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(RG) Obstetrics and Gynaecology

Molecular mechanisms contributing to the pathogenesis of endometriosis

, , &
Pages 493-504 | Published online: 07 Jul 2009

References

  • Sampson J. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927; 14:422–9
  • Halme J, Hammond MG, Hulka JF, et al. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol 1984;64:151–4
  • Kruitwagen RF, Poels LG, Willemsen WN, et al. Endometrial epithelial cells in peritoneal fluid during the early follicular phase. Fertil Steril 1991;55:297–303
  • Cramer DW, Hornstein MD, Ng WG, et al. Endo metrio sis associated with the N314D mutation of galactose-1-phosphate uridyl trans-ferase (GALT). Mol Hum Reprod 1996;2:149–52
  • Halme J. Peritoneal macrophages from patients with endometriosis release growth factor activity in vitro. J Clin Endocrinol Metab 1988; 66:1044–9
  • Fuji S. Secondary mullerian system and endo-metriosis. Am J Obstet Gynecol 1991;165:219–25
  • Baranova H, Canis M, Ivachenko T, et al. Possible involvement of arylamine N-acetyltransferase 2, glutathione S-transferases M1 and Ti genes in the development of endometriosis. Mol Hum Reprod 1999;5:636–41
  • Bulun SE, Zeitoun KM, Takayama K, et al. Aromatase as therapeutic target in endometriosis. Trends Endocrinol Metab 2000;11:22–7
  • Taylor RN, Ryan IP, Moore ES, et al. Angiogenesis and macrophage activation in endo-metriosis. Ann NY Acad Sci 1997;828:194–207
  • Halme J, Becker S, Hoskin S. Altered mutation and function of p eritoneal macrophages: possible role in the pathogenesis of endometriosis. Am J Obstet Gynecol 1987;156:783–5
  • Haney AF, Jenkins S, Weinberg JF. The stimulus responsible for the peritoneal fluid inflammation observed in infertile women with endometriosis. Fertil Steril 1991;56:408–13
  • Homung D, Ryan IP, Chao VA, et al. Immuno-localization and regulation of the chemokine RANTES in the human endometrial and endometriosis tissue and cells. J Clin Endocrinol Metab 1997;82:1612–28
  • McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 2000;6:45–55
  • Osteen KG, Bruner KL, Sharpe-Timms KL. Steroid and growth factor regulation of matrix metalloproteinase expression in endometriosis. Semin Reprod Endocrinol 1996; 15:301–8
  • Hornung D, Dohm K, Sotlar K, et al. Localization in tissues and secretion of eotaxin by cells from normal endometrium and endometriosis. J Clin Endocrinol Metab 2000;85:2604–7
  • Sidell N, Han SW, Parthasarthy S. Regulation and modulation of abnormal immune responses in endometriosis. Ann N Y Acad Sci 2002;955:159–73
  • Oosterlynck DJ, Cornillie FJ, Waer M, et al. Women with endometriosis show a defect in natural killer cell activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril 1991;56:45–51
  • Vigano P, Gaffuri B, Somigliana E, etal. Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture. Mol Hum Reprod 1998; 5:642–50
  • Garcio-Valesco JA, Arici A, Zreik T, et al. Macrophage-derived growth factors modulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Mol Hum Reprod 1999;5:642–50
  • Yeoman GR, Collins JE, Lang GA. Autoantibody responses to carbohydrate epitopes in endo-metriosis. Ann N Y Acad Sci 2002;955:174–82
  • Jones RK, Bulmer JN, Searle RF. Immuno-histo chemical characterization of proliferation, oestrogen receptor and progesterone receptor expression in endometriosis: comparison of eutopic and ectopic endometrium with normal cycling endometrium. Hum Reprod 1995;10:3227–9
  • Attia GR, Zeitoun K, Edwards D, etal. Progesterone receptor isoform A but not B is expressed in endo-metriosis. J Clin Endocrinol Metab 2000;85:2897–902
  • Kitawaki J, Obayashi H, Ishihara H, et al. Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata. Hum Reprod 2001;16:51–5
  • Simpson ER, Clyne C, Speed C, et al. Tissue-specific estrogen biosynthesis and metabolism. Ann N Y Acad Sci 2001;949:58–67
  • Matsuzaki S, Murakami T, Uehara S, et al. Expression of estrogen receptor alpha and beta in peritoneal and ovarian endometriosis. Fertil Steril 2001;75:1198–205
  • Shifren JL, Tseng JF, Zaloudek CJ, et al. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 1996;64:3112–18
  • Berube S, Marcoux S, Langevin M, et al. Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility. The Canadian Collaborative Group on Endo metrio sis. Fertil Steril 1998;69:1034–41
  • Cahill DJ, Hull MGR. Pituitary-ovarian dys-function and endometriosis. Hum Reprod Update 2000;6:56–66
  • Lessey BA. Implantation defects in infertile women with endometriosis. Ann N Y Acad Sci 2002; 955:265–80
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998;4:312–22
  • Rodgers PA, Au CL, Affandi B. Endometrial microvascular density during the normal menstrual cycle and following exposure to long-term levonorgestrel. Hum Reprod 1993;8:1396–404
  • Schindl M, Bimer P, Obermair A, et al. Increased microvessel density in adenomyosis uteri. Fertil Steril 2001;75:131–5
  • Folkman J. Angiogenesis in cancer, vascular, rheu-matoid and other diseases. Nature Med 1995;1:27–31
  • Obermair A, Preyer O, Leodolter S. Angiogenesis in Gynäkologie und Geburtshilfe. Wien Klin Wochenschr 1999;111:262–77
  • Parangi S, O'Reilly M, Chrisofori G, et al. Anti-angio genic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci USA 1996;93:2002–7
  • Mon T, Nagasawa H. Mechanisms of development of prolactin-induced adenomyosis in mice. Acta Anat (Basel) 1983;116:46–54
  • Wingfield M, Macpherson A, Healy DL, Rogers PA. Cell proliferation is increased in the endo-metrium of women with endometriosis. Fertil Steril 1995;64:340–6
  • Taylor RN, Lebovic DI, Mueller MD. Angiogenic factors in endometriosis. Ann N Y Acad Sci 2002; 955:89–100
  • Levine Z, Efitathiuo JA, Sampson DA, et al. Angiogenesis inhibitors suppress endometriosis in a murine model. J Soc Gynecol Invest 2002;9:264 (abstr. 612)
  • Regidor PA, Vogal C, Regidor M, etal. Expression pattern of integrin adhesion molecules in endo-metriosis and human endometrium. Hum Reprod Update 1998;4:710–18
  • Van den Linden PJQ, de Go eij AFPM, Dunselmann GAJ. Expression of integrins and E-cadherin in cells from menstrual effluent, endometrium, peritoneal fluid, peritoneum, and endometriosis. Fertil Steril 1994;63:85–90
  • Koks CA, Groothuis PG, Dunselman GA, et al. Adhesion of menstrual endometrium to extra-cellular matrix: the possible role of integrin alpha(6)beta(1) and laminin interaction. Mol Hum Reprod 2000;6:170–7
  • Witz CA, Takahashi A, Montoya-Rodriguez IA, et al. Expression of the alphazbetai and alpha3betai integrins at the surface of mesothelial cells: a potential attachment site of endometrial cells. Fertil Steril 2000;74: 579–84
  • Dechaud H, Witz CA, Montoya-Rodriguez IA, et al. Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium. Fertil Steril 2001;76:1012–18
  • Schenken RS. Pathogenesis of endometriosis. J Soc Gynecol Invest 2002;9:xi
  • Gaetje R, Kotzian S, Herrmann G, et al. Invasiveness of endometriotic cells in vitro. Lancet 1995;346:1463–4
  • Starzinski-Powitz A, Gaetje R, Zeitvogel A, et al. Tracing cellular and molecular mechanisms involved in endometriosis. Hum Reprod Update 1998;4:724–9
  • Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993; 73:161–95
  • Rodgers WH, Matrisian LM, Guidice LC. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest 1994;94:946–53
  • Sillem M, Prifti S, Neher M, et al. Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis in endo-metriosis. Hum Reprod Update 1998;4:730–35
  • Wenzl RJ, Heinzl H. Localintion of matrix metallo-proteinase-2 in uterine endometrium and ectopic implants. Gynecol Obstet Invest 1998;45:253–7
  • Donnez J, Smoes P, Gillerot S, et al. Vascular endo-thelial growth factor (VEGF) in endometriosis. Hum Reprod 1998;13:1686–90
  • Saito T, Mizumoto K, Kuroki K. Expression of MMP3 and TIMP-1 in endometriosis and the influence of danazol. Acta Obstet Gynecol Jpn 1995;47: 495–6
  • Osteen KG. Mediators of progesterone in endo-metriosis. J Soc Gynecol Invest 2002;9;xi
  • Koninckx PR, Kennedy SH, Barlow DH. Endometriotic disease: the role of the peritoneal fluid. Hum Reprod Update 1998;4:741–51
  • Halme J, Becker S, Hammond MG, etal. Increased activation of pelvic macrophages in infertile women with mild endometriosis. Am J Obstet Gynecol 1983;145:333–57
  • Ramey JW, Archer DF. Peritoneal fluid. Its relevance to the development of endometriosis. Fertil Steril 1993;60:1–14
  • Kiesel L, Greb R, Hornung D, et al. Molekulare aspekte zur angiogenese und immunologie der endometriose. Zentralbl Gynakol 1999;121:320–4
  • Chauhan S, Saed GM, Johns DA, et al. Increased IL-10 gene expression in endometriotic tissues. J Soc Gynecol Invest 2002;9:156(abstr. 286)
  • CheongYC, SheltonJB, Laird SM, etal. IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions. Hum Reprod 2002;17:69–75
  • Santanam N, Murphy AA, Parthasarthy S. Macrophages, oxidation and endometriosis. Ann N Y Acad Sci 2002;955:183–98
  • Leyendecker G, Kunz G, Noe M, et al. Endometriosis: a dysfunction and disease of the archimetra. Hum Reprod Update 1998;4:752–62
  • Simpson JL, Elias S, Malinak LR, et al. Heritable aspects of endometriosis. I. Genetic studies. AmJ Obstet Gynecol 1980;137:327–31
  • Moen MH, Magnus P. The familial risk of endo-metriosis. Acta Obstet Gynecol Scand 1993; 72:560–4
  • Kennedy S, Hadfield R, Mardon H. et al. Age of onset of pain symptoms in non-twin sisters concordant for endometriosis. Hum Reprod 1996; 11:403–5
  • Gibbons A. Dioxin tied to endometriosis. Science 1993;262:2
  • Rier SE, Martin DC, Bowman RE, et al. Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin. Fundam Appl Toxicol 1993;21: 433–41
  • Shin JC, Ross HL, Elias S, et al. Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridisation (FISH). Hum Genet 1997;100:401–6
  • Jiang X, Hitchcock A, Bryan E, et al. Micro satellite analysis of endometriosis reveals loss of hetero-zygosity at candidate ovarian tumor suppressor gene loci. Cancer Res 1996;3534–9
  • Gogusev J, Bouget de Joliniere J, Telvi L, et al. Genetic abnormalities detected by comparative genomic hybridisation in a human endometriosis-derived cell line. Mol Hum Reprod 2000;6:821–7
  • Bischoff FZ, Heard M, Simpson JL. Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis. J Reprod Immunol 2002;55: 49–64
  • Bischoff FZ, Simpson JL. Heritability and mol-ecular genetic studies of endometriosis. Hum Reprod Update 2000;6:37–44
  • Watanabe H, Kanzaki H, Narukawa S, et al. Bcl-2 and Fas expression in eutopic and ectopic human endometrium during the menstrual cycle in rela-tion to endometrial cell apoptosis. Am J Obstet Gynecol 1997;176:360–8
  • Dmowski W, Gebel H, Braun DP. Decreased apoptosis and sensitivity to macrophage-mediated cytolysis of endometrial cells in endometriosis. Hum Reprod Update 1998;4:696–701
  • Taylor HS, Bagot C, Kardana A, et al. HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod 1999;14: 1328–31
  • Bulun SE. Aromatase inhibitors in the treatment of endometriosis. J Soc Gynecol Invest 2002;9:xi
  • Ho HN, Wu MY, Yang YS. Peritoneal cellular immunity and endometriosis. AmJ Reprod Immunol 1997;38:400–12
  • Punnonen J, Teisala K, Ranta H, et al. Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis. Am J Obstet Gynecol 1996;174:1522–6
  • Rana N, Braun DP, House R, et al. Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis. Fertil Steril 1996;65:925–30
  • Richter O, Mallmann P, van der Ven H, Krebs D. TNF-alpha secretion by peritoneal macrophages in endometriosis. Zentralbl Gynakol 1998;120:332–6
  • Leiva MC, Hasty LA, Pfeifer S, et al. Increased chemotactic activity of peritoneal fluid in patients with endometriosis. AmJ Obstet Gynecol 1993;168: 592–8
  • Khorram O, Taylor RN, Ryan IP, et al. Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis. AmJ Obstet Gynecol 1993;169:1545–9
  • Kim JG, Suh CS, Kim SH, etal. Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis. Fertil Steril 2000;73:996–1000
  • Wu MH, Yang BC, Hsu CC, et al. The expression of soluble intercellular adhesion molecule-1 in endometriosis. Fertil Steril 1998;70:1139–42
  • Kupker W, Schultze-Mosgau A, Diedrich K. Paracrine changes in the peritoneal environment of women with endometriosis. Hum Reprod Update 1998;4:719–23
  • Keenan JA, Chen TT, Chadwell NL, et al. Inter-feron-gamma (IFN gamma) and interleukin-6 (IL-6) in peritoneal fluid and macrophage-condi-tioned media of women with endometriosis. AmJ Reprod Immunol 1994;32:180–3
  • Koyama N, Matsuura K, Okamura H. Cytokines in the peritoneal fluid of patients with endometriosis. Int J Gynaecol Obstet 1993;43:45–50
  • De Leon FD, Vijayakumar R, Brown M, et al. Peritoneal fluid volume, estrogen, progesterone, prostaglandin, and epidermal growth factor con-centrations in patients with and without endometriosis. Obstet Gynecol 1986;68:189–94

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