenen R, Kooy KVD, Duerenberg P, et al. Visceral fat accumulation in obese subjects: rela-tion to energy expenditure and response to weight loss. Am J Physiol 1992;263:E913—E919
- Harmelen VV, Reynisdottir S, Erikkson P, et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998;47: 913–17
- Nagy T, Bower G, Trowbridge C, et al. Effects of gender, ethnicity, body composition, and fat distribution on serum leptin levels in children. J Clin Endocrinol Metab 1997;82:2148–52
- Hube F, Lietz U, Igel M, et al. Differences in leptin mRNA levels between omental and sub-cutaneous adipose tissue from obese humans. Horm Metab Res 1996;28:690–3
- Roemmich J, Clark P, Berr S, et al. Gender differ-ences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol 1998;275:E543—E551
- Mantzoros CS, Flier JS, Rogol AD. A longi-tudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82:1066–70
- Clayton P, Gill M, Hall C, et al. Serum leptin through childhood and adolescence. Clin Endocrinol 1997;46:733–7
- Jockenhovel M, Bum W, Vogel E, et al. Testos-terone substitution normalizes elevated serum leptin levels in hypo gonadal men. J Clin Endocrinol Metab 1997;82:2510–13
- Elbers J, Asscheman H, Seidell J, et al. Reversal of sex hormone difference in serum leptin levels upon cross-sex hormone administration in trans-sexual. J Clin Endocrinol Metab 1997;82:3267–70
- Laughlin G, Morales A, Yen SSC. Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J Clin Endocrinol Metab 1997;82:1692–6
- Rouru J, Antilla L, Koskinen P, et al. Serum leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82:1697–1700
- Mantzoros CS, DunaifA, Flier JS. Leptin concen-tration in the polycystic ovary syndrome. J Clin Endocrinol Metab 1997;82:1687–91
- Hardie L, Trayhurn P, Abramovich D, et al. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol 1997;47:101–6
- Riad-Gabriel M, Jinagouda SD, Sharma A, et al. Changes in plasma leptin during the menstrual cycle. Eur J Endocrinol 1998;139:528–31
- Buffenstein R, Poppit SD, McDevitt RM, et al. Food intake and the menstrual cycle: a retrospec-tive analysis, with implications for appetite research. Physiol Behav 1995;58:1067–77
- Poehlman ET, Tchemof A. Traversing the menopause: changes in energy expenditure and body composition. Coron Artery Dis 1998; 9:799–803
- Gower BA, Nagy TR, Goran MI, et al. Fat distribution and plasma lipid-lipoprotein concen-trations in pre- and post-menopausal women. Int J Obes Re/at Metab Disord 1998;22:605–11
- Tchemof A, Poehlman ET. Effects of the menopause transition on body fatness and body fat distribution. Obes Res 1998;6:246–54
- Toth MJ, Tchemof A, Sites CK, et al. Meno-pause-related changes in body fat distribution. Ann N Y Acad Sci 2000;904:502–6
- Corpas E, Hannan SM, Blackman MR. Human growth hormone and human aging. Endocr Rev 1993;14:20–39
- Iranmanesh A, Lizzaralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991;73:1081–8
- Veldhuis JD, Iranmanesh A, Ho KKY, et al. Dual defects in pulsatile GH secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991;72: 51–9
- Salomon F, Cuneo RC, Hesp R, et al. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adult with growth hormone deficiency. N Engl J Med 1989;321:1797–803
- Moller N, Jorgensen JOL, Alberti KG, et al. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 1990; 70:1179–86
- O'Sullivan AJ, Kelly JJ, Hoffman DM, et al. Body composition and energy expenditure in acromegalia. J Clin Endocrinol Metab 1994; 78:381–6
- Hoffman DM, O'Sullivan AJ, Freund J, et al. Adults with growth hormone deficiency have abnormal body composition but normal energy metabolismj Clin Endocrinol Metab 1995;80:72–7
- Goodman HM. In vitro actions of growth hormone on glucose metabolism in adipose tissue. Endocrinology 1965;76:216–25
- Goodman HM, Kostyo JL. Altered profiles of biological activity of growth hormone fragments on adipocyte metabolism. Endocrin-ology 1981;108:553–8
- Gavin J, Gorden P, Roth J, et al. Characteristics of the human lymphocyte insulin receptor. J Biol Chem 1973;248:2202–7
- Pascual M, Larralde J, Martinez JA. Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes. Life Sci 1995;57:1213–18
- Guo SS, Zeller C, Chumlea WC, et al. Aging body composition, and lifestyle: the Fels Longitudinal Study. Am J Clin Nutr 1999;70: 405–11
- Hassager C, Christiansen C. Estrogen/gestagen therapy changes soft tissue body composition in postmenopausal women. Metabolism 1989;38: 662–5
- Hanggi W, Lippuner K, Jaeger P, et al. Differen-tial impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women. Clin Endocrinol 1998;48:691–9
- Aloia JF, Vaswani A, Russo L, et al. The influence of menopause and hormonal replacement therapy on body composition. Am J Obstet Gynecol 1995; 172:896–900
- Castracane VD, Kraemer RR, Franken MA, et al. Serum leptin concentration in women: effect of age, obesity, and estrogen. Fertil Steril 1998;70: 472–7
- Moller N, O'Brien P, Nair KS. Disruption of the relationship between fat content and leptin levels with aging in humans. J Clin Endocrinol Metab 1998;83:931–4
- Havel PJ, Kasim-Karakas S, Dubuc GR, et al. Gender differences in plasma leptin concen-trations. Nat Med 1996;2:949–50
- Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition, and meno-pause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996;81:3424–7
- Haffner SM, Mykkanen L, Stern MP. Leptin concentrations in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy. Am J Epidemiol 1997;146:581–5
- Kohrt WM, Landt M, Birge SJ Jr. Serum leptin levels are reduced in response to exercise training but not hormone replacement therapy, in older women. J Clin Endocrinol Metab 1996;81: 3980–5
- Nick_las BJ, Toth MJ, Goldberg AP, et al. Racial differences in plasma leptin concentration in obese postmenopausal women. J Clin Endocrinol Metab 1997;82:315–17
- Hadji P, Hars O, Bock K, et al. The influence of menopause and body mass index on serum leptin concentrations. Eur J Endocrinol 2000;143:55–60
- Lavoie HB, Taylor AE, Sharpless JL, et al. Effects of short hormone replacement on serum leptin levels in postmenopausal women. Clin Endocrinol 1999;51:415–42
- Cento RI\4, Proto C, Spada RS, et al. Leptin levels in menopause: effect of estrogen replace-ment therapy. Horm Res 1999;52: 269–73
- Milewicz A, Bidzinska B, Mikulski E, et al. Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuro-peptide Y levels. Gynecol Endocrinol 2000;14: 196–203
- Kristiens en K, Pedersen SB, Vestergaard PV, et al. Hormone replacement therapy affects body composition and leptin differently in obese and non-obese postmenopausal women. J Endocrinol 1999;163:55–62
- Riondino G, Isidori AM, Fabbri A, et al. Leptin changes in normal weight and obese women in pre- and post-menopausal conditions. JEndocrino/ Invest 1999;22:(Suppl. to no. 10), 66–7
- Gower BA, Nagy TR, Goran MI, et al. Leptin in postmenopausal women: influence of hormone therapy, insulin, and fat distribution. J Clin Endocrinol Metab 2000;85:1770–5
- Salbach B, Nawroth PP, Kubler W, et al. Serum leptin and body weight in postmenopausal women under trans dermal hormone replacement therapy. Eur J Med Res 2000;28:63–6
- Baranowska B, Radzikowska M, Wasilewska-Dziubinska E, et al. Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women. Menopause 2000;7:149–55
- Laivuori H, Koistinen HA, Karonen S-L, et al. Comparison between 1 year oral transdermal oestradiol and sequential norethisterone acetate on circulating concentrations of leptin in post-menopausal women. Hum Reprod 2001;16: 1632–5
- Elbers JM, de Valk-de Roo GW, Popp-Snijders C, et al. Effects of administration of 1713-oestradiol on serum leptin levels in healthy postmenopausal women. Clin Endocrinol 1999; 51:449–54
- Sumner AE, Falkner B, Kushner H, et al. Relationship of leptin concentration to gender, menopause, age, diabetes, and fat mass in african americans. Obes Res 1998;6:128–33
- Licinio J, Mantzoros C, Negrao AB, et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997;3:575–9