Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1–associated dementia: Chemokine receptors, excitotoxicity, and beyond

References

• Adamson DC, Wildemann B, Sasaki M, Glass JD, McArthur JC, Christov VI, Dawson TM, Dawson VL (1996). Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 274: 1917–1921.
   PubMed Web of Science ®Google Scholar
• Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001). CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat Neurosci 4: 702–710.
   PubMed Web of Science ®Google Scholar
• Brenneman DE, Westbrook GL, Fitzgerald SP, Ennist DL, Elkins KL, Ruff MR, Pert CB (1988). Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 335: 639–642.
   PubMed Web of Science ®Google Scholar
• Bruno V, Copani A, Besong G, Scoto G, Nicoletti F (2000). Neuroprotective activity of chemokines against N-methyl-d-aspartate or beta-amyloid-induced toxicity in culture. Eur J Pharmacol 399: 117–121.
   PubMed Web of Science ®Google Scholar
• Budka H (1991). Neuropathology of human immunodeficiency virus infection. Brain Pathol 1: 163–175.
   PubMed Web of Science ®Google Scholar
• Chen HS, Pellegrini JW, Aggarwal SK, Lei SZ, Warach S, Jensen FE, Lipton SA (1992). Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci 12: 4427–4436.
   PubMed Web of Science ®Google Scholar
• Chen W, Sulcove J, Frank I, Jaffer S, Ozdener H, Kolson DL (2002). Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pathway. J Virol 76: 9407–9419.
   PubMedGoogle Scholar
• Dawson VL, Dawson TM, Uhl GR, Snyder SH (1993). Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci U S A 90: 3256–3259.
   PubMed Web of Science ®Google Scholar
• Dreyer EB, Kaiser PK, Offermann JT, Lipton SA (1990). HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248: 364–367.
   PubMed Web of Science ®Google Scholar
• Dreyer EB, Zurakowski D, Gorla M, Vorwerk CK, Lipton SA (1999). The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury. Invest Ophthalmol Vis Sci 40: 983–989.
   Google Scholar
• Galasso JM, Harrison JK, Silverstein FS (1998). Excitotoxic brain injury stimulates expression of the chemokine receptor CCR5 in neonatal rats. Am J Pathol 153: 1631–1640.
   Google Scholar
• Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D’Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA (2002). Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci 22: 4015–4024.
   PubMedGoogle Scholar
• Gartner S (2000). HIV infection and dementia. Science 287: 602–604.
   PubMed Web of Science ®Google Scholar
• Giulian D, Vaca K, Noonan CA (1990). Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250: 1593–1596.
   PubMed Web of Science ®Google Scholar
• Giulian D, Yu J, Li X, Tom D, Li J, Wendt E, Lin SN, Schwarcz R, Noonan C (1996). Study of receptor-mediated neurotoxins released by HIV-1 infected mononuclear phagocytes found in human brain. J Neurosci 16: 3139–3153.
   PubMed Web of Science ®Google Scholar
• Glass JD, Fedor H, Wesselingh SL, McArthur JC (1995). Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 38: 755–762.
   PubMed Web of Science ®Google Scholar
• Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith J W, Liddington RC, Lipton SA (2002). S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297: 1186–1190.
   PubMed Web of Science ®Google Scholar
• Hesselgesser J, Taub D, Baskar P, Greenberg M, Hoxie J, Kolson DL, Horuk R (1998). Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Curr Biol 8: 595–598.
   PubMed Web of Science ®Google Scholar
• Johnston JB, Jiang Y, van Marle G, Mayne MB, Ni W, Holden J, McArthur JC, Power C (2000). Lentivirus infection in the brain induces matrix metalloproteinase expression: role of envelope diversity. J Virol 74: 7211–7220.
   PubMed Web of Science ®Google Scholar
• Kaul M (2002). Chemokines and their receptors in HIV-associated dementia. J NeuroVirol 8(Suppl. 1): 41–42.
   Google Scholar
• Kaul M, Garden GA, Lipton SA (2001). Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410: 988–994.
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton SA (1999). Chemokines and activated macrophages in gp120-induced neuronal apoptosis. Proc Natl Acad Sci U S A 96: 8212–8216.
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton SA (2002). AIDS. In: Ionotropic glutamate receptors as therapeutic targets, Lodge D, Danysz W, Parsons CG (eds). Johnson City TN: FP Graham Publishing Co, pp 1701–1729.
   Google Scholar
• Langford D, Sanders VJ, Mallory M, Kaul M, Masliah E (2002). Expression of stromal cell-derived factor 1alpha protein in HIV encephalitis. J Neuroimmunol 127: 115–126.
   Google Scholar
• Le DA, Lipton SA (2001). Potential and current use of N-methyl-d-aspartate (NMDA) receptor antagonists in diseases of aging. Drugs Aging 18: 717–724.
   PubMed Web of Science ®Google Scholar
• Letendre SL, Lanier ER, McCutchan JA (1999). Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1. J Infect Dis 180: 310–319.
   PubMed Web of Science ®Google Scholar
• Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998). Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A 95: 14500–14505.
   PubMed Web of Science ®Google Scholar
• Ohagen A, Ghosh S, He J, Huang K, Chen Y, Yuan M, Osathanondh R, Gartner S, Shi B, Shaw G, Gabuzda D (1999). Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope. J Virol 73: 897–906.
   PubMed Web of Science ®Google Scholar
• Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA (2002). Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A 99: 3974–3979.
   PubMedGoogle Scholar
• Power C, Gill MJ, Johnson RT (2002). Progress in clinical neurosciences: the neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy. Can J Neurol Sci 29: 19–32.
   PubMed Web of Science ®Google Scholar
• Reisberg B, Doody R, Stoffler A, Schmitt F, Ferris S, Mobius HJ (2003). Memantine in moderate-to-severe Alzheimer’s disease. N Engl J Med 348: 1333–1341.
   PubMed Web of Science ®Google Scholar
• Sardar AM, Hutson PH, Reynolds GP (1999). Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS. Neuroreport 10: 3513–3515.
   Google Scholar
• Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M (1999). Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284: 1845–1848.
   PubMed Web of Science ®Google Scholar
• Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L (1994). Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367: 188–193.
   PubMed Web of Science ®Google Scholar
• Zheng J, Ghorpade A, Niemann D, Cotter RL, Thylin MR, Epstein L, Swartz JM, Shepard RB, Liu X, Nukuna A, Gendelman HE (1999). Lymphotropic virions affect chemokine receptor-mediated neural signaling apoptosis: implications for human immunodeficiency virus type 1-associated dementia. J Virol 73: 8256–8267.
   PubMed Web of Science ®Google Scholar